T. Rajendra Kumar, PhD

Publications

• Fshb iCre mice are efficient and specific Cre deleters for the gonadotrope lineage. Mol Cell Endocrinol. 419:124-138.
• A human FSHB transgene encoding the double N-glycosylation mutant FSHb fails to rescue Fshb null mice. Molecular Cellular Endocrinology 426: 113-124.
• Evaluation of In vivo bioactivities of recombinant hypo-and fully-glycosylated human FSH glycoforms in Fshb null mice. Molecular and Cellular Endocrinology 437: 224-236.
• Mouse Models for the Study of Synthesis, Secretion, and Action of Pituitary Gonadotropins. Prog Mol Biol Transl Sci. 2016;143:49-84.
• Progress in Molecular Biology and Translational Science Volume 143, 2016, Pages 49–84 Gonadotropins: from Bench Side to Bedside
• Kumar TR (2017) The SO(H)L(H) “O” drivers of oocyte growth and survival but not meiosis I, Commentary, Journal of Clinical Investigation, 127: 2044-2047.
• MacLean PS, Santoro N and Rothman M and Kumar TR, (2017), Invited Tri-Point Review Article, Endocrine News, August Issue, pages: 35-39.
• Kumar TR, Guest Editor (2017), Special Issue on Innovations in Reproductive Sciences, Seminars in Reproductive Medicine, Thieme Press, New York., pp 117-199.
• Kumar TR (2017) Innovations in Reproductive Sciences, Editorial Preface to the Special Issue, Seminars in Reproductive Medicine, 35: 119.
• Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin A, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F< Lu P, Zhou Y, Zhu L-L, Oberlin DJ, Davies TF. Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ and Zaidi M, (2017). Blocking FSH Induces Thermogenic Adipose Tissue and Reduces Body Fat. Nature, 546: 107-112.
• Panneerdoss S, Suryavathi V, Timilsina S, Abdelfattah N, Onyeagucha BC, Mohammad TA, Chen Y, Drake M, Vuori K, Kumar TR and Rao MK (2017). Androgen regulates phagocytosis of apoptotic germ cells via miR471-5p-Doc1-Rac1 GTPase signaling pathway and autophagy component proteins. Nature Communications, 8, Article number: 598, 1-14.
• Jayaraman A and Kumar TR (2017). Extra-pituitary expressed FSH: is it physiologically important? Biology of Reproduction, 97: 622-626.
• Kumar TR. An interview with Dr Kenneth S. Korach. Biol Reprod. 2018 Oct 1;99(4):681-683. PubMed PMID: 30371770
• Kumar TR. An interview with Professor Irving Boime. Biol Reprod. 2018 Oct 1;99(4):678-680. PubMed PMID: 30371769
• Kumar TR. An interview with Professor Martin Matzuk. Biol Reprod. 2018 Sep 1;99(3):473-475. PubMed PMID: 30219907
• Roy S, Gandra D, Seger C, Biswas A, Kushnir VA, Gleicher N, Kumar TR, Sen A. Oocyte-Derived Factors (GDF9 and BMP15) and FSH Regulate AMH Expression Via Modulation of H3K27AC in Granulosa Cells. Endocrinology. 2018 Sep 1;159(9):3433-3445. PubMed PMID: 30060157
• Bousfield GR, May JV, Davis JS, Dias JA, Kumar TR. In Vivo and In Vitro Impact of Carbohydrate Variation on Human Follicle-Stimulating Hormone Function. Front Endocrinol (Lausanne). 2018;9:216. PubMed PMID: 29867757
• Kumar TR. Fshb Knockout Mouse Model, Two Decades Later and Into the Future. Endocrinology. 2018 May 1;159(5):1941-1949. PubMed PMID: 29579177
• Kumar TR. An interview with Professor Bert O' Malley. Biol Reprod. 2018 Aug 1;99(2):269-270. PubMed PMID: 29462460
