Sunita Sharma, MD
Associate Professor, Medicine-Pulmonary Sciences & Critical Care

Publications

• Perez-Garcia J, Pino-Yanes M, Plender EG, Everman JL, Eng C, Jackson ND, Moore CM, Beckman KB, Medina V, Sharma S, Winnica DE, Holguin F, Rodríguez-Santana J, Villar J, Ziv E, Seibold MA, Burchard EG. Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells. Clin Epigenetics. 2023 Oct 3;15(1):156. PubMed PMID: 37784136
• Hudler AC, Díaz IRR, Sharma S, Holguin F. Gaps and Future Directions in Clinical Research on Obesity-Related Asthma. Pulm Ther. 2023 Sep;9(3):309-327. PubMed PMID: 37330948
• Althoff MD, Peterson R, McGrath M, Jin Y, Grasemann H, Sharma S, Federman A, Wisnivesky JP, Holguin F. Phenotypic characteristics of asthma and morbidity are associated with distinct longitudinal changes in L-arginine metabolism. BMJ Open Respir Res. 2023 Jun;10(1). PubMed PMID: 37270184
• Hudler A, Holguin F, Althoff M, Fuhlbrigge A, Sharma S. Pathophysiology and clinical evaluation of the patient with unexplained persistent dyspnea. Expert Rev Respir Med. 2022 Jan 20;:1-8. [Epub ahead of print] PubMed PMID: 35034521
• Liu C, Gaydos J, Johnson-Paben R, Kechris K, Burnham EL, Sharma S. Chronic Marijuana Use Is Associated with Gene Expression Changes in BAL. Am J Respir Cell Mol Biol. 2022 Feb;66(2):238-239. PubMed PMID: 35103554
• Lin NW, Liu C, Yang IV, Maier LA, DeMeo DL, Wood C, Ye S, Cruse MH, Smith VL, Vyhlidal CA, Kechris K, Sharma S. Sex-Specific Differences in MicroRNA Expression During Human Fetal Lung Development. Front Genet. 2022;13:762834. PubMed PMID: 35480332
• Althoff MD, Jimenez G, Peterson R, Jin Y, Grasemann H, Sharma S, Federman AD, Wisnivesky JP, Holguin F. Differences in L-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea. Respir Res. 2022 Sep 5;23(1):230. PubMed PMID: 36064404
• Hudler A, Holguin F, Sharma S. Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap. Immunol Allergy Clin North Am. 2022 Aug;42(3):521-532. PubMed PMID: 35965042
• Hudler A, Holguin F, Sharma S. Type 2 or Non-Type 2 Asthma Exacerbations? That Is the Question. Am J Respir Crit Care Med. 2022 Sep 1;206(5):521-522. PubMed PMID: 35584351
• Winnica DE, Monzon A, Ye S, Vladar EK, Saal M, Cooney R, Liu C, Sharma S, Holguin F. Airway epithelial Paraoxonase-2 in obese asthma. PLoS One. 2022;17(3):e0261504. PubMed PMID: 35286330
• Hudler A, Holguin F, Althoff M, Fuhlbrigge A, Sharma S. Pathophysiology and clinical evaluation of the patient with unexplained persistent dyspnea. Expert Rev Respir Med. 2022 May;16(5):511-518. PubMed PMID: 35034521
• Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 Feb;149(2):488-516.e9. PubMed PMID: 34848210
• Fuhlbrigge AL, Sharma S. Oral Corticosteroid Use in Asthma: A Wolf in Sheep's Clothing. J Allergy Clin Immunol Pract. 2021 Jan;9(1):347-348. PubMed PMID: 33429707
• Shaefi S, Brenner SK, Gupta S, O'Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE. Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19. Intensive Care Med. 2021 Feb;47(2):208-221. PubMed PMID: 33528595
• Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE. AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19. J Am Soc Nephrol. 2021 Jan;32(1):161-176. PubMed PMID: 33067383
• Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE. AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19. J Am Soc Nephrol. 2021 Jan;32(1):161-176. PubMed PMID: 33067383
• Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2021 Jan 1;181(1):41-51. PubMed PMID: 33080002
• Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, Hayek SS, Berlin H, Kapoor R, Shaefi S, Melamed ML, Sutherland A, Radbel J, Green A, Garibaldi BT, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Goyal N, Chan L, Mathews KS, Hedayati SS, Dy R, Toth-Manikowski SM, Zhang J, Mallappallil M, Redfern RE, Bansal AD, Short SAP, Vangel MG, Admon AJ, Semler MW, Bauer KA, Hernán MA, Leaf DE. Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19. Ann Intern Med. 2021 May;174(5):622-632. PubMed PMID: 33493012
• Althoff MD, Ghincea A, Wood LG, Holguin F, Sharma S. Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD. J Allergy Clin Immunol Pract. 2021 Nov;9(11):3877-3884. PubMed PMID: 34506967
• Charokopos A, Braman SS, Brown SAW, Mhango G, de-Torres JP, Zulueta JJ, Sharma S, Holguin F, Sigel KM, Powell CA, Federman AD, Wisnivesky JP. Lung Cancer Risk among Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap. Ann Am Thorac Soc. 2021 Nov;18(11):1894-1900. PubMed PMID: 34019783
• Kho AT, Sordillo J, Wu AC, Cho MH, Sharma S, Tiwari A, Lasky-Su J, Weiss ST, Tantisira KG, McGeachie MJ. CASTER: Cross-Sectional Asthma STEroid Response Measurement. J Pers Med. 2020 Aug 20;10(3). PubMed PMID: 32825299
• Sharma S, Khurana S, Federman AD, Wisnivesky J, Holguin F. Asthma-Chronic Obstructive Pulmonary Disease Overlap. Immunol Allergy Clin North Am. 2020 Nov;40(4):565-573. PubMed PMID: 33012320
• Broadhurst R, Peterson R, Wisnivesky JP, Federman A, Zimmer SM, Sharma S, Wechsler M, Holguin F. Asthma in COVID-19 Hospitalizations: An Overestimated Risk Factor?. Ann Am Thorac Soc. 2020 Dec;17(12):1645-1648. PubMed PMID: 32864985
• Reihman AE, Holguin F, Sharma S. Management of Severe Asthma Beyond the Guidelines. Curr Allergy Asthma Rep. 2020 Jun 16;20(9):47. PubMed PMID: 32548649
• Sharma S, Kho AT, Chhabra D, Haley K, Vyhlidal C, Gaedigk R, Leeder JS, Tantisira KG, Raby B, Weiss ST. Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk. Healthcare (Basel). 2020 Dec 4;8(4). PubMed PMID: 33291534
• Hayek SS, Brenner SK, Azam TU, Shadid HR, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O'Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan DM, Bansal A, Mallappallil M, Melamed ML, Shehata AM, Sunderram J, Mathews KS, Sutherland AK, Nallamothu BK, Leaf DE. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. BMJ. 2020 Sep 30;371:m3513. PubMed PMID: 32998872
• Gupta S, Hayek SS, Wang W, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Sutherland A, Green A, Shehata AM, Goyal N, Vijayan A, Velez JCQ, Shaefi S, Parikh CR, Arunthamakun J, Athavale AM, Friedman AN, Short SAP, Kibbelaar ZA, Abu Omar S, Admon AJ, Donnelly JP, Gershengorn HB, Hernán MA, Semler MW, Leaf DE. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Intern Med. 2020 Jul 15. [Epub ahead of print] PubMed PMID: 32667668
• Holguin F, Grasemann H, Sharma S, Winnica D, Wasil K, Smith V, Cruse MH, Perez N, Coleman E, Scialla TJ, Que LG. L-Citrulline increases nitric oxide and improves control in obese asthmatics. JCI Insight. 2019 Dec 19;4(24). PubMed PMID: 31714895
