Lauren Fishbein, MD, PhD

Research Interests

My research interests are to understand what causes neuroendocrine tumors to form (pheochromocytomas, paragangliomas, gastrointestinal and pancreatic neuroendocrine tumors). I am particularly interested in studying the inherited and tumor specific genetic changes that lead to tumor formation. The long terms goals of my research are to identify markers to predict aggressive or metastatic disease which can ultimately be used to develop therapies for prevention and/or treatment of these tumors.

Publications

• Wachtel H, Kennedy EH, Zaheer S, Bartlett EK, Fishbein L, Roses RE, Fraker DL, Cohen DL. Preoperative Metyrosine Improves Cardiovascular Outcomes for Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma. Ann Surg Oncol. 2015 Dec;22 Suppl 3:646-54. PubMed PMID: 26374407
• Jean S, Li J, Katsaros D, Wubbenhorst B, Maxwell KN, Fishbein L, McLane MW, Benedetto C, Canuto EM, Mitra N, Zhang L, Nathanson KL, Tanyi JL. Paclitaxel is necessary for improved survival in epithelial ovarian cancers with homologous recombination gene mutations. Oncotarget. 2016 Jul 26;7(30):48577-48585. PubMed PMID: 27191893
• DeBrosse C, Nanga RP, Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Wade K, Nguyen S, Worsley D, Parris-Skeete C, McCormick E, Xiao R, Cunningham ZZ, Fishbein L, Nathanson KL, Lynch DR, Stallings VA, Yudkoff M, Falk MJ, Reddy R, McCormack SE. Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders. JCI Insight. 2016 Nov 3;1(18):e88207. PubMed PMID: 27812541
• Santen RJ, Joham A, Fishbein L, Vella KR, Ebeling PR, Gibson-Helm M, Teede H. Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers. J Clin Endocrinol Metab. 2016 Dec;101(12):4512-4520. PubMed PMID: 27691051
• Fishbein L. Pheochromocytoma and Paraganglioma: Genetics, Diagnosis, and Treatment. Hematol Oncol Clin North Am. 2016 Feb;30(1):135-50. PubMed PMID: 26614373
• Fishbein L, Leshchiner I, Walter V, Danilova L, Robertson AG, Johnson AR, Lichtenberg TM, Murray BA, Ghayee HK, Else T, Ling S, Jefferys SR, de Cubas AA, Wenz B, Korpershoek E, Amelio AL, Makowski L, Rathmell WK, Gimenez-Roqueplo AP, Giordano TJ, Asa SL, Tischler AS, Pacak K, Nathanson KL, Wilkerson MD. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma. Cancer Cell. 2017 Feb 13;31(2):181-193. PubMed PMID: 28162975
• Fishbein L, Ben-Maimon S, Keefe S, Cengel K, Pryma DA, Loaiza-Bonilla A, Fraker DL, Nathanson KL, Cohen DL. SDHB mutation carriers with malignant pheochromocytoma respond better to CVD. Endocr Relat Cancer. 2017 Aug;24(8):L51-L55. PubMed PMID: 28566531
• Santen RJ, Barrett EJ, Siragy HM, Farhi LS, Fishbein L, and Carey RM. The jewel in the crown: specific aims section of investigator-initiated grant proposals. Journal of the Endocrine Society. 2017; 1(9):1194-1202. doi:10.1210/js.2017-00318
• Fishbein L, Nathanson KL. Pheochromocytoma and Paraganglioma Susceptibility Genes: Estimating the Associated Risk of Disease. JAMA Oncol. 2017 Sep 1;3(9):1212-1213. PubMed PMID: 28384677
• Cohen DL and Fishbein L. Secondary hypertension: pheochromocytoma and paraganglioma in Hypertension: A companion to Braunwald’s Heart Disease, 3rd edition. Eds. George L. Bakris and Matthew Sorrentino. p. 136-143. Elsevier, Philadelphia, 2018. (online March 2017)
