Ethan Hughes, PhD

Publications

• Della-Flora Nunes G, Osso LA, Haynes JA, Conant L, Thornton MA, Stockton ME, Brassell KA, Morris A, Mancha Corchado YI, Gaynes JA, Chavez AR, Woerner MB, MacKenna DA, Alavi A, Danks A, Poleg-Polsky A, Gandhi R, Vivian JA, Denman DJ, Hughes EG. Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function. Nat Commun. 2025 Jan 16;16(1):732. PubMed PMID: 39820244
• Nunes GD, Osso LA, Haynes JA, Morris A, Conant L, Stockton ME, Thornton MA, Vivian JA, Gandhi R, Denman DJ, Hughes EG. Incomplete remyelination via endogenous or therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function. bioRxiv. 2024 Feb 22. PubMed PMID: 39411163
• Osso LA, Hughes EG. Dynamics of mature myelin. Nat Neurosci. 2024 Aug;27(8):1449-1461. PubMed PMID: 38773349
• Huang R, Carter ER, Hughes EG, Welle CG. Paired vagus nerve stimulation drives precise remyelination and motor recovery after myelin loss. bioRxiv. 2024 May 12. PubMed PMID: 38766201
• Thornton MA, Futia GL, Stockton ME, Budoff SA, Ramirez AN, Ozbay B, Tzang O, Kilborn K, Poleg-Polsky A, Restrepo D, Gibson EA, Hughes EG. Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis. Nat Neurosci. 2024 May;27(5):846-861. PubMed PMID: 38539013
• Hill RA, Nishiyama A, Hughes EG. Features, Fates, and Functions of Oligodendrocyte Precursor Cells. Cold Spring Harb Perspect Biol. 2024 Mar 1;16(3). PubMed PMID: 38052500
• Poleg S, Li BZ, Sergison M, Ridenour M, Hughes EG, Tollin D, Klug A. Age-related myelin deficits in the auditory brain stem contribute to cocktail-party deficits. bioRxiv. 2024 Nov 18. PubMed PMID: 39211072
• Hill RA, Nishiyama A, Hughes EG. Features, Fates, and Functions of Oligodendrocyte Precursor Cells. Cold Spring Harb Perspect Biol. 2023 Dec 5. [Epub ahead of print] PubMed PMID: 38052500
• Thornton MA, Futia GL, Stockton ME, Budoff SA, Ramirez AN, Ozbay B, Tzang O, Kilborn K, Poleg-Polsky A, Restrepo D, Gibson EA, Hughes EG. Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis. bioRxiv. 2023 Nov 1. PubMed PMID: 37961298
• Owens GP, Fellin TJ, Matschulat A, Salas V, Schaller KL, Given KS, Ritchie AM, Navarro A, Blauth K, Hughes EG, Macklin WB, Bennett JL. Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains. J Clin Invest. 2023 Oct 2;133(19). PubMed PMID: 37561592
• Bacmeister CM, Huang R, Osso LA, Thornton MA, Conant L, Chavez AR, Poleg-Polsky A, Hughes EG. Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons. Nat Neurosci. 2022 Oct;25(10):1300-1313. PubMed PMID: 36180791
• Supekar OD, Sias A, Hansen SR, Martinez G, Peet GC, Peng X, Bright VM, Hughes EG, Restrepo D, Shepherd DP, Welle CG, Gopinath JT, Gibson EA. Miniature structured illumination microscope for in vivo 3D imaging of brain structures with optical sectioning. Biomed Opt Express. 2022 Apr 1;13(4):2530-2541. PubMed PMID: 35519247
• Thornton MA, Futia GL, Stockton ME, Ozbay BN, Kilborn K, Restrepo D, Gibson EA, Hughes EG. Characterization of red fluorescent reporters for dual-color in vivo three-photon microscopy. Neurophotonics. 2022 Jul;9(3):031912. PubMed PMID: 35496497
• Hughes EG, Stockton ME. Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration. Front Cell Dev Biol. 2021;9:714169. PubMed PMID: 34368163
• Majewska AK, Verkhratsky A, Hughes EG. Special issue editorial: Glial plasticity in health and disease. Eur J Neurosci. 2021 Sep;54(5):5643-5648. PubMed PMID: 34363271
• Bacmeister CM, Huang R, Thornton MA, Conant L, Chavez AR, Poleg-Polsky A, Hughes EG (2021) Motor Learning Drives Dynamic Patterns of Intermittent Myelination on Behaviorally-Activated Axons. bioRxiv 464319; doi: https://doi.org/10.1101/2021.10.13.46431.
• Thornton MA, Futia GL, Stockton ME, Ozbay BN, Kilborn K, Restrepo D, Gibson EA#, Hughes EG#. (2021) Characterization of red fluorescent reporters for dual-color in vivo three-photon microscopy. bioRxiv 464840; doi: doi.org/10.1101/2021.10.18.464840.
• Thornton MA, Hughes EG. Neuron-oligodendroglia interactions: Activity-dependent regulation of cellular signaling. Neurosci Lett. 2020 May 14;727:134916. PubMed PMID: 32194135
• Bacmeister CM, Barr HJ, McClain CR, Thornton MA, Nettles D, Welle CG, Hughes EG. Motor learning promotes remyelination via new and surviving oligodendrocytes. Nat Neurosci. 2020 Jul;23(7):819-831. PubMed PMID: 32424285
• Bacmeister CM*, Barr HJ*, McClain CR*, Nettles D, Thornton MA, Welle CG, Hughes EG. (2019) Motor Learning Promotes Remyelination via New and Surviving Oligodendrocytes.
• Thornton, MA, Hughes, EG. Neuron-Oligodendroglia Interactions: Activity-Dependent Regulation of Cellular Signaling.
• Ozbay BN, Futia GL, Ma M, Bright VM, Gopinath JT, Hughes EG, Restrepo D, Gibson EA. Three dimensional two-photon brain imaging in freely moving mice using a miniature fiber coupled microscope with active axial-scanning. Sci Rep. 2018 May 25;8(1):8108. PubMed PMID: 29802371
• Hughes EG, Orthmann-Murphy JL, Langseth AJ, Bergles DE. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci. 2018 May;21(5):696-706. PubMed PMID: 29556025
• Benichoux V, Ferber A, Hunt S, Hughes E, Tollin D. Across Species "Natural Ablation" Reveals the Brainstem Source of a Noninvasive Biomarker of Binaural Hearing. J Neurosci. 2018 Oct 3;38(40):8563-8573. PubMed PMID: 30126974
• Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci. 2017 Sep 13;37(37):9037-9053. PubMed PMID: 28821643
• Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 8;93(3):587-605.e7. PubMed PMID: 28132831
• Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 8;93(3):587-605.e7. PubMed PMID: 28132831
• Hughes EG, Appel B. The cell biology of CNS myelination. Curr Opin Neurobiol. 2016 Aug;39:93-100. PubMed PMID: 27152449
• Osso LA, Hughes EG. Dynamics of pre-existing myelin: linking turnover, remodeling, and neural function. In press at Nature Neuroscience

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties

• Psychology