Johannes Von Alvensleben, MD

Professional Titles

• Pediatric Electrophysiologist
• Pediatric Cardiologist
• Director of Electrophysiology
• Director of Adult Congenital Arrhythmia Program

Recognitions

• Pediatric Cardiology Fellows Teaching Award, Children's Hospital Colorado (2016)
• Patient-Family Experience Excellence in Patient Care Award, Children's Hospital Colorado (2017)
• Patient-Family Experience Excellence in Patient Care Award, Children's Hospital Colorado (2018)
• Patient-Family Experience Excellence in Patient Care Award, Children's Hospital Colorado (2019)
• Patient-Family Experience Excellence in Patient Care Award, Children's Hospital Colorado (2021)
• Patient-Family Experience Excellence in Patient Care Award, Children's Hospital Colorado (2022)

Publications

• Dalal A, Czosek RJ, Kovach J, von Alvensleben JC, Valdes S, Etheridge SP, Ackerman MJ, Auld D, Huckaby J, McCracken C, Campbell R. Clinical Presentation of Pediatric Patients at Risk for Sudden Cardiac Arrest. J Pediatr. 2016 Oct;177:191-6. PubMed PMID: 27502104
• von Alvensleben JC, LaPage MJ, Caruthers R, Bradley DJ. Nadolol for Treatment of Supraventricular Tachycardia in Infants and Young Children. Pediatr Cardiol. 2016 Dec 19. [Epub ahead of print] PubMed PMID: 27995288
• Cuneo BF, Mitchell MB, Marwan AI, Green M, von Alvensleben JC, Reynolds R, Crombleholme TM, Galan HL. Ex utero Intrapartum Treatment to Ventricular Pacing: A Novel Delivery Strategy for Complete Atrioventricular Block with Severe Bradycardia. Fetal Diagn Ther. 2017 Jun 3. [Epub ahead of print] PubMed PMID: 28578350
• von Alvensleben JC, Schaffer M, Brateng C, Collins KK. Atrial undersensing secondary to quiet timer blanking in pediatric and congenital heart disease patients. Pacing Clin Electrophysiol. 2017 Jul;40(7):843-849. PubMed PMID: 28436549
• von Alvensleben JC, LaPage MJ, Caruthers R, Bradley DJ. Nadolol for Treatment of Supraventricular Tachycardia in Infants and Young Children. Pediatr Cardiol. 2017 Mar;38(3):525-530. PubMed PMID: 27995288
• Moore JP, Shannon KM, Gallotti RG, McLeod CJ, Chiriac A, Walsh EP, Sreeram N, Patel AR, De Groot NM, von Alvensleben J, Balaji S, Frankel DS, Miyake CY, Perry JC, Shivkumar K. Catheter Ablation of Ventricular Arrhythmia for Ebstein's Anomaly in Unoperated and Post-Surgical Patients. JACC Clin Electrophysiol. 2018 Oct;4(10):1300-1307. PubMed PMID: 30336876
• Schäfer M, Collins KK, Browne LP, Ivy DD, Abman S, Friesen R, Frank B, Fonseca B, DiMaria M, Hunter KS, Truong U, von Alvensleben JC. Effect of electrical dyssynchrony on left and right ventricular mechanics in children with pulmonary arterial hypertension. J Heart Lung Transplant. 2018 Jul;37(7):870-878. PubMed PMID: 29496397
• Campbell M, Moore JP, Sreeram N, von Alvensleben JC, Shah A, Batra A, Law I, Sanatani S, Thomas V, Nik-Ahd F, Williams S, Nosavan N, Maldonado J, Hart A, Nguyen T, Balaji S. Predictors of electrocardiographic screening failure for the subcutaneous implantable cardioverter-defibrillator in children: A prospective multicenter study. Heart Rhythm. 2018 May;15(5):703-707. PubMed PMID: 29309839
• von Alvensleben JC, Collins KK. Leadless Pacemakers in Pediatric Patients: Is Less Actually More?. J Innov Card Rhythm Manag. 2020 Oct;11(10):4263-4264. PubMed PMID: 33125005
• von Alvensleben JC. Syncope and Palpitations: A Review. Pediatr Clin North Am. 2020 Oct;67(5):801-810. PubMed PMID: 32888682
• McIntosh A, Benson DW, von Alvensleben JC, Collins KK, Gilbert L, Cuneo BF. Home monitoring detects fetal supraventricular tachyarrhythmia recurrence during dose reduction of antiarrhythmic therapy. Ultrasound Obstet Gynecol. 2020 Aug 16. [Epub ahead of print] PubMed PMID: 32830393
