Connie Hess, MD

Research Interests

My research is focused on modification of ischemic cardiac and limb-related risk in patients with atherosclerotic vascular disease through medical therapies, including antithrombotic and lipid-lowering strategies. I am also interested in device-based therapies and optimization of peri-procedural care for patients undergoing percutaneous coronary and peripheral vascular interventions. My research is conducted through a combination of clinical trials, observational studies, and implementation science.

Publications

• Hess CN, Wang TY, McCoy LA, Messenger JC, Effron MB, Zettler ME, Henry TD, Peterson ED, Fonarow GC. Unplanned Inpatient and Observation Rehospitalizations After Acute Myocardial Infarction: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circulation. 2016 Feb 2;133(5):493-501. PubMed PMID: 26680241
• Hess CN, Krucoff MW, Sheng S, Anstrom KJ, Barham WB, Gilchrist IC, Harrington RA, Jacobs AK, Mehran R, Messenger JC, Mark DB, Rao SV. Comparison of quality-of-life measures after radial versus femoral artery access for cardiac catheterization in women: Results of the Study of Access Site for Enhancement of Percutaneous Coronary Intervention for Women quality-of-life substudy. Am Heart J. 2015 Aug;170(2):371-9. PubMed PMID: 26299236
• Hess CN, James S, Lopes RD, Wojdyla DM, Neely ML, Liaw D, Hagstrom E, Bhatt DL, Husted S, Goodman SG, Lewis BS, Verheugt FW, De Caterina R, Ogawa H, Wallentin L, Alexander JH. Apixaban Plus Mono Versus Dual Antiplatelet Therapy in Acute Coronary Syndromes: Insights From the APPRAISE-2 Trial. J Am Coll Cardiol. 2015 Aug 18;66(7):777-87. PubMed PMID: 26271059
• Hess CN, Peterson ED, Peng SA, de Lemos JA, Fosbol EL, Thomas L, Bhatt DL, Saucedo JF, Wang TY. Use and Outcomes of Triple Therapy Among Older Patients With Acute Myocardial Infarction and Atrial Fibrillation. J Am Coll Cardiol. 2015 Aug 11;66(6):616-27. PubMed PMID: 26248987
• Goldberg RJ, Gore JM, McManus DD, McManus R, Tisminetzky M, Lessard D, Gurwitz JH, Parish DC, Allison J, Hess CN, Wang T, Kiefe C. Race and place differences in patients hospitalized with an acute coronary syndrome: Is there double jeopardy? Findings from TRACE-CORE. Prev Med Rep. 2017 Jan 24;6:1-8. PubMed PMID: 28210536
• Hess CN, Kaltenbach LA, Doll JA, Cohen DJ, Peterson ED, Wang TY. Race and Sex Differences in Post-Myocardial Infarction Angina Frequency and Risk of 1-Year Unplanned Rehospitalization. Circulation. 2017 Feb 7;135(6):532-543. PubMed PMID: 28153990
• Hess CN, Roe MT. Treatment of coronary artery disease in cancer survivors: an emerging challenge. Coron Artery Dis. 2017 Jan;28(1):1-2. PubMed PMID: 27776090
• Hess CN, Lopes RD, Gibson CM, Hager R, Wojdyla DM, Englum BR, Mack MJ, Kouchoukos NT, Peterson ED, Alexander JH. Response to Letters Regarding Article, "Saphenous Vein Graft Failure After Coronary Artery Bypass Surgery: Insights From PREVENT IV". Circulation. 2015 Jul 28;132(4):e29. PubMed PMID: 26216091
• Low Wang CC, Hess CN, Hiatt WR, Goldfine AB. Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations. Circulation. 2016 Jun 14;133(24):2459-502. PubMed PMID: 27297342