• Das N, Kumar TR. Molecular regulation of follicle-stimulating hormone synthesis, secretion and action. J Mol Endocrinol. 2018 Apr;60(3):R131-R155. PubMed PMID: 29437880
• Reusch JEB, Kumar TR, Regensteiner JG, Zeitler PS. Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span. Endocrinology. 2018 Jan 1;159(1):9-19. PubMed PMID: 29300998
• Kumar TR. Extragonadal Actions of FSH: A Critical Need for Novel Genetic Models. Endocrinology. 2018 Jan 1;159(1):2-8. PubMed PMID: 29236987
• Gilbert SB, Roof AK, Rajendra Kumar T. Mouse models for the analysis of gonadotropin secretion and action. Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):219-239. PubMed PMID: 29779578
• Simon LE, Liu Z, Bousfield G, Kumar TR, Duncan FE. Recombinant FSH glycoforms are bioactive in mouse preantral ovarian follicles. Reproduction. 2019 Oct 1. [Epub ahead of print] PubMed PMID: 31600726
• Kumar TR. An interview with Dr Blanche Capel. Biol Reprod. 2019 Apr 1;100(4):865-868. PubMed PMID: 30801633
• McDonald R, Sadler C, Kumar TR. Gain-of-Function Genetic Models to Study FSH Action. Front Endocrinol (Lausanne). 2019;10:28. PubMed PMID: 30792692
• Kumar TR. An interview with Dr Richard Behringer. Biol Reprod. 2019 Jan 1;100(1):8-10. PubMed PMID: 30657894
• An Interview with Dr. John Eppig
• An Interview with JoAnn Richards
• Gera S, Sant D, Haider S, Korkmaz F, Kuo TC, Mathew M, Perez-Pena H, Xie H, Chen H, Batista R, Ma K, Cheng Z, Hadelia E, Robinson C, Macdonald A, Miyashita S, Williams A, Jebian G, Miyashita H, Gumerova A, Ievleva K, Smith P, He J, Ryu V, DeMambro V, Quinn MA, Meseck M, Kim SM, Kumar TR, Iqbal J, New MI, Lizneva D, Rosen CJ, Hsueh AJ, Yuen T, Zaidi M. First-in-class humanized FSH blocking antibody targets bone and fat. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28971-28979. PubMed PMID: 33127753
• Jordan KR, Sikora MJ, Slansky JE, Minic A, Richer JK, Moroney MR, Hu J, Wolsky RJ, Watson ZL, Yamamoto TM, Costello JC, Clauset A, Behbakht K, Kumar TR, Bitler BG. The Capacity of the Ovarian Cancer Tumor Microenvironment to Integrate Inflammation Signaling Conveys a Shorter Disease-free Interval. Clin Cancer Res. 2020 Dec 1;26(23):6362-6373. PubMed PMID: 32928797
• Kumar TR, Reusch JEB, Kohrt WM, Regensteiner JG. Sex Differences Across the Lifespan: A Focus on Cardiometabolism. J Womens Health (Larchmt). 2020 Jul;29(7):899-909. PubMed PMID: 32423340
• Simon LE, Kumar TR, Duncan FE. In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables†. Biol Reprod. 2020 Aug 21;103(3):455-470. PubMed PMID: 32406908
• Ongaro L, Schang G, Zhou Z, Kumar TR, Treier M, Deng CX, Boehm U, Bernard DJ. Human Follicle-Stimulating Hormone ß Subunit Expression Depends on FOXL2 and SMAD4. Endocrinology. 2020 May 1;161(5). PubMed PMID: 32191302
• An Interview with Dr. JoAnne S. Richards, Biology of Reproduction, 102:1-4.
• An Interview with Professor Ilpo Huhtaniemi, Biology of Reproduction Biology of Reproduction 103: 909-911.
• Narasimhan S, Clemente EG, Vyas NV and Kumar TR (2020) Luteinizing hormone and Follicle -Stimulating Hormone Secretion in the Fetus and Newborn Infant, In: Fetal and Neonatal Physiology (6th Edition), Volume 2: Chapter 142, Editors: Polin RA, Abman SH, Rowitch DH, Benitz WE and Fox WW, Elsevier, New York, (In Press).
