Director, University of Colorado Hearing and Balance Clinics
Co-Director, University of Colorado Skull Base Program
Recognition & Awards
Denver Top Doc Award, 5280 Magazine
(2019)
Outstanding Teacher of the Year Award, University of Colorado, Department of Otolaryngology
(2017)
Faculty of the Year, University of Wisconsin Division of Otolaryngology
(2013)
Research Interests
My research interests are focused on cochlear implantation, temporal bone imaging and the development of novel approaches to better understand and treat hearing loss.
Teaching
Faculty
(2016)
School of Medicine,
Otolaryngology - Head and Neck Surgery
Research Training in Otolaryngology T32 Training Grant
University of Colorado 2016 to present
Publications
Kalmanson O, Takeda H, Anderson SR, Dondzillo A, Gubbels S. Nestin-expressing cells are mitotically active in the mammalian inner ear. Hear Res. 2024 Jan 23;443:108962. [Epub ahead of print] PubMed PMID: 38295585
Kalmanson OA, Talmage GD, Honce JM, Gubbels SP. Effect of Head Position and Magnetic Resonance Sequence on Cochlear Implant-Related Artifact Size and Internal Auditory Canal Visibility. Otol Neurotol. 2023 Feb 1;44(2):e73-e80. PubMed PMID: 36624593
Kalmanson OA, McLoughlin KC, Kiser TH, Gubbels SP. Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis. Ann Otol Rhinol Laryngol. 2023 Dec;132(12):1686-1689. PubMed PMID: 37243327
Kalmanson OA, Talmage GD, Honce JM, Gubbels SP. Effect of Head Position and Magnetic Resonance Sequence on Cochlear Implant-Related Artifact Size and Internal Auditory Canal Visibility. Otol Neurotol. 2023 Feb 1;44(2):e73-e80. PubMed PMID: 36624593
Boscoe EF, Banakis Hartl RM, Gubbels SP, Greene NT. Effects of Varying Laser Parameters During Laser Stapedotomy on Intracochlear Pressures. Otolaryngol Head Neck Surg. 2023 Mar;168(3):462-468. PubMed PMID: 35671134
Sobczak G, Marchant W, Misurelli S, Pyle GM, Gubbels S, Roche J. Efficacy of Cochlear Implantation in Neurofibromatosis Type 2 Related Hearing Loss. Ann Otol Rhinol Laryngol. 2023 Mar;132(3):284-293. PubMed PMID: 35450430
Boscoe EF, Banakis Hartl RM, Gubbels SP, Greene NT. Effects of Varying Laser Parameters During Laser Stapedotomy on Intracochlear Pressures. Otolaryngol Head Neck Surg. 2022 Jun 7;:1945998221104658. [Epub ahead of print] PubMed PMID: 35671134
Sobczak G, Marchant W, Misurelli S, Pyle GM, Gubbels S, Roche J. Efficacy of Cochlear Implantation in Neurofibromatosis Type 2 Related Hearing Loss. Ann Otol Rhinol Laryngol. 2022 Apr 21;:34894221091010. [Epub ahead of print] PubMed PMID: 35450430
Lee NK, Cass SP, Gubbels SP, Gomez HZ, Scholes MA, Jenkins HA, Santos-Cortez RLP. Novel candidate genes for cholesteatoma in chronic otitis media. Front Genet. 2022;13:1033965. PubMed PMID: 36699445
Lundberg EMH, Strong D, Anderson M, Kaizer AM, Gubbels S. Do Patients Benefit From a Cochlear Implant When They Qualify Only in the Presence of Background Noise?. Otol Neurotol. 2021 Feb 1;42(2):251-259. PubMed PMID: 33229878
Labib MA, Inoue M, Banakis Hartl RM, Cass S, Gubbels S, Lawton MT, Youssef AS. Impact of vestibular nerve preservation on facial and hearing outcomes in small vestibular schwannoma surgery: a technical feasibility study. Acta Neurochir (Wien). 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389124
Elling CL, Scholes MA, Streubel SO, Larson ED, Wine TM, Bootpetch TC, Yoon PJ, Kofonow JM, Gubbels SP, Cass SP, Robertson CE, Jenkins HA, Prager JD, Frank DN, Chan KH, Friedman NR, Ryan AF, Santos-Cortez RLP. The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. Front Cell Infect Microbiol. 2021;11:798246. PubMed PMID: 35096646