• Hess CN, Hellkamp AS, Roe MT, Thomas L, Scirica BM, Peng SA, Peterson ED, Wang TY. Outcomes According to Cardiac Catheterization Referral and Clopidogrel Use Among Medicare Patients With Non-ST-Segment Elevation Myocardial Infarction Discharged Without In-hospital Revascularization. J Am Heart Assoc. 2016 Mar 14;5(3):e002784. PubMed PMID: 26976877
• Hess CN, Roe MT, Clare RM, Chiswell K, Kelly J, Tcheng JE, Hagstrom E, James SK, Khouri MG, Hirsch BR, Kong DF, Abernethy AP, Krucoff MW. Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention. J Am Heart Assoc. 2015 Jul 6;4(7). PubMed PMID: 26150477
• Wang TY, Henry TD, Effron MB, Honeycutt E, Hess CN, Zettler ME, Cohen DJ, Baker BA, Berger PB, Anstrom KJ, Angiolillo DJ, Peterson ED. Cluster-randomized clinical trial examining the impact of platelet function testing on practice: the treatment with adenosine diphosphate receptor inhibitors: longitudinal assessment of treatment patterns and events after acute coronary syndrome prospective open label antiplatelet therapy study. Circ Cardiovasc Interv. 2015 Jun;8(6):e001712. PubMed PMID: 26025216
• Hess CN, Krucoff MW, Rao SV. Reply: Transradial PCI in Women: Zeroing in on Crossovers. JACC Cardiovasc Interv. 2015 Apr 20;8(4):639. PubMed PMID: 25907092
• Hess CN, Peterson ED, Neely ML, Dai D, Hillegass WB, Krucoff MW, Kutcher MA, Messenger JC, Pancholy S, Piana RN, Rao SV. Response to letter regarding article, "The learning curve for transradial percutaneous coronary intervention among operators in the United States: a study from the National Cardiovascular Data Registry". Circulation. 2015 Feb 24;131(8):e358. PubMed PMID: 25712065
• Hess CN, Wang TY, McCoy LA, Messenger JC, Effron MB, Zettler ME, Henry TD, Peterson ED, Fonarow GC. Unplanned Inpatient and Observation Rehospitalizations After Acute Myocardial Infarction: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circulation. 2016 Feb 2;133(5):493-501. PubMed PMID: 26680241
• Hess CN, Rao SV, McCoy LA, Neely ML, Singh M, Spertus JA, Krone RJ, Weaver WD, Peterson ED. Identification of hospital outliers in bleeding complications after percutaneous coronary intervention. Circ Cardiovasc Qual Outcomes. 2015 Jan;8(1):15-22. PubMed PMID: 25424242
• Hess CN, Hiatt WR. Response by Hess and Hiatt to Letter Regarding Article, "A Structured Review of Antithrombotic Therapy in Peripheral Artery Disease With a Focus on Revascularization: A TASC (InterSociety Consensus for the Management of Peripheral Artery Disease) Initiative". Circulation. 2017 Dec 19;136(25):2524-2525. PubMed PMID: 29255130
• Hess CN, Low Wang CC, Hiatt WR. PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes. Annu Rev Med. 2018 Jan 29;69:133-145. PubMed PMID: 29095667
• Fanaroff AC, Kaltenbach LA, Peterson ED, Hess CN, Cohen DJ, Fonarow GC, Wang TY. Management of Persistent Angina After Myocardial Infarction Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study. J Am Heart Assoc. 2017 Oct 19;6(10). PubMed PMID: 29051217
• Pagidipati NJ, Clare RM, Keenan RT, Chiswell K, Roe MT, Hess CN. Association of Gout With Long-Term Cardiovascular Outcomes Among Patients With Obstructive Coronary Artery Disease. J Am Heart Assoc. 2018 Aug 21;7(16):e009328. PubMed PMID: 30369327
