Samuel Gubbels, MD

Professional Titles

• Director, University of Colorado Hearing and Balance Clinics
• Co-Director, University of Colorado Skull Base Program

Recognitions

• Faculty of the Year, University of Wisconsin Division of Otolaryngology (2013)
  
• Outstanding Teacher of the Year Award, University of Colorado, Department of Otolaryngology (2017)
• Denver Top Doc Award, 5280 Magazine (2019)

Research Interests

My research interests are focused on cochlear implantation, temporal bone imaging and the development of novel approaches to better understand and treat hearing loss.

Publications

• Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2)/tdTomato-reporter mice. Chow CL, Guo W, Trivedi P, Zhao X, Gubbels SP. J Comp Neurol. 2015 Jul 1;523(10):1474-87. doi: 10.1002/cne.23747. Epub 2015 Mar 10. PMID: 25611038
• Gubbels SP, Gartrell BC, Ploch JL, Hanson KD. Can routine office-based audiometry predict cochlear implant evaluation results?. Laryngoscope. 2017 Jan;127(1):216-222. PubMed PMID: 27797418
• Britt CJ, Coughlin AR, Gubbels SP. Bone-anchored hearing aid and skin graft removal with subsequent cochlear implantation. Laryngoscope. 2016 Nov;126(11):2601-2604. PubMed PMID: 26864146
• Kennedy TA, Connell N, Szczykutowicz T, Schafer S, Royalty K, Nace S, Gartrell B, Gubbels S. Flat-Panel CT for Cochlear Implant Electrode Imaging: Comparison to Multi-Detector CT. Otol Neurotol. 2016 Dec;37(10):1646-1653. PubMed PMID: 27668790
• Chow CL, Trivedi P, Pyle MP, Matulle JT, Fettiplace R, Gubbels SP. Evaluation of Nestin Expression in the Developing and Adult Mouse Inner Ear. Stem Cells Dev. 2016 Oct 1;25(19):1419-32. PubMed PMID: 27474107
• Guide to Academic Research Career Development, Neely JG, Smith RJH, Graboyes E, Paniello R, Gubbels SP, Laryngoscope Investigative Otolaryngology, 2016; 1(1): 19-24.
• Banakis Hartl RM, Mattingly JK, Greene NT, Farrell NF, Gubbels SP, Tollin DJ. Drill-induced Cochlear Injury During Otologic Surgery: Intracochlear Pressure Evidence of Acoustic Trauma. Otol Neurotol. 2017 Aug;38(7):938-947. PubMed PMID: 28598950
• Mowry SE, Woodson E, Gubbels S, Carfrae M, Hansen MR. A simple assessment tool for evaluation of cadaveric temporal bone dissection. Laryngoscope. 2018 Feb;128(2):451-455. PubMed PMID: 28425611
• Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Steiner RW, Do BT, Voelker CC, Waguespack RW, Corrigan MD. Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update). Otolaryngol Head Neck Surg. 2017 Mar;156(3_suppl):S1-S47. PubMed PMID: 28248609
• Kunigelis KE, Craig D, Yang A, Gubbels S, Youssef AS. Presigmoid Approach to Dumbbell Trigeminal Schwannoma. J Neurol Surg B Skull Base. 2018 Dec;79(Suppl 5):S391-S392. PubMed PMID: 30456036
• Santos-Cortez RLP, Chiong CM, Frank DN, Ryan AF, Giese APJ, Bootpetch Roberts T, Daly KA, Steritz MJ, Szeremeta W, Pedro M, Pine H, Yarza TKL, Scholes MA, Llanes EGDV, Yousaf S, Friedman N, Tantoco MLC, Wine TM, Labra PJ, Benoit J, Ruiz AG, de la Cruz RAR, Greenlee C, Yousaf A, Cardwell J, Nonato RMA, Ray D, Ong KMC, So E, Robertson CE, Dinwiddie J, Lagrana-Villagracia SM, Gubbels SP, Shaikh RS, Cass SP, Einarsdottir E, Lee NR, Schwartz DA, Gloria-Cruz TLI, Bamshad MJ, Yang IV, Kere J, Abes GT, Prager JD, Riazuddin S, Chan AL, Yoon PJ, Nickerson DA, Cutiongco-de la Paz EM, Streubel SO, Reyes-Quintos MRT, Jenkins HA, Mattila P, Chan KH, Mohlke KL, Leal SM, Hafrén L, Chonmaitree T, Sale MM, Ahmed ZM. FUT2 Variants Confer Susceptibility to Familial Otitis Media. Am J Hum Genet. 2018 Nov 1;103(5):679-690. PubMed PMID: 30401457
• Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Prasaad Steiner RW, Tsai Do B, Voelker CC, Waguespack RW, Corrigan MD. Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update) Executive Summary. Otolaryngol Head Neck Surg. 2017 Mar;156(3):403-416. PubMed PMID: 28248602
• Coughlin AR, Hunt AA, Gubbels SP. Is hearing preserved following radiotherapy for vestibular schwannoma?. Laryngoscope. 2018 Oct 3. [Epub ahead of print] PubMed PMID: 30284268
• Maxwell AK, Takeda H, Gubbels SP. Primary Middle Ear Mucosal Melanoma: Case Report and Comprehensive Literature Review of 21 Cases of Primary Middle Ear and Eustachian Tube Melanoma. Ann Otol Rhinol Laryngol. 2018 Nov;127(11):856-863. PubMed PMID: 30103615
• Gubbels SP, Gartrell BC, Ploch JL, Hanson KD. Can routine office-based audiometry predict cochlear implant evaluation results?. Laryngoscope. 2017 Jan;127(1):216-222. PubMed PMID: 27797418
• Takeda H, Dondzillo A, Randall JA, Gubbels SP. Challenges in Cell-Based Therapies for the Treatment of Hearing Loss. Trends Neurosci. 2018 Nov;41(11):823-837. PubMed PMID: 30033182
• Cass ND, Gubbels SP, Portnuff CDF. Sudden Bilateral Hearing Loss, Tinnitus, and Vertigo as Presenting Symptoms of Chronic Myeloid Leukemia. Ann Otol Rhinol Laryngol. 2018 Oct;127(10):731-734. PubMed PMID: 30032641
• Devare J, Gubbels S, Raphael Y. Outlook and future of inner ear therapy. Hear Res. 2018 Oct;368:127-135. PubMed PMID: 29804723
• Coughlin AR, Willman TJ, Gubbels SP. Systematic Review of Hearing Preservation After Radiotherapy for Vestibular Schwannoma. Otol Neurotol. 2018 Mar;39(3):273-283. PubMed PMID: 29342035
• Mowry SE, Woodson E, Gubbels S, Carfrae M, Hansen MR. A simple assessment tool for evaluation of cadaveric temporal bone dissection. Laryngoscope. 2018 Feb;128(2):451-455. PubMed PMID: 28425611
• Misch ES, Banakis Hartl RM, Gubbels SP, Greene NT. Risks of Intracochlear Pressures From Laser Stapedotomy. Otol Neurotol. 2020 Mar;41(3):308-317. PubMed PMID: 31746814
• Baschal EE, Larson ED, Bootpetch Roberts TC, Pathak S, Frank G, Handley E, Dinwiddie J, Moloney M, Yoon PJ, Gubbels SP, Scholes MA, Cass SP, Jenkins HA, Frank DN, Yang IV, Schwartz DA, Ramakrishnan VR, Santos-Cortez RLP. Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses. Front Genet. 2019;10:1352. PubMed PMID: 32010199
• Baschal EE, Larson ED, Bootpetch Roberts TC, Pathak S, Frank G, Handley E, Dinwiddie J, Moloney M, Yoon PJ, Gubbels SP, Scholes MA, Cass SP, Jenkins HA, Frank DN, Yang IV, Schwartz DA, Ramakrishnan VR, Santos-Cortez RLP. Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses. Front Genet. 2019;10:1352. PubMed PMID: 32010199
• Hunt AA, Cass ND, Coughlin A, Gubbels SP. Time-based Assessment of Hearing Preservation Rates After Microsurgical Resection of Vestibular Schwannomas: A Systematic Review. Otol Neurotol. 2020 Jun;41(5):679-685. PubMed PMID: 32150025
• Lee S, Dondzillo A, Gubbels SP, Raphael Y. Practical aspects of inner ear gene delivery for research and clinical applications. Hear Res. 2020 Sep 1;394:107934. PubMed PMID: 32204962
• Misch ES, Banakis Hartl RM, Gubbels SP, Greene NT. Risks of Intracochlear Pressures From Laser Stapedotomy. Otol Neurotol. 2019 Nov 7. [Epub ahead of print] PubMed PMID: 31746814
• Cass ND, Honce JM, O'Dell AL, Gubbels SP. First MRI With New Cochlear Implant With Rotatable Internal Magnet System and Proposal for Standardization of Reporting Magnet-Related Artifact Size. Otol Neurotol. 2019 Aug;40(7):883-891. PubMed PMID: 31219967
• Cass ND, Schopper MA, Lubin JA, Fishbein L, Gubbels SP. The Changing Paradigm of Head and Neck Paragangliomas: What Every Otolaryngologist Needs to Know. Ann Otol Rhinol Laryngol. 2020 Nov;129(11):1135-1143. PubMed PMID: 32486832