• Fishbein L. Pheochromocytomas and Paragangliomas: Genetics and Pathophysiology in Adrenal Disorders: Physiology, Pathophysiology and Treatment. Ed. Alice Levine. In press.
• Kiseljak-Vassiliades K, Zhang Y, Bagby SM, Kar A, Pozdeyev N, Xu M, Gowan K, Sharma V, Raeburn CD, Albuja-Cruz M, Jones KL, Fishbein L, Schweppe RE, Somerset H, Pitts TM, Leong S, Wierman ME. Development of new preclinical models to advance adrenocortical carcinoma research. Endocr Relat Cancer. 2018 Apr;25(4):437-451. PubMed PMID: 29371329
• Pozdeyev N, Gay LM, Sokol ES, Hartmaier R, Deaver KE, Davis S, French JD, Borre PV, LaBarbera DV, Tan AC, Schweppe RE, Fishbein L, Ross JS, Haugen BR, Bowles DW. Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers. Clin Cancer Res. 2018 Jul 1;24(13):3059-3068. PubMed PMID: 29615459
• Kiseljak-Vassiliades K, Zhang Y, Kar A, Razzaghi R, Xu M, Gowan K, Raeburn CD, Albuja-Cruz M, Jones KL, Somerset H, Fishbein L, Leong S, Wierman ME. Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma. Endocrinology. 2018 Jul 1;159(7):2532-2544. PubMed PMID: 29790920
• Fishbein L, Wilkerson MD. Chromaffin cell biology: inferences from The Cancer Genome Atlas. Cell Tissue Res. 2018 May;372(2):339-346. PubMed PMID: 29450724
• Else T, Fishbein L. Discovery of new susceptibility genes: proceed cautiously. Genet Med. 2018 Dec;20(12):1512-1514. PubMed PMID: 30100611
• Else T, Greenberg S, Fishbein L. Hereditary Paraganglioma-Pheochromocytoma Syndromes. 2008 May 21 [Updated 2018 Oct 4]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from http://www.ncbi.nlm.nih.gov/books/NBK1548/ PMID: 20301715.
• Fishbein L. Pheochromocytomas and Paragangliomas: Genetics and Pathophysiology in Adrenal Disorders: Physiology, Pathophysiology and Treatment. Ed. Alice C. Levine. p. 173-196. Humana Press. Springer International Publishing AG, Switzerland, 2018.
• Fishbein L and Else T. Disorders of the Adrenal Medulla in Pathophysiology of Disease: An Introduction to Clinical Medicine, Eighth Edition. Eds. Gary D. Hammer and Stephen J. McPhee. McGraw-Hill Education. New York, in press
• Saxon, D and Fishbein L. Pseudopheochromocytoma in Management of the Pseudo-Endocrine Patient. Ed. Michael T. McDermott. Springer, in press.
• Berends AMA, Eisenhofer G, Fishbein L, Horst-Schrivers ANAVD, Kema IP, Links TP, Lenders JWM, Kerstens MN. Intricacies of the Molecular Machinery of Catecholamine Biosynthesis and Secretion by Chromaffin Cells of the Normal Adrenal Medulla and in Pheochromocytoma and Paraganglioma. Cancers (Basel). 2019 Aug 6;11(8). PubMed PMID: 31390824
• Haag J, Hardie L, Berning A, Fishbein L, Corr BR. Case report of a paraganglioma arising from a mature cystic teratoma of the ovary. Gynecol Oncol Rep. 2020 May;32:100537. PubMed PMID: 32042879
• Fishbein L. Pheochromocytoma/Paraganglioma: Is This a Genetic Disorder?. Curr Cardiol Rep. 2019 Jul 31;21(9):104. PubMed PMID: 31367972
• Greenberg SE, Jacobs MF, Wachtel H, Anson A, Buchmann L, Cohen DL, Bonanni M, Bennett B, Naumer A, Schaefer AM, Kohlmann W, Nathanson KL, Else T, Fishbein L. Tumor detection rates in screening of individuals with SDHx-related hereditary paraganglioma-pheochromocytoma syndrome. Genet Med. 2020 Dec;22(12):2101-2107. PubMed PMID: 32741965