• Ibrahim H, Kaltenbach LA, Hess CN, Recchia T, Effron MB, Stone GW, Wang TY. Glycoprotein IIb/IIIa inhibitor use in patients with acute myocardial infarction undergoing PCI: Insights from the TRANSLATE ACS study. Catheter Cardiovasc Interv. 2018 Sep 23. [Epub ahead of print] PubMed PMID: 30244509
• Koshy LM, Aberle LH, Krucoff MW, Hess CN, Mazzaferri E Jr, Jolly SS, Jacobs A, Gibson CM, Mehran R, Gilchrist IC, Rao SV. Comparison of Radial Access, Guided Femoral Access, and Non-Guided Femoral Access Among Women Undergoing Percutaneous Coronary Intervention. J Invasive Cardiol. 2018 Jan;30(1):18-22. PubMed PMID: 29035844
• Hess CN, Rogers RK, Wang TY, Fu R, Gundrum J, Allen LaPointe NM, Hiatt WR. Major Adverse Limb Events and 1-Year Outcomes After Peripheral Artery Revascularization. J Am Coll Cardiol. 2018 Aug 28;72(9):999-1011. PubMed PMID: 30139446
• Hess CN, Hiatt WR. Antithrombotic Therapy for Peripheral Artery Disease in 2018. JAMA. 2018 Jun 12;319(22):2329-2330. PubMed PMID: 29860284
• Hess CN, Low Wang CC, Hiatt WR. PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes. Annu Rev Med. 2018 Jan 29;69:133-145. PubMed PMID: 29095667
• Koshy LM, Aberle LH, Krucoff MW, Hess CN, Mazzaferri E Jr, Jolly SS, Jacobs A, Gibson CM, Mehran R, Gilchrist IC, Rao SV. Comparison of Radial Access, Guided Femoral Access, and Non-Guided Femoral Access Among Women Undergoing Percutaneous Coronary Intervention. J Invasive Cardiol. 2018 Jan;30(1):18-22. PubMed PMID: 29035844
• Hess CN, Norgren L, Ansel GM, Capell WH, Fletcher JP, Fowkes FGR, Gottsäter A, Hitos K, Jaff MR, Nordanstig J, Hiatt WR. A Structured Review of Antithrombotic Therapy in Peripheral Artery Disease With a Focus on Revascularization: A TASC (InterSociety Consensus for the Management of Peripheral Artery Disease) Initiative. Circulation. 2017 Jun 20;135(25):2534-2555. PubMed PMID: 28630267
• Pagidipati NJ, Hess CN, Clare RM, Akerblom A, Tricoci P, Wojdyla D, Keenan RT, James S, Held C, Mahaffey KW, Klein AB, Wallentin L, Roe MT. An examination of the relationship between serum uric acid level, a clinical history of gout, and cardiovascular outcomes among patients with acute coronary syndrome. Am Heart J. 2017 May;187:53-61. PubMed PMID: 28454808
• Hess CN, Clare RM, Neely ML, Tricoci P, Mahaffey KW, James SK, Alexander JH, Held C, Lopes RD, Fox KAA, White HD, Wallentin L, Armstrong PW, Harrington RA, Ohman EM, Roe MT. Differential occurrence, profile, and impact of first recurrent cardiovascular events after an acute coronary syndrome. Am Heart J. 2017 May;187:194-203. PubMed PMID: 28454804
• Hess CN, Wang TY, Weleski Fu J, Gundrum J, Allen LaPointe NM, Rogers RK, Hiatt WR. Long-Term Outcomes and Associations With Major Adverse Limb Events After Peripheral Artery Revascularization. J Am Coll Cardiol. 2020 Feb 11;75(5):498-508. PubMed PMID: 32029132
• Hess CN, Hiatt WR. Progress in the prevention and treatment of atherosclerotic cardiovascular disease: two steps forward, one step back. Eur Heart J. 2020 Jan 31. [Epub ahead of print] PubMed PMID: 32003776