• Liu Z, Wang, H, Larsen M, Gunewardan S, Cendali FI, Reisz JR, Akiyama H, Behringer RR and Kumar TR. The Solute Carrier Family 7 Member 11 (SLC7A11) is regulated by LH/androgen and required for cystine/glutathione homeostasis in mouse Sertoli cells. (Submitted to Mol Cell Endocrinology, In Review)
• Gilbert SB, Liu Z, Sadler C, Johnson R, Carlson N, Polotsky A and Kumar TR. The effects of a high fat and high sugar diet on FSH secretion and ovarian responses in transgenic mice. (To be submitted to Endocrinology)
• Liu Z, Larson M and Kumar TR. Sertoli cell-specific deletion of Fshr results in reduced testis size and normal male fertility. (To be submitted to J Biological Chemistry)
• Narasimhan S, Clemente EG, Vyas NV and Kumar TR (2021) Luteinizing hormone and Follicle -Stimulating Hormone Secretion in the Fetus and Newborn Infant, In: Fetal and Neonatal Physiology (6th Edition), Volume 2: Chapter 142, pp: 1520-1531, Editors: Polin RA, Abman SH, Rowitch DH, Benitz WE and Fox WW, Elsevier, New York.
• Liu Z, Larsen M, Lei Z, Rao CV, Kumar TR. Lhb(-/-)Lhr(-/-) Double Mutant Mice Phenocopy Lhb(-/-) or Lhr(-/-) Single Mutants and Display Defects in Leydig Cells and Steroidogenesis. Int J Mol Sci. 2022 Dec 11;23(24). PubMed PMID: 36555365
• Kumar TR. Rerouting of follicle-stimulating hormone secretion and gonadal function. Fertil Steril. 2022 Dec 7. [Epub ahead of print] PubMed PMID: 36496082
• Liu Z, Wang H, Larsen M, Gunewardana S, Cendali FI, Reisz JA, Akiyama H, Behringer RR, Ma Q, Hammoud SS, Kumar TR. The solute carrier family 7 member 11 (SLC7A11) is regulated by LH/androgen and required for cystine/glutathione homeostasis in mouse Sertoli cells. Mol Cell Endocrinol. 2022 Jun 1;549:111641. PubMed PMID: 35398053
• Morgan I, Coulombe JC, Larsen M, Liu Z, Ferguson VL and Kumar TR (2022) VISIONS:FSH and bone microarchitecture, Molecular Reproduction and Development, 89: 315-315.
• An Interview with Dr. Gregory S Kopf. Biology of Reproduction (In press)
• An Interview with Dr. Francesco J DeMayo. Biology of Reproduction (In Press)
• Converse A, Liu Z, Patel JC, Shakyawar S, Guda C, Bousfield GR, Kumar TR*, Duncan FE*. Oocyte quality is enhanced by hypoglycosylated FSH through increased cell-to-cell interaction during mouse follicle development. Development. 2023 Nov 15;150(22). PubMed PMID: 37870089; * Corresponding Authors
• Safar AM, Santacruz-Márquez R, Laws MJ, Meling DD, Liu Z, Kumar TR, Nowak RA, Raetzman LT, Flaws JA. Dietary exposure to an environmentally relevant phthalate mixture alters follicle dynamics, hormone levels, ovarian gene expression, and pituitary gene expression in female mice. Reprod Toxicol. 2023 Dec;122:108489. PubMed PMID: 37839492
• Kumar TR. An interview with Dr David Albertini. Biol Reprod. 2023 Oct 13;109(4):381-385. PubMed PMID: 37738136
• McDonald R, Larsen M, Liu Z, Southekal S, Eudy J, Guda C, Kumar TR. RNA-seq analysis identifies age-dependent changes in expression of mRNAs - encoding N-glycosylation pathway enzymes in mouse gonadotropes. Mol Cell Endocrinol. 2023 Aug 20;574:111971. PubMed PMID: 37301504
• Luu TH, Kuhn K, Bradford AP, Wempe MF, Wittenburg L, Johnson RL, Carlson NE, Kumar TR, Polotsky AJ. Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity. Fertil Steril. 2023 Oct;120(4):890-898. PubMed PMID: 37276947
• Wang H, Liu Z, Larsen M, Hastings R, Gunewardena S, Kumar TR. Identification of follicle-stimulating hormone-responsive genes in Sertoli cells during early postnatal mouse testis development. Andrology. 2023 Jul;11(5):860-871. PubMed PMID: 37208854
• Kumar TR. An interview with Dr. Vasantha Padmanabhan. Biol Reprod. 2023 Jun 9;108(6):850-853. PubMed PMID: 37186133
• Kumar TR. Rerouting of follicle-stimulating hormone secretion and gonadal function. Fertil Steril. 2023 Feb;119(2):180-183. PubMed PMID: 36496082