• Saxon D and Fishbein L. Pseudopheochromocytoma in Management of Patients with Pseudo-Endocrine Disorders. Ed. Michael T. McDermott. p. 193-201. Springer Nature Switzerland AG, 2019.
• Wachtel H, Hutchens T, Baraban E, Schwartz LE, Montone K, Baloch Z, LiVolsi V, Krumeich L, Fraker DL, Nathanson KL, Cohen DL, Fishbein L. Predicting Metastatic Potential in Pheochromocytoma and Paraganglioma: A Comparison of PASS and GAPP Scoring Systems. J Clin Endocrinol Metab. 2020 Dec 1;105(12). PubMed PMID: 32877928
• Bancos I, Atkinson E, Eng C, Young WF Jr, Neumann HPH. Maternal and fetal outcomes in phaeochromocytoma and pregnancy: a multicentre retrospective cohort study and systematic review of literature. Lancet Diabetes Endocrinol. 2021 Jan;9(1):13-21. PubMed PMID: 33248478
• Fishbein L and Else T. Disorders of the Adrenal Medulla in Pathophysiology of Disease: An Introduction to Clinical Medicine, Eighth Edition. Eds. Gary D. Hammer and Stephen J. McPhee. p. 355-368. McGraw-Hill Education, Lange. New York, 2019.
• Armaiz-Pena G, Flores SK, Cheng ZM, Zhang X, Esquivel E, Poullard N, Vaidyanathan A, Liu Q, Michalek J, Santillan-Gomez AA, Liss M, Ahmadi S, Katselnik D, Maldonado E, Salgado SA, Jimenez C, Fishbein L, Hamidi O, Else T, Lechan R, Tischler AS, Benn DE, Dwight T, Clifton-Bligh R, Sanso G, Barontini M, Vincent D, Aronin N, Biondi B, Koops M, Bowhay-Carnes E, Gimenez-Roqueplo AP, Alvarez-Eslava A, Bruder JM, Kitano M, Burnichon N, Ding Y, Dahia PLM. Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update. J Clin Endocrinol Metab. 2021 Jan 1;106(1):e350-e364. PubMed PMID: 33051659
• Waguespack SG and Fishbein L. Pheochromocytoma/Paraganglioma, Medullary Thyroid Carcinoma and Hereditary Endocrine Neoplasia Syndromes in Sperling’s Pediatric Endocrinology 5th Edition; Ed. Mark A. Sperling, in press.
• Halfdanarson TR, Strosberg JR, Tang L, Bellizzi AM, Bergsland EK, O'Dorisio TM, Halperin DM, Fishbein L, Eads J, Hope TA, Singh S, Salem R, Metz DC, Naraev BG, Reidy-Lagunes DL, Howe JR, Pommier RF, Menda Y, Chan JA. The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Pancreatic Neuroendocrine Tumors. Pancreas. 2020 Aug;49(7):863-881. PubMed PMID: 32675783
• Haag J, Hardie L, Berning A, Fishbein L and Corr, BR. Case report of a paraganglioma arising from a mature cystic teratoma of the ovary. Gynecologic Oncology Reports. 2019; Accepted for publication.
• Clay MR, Pinto EM, Fishbein L, Else T, Kiseljak-Vassiliades K. Pathological and Genetic Stratification for Management of Adrenocortical Carcinoma. J Clin Endocrinol Metab. 2021 Nov 30. [Epub ahead of print] PubMed PMID: 34850906
• Pozdeyev N, Fishbein L, Gay LM, Sokol ES, Hartmaier R, Ross JS, Darabi S, Demeure MJ, Kar A, Foust LJ, Koc K, Bowles DW, Leong S, Wierman ME, Kiseljak-Vassiliades K. Targeted genomic analysis of 364 adrenocortical carcinomas. Endocr Relat Cancer. 2021 Aug 16;28(10):671-681. PubMed PMID: 34410225