• Goldberg RJ, Gore JM, McManus DD, McManus R, Tisminetzky M, Lessard D, Gurwitz JH, Parish DC, Allison J, Hess CN, Wang T, Kiefe C. Race and place differences in patients hospitalized with an acute coronary syndrome: Is there double jeopardy? Findings from TRACE-CORE. Prev Med Rep. 2017 Jun;6:1-8. PubMed PMID: 28210536
• Hiatt WR, Hess CN, Bonaca MP. Heterogeneity of Risk and Benefit in Subgroups of COMPASS: Relatively Similar But Absolutely Different. J Am Coll Cardiol. 2019 Jul 2;73(25):3292-3294. PubMed PMID: 31248550
• Hess CN, Huang Z, Patel MR, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Held P, Jones WS, Katona B, Mahaffey KW, Norgren L, Rockhold FW, Hiatt WR. Acute Limb Ischemia in Peripheral Artery Disease. Circulation. 2019 Aug 13;140(7):556-565. PubMed PMID: 31238713
• Hess CN, Kaltenbach LA, Doll JA, Cohen DJ, Peterson ED, Wang TY. Race and Sex Differences in Post-Myocardial Infarction Angina Frequency and Risk of 1-Year Unplanned Rehospitalization. Circulation. 2017 Feb 7;135(6):532-543. PubMed PMID: 28153990
• Hess CN, Roe MT. Treatment of coronary artery disease in cancer survivors: an emerging challenge. Coron Artery Dis. 2017 Jan;28(1):1-2. PubMed PMID: 27776090
• Hess CN, Hiatt WR. Lost in translation: Why 'lost to follow-up' matters. Vasc Med. 2019 Aug;24(4):339-340. PubMed PMID: 31195921
• Rymer JA, Kaltenbach LA, Kochar A, Hess CN, Gilchrist IC, Messenger JC, Harrington RA, Jolly SS, Jacobs AK, Abbott JD, Wojdyla DM, Krucoff MW, Rao SV. Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women. Circ Cardiovasc Interv. 2019 May;12(5):e007086. PubMed PMID: 31014090
• Ibrahim H, Kaltenbach LA, Hess CN, Recchia T, Effron MB, Stone GW, Wang TY. Glycoprotein IIb/IIIa inhibitor use in patients with acute myocardial infarction undergoing PCI: Insights from the TRANSLATE ACS study. Catheter Cardiovasc Interv. 2019 Mar 1;93(4):E204-E210. PubMed PMID: 30244509
• Rao SV, Vidovich MI, Gilchrist IC, Gulati R, Gutierrez JA, Hess CN, Kaul P, Martinez SC, Rymer J. 2021 ACC Expert Consensus Decision Pathway on Same-Day Discharge After Percutaneous Coronary Intervention: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2021 Feb 16;77(6):811-825. PubMed PMID: 33423859
• Secemsky EA, Barrette E, Bockstedt L, Bonaca MP, Hess CN, Hanson T, Monteiro J, Manda B, Yeh RW. Long-Term Safety of Drug-Coated Devices for Peripheral Revascularisation. EuroIntervention. 2020 Dec 22. [Epub ahead of print] PubMed PMID: 33342764
• Hiatt WR, Bonaca MP, Patel MR, Nehler MR, Debus ES, Anand SS, Capell WH, Brackin T, Jaeger N, Hess CN, Pap AF, Berkowitz SD, Muehlhofer E, Haskell L, Brasil D, Madaric J, Sillesen H, Szalay D, Bauersachs R. Rivaroxaban and Aspirin in Peripheral Artery Disease Lower Extremity Revascularization: Impact of Concomitant Clopidogrel on Efficacy and Safety. Circulation. 2020 Dec 8;142(23):2219-2230. PubMed PMID: 33138628
• Hess CN, Bonaca MP. Contemporary Review of Antithrombotic Therapy in Peripheral Artery Disease. Circ Cardiovasc Interv. 2020 Oct;13(10):e009584. PubMed PMID: 33023325
• Bonaca MP, Hess CN. ASCVD Risk and Statin Use in PAD: Implementing a New Approach to an Old Problem. J Am Coll Cardiol. 2020 Jul 21;76(3):265-267. PubMed PMID: 32674790