• Schäfer M, Bjornstad P, Frank BS, Baumgartner A, Truong U, Enge D, von Alvensleben JC, Mitchell MB, Ivy DD, Barker AJ, Reusch JEB, Nadeau KJ. Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). Am J Cardiol. 2020 Aug 1;128:45-53. PubMed PMID: 32650923
• Knight LM, Miller E, Kovach J, Arscott P, von Alvensleben JC, Bradley D, Valdes SO, Ware SM, Meyers L, Travers CD, Campbell RM, Etheridge SP. Genetic testing and cascade screening in pediatric long QT syndrome and hypertrophic cardiomyopathy. Heart Rhythm. 2020 Jan;17(1):106-112. PubMed PMID: 31229680
• Frank BS, Schäfer M, Douwes JM, Ivy DD, Abman SH, Davidson JA, Burzlaff S, Mitchell MB, Morgan GJ, Browne LP, Barker AJ, Truong U, von Alvensleben JC. Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H401-H412. PubMed PMID: 31858817
• Turan O, Marshall T, Runciman M, Schaffer M, von Alvensleben J, Collins KK. Assessment of paediatric exertional or peri-exertional syncope: does the story matter?. Cardiol Young. 2023 Jan 6;:1-6. [Epub ahead of print] PubMed PMID: 36606400
• Stone ML, Schäfer M, von Alvensleben JC, Frank BS, Campbell DN, Mitchell MB, Jaggers J. Left Ventricular Dysfunction Following the Ross-Konno Reconstruction is Independent of the Operation. Pediatr Cardiol. 2022 Nov 12. [Epub ahead of print] PubMed PMID: 36370189
• Bou Sleiman M, Roy S, Gao AW, Sadler MC, von Alvensleben GVG, Li H, Sen S, Harrison DE, Nelson JF, Strong R, Miller RA, Kutalik Z, Williams RW, Auwerx J. Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Science. 2022 Sep 30;377(6614):eabo3191. PubMed PMID: 36173858
• von Alvensleben JC, Sandhu A, Chang S, Runciman DM, Wehrmann M, Tzou DW, Schäfer M, Collins KK. High-density electroanatomic mapping with grid catheter in pediatrics and congenital heart disease. J Interv Card Electrophysiol. 2022 Sep 15. [Epub ahead of print] PubMed PMID: 36104612
• Schäfer M, Frank BS, Ivy DD, Mitchell MB, Collins KK, Jone PN, von Alvensleben JC. Repolarization Dispersion Is Associated With Diastolic Electromechanical Discoordination in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2022 Mar 15;11(6):e024787. PubMed PMID: 35229614
• von Alvensleben JC, Collins KK. The Year in Pediatric Electrophysiology: 2021. J Innov Card Rhythm Manag. 2022 Jan;13(1):4825-4828. PubMed PMID: 35127234
• Stone ML, Schäfer M, DiMaria MV, von Alvensleben JC, Campbell DN, Jaggers J, Mitchell MB. Diastolic inflow is associated with inefficient ventricular flow dynamics in Fontan patients. J Thorac Cardiovasc Surg. 2022 Mar;163(3):1195-1207. PubMed PMID: 34429192
• Li H, Perino A, Huang Q, Von Alvensleben GVG, Banaei-Esfahani A, Velazquez-Villegas LA, Gariani K, Korbelius M, Bou Sleiman M, Imbach J, Sun Y, Li X, Bachmann A, Goeminne LJE, Gallart-Ayala H, Williams EG, Ivanisevic J, Auwerx J, Schoonjans K. Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis. Cell Metab. 2022 Oct 4;34(10):1594-1610.e4. PubMed PMID: 36099916
• Heath-Freudenthal A, Toledo-Jaldin L, von Alvensleben I, Lazo-Vega L, Mizutani R, Stalker M, Yasini H, Mendizabal F, Dorado Madera J, Mundo W, Castro-Monrroy M, Houck JA, Moreno-Aramayo A, Miranda-Garrido V, Su EJ, Giussani DA, Abman SH, Moore LG, Julian CG. Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations. Hypertension. 2022 Jun;79(6):1286-1296. PubMed PMID: 35437031
• Kohli U, von Alvensleben J, Srinivasan C. Subcutaneous Implantable Cardioverter Defibrillators in Pediatrics and Congenital Heart Disease. Card Electrophysiol Clin. 2023 Dec;15(4S):e1-e16. PubMed PMID: 38030336