• Krumeich LN, Cucchiara AJ, Nathanson KL, Kelz RR, Fishbein L, Fraker DL, Roses RE, Cohen DL, Wachtel H. Correlation Between Plasma Catecholamines, Weight, and Diabetes in Pheochromocytoma and Paraganglioma. J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4028-e4038. PubMed PMID: 34089611
• Alzofon N, Koc K, Panwell K, Pozdeyev N, Marshall CB, Albuja-Cruz M, Raeburn CD, Nathanson KL, Cohen DL, Wierman ME, Kiseljak-Vassiliades K, Fishbein L. Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression. Mol Cancer Res. 2021 Sep;19(9):1476-1485. PubMed PMID: 33986121
• Fishbein L, Del Rivero J, Else T, Howe JR, Asa SL, Cohen DL, Dahia PLM, Fraker DL, Goodman KA, Hope TA, Kunz PL, Perez K, Perrier ND, Pryma DA, Ryder M, Sasson AR, Soulen MC, Jimenez C. The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma. Pancreas. 2021 Apr 1;50(4):469-493. PubMed PMID: 33939658
• Wachtel H, Fishbein L. Genetics of pheochromocytoma and paraganglioma. Curr Opin Endocrinol Diabetes Obes. 2021 Jun 1;28(3):283-290. PubMed PMID: 33764930
• Armaiz-Pena G, Flores SK, Cheng ZM, Zhang X, Esquivel E, Poullard N, Vaidyanathan A, Liu Q, Michalek J, Santillan-Gomez AA, Liss M, Ahmadi S, Katselnik D, Maldonado E, Salgado SA, Jimenez C, Fishbein L, Hamidi O, Else T, Lechan R, Tischler AS, Benn DE, Dwight T, Clifton-Bligh R, Sanso G, Barontini M, Vincent D, Aronin N, Biondi B, Koops M, Bowhay-Carnes E, Gimenez-Roqueplo AP, Alvarez-Eslava A, Bruder JM, Kitano M, Burnichon N, Ding Y, Dahia PLM. Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update. J Clin Endocrinol Metab. 2021 Jan 1;106(1):e350-e364. PubMed PMID: 33051659
• Meier KM, Meyers ML, Fishbein L, Maroni PD, Cost NG. Multifocal Paraganglioma in Teenager Presenting With Hypertension. Urology. 2022 Oct 22. [Epub ahead of print] PubMed PMID: 36283505
• Zethoven M, Martelotto L, Pattison A, Bowen B, Balachander S, Flynn A, Rossello FJ, Hogg A, Miller JA, Frysak Z, Grimmond S, Fishbein L, Tischler AS, Gill AJ, Hicks RJ, Dahia PLM, Clifton-Bligh R, Pacak K, Tothill RW. Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment. Nat Commun. 2022 Oct 21;13(1):6262. PubMed PMID: 36271074
• Yu K, Ebbehøj AL, Obeid H, Vaidya A, Else T, Wachtel H, Main AM, Søndergaard E, Lehmann Christensen L, Juhlin C, Calissendorff J, Cohen DL, Bennett B, Andersen MS, Larsson C, Almeida MQ, Fishbein L, Boorjian SA, Young WF, Bancos I. Presentation, Management, and Outcomes of Urinary Bladder Paraganglioma: Results From a Multicenter Study. J Clin Endocrinol Metab. 2022 Sep 28;107(10):2811-2821. PubMed PMID: 35882219
• Lin EP, Chin BB, Fishbein L, Moritani T, Montoya SP, Ellika S, Newlands S. Head and Neck Paragangliomas: An Update on the Molecular Classification, State-of-the-Art Imaging, and Management Recommendations. Radiol Imaging Cancer. 2022 May;4(3):e210088. PubMed PMID: 35549357
• Armstrong N, Storey CM, Noll SE, Margulis K, Soe MH, Xu H, Yeh B, Fishbein L, Kebebew E, Howitt BE, Zare RN, Sage J, Annes JP. SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. Cell Rep. 2022 Mar 1;38(9):110453. PubMed PMID: 35235785
• Colton MD, Tompkins K, O'Donnell E, Aisner D, Lieu CH, Konnick EQ, Fishbein L. Case of Metastatic Pheochromocytoma and Meningiomas in a Patient With Lynch Syndrome. JCO Precis Oncol. 2022 Jan;6:e2100251. PubMed PMID: 35025617