• Bonaca MP, Bauersachs RM, Anand SS, Debus ES, Nehler MR, Patel MR, Fanelli F, Capell WH, Diao L, Jaeger N, Hess CN, Pap AF, Kittelson JM, Gudz I, Mátyás L, Krievins DK, Diaz R, Brodmann M, Muehlhofer E, Haskell LP, Berkowitz SD, Hiatt WR. Rivaroxaban in Peripheral Artery Disease after Revascularization. N Engl J Med. 2020 May 21;382(21):1994-2004. PubMed PMID: 32222135
• Bonaca MP, Hess CN, Hiatt WR. The Pathobiology of Acute Limb Ischemic Events and Stent Failure in Peripheral Artery Disease: A Step in the Right Direction. JACC Cardiovasc Interv. 2020 Feb 24;13(4):428-430. PubMed PMID: 32081235
• Haine A, Kavanagh S, Berger JS, Hess CN, Norgren L, Fowkes FGR, Katona BG, Mahaffey KW, Blomster JI, Patel MR, Jones WS, Rockhold FW, Hiatt WR, Baumgartner I. Sex-Specific Risks of Major Cardiovascular and Limb Events in Patients With Symptomatic Peripheral Artery Disease. J Am Coll Cardiol. 2020 Feb 18;75(6):608-617. PubMed PMID: 32057375
• Pabon M, Cheng S, Altin SE, Sethi SS, Nelson MD, Moreau KL, Hamburg N, Hess CN. Sex Differences in Peripheral Artery Disease. Circ Res. 2022 Feb 18;130(4):496-511. PubMed PMID: 35175843
• Berkowitz SD, Bauersachs RM, Szarek M, Nehler MR, Debus ES, Patel MR, Anand SS, Capell WH, Hess CN, Hsia J, Leeper NJ, Brasil D, Mátyás L, Diaz R, Brodmann M, Muehlhofer E, Haskell LP, Bonaca MP. Prevention of arterial and venous thrombotic events in symptomatic peripheral arterial disease patients after lower extremity revascularization in the VOYAGER PAD trial: Dual anticoagulant/antiplatelet regimen vs antiplatelet therapy alone. J Thromb Haemost. 2022 Feb 16. [Epub ahead of print] PubMed PMID: 35170216
• Morrison JT, Govsyeyev N, Hess CN, Bonaca MP. Vorapaxar for Prevention of Major Adverse Cardiovascular and Limb Events in Peripheral Artery Disease. J Cardiovasc Pharmacol Ther. 2022 Jan-Dec;27:10742484211056115. PubMed PMID: 35006035
• Secemsky EA, Barrette E, Bockstedt L, Bonaca MP, Hess CN, Hanson T, Monteiro J, Manda B, Yeh RW. Long-term safety of drug-coated devices for peripheral revascularisation. EuroIntervention. 2021 Sep 20;17(7):590-598. PubMed PMID: 33342764
• Hess CN, Hiatt WR. Progress in the prevention and treatment of atherosclerotic cardiovascular disease: two steps forward, one step back. Eur Heart J. 2020 May 1;41(17):1650-1652. PubMed PMID: 32003776
• Rao SV, Vidovich MI, Gilchrist IC, Gulati R, Gutierrez JA, Hess CN, Kaul P, Martinez SC, Rymer J. 2021 ACC Expert Consensus Decision Pathway on Same-Day Discharge After Percutaneous Coronary Intervention: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2021 Feb 16;77(6):811-825. PubMed PMID: 33423859
• Desai U, Kharat A, Hess CN, Milentijevic D, Laliberté F, Zuckerman P, Benson J, Lefebvre P, Hiatt WR, Bonaca MP. Healthcare resource utilization and costs of major atherothrombotic vascular events among patients with peripheral artery disease after revascularization. J Med Econ. 2021 Jan-Dec;24(1):402-409. PubMed PMID: 33634723
• Desai U, Kharat A, Hess CN, Milentijevic D, Laliberté F, Zuckerman P, Benson J, Lefebvre P, Hiatt WR, Bonaca MP. Incidence of Major Atherothrombotic Vascular Events among Patients with Peripheral Artery Disease after Revascularization. Ann Vasc Surg. 2021 Aug;75:217-226. PubMed PMID: 33819600
