Hui Zhang, MD, PhD
Instructor, Pediatrics-Critical Care Medicine

Publications

• Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L58-L68. PubMed PMID: 35608266
• Combined inhibition of Histone Deacetylases and Bromodomain Proteins normalizes persistent activation of pulmonary hypertensive adventitial fibroblasts
• ATAC-Seq Reveals That Genes Involved In The Persistently Activated Phenotype of PH Fibroblasts Exhibit Open Enhancers and Promoters That Are Enriched In Binding Sites For Several Transcription Factors
• SIRT3 Regulates Mitochondrial Function of Adventitial Fibroblasts in Pulmonary Hypertension
• Plasma-Derived Small Extracellular Vesicles from Hypoxic Calves Drive Pro-Inflammatory and Metabolic Reprogramming in Macrophages
• Hypoxia, Cytokines, and Growth Factors Exhibit Distinct and Synergistic Roles in Transforming Normal Pulmonary Fibroblasts intoPersistently Activated Fibroblasts
• Applegate TJ, Krafsur GM, Boon JA, Zhang H, Li M, Holt TN, Ambler SK, Abrams BA, Gustafson DL, Bartels K, Garry FB, Stenmark KR, Brown RD. Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension. Front Physiol. 2021;12:712583. PubMed PMID: 34552503
• Kumar S, Frid MG, Zhang H, Li M, Riddle S, Brown RD, Yadav SC, Roy MK, Dzieciatkowska ME, D'Alessandro A, Hansen KC, Stenmark KR. Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages. JCI Insight. 2021 Nov 8;6(21). PubMed PMID: 34499621
• Stenmark KR, Frid MG, Gerasimovskaya E, Zhang H, McCarthy MK, Thurman JM, Morrison TE. Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement. Pulm Circ. 2021 Apr-Jun;11(2):20458940211015799. PubMed PMID: 34046161
• Zhang H, Laux A, Stenmark KR, Hu CJ. Mechanisms Contributing to the Dysregulation of miRNA-124 in Pulmonary Hypertension. Int J Mol Sci. 2021 Apr 8;22(8). PubMed PMID: 33917769
• Li M, Riddle S, Kumar S, Poczobutt J, McKeon BA, Frid MG, Ostaff M, Reisz JA, Nemkov T, Fini MA, Laux A, Hu CJ, El Kasmi KC, D'Alessandro A, Brown RD, Zhang H, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol. 2021;12:640718. PubMed PMID: 33868271
• Hui Zhang, Christine Vohwinkel, Aline Maddux, and Kurt R. Stenmark. Disease of Pulmonary Circulation. Pediatric Critical Care, 6th Edition. ISBN: 9780323672696. ELSEVIER 2021, pp 608-624.
• Hui Zhang, R. Dale Brown, Jason Williams, Cassidy Delaney and Kurt R. Stenmark. Hypoxic remodeling of neonatal pulmonary artery and myocardium. Hypoxic Respiratory Failure in the Newborn, 1st Edition. ISBN 9780367493998. 2021.
• Hui Zhang, Aya Laux, Kurt R. Stenmark, and Cheng-Jun Hu. Mechanisms Contributing to the Dysregulation of miRNA-124 in Pulmonary Hypertension. Am J Respir Crit Care Med 2021;201:A3664.
• Min Li, Aya Laux, Hui Zhang, Cheng-Jun Hu, Kurt R. Stenmark. C-Terminal Binding Protein-1 Regulates Adventitial Fibroblast Metabolic and Mitochondrial Reprogramming in Pulmonary Hypertension Through Sirtuins. Am J Respir Crit Care Med 2021;201:A3635.
• Cheng Jun Hu, Aya Laux, Liyi Wang, Hui Zhang ,Maria G Frid, Li Min, Suzette Riddle, Kurt R. Stenmark. Induction and maintenance of the activated phenotype of fibroblasts from hypoxia-induced pulmonary hypertensive calves depend on transcription factors activated by growth factors and cytokines, but not directly by hypoxia inducible factors. Am J Respir Crit Care Med 2021;201:A3633.
• Zhang H, Brown RD, Stenmark KR, Hu CJ. RNA-Binding Proteins in Pulmonary Hypertension. Int J Mol Sci. 2020 May 26;21(11). PubMed PMID: 32466553
• Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L773-L786. PubMed PMID: 32159369
• Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 Jan 15;201(2):224-239. PubMed PMID: 31545648
• Epigenetic-targeted Therapies in Pulmonary Hypertension: Combined inhibition of Histone Deacetylases and Bromodomain Proteins Normalizes the Persistent Activation of Pulmonary Vascular Adventitial Fibroblasts in Vitro
• Chromatin Structure Alterations in Genes Involved in The Persistently Activated Phenotype of PH Vascular Cells
• C-Terminal Binding Protein-1 Regulates Adventitial Fibroblast Metabolic and Mitochondrial Reprogramming in Pulmonary Hypertension Through Sirtuins
• Fibroblast-secreted exosomal complement protein promotes macrophage polarization towards a pro-inflammatory phenotype
• Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Frid MG, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 Sep 12. [Epub ahead of print] PubMed PMID: 31515405
• Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension. J Physiol. 2019 Feb;597(4):1103-1119. PubMed PMID: 29920674
• Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-Driven Complement Activation Regulates Pro-Inflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2019 Sep 23. [Epub ahead of print] PubMed PMID: 31545648
• Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 Dec;54(6). PubMed PMID: 31515405
• Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension. J Physiol. 2019 Feb;597(4):1103-1119. PubMed PMID: 29920674
• D'Alessandro A, El Kasmi KC, Plecitá-Hlavatá L, Ježek P, Li M, Zhang H, Gupte SA, Stenmark KR. Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming. Antioxid Redox Signal. 2018 Jan 20;28(3):230-250. PubMed PMID: 28637353
• Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension. J Physiol. 2018 Jun 19. [Epub ahead of print] PubMed PMID: 29920674
• D'Alessandro A, El Kasmi KC, Plecitá-Hlavatá L, Ježek P, Li M, Zhang H, Gupte SA, Stenmark KR. Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming. Antioxid Redox Signal. 2018 Jan 20;28(3):230-250. PubMed PMID: 28637353
• Plecitá-Hlavatá L, D'alessandro A, El Kasmi K, Li M, Zhang H, Ježek P, Stenmark KR. Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension. Adv Exp Med Biol. 2017;967:241-260. PubMed PMID: 29047090
• Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19;136(25):2451-2467. PubMed PMID: 28971999
• Plecitá-Hlavatá L, D'alessandro A, El Kasmi K, Li M, Zhang H, Ježek P, Stenmark KR. Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension. Adv Exp Med Biol. 2017;967:241-260. PubMed PMID: 29047090
• Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017 Dec 19;136(25):2468-2485. PubMed PMID: 28972001
• Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19;136(25):2451-2467. PubMed PMID: 28971999
• Diseases of the Pulmonary Circulation
• Hypoxic remodeling of neonatal pulmonary artery and myocardium