• Clay MR, Pinto EM, Fishbein L, Else T, Kiseljak-Vassiliades K. Pathological and Genetic Stratification for Management of Adrenocortical Carcinoma. J Clin Endocrinol Metab. 2022 Mar 24;107(4):1159-1169. PubMed PMID: 34850906
• Turn CG, Crenshaw M and Fishbein L. Pheochromocytoma and Paraganglioma: Germline Genetics and Hereditary Syndromes. Endocrine Oncology. 2022; 2(1):R65-77. DOI: 10.1530/EO-22-0044.
• Chatzikyriakou P, Brempou D, Quinn M, Fishbein L, Noberini R, Anastopoulos IN, Tufton N, Lim ES, Obholzer R, Hubbard JG, Moonim M, Bonaldi T, Nathanson KL, Izatt L, Oakey RJ. A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide. Clin Epigenetics. 2023 Dec 20;15(1):196. PubMed PMID: 38124114
• Fu R, Walters K, Kaufman ML, Koc K, Baldwin A, Clay MR, Basham KJ, Kiseljak-Vassiliades K, Fishbein L, Mukherjee N. In Situ Spatial Reconstruction of Distinct Normal and Pathological Cell Populations Within the Human Adrenal Gland. J Endocr Soc. 2023 Nov 2;7(12):bvad131. PubMed PMID: 37953901
• Else T, Greenberg S, Fishbein L. Hereditary Paraganglioma-Pheochromocytoma Syndromes. . 1993. PubMed PMID: 20301715
• Sharma S, Fishbein L. Diagnosis and Management of Pheochromocytomas and Paragangliomas: A Guide for the Clinician. Endocr Pract. 2023 Dec;29(12):999-1006. PubMed PMID: 37586639
• Del Rivero J, Mailman J, Rabow MW, Chan JA, Creed S, Kennecke HF, Pasieka J, Zuar J, Singh S, Fishbein L. Practical considerations when providing palliative care to patients with neuroendocrine tumors in the context of routine disease management or hospice care. Endocr Relat Cancer. 2023 Jul 1;30(7). PubMed PMID: 37017232
• Zethoven M, Martelotto L, Pattison A, Bowen B, Balachander S, Flynn A, Rossello FJ, Hogg A, Miller JA, Frysak Z, Grimmond S, Fishbein L, Tischler AS, Gill AJ, Hicks RJ, Dahia PLM, Clifton-Bligh R, Pacak K, Tothill RW. Author Correction: Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment. Nat Commun. 2023 Jan 9;14(1):123. PubMed PMID: 36624099
• Meier KM, Meyers ML, Fishbein L, Maroni PD, Cost NG. Multifocal Paraganglioma in Teenager Presenting With Hypertension. Urology. 2023 Feb;172:192-195. PubMed PMID: 36283505

Professional Memberships

• Endocrine Society, Member
• American Association of Clinical Endocrinologists (AACE), Member
• North American Neuroendocrine Tumor Society (NANETS), Member
• American Association for Cancer Research (AACR), Member
• Women in Endocrinology (WE), Member

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

UCHealth Diabetes and Endocrinology Clinic - Anschutz Medical Campus
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2650

Rocky Mountain Regional Veterans Administration Medical Center
1700 Wheeling St
Aurora, CO 80045
303-399-8020

Specialty Information

Specialties

• Internal Medicine, Board Certification
• Endocrinology, Diabetes and Metabolism, Board Certification

Conditions & Treatments

• Endocrine System (Hormones) - Endocrine Cancer (Parathyroid, Adrenal, Carcinoid)
• Endocrine System (Hormones) - Thyroid Cancer
• Endocrine System (Hormones) - Adrenal Diseases
• Brain and Nervous System - Pituitary Disorders
• Brain and Nervous System
• Endocrine System (Hormones)