• Bauersachs RM, Szarek M, Brodmann M, Gudz I, Debus ES, Nehler MR, Anand SS, Patel MR, Hess CN, Capell WH, Rogers K, Muehlhofer E, Haskell LP, Berkowitz SD, Hiatt WR, Bonaca MP. Total Ischemic Event Reduction With Rivaroxaban After Peripheral Arterial Revascularization in the VOYAGER PAD Trial. J Am Coll Cardiol. 2021 Jul 27;78(4):317-326. PubMed PMID: 34010631
• Hess CN, Wang TY, Weleski Fu J, Gundrum J, Allen LaPointe NM, Rogers RK, Hiatt WR. Long-Term Outcomes and Associations With Major Adverse Limb Events After Peripheral Artery Revascularization. J Am Coll Cardiol. 2020 Feb 11;75(5):498-508. PubMed PMID: 32029132
• Hess CN, Fu JW, Gundrum J, Allen LaPointe NM, Wang TY, Rogers RK, Hiatt WR, Bonaca MP. Diabetes Mellitus and Risk Stratification After Peripheral Artery Revascularization. J Am Coll Cardiol. 2021 Jun 8;77(22):2867-2869. PubMed PMID: 34082916
• Hess CN, Cannon CP, Beckman JA, Goodney PP, Patel MR, Hiatt WR, Mues KE, Orroth KK, Shannon E, Bonaca MP. Effectiveness of Blood Lipid Management in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2021 Jun 22;77(24):3016-3027. PubMed PMID: 34140105
• Hiatt WR, Hess CN, Bonaca MP, Kavanagh S, Patel MR, Baumgartner I, Berger JS, Blomster JI, Jones WS, Katona BG, Mahaffey KW, Norgren L, Rockhold FW, Fowkes FGR. Ankle-Brachial Index for Risk Stratification in Patients With Symptomatic Peripheral Artery Disease With and Without Prior Lower Extremity Revascularization: Observations From the EUCLID Trial. Circ Cardiovasc Interv. 2021 Jul;14(7):e009871. PubMed PMID: 34253048
• Criqui MH, Matsushita K, Aboyans V, Hess CN, Hicks CW, Kwan TW, McDermott MM, Misra S, Ujueta F. Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement From the American Heart Association. Circulation. 2021 Aug 31;144(9):e171-e191. PubMed PMID: 34315230
• Arps K, Chakravartti J, Hess CN, Rao SV. Ventricular Fibrillation Due to Aortocoronary Vein Graft Spasm During Angiography: Case Report and Literature Review. JACC Case Rep. 2021 Mar;3(3):388-391. PubMed PMID: 34317543
• Debus ES, Nehler MR, Govsyeyev N, Bauersachs RM, Anand SS, Patel MR, Fanelli F, Capell WH, Brackin T, Hinterreiter F, Krievins D, Nault P, Piffaretti G, Svetlikov A, Jaeger N, Hess CN, Sillesen HH, Conte M, Mills J, Muehlhofer E, Haskell LP, Berkowitz SD, Hiatt WR, Bonaca MP. Effect of Rivaroxaban and Aspirin in Patients With Peripheral Artery Disease Undergoing Surgical Revascularization: Insights From the VOYAGER PAD Trial. Circulation. 2021 Oct 5;144(14):1104-1116. PubMed PMID: 34380322
• Krantz MJ, Debus SE, Hsia J, Patel MR, Anand SS, Nehler MR, Hess CN, Capell WH, Bracken T, Szarek M, Mátyás L, Krievins DK, Nault P, Stefanov S, Haskell LP, Berkowitz SD, Muehlhofer E, Hiatt WR, Bauersachs RM, Bonaca MP. Low-dose rivaroxaban plus aspirin in older patients with peripheral artery disease undergoing acute limb revascularization: insights from the VOYAGER PAD trial. Eur Heart J. 2021 Oct 14;42(39):4040-4048. PubMed PMID: 34430972