• Sharma S, Holguin F. IFN-stimulated Genes and Non-Type 2 Inflammation. New Pathway or Red Herring?. Am J Respir Crit Care Med. 2018 Feb 1;197(3):277-278. PubMed PMID: 29120663
• Trivedi MK, Sharma S, Rifas-Shiman SL, Camargo CA Jr, Weiss ST, Oken E, Gillman MW, Gold DR, DeMeo DL, Litonjua AA. Folic Acid in Pregnancy and Childhood Asthma: A US Cohort. Clin Pediatr (Phila). 2018 Apr;57(4):421-427. PubMed PMID: 28884603
• Sharma S, Holguin F. IFN-stimulated Genes and Non-Type 2 Inflammation. New Pathway or Red Herring?. Am J Respir Crit Care Med. 2018 Feb 1;197(3):277-278. PubMed PMID: 29120663
• Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 Mar;56(3):332-341. PubMed PMID: 27854507
• Trivedi MK, Sharma S, Rifas-Shiman SL, Camargo CA Jr, Weiss ST, Oken E, Gillman MW, Gold DR, DeMeo DL, Litonjua AA. Folic Acid in Pregnancy and Childhood Asthma: A US Cohort. Clin Pediatr (Phila). 2017 Sep 1;:9922817729482. [Epub ahead of print] PubMed PMID: 28884603
• Sharma S. The Epigenetics of Intrauterine Smoke Exposure: Can Maternal Vitamin C Supplementation Prevent Neonatal Respiratory Disease?. Am J Respir Crit Care Med. 2017 Sep 15;196(6):672-674. PubMed PMID: 28504906
• Sharma S. Integrative Genomics of Emphysema-Associated Genes: Are We Closer to Identifying the Genetic Determinants of Lung Function?. Am J Respir Cell Mol Biol. 2017 Oct;57(4):377-378. PubMed PMID: 28960108
• Hardin M, Cho MH, Sharma SS, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo J, Beaty TH, Laird N, Silverman EK, DeMeo DL. Sex-based Genetic Association Study Identifies CELSR1 as a Possible COPD Risk Locus Among Women. Am J Respir Cell Mol Biol. 2016 Nov 17. [Epub ahead of print] PubMed PMID: 27854507
• McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1465-1474. PubMed PMID: 27367781
• Kho AT, Sharma S, Davis JS, Spina J, Howard D, McEnroy K, Moore K, Sylvia J, Qiu W, Weiss ST, Tantisira KG. Circulating MicroRNAs: Association with Lung Function in Asthma. PLoS One. 2016 Jun 30;11(6):e0157998. PubMed PMID: 27362794
• McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Weiss ST, Strunk RC. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12;374(19):1842-52. PubMed PMID: 27168434
• Kho AT, Chhabra D, Sharma S, Qiu W, Carey VJ, Gaedigk R, Vyhlidal CA, Leeder JS, Tantisira KG, Weiss ST. Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome. Am J Respir Cell Mol Biol. 2016 Jun;54(6):814-21. PubMed PMID: 26584061
• Sharma S, Kho AT, Chhabra D, Qiu W, Gaedigk R, Vyhlidal CA, Leeder JS, Barraza-Villarreal A, London SJ, Gilliland F, Raby BA, Weiss ST, Tantisira KG. Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response. Am J Respir Cell Mol Biol. 2015 May;52(5):543-53. PubMed PMID: 25192440
• Kho AT, Chhabra D, Sharma S, Qiu W, Carey VJ, Gaedigk R, Vyhlidal CA, Leeder JS, Tantisira KG, Weiss ST. Age, Sexual Dimorphism and Disease Associations in the Developing Human Fetal Lung Transcriptome. Am J Respir Cell Mol Biol. 2015 Nov 19. [Epub ahead of print] PubMed PMID: 26584061
• Haas DM, Lai D, Sharma S, Then J, Kho A, Flockhart DA, Tantisira K, Foroud T. Steroid Pathway Genes and Neonatal Respiratory Distress After Betamethasone Use in Anticipated Preterm Birth. Reprod Sci. 2015 Oct 27. [Epub ahead of print] PubMed PMID: 26507871