Jason Aoto, PhD

Publications

• Stokes EG, Vasquez JJ, Azouz G, Nguyen M, Tierno A, Zhuang Y, Galinato VM, Hui M, Toledano M, Tyler I, Shi X, Hunt RF, Aoto J, Beier KT. Cationic peptides cause memory loss through endophilin-mediated endocytosis. Nature. 2025 Jan 15. [Epub ahead of print] PubMed PMID: 39814881
• Kareemo DJ, Winborn CS, Olah SS, Miller CN, Kim J, Kadgien CA, Actor-Engel HS, Ramsay HJ, Ramsey AM, Aoto J, Kennedy MJ. Genetically encoded intrabody probes for labeling and manipulating AMPA-type glutamate receptors. Nat Commun. 2024 Nov 29;15(1):10374. PubMed PMID: 39613728
• Stokes EG, Kim H, Ko J, Aoto J. A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3a Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses. J Neurosci. 2024 Oct 9;44(41). PubMed PMID: 39231636
• Tian G, Bartas K, Hui M, Chen L, Vasquez JJ, Azouz G, Derdeyn P, Manville RW, Ho EL, Fang AS, Li Y, Tyler I, Setola V, Aoto J, Abbott GW, Beier KT. Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity. Neuron. 2024 Oct 23;112(20):3470-3485.e12. PubMed PMID: 39153478
• Miller CN, Li Y, Beier KT, Aoto J. Acute stress causes sex-dependent changes to ventral subiculum synapses, circuitry, and anxiety-like behavior. bioRxiv. 2024 Aug 3. PubMed PMID: 39131353
• Boxer EE, Kim J, Dunn B, Aoto J. Ventral subiculum inputs to nucleus accumbens medial shell preferentially innervate D2R medium spiny neurons and contain calcium permeable AMPARs. J Neurosci. 2023 Jan 5. [Epub ahead of print] PubMed PMID: 36609456
• Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J, Beier KT. Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis. Res Sq. 2023 Nov 21. PubMed PMID: 38045269
• Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, Smith KR, Kennedy MJ. Acute reorganization of postsynaptic GABA(A) receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Rep. 2023 Nov 28;42(11):113331. PubMed PMID: 37910506
• Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep;621(7977):146-153. PubMed PMID: 37648853
• Lloyd BA, Han Y, Roth R, Zhang B, Aoto J. Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nat Commun. 2023 Aug 5;14(1):4706. PubMed PMID: 37543682
• Boxer EE, Kim J, Dunn B, Aoto J. Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs. J Neurosci. 2023 Feb 15;43(7):1166-1177. PubMed PMID: 36609456
• Boxer EE, Aoto J. Neurexins and their ligands at inhibitory synapses. Front Synaptic Neurosci. 2022;14:1087238. PubMed PMID: 36618530
• Boxer, E.B., Seng, C., Lukacsovich, D., Kim, J., Schwartz, S., Kennedy, M.J., Földy, C., Aoto, J. (2021). Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum. Cell Reports. 37, 110098. https://doi.org/10.1016/j.celrep.2021.110098.
• Mermer F, Poliquin S, Rigsby K, Rastogi A, Shen W, Romero-Morales A, Nwosu G, McGrath P, Demerast S, Aoto J, Bilousova G, Lal D, Gama V, Kang JQ. Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons. Brain. 2021 Sep 4;144(8):2499-2512. PubMed PMID: 34028503
• Cai Y, Nielsen BE, Boxer EE, Aoto J, Ford CP. Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron. 2021 Apr 7;109(7):1137-1149.e5. PubMed PMID: 33600762
• Restrepo S, Schwartz SL, Kennedy MJ, Aoto J. Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. J Vis Exp. 2020 May 22;(159). PubMed PMID: 32510501
• Restrepo S, Schwartz SL, Kennedy MJ, Aoto J. Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. J Vis Exp. 2020 May 22;(159). PubMed PMID: 32510501
• Restrepo, S., Langer, N.J., Nelson, K.A., and Aoto, J. (2019). Modeling a Neurexin-3a Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses. J. Neurosci. 39, 9065–9082. PMID: 31578233
• Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca(2 )-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 Oct 23;25(4):974-987.e4. PubMed PMID: 30355502
• Liu, Q. Sinnen, B.L., Boxer, E.B., Buchta, W.C., Gibson, E.S., Aoto, J., Tucker, C.L., Kennedy, M.J. A photoactivatable botulinum neurotoxin for conditional synapse silencing. Neuron (accepted). 2019
• Földy C, Darmanis S, Aoto J, Malenka RC, Quake SR, Südhof TC. Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5222-31. PubMed PMID: 27531958