• Hess CN, Debus ES, Nehler MR, Anand SS, Patel MR, Szarek M, Capell WH, Hsia J, Beckman JA, Brodmann M, Diaz R, Habertheuer P, Leeper NJ, Powell RJ, Sillesen H, Muehlhofer E, Berkowitz SD, Haskell LP, Bauersachs RM, Bonaca MP. Reduction in Acute Limb Ischemia With Rivaroxaban Versus Placebo in Peripheral Artery Disease After Lower Extremity Revascularization: Insights From VOYAGER PAD. Circulation. 2021 Dec 7;144(23):1831-1841. PubMed PMID: 34637332
• Rogers RK, Reece TB, Bonaca MP, Hess CN. Acute Aortic Syndromes. Cardiol Clin. 2021 Nov;39(4):495-503. PubMed PMID: 34686262
• Hess CN, Patel MR, Bauersachs RM, Anand SS, Debus ES, Nehler MR, Fanelli F, Yeh RW, Secemsky EA, Beckman JA, Mauri L, Govsyeyev N, Capell WH, Brackin T, Berkowitz SD, Muehlhofer E, Haskell LP, Hiatt WR, Bonaca MP. Safety and Effectiveness of Paclitaxel Drug-Coated Devices in Peripheral Artery Revascularization: Insights From VOYAGER PAD. J Am Coll Cardiol. 2021 Nov 2;78(18):1768-1778. PubMed PMID: 34711335
• Hess CN, Bonaca MP. Risk of remnants and remnant risk in peripheral artery disease. Eur Heart J. 2021 Dec 9. [Epub ahead of print] PubMed PMID: 34888625
• Hess CN, Capell WH, Bristow MR, Ruf W, Szarek M, Morrow DA, Nicolau JC, Graybill CA, Marshall D, Hsia J, Bonaca MP. Rationale and design of a study to assess the safety and efficacy of rNAPc2 in COVID-19: the Phase 2b ASPEN-COVID-19 trial. Am Heart J. 2022 Apr;246:136-143. PubMed PMID: 34986394
• Govsyeyev N, Nehler M, Conte M, Debus S, Chung J, Dorigo W, Gudz I, Krievins D, Mills J, Moll F, Norgren L, Piffaretti G, Powell R, Szalay D, Sillesen H, Wohlauer M, Szarek M, Bauersachs RM, Anand SS, Patel MR, Capell WH, Jaeger N, Hess CN, Muehlhofer E, Haskell LP, Berkowitz SD, Bonaca MP. Rivaroxaban in Patients with Symptomatic Peripheral Artery Disease after Lower Extremity Bypass Surgery with Venous and Prosthetic Conduits. J Vasc Surg. 2022 Dec 2. [Epub ahead of print] PubMed PMID: 36470531
• Altin SE, Gitto M, Secemsky EA, Rao SV, Hess CN. Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention. Circ Cardiovasc Interv. 2022 Aug;15(8):e011768. PubMed PMID: 35938403
• Hess CN, Szarek M, Anand SS, Bauersachs RM, Patel MR, Debus ES, Nehler MR, Capell WH, Beckman JA, Piazza G, Henkin S, Bura-Rivière A, Lawall H, Roztocil K, Hsia J, Muehlhofer E, Berkowitz SD, Haskell LP, Bonaca MP. Rivaroxaban and Risk of Venous Thromboembolism in Patients With Symptomatic Peripheral Artery Disease After Lower Extremity Revascularization. JAMA Netw Open. 2022 Jun 1;5(6):e2215580. PubMed PMID: 35731517
• Hess CN, Baumgartner I, Anand SS, Nehler MR, Patel MR, Debus ES, Szarek M, Capell W, Muehlhofer E, Berkowitz SD, Haskell LP, Bauersachs RM, Bonaca MP, Hsia J. Sex-Based Differences in Outcomes Following Peripheral Artery Revascularization: Insights From VOYAGER PAD. J Am Heart Assoc. 2022 Jun 21;11(12):e024655. PubMed PMID: 35699170
• Rymer J, Anand SS, Sebastian Debus E, Haskell LP, Hess CN, Jones WS, Muehlhofer E, Berkowitz SD, Bauersachs RM, Bonaca MP, Patel MR. Rivaroxaban Plus Aspirin Versus Aspirin Alone After Endovascular Revascularization for Symptomatic PAD: Insights From VOYAGER PAD. Circulation. 2023 Dec 12;148(24):1919-1928. PubMed PMID: 37850397
