Associate Professor, Neurosurgery and Physiology & Biophysics
Vice-Chair for Research, Neurosurgery
Research Interests
Dr. Welle’s BIOElectrics Lab investigates how neurological medical devices interact with the nervous system. We dissect circuit-level structural and functional implications of neuromodulatory and brain-computer-interface devices using optogenetics, chronic electrophysiology and longitudinal in-vivo imaging in animal models. Our goal is to understand the dynamic interactions between devices and neural circuits in the context of translational neurotechnology.
Supekar OD, Sias A, Hansen SR, Martinez G, Peet GC, Peng X, Bright VM, Hughes EG, Restrepo D, Shepherd DP, Welle CG, Gopinath JT, Gibson EA. Miniature structured illumination microscope for in vivo 3D imaging of brain structures with optical sectioning. Biomed Opt Express. 2022 Apr 1;13(4):2530-2541. PubMed PMID: 35519247
Bowles S, Williamson WR, Nettles D, Hickman J, Welle CG. Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors. J Neural Eng. 2021 Aug 31;18(4). PubMed PMID: 34407518
Mughrabi IT, Hickman J, Jayaprakash N, Thompson D, Ahmed U, Papadoyannis ES, Chang YC, Abbas A, Datta-Chaudhuri T, Chang EH, Zanos TP, Lee SC, Froemke RC, Tracey KJ, Welle C, Al-Abed Y, Zanos S. Development and characterization of a chronic implant mouse model for vagus nerve stimulation. Elife. 2021 Apr 6;10. PubMed PMID: 33821789
Welle CG, Gao YR, Ye M, Lozzi A, Boretsky A, Abliz E, Hammer DX. Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation. Biomaterials. 2020 Jan 31;238:119831. [Epub ahead of print] PubMed PMID: 32045783
Bacmeister CM, Barr HJ, McClain CR, Thornton MA, Nettles D, Welle CG, Hughes EG. Motor learning promotes remyelination via new and surviving oligodendrocytes. Nat Neurosci. 2020 Jul;23(7):819-831. PubMed PMID: 32424285
Welle CG, Gao YR, Ye M, Lozzi A, Boretsky A, Abliz E, Hammer DX. Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation. Biomaterials. 2020 Apr;238:119831. PubMed PMID: 32045783
Ye M, Solarana K, Rafi H, Patel S, Nabili M, Liu Y, Huang S, Fisher JAN, Krauthamer V, Myers M, Welle C. Longitudinal Functional Assessment of Brain Injury Induced by High-Intensity Ultrasound Pulse Sequences. Sci Rep. 2019 Oct 29;9(1):15518. PubMed PMID: 31664091
Ereifej ES, Shell CE, Schofield JS, Charkhkar H, Cuberovic I, Dorval AD, Graczyk EL, Kozai TDY, Otto KJ, Tyler DJ, Welle CG, Widge AS, Zariffa J, Moritz CT, Bourbeau DJ, Marasco PD. Neural engineering: the process, applications, and its role in the future of medicine. J Neural Eng. 2019 Nov 12;16(6):063002. PubMed PMID: 31557730
Shafer B, Welle C, Vasudevan S. A rat model for assessing the long-term safety and performance of peripheral nerve electrode arrays. J Neurosci Methods. 2019 Dec 1;328:108437. PubMed PMID: 31526764
Wang J, Lin J, Chen Y, Welle CG, Pfefer TJ. Phantom-based evaluation of near-infrared intracranial hematoma detector performance. J Biomed Opt. 2019 Apr;24(4):1-10. PubMed PMID: 30989838
Jang H, Huang S, Hammer DX, Wang L, Rafi H, Ye M, Welle CG, Fisher JAN. Alterations in neurovascular coupling following acute traumatic brain injury. Neurophotonics. 2017 Oct;4(4):045007. PubMed PMID: 29296629
Welle CG, Contreras D. New Light on Gamma Oscillations. Neuron. 2017 Jan 18;93(2):247-249. PubMed PMID: 28103471
Vasudevan S, Patel K, Welle C. Rodent model for assessing the long term safety and performance of peripheral nerve recording electrodes. J Neural Eng. 2017 Feb;14(1):016008. PubMed PMID: 27934777
Fisher JA, Huang S, Ye M, Nabili M, Wilent WB, Krauthamer V, Myers MR, Welle CG. Real-Time Detection and Monitoring of Acute Brain Injury Utilizing Evoked Electroencephalographic Potentials. IEEE Trans Neural Syst Rehabil Eng. 2016 Sep;24(9):1003-1012. PubMed PMID: 26955039
Bowsher K, Civillico EF, Coburn J, Collinger J, Contreras-Vidal JL, Denison T, Donoghue J, French J, Getzoff N, Hochberg LR, Hoffmann M, Judy J, Kleitman N, Knaack G, Krauthamer V, Ludwig K, Moynahan M, Pancrazio JJ, Peckham PH, Pena C, Pinto V, Ryan T, Saha D, Scharen H, Shermer S, Skodacek K, Takmakov P, Tyler D, Vasudevan S, Wachrathit K, Weber D, Welle CG, Ye M. Brain-computer interface devices for patients with paralysis and amputation: a meeting report. J Neural Eng. 2016 Apr;13(2):023001. PubMed PMID: 26924826
Cogan SF, Ludwig KA, Welle CG, Takmakov P. Tissue damage thresholds during therapeutic electrical stimulation. J Neural Eng. 2016 Apr;13(2):021001. PubMed PMID: 26792176
Welle CG, Contreras D. Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry. J Neurophysiol. 2016 Apr;115(4):1821-35. PubMed PMID: 26719085