Joshua Black, PhD

Publications

• Black JC, Zhang H, Kim J, Getz G, Whetstine JR. Regulation of Transient Site-specific Copy Gain by MicroRNA. J Biol Chem. 2016 Mar 4;291(10):4862-71. PubMed PMID: 26755726
• Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 2018 Aug 9;174(4):803-817.e16. PubMed PMID: 30057114
• Zhang Y, Bertulat B, Tencer AH, Ren X, Wright GM, Black J, Cardoso MC, Kutateladze TG. MORC3 Forms Nuclear Condensates through Phase Separation. iScience. 2019 Jul 26;17:182-189. PubMed PMID: 31284181
• Zhang Y, Ahn J, Green KJ, Vann KR, Black J, Brooke CB, Kutateladze TG. MORC3 Is a Target of the Influenza A Viral Protein NS1. Structure. 2019 Jun 4;27(6):1029-1033.e3. PubMed PMID: 31006586
• Zhang Y, Klein BJ, Cox KL, Bertulat B, Tencer AH, Holden MR, Wright GM, Black J, Cardoso MC, Poirier MG, Kutateladze TG. Mechanism for autoinhibition and activation of the MORC3 ATPase. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6111-6119. PubMed PMID: 30850548
• Tencer AH, Cox KL, Wright GM, Zhang Y, Petell CJ, Klein BJ, Strahl BD, Black JC, Poirier MG, Kutateladze TG. Molecular mechanism of the MORC4 ATPase activation. Nat Commun. 2020 Oct 29;11(1):5466. PubMed PMID: 33122719
• Sobral LM, Hicks HM, Parrish JK, McCann TS, Hsieh J, Goodspeed A, Costello JC, Black JC, Jedlicka P. KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma. Mol Oncol. 2020 Oct;14(10):2471-2486. PubMed PMID: 32697014
• Sobral LM, Sechler M, Parrish JK, McCann TS, Jones KL, Black JC, Jedlicka P. KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma. Genes Cancer. 2020;11(1-2):53-65. PubMed PMID: 32577157
• Menzel J, Tatman P, Black JC. Isolation and analysis of rereplicated DNA by Rerep-Seq. Nucleic Acids Res. 2020 Jun 4;48(10):e58. PubMed PMID: 32239215
• Menzel J, Black JC. Epigenetic Modulation of the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade Therapy. Cancer Discov. 2020 Feb;10(2):179-181. PubMed PMID: 32024681
• Van Rechem C, Ji F, Chakraborty D, Black JC, Sadreyev RI, Whetstine JR. Collective regulation of chromatin modifications predicts replication timing during cell cycle. Cell Rep. 2021 Oct 5;37(1):109799. PubMed PMID: 34610305
• SIX1 is a master regulator of the Rhabdomyosarcoma undifferentiated state Jessica Y. Hsu, Etienne P. Danis, Stephanie Nance, Jenean O’Brien, Veronica M. Wessells, Andrew E. Goodspeed, Jared C. Talbot, Sharon L. Amacher, Paul Jedlicka, Joshua C. Black, James C. Costello, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford. Cell Reports. In press.
• Tatman PD, Black JC. Extrachromosomal Circular DNA from TCGA Tumors Is Generated from Common Genomic Loci, Is Characterized by Self-Homology and DNA Motifs near Circle Breakpoints. Cancers (Basel). 2022 May 6;14(9). PubMed PMID: 35565439
• Hsu JY, Danis EP, Nance S, O'Brien JH, Gustafson AL, Wessells VM, Goodspeed AE, Talbot JC, Amacher SL, Jedlicka P, Black JC, Costello JC, Durbin AD, Artinger KB, Ford HL. SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state. Cell Rep. 2022 Feb 1;38(5):110323. PubMed PMID: 35108532
• Wright GM, Black JC. Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells. Cells. 2023 Mar 21;12(6). PubMed PMID: 36980293
• Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME. PKCd Regulates Chromatin Remodeling and DNA Repair through SIRT6. Mol Cancer Res. 2024 Feb 1;22(2):181-196. PubMed PMID: 37889141
• Black JC, Kutateladze TG. Atypical histone targets of PHD fingers. J Biol Chem. 2023 Apr;299(4):104601. PubMed PMID: 36907441
• Wright GM, Menzel J, Tatman PD, Black JC. Transition from Transient DNA Rereplication to Inherited Gene Amplification Following Prolonged Environmental Stress. bioRxiv. 2023 May 9. PubMed PMID: 37214911