• Youssef AS, Arnone GD, Farell NF, Thompson JA, Ramakrishnan VR, Gubbels S, Cohen-Gadol AA, Cass S, Labib MA. The Combined Endoscopic Endonasal Far Medial and Open Postauricular Transtemporal Approaches As a Lesser Invasive Approach to the Jugular Foramen: Anatomic Morphometric Study With Case Illustration. Oper Neurosurg (Hagerstown). 2020 Sep 15;19(4):471-479. PubMed PMID: 32510567
• Bootpetch TC, Hafrén L, Elling CL, Baschal EE, Manichaikul AW, Pine HS, Szeremeta W, Scholes MA, Cass SP, Larson ED, Chan KH, Ishaq R, Prager JD, Shaikh RS, Gubbels SP, Yousaf A, Wine TM, Bamshad MJ, Yoon PJ, Jenkins HA, Nickerson DA, Streubel SO, Friedman NR, Frank DN, Einarsdottir E, Kere J, Riazuddin S, Daly KA, Leal SM, Ryan AF, Mattila PS, Ahmed ZM, Sale MM, Chonmaitree T, Santos-Cortez RLP. Multi-omic studies on missense PLG variants in families with otitis media. Sci Rep. 2020 Sep 14;10(1):15035. PubMed PMID: 32929111
• Lundberg EMH, Strong D, Anderson M, Kaizer AM, Gubbels S. Do Patients Benefit From a Cochlear Implant When They Qualify Only in the Presence of Background Noise?. Otol Neurotol. 2021 Feb 1;42(2):251-259. PubMed PMID: 33229878
• Larson ED, Magno JPM, Steritz MJ, Llanes EGDV, Cardwell J, Pedro M, Roberts TB, Einarsdottir E, Rosanes RAQ, Greenlee C, Santos RAP, Yousaf A, Streubel SO, Santos ATR, Ruiz AG, Lagrana-Villagracia SM, Ray D, Yarza TKL, Scholes MA, Anderson CB, Acharya A, Gubbels SP, Bamshad MJ, Cass SP, Lee NR, Shaikh RS, Nickerson DA, Mohlke KL, Prager JD, Cruz TLG, Yoon PJ, Abes GT, Schwartz DA, Chan AL, Wine TM, Cutiongco-de la Paz EM, Friedman N, Kechris K, Kere J, Leal SM, Yang IV, Patel JA, Tantoco MLC, Riazuddin S, Chan KH, Mattila PS, Reyes-Quintos MRT, Ahmed ZM, Jenkins HA, Chonmaitree T, Hafrén L, Chiong CM, Santos-Cortez RLP. A2ML1 and otitis media: novel variants, differential expression, and relevant pathways. Hum Mutat. 2019 Aug;40(8):1156-1171. PubMed PMID: 31009165
• Coughlin AR, Hunt AA, Gubbels SP. Is hearing preserved following radiotherapy for vestibular schwannoma?. Laryngoscope. 2019 Apr;129(4):775-776. PubMed PMID: 30284268
• 47. Time-Based Assessment of Hearing Preservation Rates after Microsurgical Resection of Vestibular Schwannomas: A Systematic Review, Hunt A, Cass N, Gubbels SP, Targeted Journal – Otology and Neurotology (Accepted 12/19)
• Labib MA, Inoue M, Banakis Hartl RM, Cass S, Gubbels S, Lawton MT, Youssef AS. Impact of vestibular nerve preservation on facial and hearing outcomes in small vestibular schwannoma surgery: a technical feasibility study. Acta Neurochir (Wien). 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389124
• Elling CL, Scholes MA, Streubel SO, Larson ED, Wine TM, Bootpetch TC, Yoon PJ, Kofonow JM, Gubbels SP, Cass SP, Robertson CE, Jenkins HA, Prager JD, Frank DN, Chan KH, Friedman NR, Ryan AF, Santos-Cortez RLP. The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. Front Cell Infect Microbiol. 2021;11:798246. PubMed PMID: 35096646
• Martinez-Perez R, Kunigelis KE, Ward RC, Ung TH, Arnone GD, Cass SP, Gubbels SP, Youssef AS. Hydroxyapatite cement cranioplasty for reconstruction of translabyrinthine approach: aesthetic results, long-term satisfaction, quality of life, and complications. Acta Neurochir (Wien). 2021 Oct 13. [Epub ahead of print] PubMed PMID: 34642820
• Takeda H, Dondzillo A, Randall JA, Gubbels SP. Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti. Stem Cell Res Ther. 2021 Jun 19;12(1):352. PubMed PMID: 34147129
• Kalmanson OA, Aasen DM, Gubbels SP, Foster CA. Reversible Canalith Jam of the Horizontal Semicircular Canal Mimicking Cupulolithiasis. Ann Otol Rhinol Laryngol. 2021 Nov;130(11):1213-1219. PubMed PMID: 33813907
• Dondzillo A, Takeda H, Gubbels SP. Sex difference in the efferent inner hair cell synapses of the aging murine cochlea. Hear Res. 2021 May;404:108215. PubMed PMID: 33677192
