Frances Meredith, PhD

Recognitions

• Travel Award, Association for Research in Otolaryngology (2015)
• Publication Funding Award, University of Colorado Denver Health Sciences Library (2015)
• Poster Presentation Award, NASA Human Research Program Investigators' Workshop (2014)
• Poster Presentation Award, University of Colorado Denver, School of Medicine (2011)

Research Interests

Dr. Meredith’s research focuses on understanding the roles that ion channels play in vestibular functioning. She uses patch clamp electrophysiology to record from vestibular hair cells and the primary afferent neurons that contact them. Studies include identification of regional and developmental differences in calyceal potassium and sodium currents and action potential firing patterns. Current research focuses on the role of sodium channels at the type I hair cell and calyx synapse using immunohistochemistry and patch clamp techniques.

Publications

• Meredith FL, Rennie KJ. Zonal variations in K currents in vestibular crista calyx terminals. J Neurophysiol. 2015 Jan 1;113(1):264-76. PubMed PMID: 25343781
• Meredith FL, Kirk ME, Rennie KJ. Kv1 channels and neural processing in vestibular calyx afferents. Front Syst Neurosci. 2015;9:85. PubMed PMID: 26082693
• Channeling your inner ear potassium: K(+) channels in vestibular hair cells. Meredith FL, Rennie KJ. Hear Res. 2016 Aug;338:40-51. doi: 10.1016/j.heares.2016.01.015. Review. PMID: 26836968
• Kirk ME, Meredith FL, Benke TA, Rennie KJ. AMPA receptor-mediated rapid EPSCs in vestibular calyx afferents. J Neurophysiol. 2017 Jun 1;117(6):2312-2323. PubMed PMID: 28298303
• Meredith FL, Rennie KJ. Regional and Developmental Differences in Na( ) Currents in Vestibular Primary Afferent Neurons. Front Cell Neurosci. 2018;12:423. PubMed PMID: 30487736
• Meredith FL, Dockstader K, Arne A, Rennie KJ. Nav1.6 Channels Mediate Persistent and Resurgent Sodium Currents in Vestibular Calyx Afferent Terminals. J Vestibular Res 29(1):25-26, 2019.
• Meredith FL, Rennie KJ. Dopaminergic Inhibition of Na( ) Currents in Vestibular Inner Ear Afferents. Front Neurosci. 2021;15:710321. PubMed PMID: 34580582

Professional Memberships

• American Association for the Advancement of Science, Member
• Association for Research in Otolaryngology, Member
• Society for Neuroscience, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties

• Otolaryngology - Head & Neck Surgery