Martinez-Perez R, Kunigelis KE, Ward RC, Ung TH, Arnone GD, Cass SP, Gubbels SP, Youssef AS. Hydroxyapatite cement cranioplasty for reconstruction of translabyrinthine approach: aesthetic results, long-term satisfaction, quality of life, and complications. Acta Neurochir (Wien). 2021 Oct 13. [Epub ahead of print] PubMed PMID: 34642820
Takeda H, Dondzillo A, Randall JA, Gubbels SP. Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti. Stem Cell Res Ther. 2021 Jun 19;12(1):352. PubMed PMID: 34147129
Kalmanson OA, Aasen DM, Gubbels SP, Foster CA. Reversible Canalith Jam of the Horizontal Semicircular Canal Mimicking Cupulolithiasis. Ann Otol Rhinol Laryngol. 2021 Nov;130(11):1213-1219. PubMed PMID: 33813907
Dondzillo A, Takeda H, Gubbels SP. Sex difference in the efferent inner hair cell synapses of the aging murine cochlea. Hear Res. 2021 May;404:108215. PubMed PMID: 33677192
Labib MA, Inoue M, Banakis Hartl RM, Cass S, Gubbels S, Lawton MT, Youssef AS. Impact of vestibular nerve preservation on facial and hearing outcomes in small vestibular schwannoma surgery: a technical feasibility study. Acta Neurochir (Wien). 2021 Aug;163(8):2219-2224. PubMed PMID: 33389124
Lundberg EMH, Strong D, Anderson M, Kaizer AM, Gubbels S. Do Patients Benefit From a Cochlear Implant When They Qualify Only in the Presence of Background Noise?. Otol Neurotol. 2021 Feb 1;42(2):251-259. PubMed PMID: 33229878
Elling CL, Scholes MA, Streubel SO, Larson ED, Wine TM, Bootpetch TC, Yoon PJ, Kofonow JM, Gubbels SP, Cass SP, Robertson CE, Jenkins HA, Prager JD, Frank DN, Chan KH, Friedman NR, Ryan AF, Santos-Cortez RLP. The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. Front Cell Infect Microbiol. 2021;11:798246. PubMed PMID: 35096646
Hunt AA, Cass ND, Coughlin A, Gubbels SP. Time-based Assessment of Hearing Preservation Rates After Microsurgical Resection of Vestibular Schwannomas: A Systematic Review. Otol Neurotol. 2020 Jun;41(5):679-685. PubMed PMID: 32150025
Lee S, Dondzillo A, Gubbels SP, Raphael Y. Practical aspects of inner ear gene delivery for research and clinical applications. Hear Res. 2020 Sep 1;394:107934. PubMed PMID: 32204962
Cass ND, Schopper MA, Lubin JA, Fishbein L, Gubbels SP. The Changing Paradigm of Head and Neck Paragangliomas: What Every Otolaryngologist Needs to Know. Ann Otol Rhinol Laryngol. 2020 Nov;129(11):1135-1143. PubMed PMID: 32486832
Youssef AS, Arnone GD, Farell NF, Thompson JA, Ramakrishnan VR, Gubbels S, Cohen-Gadol AA, Cass S, Labib MA. The Combined Endoscopic Endonasal Far Medial and Open Postauricular Transtemporal Approaches As a Lesser Invasive Approach to the Jugular Foramen: Anatomic Morphometric Study With Case Illustration. Oper Neurosurg (Hagerstown). 2020 Sep 15;19(4):471-479. PubMed PMID: 32510567
Bootpetch TC, Hafrén L, Elling CL, Baschal EE, Manichaikul AW, Pine HS, Szeremeta W, Scholes MA, Cass SP, Larson ED, Chan KH, Ishaq R, Prager JD, Shaikh RS, Gubbels SP, Yousaf A, Wine TM, Bamshad MJ, Yoon PJ, Jenkins HA, Nickerson DA, Streubel SO, Friedman NR, Frank DN, Einarsdottir E, Kere J, Riazuddin S, Daly KA, Leal SM, Ryan AF, Mattila PS, Ahmed ZM, Sale MM, Chonmaitree T, Santos-Cortez RLP. Multi-omic studies on missense PLG variants in families with otitis media. Sci Rep. 2020 Sep 14;10(1):15035. PubMed PMID: 32929111