• Schäfer M, Mitchell MB, Frank BS, Barker AJ, Stone ML, Jaggers J, von Alvensleben JC, Hunter KS, Friesen RM, Ivy DD, Jacobsen R, Di Maria MV. Myocardial strain-curve deformation patterns after Fontan operation. Sci Rep. 2023 Jul 24;13(1):11912. PubMed PMID: 37488167
• Turan O, Marshall T, Runciman M, Schaffer M, von Alvensleben J, Collins KK. Assessment of paediatric exertional or peri-exertional syncope: does the story matter?. Cardiol Young. 2023 Nov;33(11):2190-2195. PubMed PMID: 36606400
• Sandhu A, Holman B, Lammers S, Cerbin L, Barrett C, Sabzwari R, Garg L, Zipse MM, Tumolo AZ, Aleong RG, Von Alvensleben J, Rosenberg M, West JJ, Varosy P, Nguyen DT, Sauer WH, Tzou WS. Evaluating temperature gradients across the posterior left atrium with radiofrequency ablation. J Cardiovasc Electrophysiol. 2023 Apr;34(4):880-887. PubMed PMID: 36682068
• Stone ML, Schäfer M, von Alvensleben JC, Frank BS, Campbell DN, Mitchell MB, Jaggers J. Left Ventricular Dysfunction Following the Ross-Konno Reconstruction is Independent of the Operation. Pediatr Cardiol. 2023 Feb;44(2):463-471. PubMed PMID: 36370189
• Cerbin L, Sandhu A, Rosenberg M, Barrett C, Sabzwari R, Garg L, Tumolo A, Tzou W, Varosy P, Von Alvensleben J, Zipse M, Aleong R. Ventricular stimulation in patients with myotonic dystrophy type 1 may not predict future ventricular arrhythmias. Heart Rhythm O2. 2024 Oct;5(10):698-704. PubMed PMID: 39524047
• Nash D, von Alvensleben JC, Zipse M. Rapid Return to Play After Extravascular Implantable Cardioverter-Defibrillator Implantation in a Competitive Runner. JACC Case Rep. 2024 Sep 4;29(17):102490. PubMed PMID: 39359522
• Moore JP, Aboulhosn JA, Zeppenfeld K, Waldmann V, Bessière F, Blom NA, Combes N, Fish FA, McLeod CJ, Kanter RJ, Tan W, Patel N, von Alvensleben JC, Kamp A, Lloyd MS, Anderson CC, Tan RB, Mariucci E, Levi DS, Salem M, Shivkumar K, Khairy P. Rationale and Design of the Multicenter Catheter Ablation of Ventricular Tachycardia Before Transcatheter Pulmonary Valve Replacement in Repaired Tetralogy of Fallot Study. Am J Cardiol. 2023 Oct 1;204:14-21. PubMed PMID: 37536198
• Schäfer M, Miyamoto SD, Jaggers J, Everitt MD, von Alvensleben JC, Campbell DN, Mitchell MB, Stone ML. Non-invasive myocardial tissue deformation and discoordination indices predict cardiac allograft vasculopathy in pediatric heart transplantation patients. Int J Cardiovasc Imaging. 2024 Jul;40(7):1565-1574. PubMed PMID: 38780709
• Ricceri S, Barrett C, Sandhu A, von Alvensleben JC, Aleong R. Atrial isochronal late activation mapping keeps the diaphragm alive. HeartRhythm Case Rep. 2024 Feb;10(2):142-145. PubMed PMID: 38404985
• Schäfer M, Mitchell MB, Brateng C, Ivy DD, Hunter KS, Nash DB, von Alvensleben JC. Extraction and Digitization of ECG Signals from Standard Clinical Portable Document Format Files for the Principal Component Analysis of T-wave Morphology. Cardiovasc Eng Technol. 2023 Oct;14(5):631-639. PubMed PMID: 37491551
• Jassal YR, Slomowitz R, Everitt MD, Christofferson ES, von Alvensleben JC, Di Maria M, Wolfe KR. A Preliminary Study of One Year Safety and Tolerability of Attention-Deficit/Hyperactivity Disorder Medications in Youth with Fontan Palliation or Heart Transplant. Pediatr Cardiol. 2023 Feb 21. [Epub ahead of print] PubMed PMID: 36809419
• Benegiamo G, von Alvensleben GVG, Rodríguez-López S, Goeminne LJE, Bachmann AM, Morel JD, Broeckx E, Ma JY, Carreira V, Youssef SA, Azhar N, Reilly DF, D'Aquino K, Mullican S, Bou-Sleiman M, Auwerx J. The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression. J Exp Med. 2023 Apr 3;220(4). PubMed PMID: 36787127
• Morel JD, Sleiman MB, Li TY, von Alvensleben G, Bachmann AM, Hofer D, Broeckx E, Ma JY, Carreira V, Chen T, Azhar N, Gonzalez-Villalobos RA, Breyer M, Reilly D, Mullican S, Auwerx J. Mitochondrial and NAD metabolism predict recovery from acute kidney injury in a diverse mouse population. JCI Insight. 2023 Feb 8;8(3). PubMed PMID: 36752209