• Labib MA, Inoue M, Banakis Hartl RM, Cass S, Gubbels S, Lawton MT, Youssef AS. Impact of vestibular nerve preservation on facial and hearing outcomes in small vestibular schwannoma surgery: a technical feasibility study. Acta Neurochir (Wien). 2021 Aug;163(8):2219-2224. PubMed PMID: 33389124
• Lundberg EMH, Strong D, Anderson M, Kaizer AM, Gubbels S. Do Patients Benefit From a Cochlear Implant When They Qualify Only in the Presence of Background Noise?. Otol Neurotol. 2021 Feb 1;42(2):251-259. PubMed PMID: 33229878
• Kalmanson OA, Talmage GD, Honce JM, Gubbels SP. Effect of Head Position and Magnetic Resonance Sequence on Cochlear Implant-Related Artifact Size and Internal Auditory Canal Visibility. Otol Neurotol. 2023 Feb 1;44(2):e73-e80. PubMed PMID: 36624593
• Boscoe EF, Banakis Hartl RM, Gubbels SP, Greene NT. Effects of Varying Laser Parameters During Laser Stapedotomy on Intracochlear Pressures. Otolaryngol Head Neck Surg. 2022 Jun 7;:1945998221104658. [Epub ahead of print] PubMed PMID: 35671134
• Sobczak G, Marchant W, Misurelli S, Pyle GM, Gubbels S, Roche J. Efficacy of Cochlear Implantation in Neurofibromatosis Type 2 Related Hearing Loss. Ann Otol Rhinol Laryngol. 2022 Apr 21;:34894221091010. [Epub ahead of print] PubMed PMID: 35450430
• Elling CL, Scholes MA, Streubel SO, Larson ED, Wine TM, Bootpetch TC, Yoon PJ, Kofonow JM, Gubbels SP, Cass SP, Robertson CE, Jenkins HA, Prager JD, Frank DN, Chan KH, Friedman NR, Ryan AF, Santos-Cortez RLP. The FUT2 Variant c.461G>A (p.Trp154*) Is Associated With Differentially Expressed Genes and Nasopharyngeal Microbiota Shifts in Patients With Otitis Media. Front Cell Infect Microbiol. 2021;11:798246. PubMed PMID: 35096646
• Martinez-Perez R, Kunigelis KE, Ward RC, Ung TH, Arnone GD, Cass SP, Gubbels SP, Youssef AS. Hydroxyapatite cement cranioplasty for reconstruction of translabyrinthine approach: aesthetic results, long-term satisfaction, quality of life, and complications. Acta Neurochir (Wien). 2022 Mar;164(3):669-677. PubMed PMID: 34642820
• Kalmanson O, Takeda H, Anderson SR, Dondzillo A, Gubbels S. Nestin-expressing cells are mitotically active in the mammalian inner ear. Hear Res. 2024 Jan 23;443:108962. [Epub ahead of print] PubMed PMID: 38295585
• Kalmanson OA, McLoughlin KC, Kiser TH, Gubbels SP. Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis. Ann Otol Rhinol Laryngol. 2023 Dec;132(12):1686-1689. PubMed PMID: 37243327
• Sumalde AAM, Scholes MA, Kalmanson OA, Terhune EA, Frejo L, Wethey CI, Roman-Naranjo P, Carry PM, Gubbels SP, Lopez-Escamez JA, Hadley-Miller N, Santos-Cortez RLP. Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction. Genes (Basel). 2023 Mar 30;14(4). PubMed PMID: 37107589
• Lee NK, Cass SP, Gubbels SP, Gomez HZ, Scholes MA, Jenkins HA, Santos-Cortez RLP. Novel candidate genes for cholesteatoma in chronic otitis media. Front Genet. 2022;13:1033965. PubMed PMID: 36699445
• Kalmanson OA, Talmage GD, Honce JM, Gubbels SP. Effect of Head Position and Magnetic Resonance Sequence on Cochlear Implant-Related Artifact Size and Internal Auditory Canal Visibility. Otol Neurotol. 2023 Feb 1;44(2):e73-e80. PubMed PMID: 36624593
• Boscoe EF, Banakis Hartl RM, Gubbels SP, Greene NT. Effects of Varying Laser Parameters During Laser Stapedotomy on Intracochlear Pressures. Otolaryngol Head Neck Surg. 2023 Mar;168(3):462-468. PubMed PMID: 35671134
• Sobczak G, Marchant W, Misurelli S, Pyle GM, Gubbels S, Roche J. Efficacy of Cochlear Implantation in Neurofibromatosis Type 2 Related Hearing Loss. Ann Otol Rhinol Laryngol. 2023 Mar;132(3):284-293. PubMed PMID: 35450430