Baschal EE, Larson ED, Bootpetch Roberts TC, Pathak S, Frank G, Handley E, Dinwiddie J, Moloney M, Yoon PJ, Gubbels SP, Scholes MA, Cass SP, Jenkins HA, Frank DN, Yang IV, Schwartz DA, Ramakrishnan VR, Santos-Cortez RLP. Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses. Front Genet. 2019;10:1352. PubMed PMID: 32010199
Misch ES, Banakis Hartl RM, Gubbels SP, Greene NT. Risks of Intracochlear Pressures From Laser Stapedotomy. Otol Neurotol. 2019 Nov 7. [Epub ahead of print] PubMed PMID: 31746814
Cass ND, Honce JM, O'Dell AL, Gubbels SP. First MRI With New Cochlear Implant With Rotatable Internal Magnet System and Proposal for Standardization of Reporting Magnet-Related Artifact Size. Otol Neurotol. 2019 Aug;40(7):883-891. PubMed PMID: 31219967
Larson ED, Magno JPM, Steritz MJ, Llanes EGDV, Cardwell J, Pedro M, Roberts TB, Einarsdottir E, Rosanes RAQ, Greenlee C, Santos RAP, Yousaf A, Streubel SO, Santos ATR, Ruiz AG, Lagrana-Villagracia SM, Ray D, Yarza TKL, Scholes MA, Anderson CB, Acharya A, Gubbels SP, Bamshad MJ, Cass SP, Lee NR, Shaikh RS, Nickerson DA, Mohlke KL, Prager JD, Cruz TLG, Yoon PJ, Abes GT, Schwartz DA, Chan AL, Wine TM, Cutiongco-de la Paz EM, Friedman N, Kechris K, Kere J, Leal SM, Yang IV, Patel JA, Tantoco MLC, Riazuddin S, Chan KH, Mattila PS, Reyes-Quintos MRT, Ahmed ZM, Jenkins HA, Chonmaitree T, Hafrén L, Chiong CM, Santos-Cortez RLP. A2ML1 and otitis media: novel variants, differential expression, and relevant pathways. Hum Mutat. 2019 Aug;40(8):1156-1171. PubMed PMID: 31009165
Coughlin AR, Hunt AA, Gubbels SP. Is hearing preserved following radiotherapy for vestibular schwannoma?. Laryngoscope. 2019 Apr;129(4):775-776. PubMed PMID: 30284268
Baschal EE, Larson ED, Bootpetch Roberts TC, Pathak S, Frank G, Handley E, Dinwiddie J, Moloney M, Yoon PJ, Gubbels SP, Scholes MA, Cass SP, Jenkins HA, Frank DN, Yang IV, Schwartz DA, Ramakrishnan VR, Santos-Cortez RLP. Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses. Front Genet. 2019;10:1352. PubMed PMID: 32010199
Mowry SE, Woodson E, Gubbels S, Carfrae M, Hansen MR. A simple assessment tool for evaluation of cadaveric temporal bone dissection. Laryngoscope. 2018 Feb;128(2):451-455. PubMed PMID: 28425611
Kunigelis KE, Craig D, Yang A, Gubbels S, Youssef AS. Presigmoid Approach to Dumbbell Trigeminal Schwannoma. J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S391-S392. PubMed PMID: 30456036
Santos-Cortez RLP, Chiong CM, Frank DN, Ryan AF, Giese APJ, Bootpetch Roberts T, Daly KA, Steritz MJ, Szeremeta W, Pedro M, Pine H, Yarza TKL, Scholes MA, Llanes EGDV, Yousaf S, Friedman N, Tantoco MLC, Wine TM, Labra PJ, Benoit J, Ruiz AG, de la Cruz RAR, Greenlee C, Yousaf A, Cardwell J, Nonato RMA, Ray D, Ong KMC, So E, Robertson CE, Dinwiddie J, Lagrana-Villagracia SM, Gubbels SP, Shaikh RS, Cass SP, Einarsdottir E, Lee NR, Schwartz DA, Gloria-Cruz TLI, Bamshad MJ, Yang IV, Kere J, Abes GT, Prager JD, Riazuddin S, Chan AL, Yoon PJ, Nickerson DA, Cutiongco-de la Paz EM, Streubel SO, Reyes-Quintos MRT, Jenkins HA, Mattila P, Chan KH, Mohlke KL, Leal SM, Hafrén L, Chonmaitree T, Sale MM, Ahmed ZM. FUT2 Variants Confer Susceptibility to Familial Otitis Media. Am J Hum Genet. 2018 Nov 1;103(5):679-690. PubMed PMID: 30401457
Coughlin AR, Hunt AA, Gubbels SP. Is hearing preserved following radiotherapy for vestibular schwannoma?. Laryngoscope. 2018 Oct 3. [Epub ahead of print] PubMed PMID: 30284268
Maxwell AK, Takeda H, Gubbels SP. Primary Middle Ear Mucosal Melanoma: Case Report and Comprehensive Literature Review of 21 Cases of Primary Middle Ear and Eustachian Tube Melanoma. Ann Otol Rhinol Laryngol. 2018 Nov;127(11):856-863. PubMed PMID: 30103615