• Kohli U, von Alvensleben J, Srinivasan C. Subcutaneous Implantable Cardioverter Defibrillators in Pediatrics and Congenital Heart Disease. Card Electrophysiol Clin. 2023 Dec;15(4S):e1-e16. PubMed PMID: 38030336
• Moore JP, Aboulhosn JA, Zeppenfeld K, Waldmann V, Bessière F, Blom NA, Combes N, Fish FA, McLeod CJ, Kanter RJ, Tan W, Patel N, von Alvensleben JC, Kamp A, Lloyd MS, Anderson CC, Tan RB, Mariucci E, Levi DS, Salem M, Shivkumar K, Khairy P. Rationale and Design of the Multicenter Catheter Ablation of Ventricular Tachycardia Before Transcatheter Pulmonary Valve Replacement in Repaired Tetralogy of Fallot Study. Am J Cardiol. 2023 Oct 1;204:14-21. PubMed PMID: 37536198
• Schäfer M, Mitchell MB, Brateng C, Ivy DD, Hunter KS, Nash DB, von Alvensleben JC. Extraction and Digitization of ECG Signals from Standard Clinical Portable Document Format Files for the Principal Component Analysis of T-wave Morphology. Cardiovasc Eng Technol. 2023 Oct;14(5):631-639. PubMed PMID: 37491551
• Schäfer M, Mitchell MB, Frank BS, Barker AJ, Stone ML, Jaggers J, von Alvensleben JC, Hunter KS, Friesen RM, Ivy DD, Jacobsen R, Di Maria MV. Myocardial strain-curve deformation patterns after Fontan operation. Sci Rep. 2023 Jul 24;13(1):11912. PubMed PMID: 37488167
• Jassal YR, Slomowitz R, Everitt MD, Christofferson ES, von Alvensleben JC, Di Maria M, Wolfe KR. A Preliminary Study of One Year Safety and Tolerability of Attention-Deficit/Hyperactivity Disorder Medications in Youth with Fontan Palliation or Heart Transplant. Pediatr Cardiol. 2024 Mar;45(3):673-680. PubMed PMID: 36809419
• Turan O, Marshall T, Runciman M, Schaffer M, von Alvensleben J, Collins KK. Assessment of paediatric exertional or peri-exertional syncope: does the story matter?. Cardiol Young. 2023 Nov;33(11):2190-2195. PubMed PMID: 36606400
• von Alvensleben JC, Sandhu A, Chang S, Runciman DM, Wehrmann M, Tzou DW, Schäfer M, Collins KK. High-density electroanatomic mapping with grid catheter in pediatrics and congenital heart disease. J Interv Card Electrophysiol. 2023 Apr;66(3):611-619. PubMed PMID: 36104612
• Stone ML, Schäfer M, von Alvensleben JC, Frank BS, Campbell DN, Mitchell MB, Jaggers J. Left Ventricular Dysfunction Following the Ross-Konno Reconstruction is Independent of the Operation. Pediatr Cardiol. 2023 Feb;44(2):463-471. PubMed PMID: 36370189
• Sandhu A, Holman B, Lammers S, Cerbin L, Barrett C, Sabzwari R, Garg L, Zipse MM, Tumolo AZ, Aleong RG, Von Alvensleben J, Rosenberg M, West JJ, Varosy P, Nguyen DT, Sauer WH, Tzou WS. Evaluating temperature gradients across the posterior left atrium with radiofrequency ablation. J Cardiovasc Electrophysiol. 2023 Apr;34(4):880-887. PubMed PMID: 36682068
• von Alvensleben JC, Runciman DM, Schaffer M, Burkett D, Jone PN, Collins KK. Use of adjunctive 3-dimensional echocardiogram for His bundle pacing in pediatric patients. HeartRhythm Case Rep. 2023 Mar;9(3):181-184. PubMed PMID: 36970387

Professional Memberships

• Heart Rhythm Society, Member
• Pediatric and Congenital Electrophysiology Society, Member

Practice Locations

• Children's Hospital Colorado
• University of Colorado Hospital

Specialty Information

• Pediatric Cardiology, Board Certification
• Pediatrics
• International Board of Heart Rhythm Examiners-Pediatric Electrophysiology, Board Certification (2015)

• Heart and Circulation - Adult Congenital Heart Disease
• Heart and Circulation
• Heart and Circulation - Congenital Heart Disease
• Heart and Circulation - Arrhythmia