Professional Memberships

• American College of Surgeons (ACS), Fellow, Member
• American Academy of Otolaryngology / Head and Neck Surgery (AAO-HNSF), Member
• Triological Society (TRIO), Fellow
• Association for Research in Otolaryngology (ARO), Member
• American Auditory Society (AAS), Member
• American Cochlear Implant Alliance, Member
• American Neurotology Society (ANS), Fellow
• American Otological Society, Active Member
• International Society for Inner Ear Therapeutics, Member
• Egyptian Society of Neurosurgery – Skull Base Division, Board Member
• North American Skull Base Society, Active Member
• Colorado ENT Society, Member
• Acoustic Neuroma Association, Member
• American Medical Association, Member

Practice Locations

UCHealth Ear, Nose and Throat Clinic - Anschutz Medical Campus
1635 Aurora Ct
6th floor
Aurora, CO 80045
720-848-2820

Hearing and Balance Center - Anschutz
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2800

CU Medicine Otolaryngology-Head and Neck Surgery - Cherry Creek Medical Center
100 Cook Street
Suite 304
Denver, CO 80206
720-516-9407

UCHealth Ambulatory Surgery Center - Cherry Creek Medical Center
100 Cook Street
Suite 500
Denver, CO 80206
720-516-9373

Rocky Mountain Gamma Knife Center - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-1290

Hospital Affiliation

• University of Colorado Hospital
• Children's Hospital Colorado
• Denver Health Medical Center
• Veterans Affairs Medical Center
• UCHealth Highlands Ranch Hospital

Specialty Information

Specialties

• Otolaryngology - Head & Neck Surgery, Board Certification (2006)
• Otology & Neurotology, Board Certification (2010)
• National Board of Medical Examiners, Parts I-III, Certificate (1998)
• Gamma Knife Radiosurgery Training - University of Pittsburgh, Certificate (2017)
• Diplomate - Neurotology, American Board of Otolaryngology, Certificate (2010)
• Diplomate - Otolaryngology, American Board of Otolaryngology, Certificate (2006)

Conditions & Treatments

• Ear, Nose, and Throat (ENT) - Ear Infection
• Ear, Nose, and Throat (ENT) - Eardrum Perforation
• Ear, Nose, and Throat (ENT) - Facial Paralysis
• Ear, Nose, and Throat (ENT) - Hearing Loss
• Ear, Nose, and Throat (ENT) - Skull Base Tumors
• Ear, Nose, and Throat (ENT) - Dizziness and Vertigo
• Ear, Nose, and Throat (ENT)
• Symptoms and Manifestations
• Ear, Nose, and Throat (ENT) - Acoustic Neuromas
• Ear, Nose, and Throat (ENT) - Cochlear Implants
• Ear, Nose, and Throat (ENT) - Osseointegrated Devices
• Ear, Nose, and Throat (ENT) - Tinnitus
• Ear, Nose, and Throat (ENT) - Balance disorders
• Ear, Nose, and Throat (ENT) - Cerebrospinal fluids leaks
• Ear, Nose, and Throat (ENT) - Cholesteatoma
• Ear, Nose, and Throat (ENT) - Chronic ear disease
• Ear, Nose, and Throat (ENT) - Draining ear