Takeda H, Dondzillo A, Randall JA, Gubbels SP. Challenges in Cell-Based Therapies for the Treatment of Hearing Loss. Trends Neurosci. 2018 Nov;41(11):823-837. PubMed PMID: 30033182
Cass ND, Gubbels SP, Portnuff CDF. Sudden Bilateral Hearing Loss, Tinnitus, and Vertigo as Presenting Symptoms of Chronic Myeloid Leukemia. Ann Otol Rhinol Laryngol. 2018 Oct;127(10):731-734. PubMed PMID: 30032641
Devare J, Gubbels S, Raphael Y. Outlook and future of inner ear therapy. Hear Res. 2018 Oct;368:127-135. PubMed PMID: 29804723
Coughlin AR, Willman TJ, Gubbels SP. Systematic Review of Hearing Preservation After Radiotherapy for Vestibular Schwannoma. Otol Neurotol. 2018 Mar;39(3):273-283. PubMed PMID: 29342035
Mowry SE, Woodson E, Gubbels S, Carfrae M, Hansen MR. A simple assessment tool for evaluation of cadaveric temporal bone dissection. Laryngoscope. 2018 Feb;128(2):451-455. PubMed PMID: 28425611
Otolaryngology - Head & Neck Surgery, Board Certification (2006)
Otology & Neurotology, Board Certification (2010)
Gamma Knife Radiosurgery Training - University of Pittsburgh, Certificate
(2017)
Diplomate - Neurotology, American Board of Otolaryngology, Certificate
(2010)
Diplomate - Otolaryngology, American Board of Otolaryngology, Certificate
(2006)
National Board of Medical Examiners, Parts I-III, Certificate
(1998)
Conditions & Treatments
Ear, Nose, and Throat (ENT) - Ear Infection
Ear, Nose, and Throat (ENT) - Eardrum Perforation
Ear, Nose, and Throat (ENT) - Facial Paralysis
Ear, Nose, and Throat (ENT) - Hearing Loss
Ear, Nose, and Throat (ENT) - Skull Base Tumors
Ear, Nose, and Throat (ENT) - Dizziness and Vertigo
Ear, Nose, and Throat (ENT)
Symptoms and Manifestations
Ear, Nose, and Throat (ENT) - Acoustic Neuromas
Ear, Nose, and Throat (ENT) - Cochlear Implants
Ear, Nose, and Throat (ENT) - Osseointegrated Devices
Ear, Nose, and Throat (ENT) - Tinnitus
Ear, Nose, and Throat (ENT) - Balance disorders
Ear, Nose, and Throat (ENT) - Cerebrospinal fluids leaks
Ear, Nose, and Throat (ENT) - Cholesteatoma
Ear, Nose, and Throat (ENT) - Chronic ear disease
Ear, Nose, and Throat (ENT) - Draining ear
Clinical Interests
I am interested in the medical and surgical management of diseases of the ear and skull base. I have particular interests cochlear implantation in children and adults, acoustic neuroma, otosclerosis, skull base tumors, facial nerve disorders, congenital ear disorders and the treatment of vertigo.
Care Philosophy
I feel fortunate to be able to help patients with otologic disease in clinic and, when needed, with surgery. I aim to provide patients with a thorough understanding of their disease and the options available for treatment. Doing so allows us then to work as a team in making health care decisions that will be best aligned with each patient's goals and beliefs.
Public Speaking Yes
Cochlear Implantation, Hearing Loss, Management of Otological and Neurotological Diseases, Regenerative Therapies for Hearing Loss, Facial Nerve Disorders and Acoustic Neuroma Management.
General Information
Medical Schools:
MD, University of Arizona College of Medicine
(2000)
Undergraduate Schools:
BA, University of Arizona (AZ)
(1995)
BS, University of Arizona (AZ)
(1995)
Internships:
Oregon Health & Science University
(2001)
Residency Programs:
Oregon Health & Science University, Otolaryngology - Head & Neck Surgery (2005)
Fellowships:
University of Iowa Hospitals and Clinics Program, Otology & Neurotology
(2008)