• Roeters van Lennep JE, Tokgözoglu LS, Badimon L, Dumanski SM, Gulati M, Hess CN, Holven KB, Kavousi M, Kayikçioglu M, Lutgens E, Michos ED, Prescott E, Stock JK, Tybjaerg-Hansen A, Wermer MJH, Benn M. Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society. Eur Heart J. 2023 Oct 14;44(39):4157-4173. PubMed PMID: 37611089
• Dehmer GJ, Grines CL, Bakaeen FG, Beasley DL, Beckie TM, Boyd J, Cigarroa JE, Das SR, Diekemper RL, Frampton J, Hess CN, Ijioma N, Lawton JS, Shah B, Sutton NR. 2023 AHA/ACC Clinical Performance and Quality Measures for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures. J Am Coll Cardiol. 2023 Sep 12;82(11):1131-1174. PubMed PMID: 37516946
• Pabon M, Cheng S, Altin SE, Sethi SS, Nelson MD, Moreau KL, Hamburg N, Hess CN. Sex Differences in Peripheral Artery Disease. Circ Res. 2022 Feb 18;130(4):496-511. PubMed PMID: 35175843
• Dehmer GJ, Grines CL, Bakaeen FG, Beasley DL, Beckie TM, Boyd J, Cigarroa JE, Das SR, Diekemper RL, Frampton J, Hess CN, Ijioma N, Lawton JS, Shah B, Sutton NR. 2023 AHA/ACC Clinical Performance and Quality Measures for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures. Circ Cardiovasc Qual Outcomes. 2023 Sep;16(9):e00121. PubMed PMID: 37499042
• Altin SE, Parise H, Hess CN, Rosenthal NA, Creager MA, Aronow HD, Curtis JP. Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication. JACC Cardiovasc Interv. 2023 Jul 10;16(13):1668-1678. PubMed PMID: 37438035
• Berkowitz SD, Bauersachs RM, Szarek M, Nehler MR, Debus ES, Patel MR, Anand SS, Capell WH, Hess CN, Hsia J, Leeper NJ, Brasil D, Mátyás L, Diaz R, Brodmann M, Muehlhofer E, Haskell LP, Bonaca MP. Prevention of arterial and venous thrombotic events in symptomatic peripheral arterial disease patients after lower extremity revascularization in the VOYAGER PAD trial: Dual anticoagulant/antiplatelet regimen vs antiplatelet therapy alone. J Thromb Haemost. 2022 May;20(5):1193-1205. PubMed PMID: 35170216
• Hess CN, Hsia J, Carroll IA, Nehler MR, Ruf W, Morrow DA, Nicolau JC, Berwanger O, Szarek M, Capell WH, Johri S, Pursley MS, Gupta R, Meehan PS, Franchi F, Effron MB, Marshall D, Graybill CA, Huebler SP, Keuer T, Bristow MR, Bonaca MP. Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial. Arterioscler Thromb Vasc Biol. 2023 Aug;43(8):1572-1582. PubMed PMID: 37381988
• Canonico ME, Hess CN, Cannon CP. In-Hospital Use of PCSK9 Inhibitors in the Post ACS Patient: What Does the Evidence Show?. Curr Atheroscler Rep. 2023 Jul;25(7):381-389. PubMed PMID: 37223853
• Morrison JT, Govsyeyev N, Hess CN, Bonaca MP. Vorapaxar for Prevention of Major Adverse Cardiovascular and Limb Events in Peripheral Artery Disease. J Cardiovasc Pharmacol Ther. 2022 Jan-Dec;27:10742484211056115. PubMed PMID: 35006035
• Canonico ME, Piccolo R, Avvedimento M, Leone A, Esposito S, Franzone A, Giugliano G, Gargiulo G, Hess CN, Berkowitz SD, Hsia J, Cirillo P, Esposito G, Bonaca MP. Antithrombotic Therapy in Peripheral Artery Disease: Current Evidence and Future Directions. J Cardiovasc Dev Dis. 2023 Apr 10;10(4). PubMed PMID: 37103043
• Canonico ME, Hsia J, Hess CN, Bonaca MP. Sex differences in guideline-directed medical therapy in 2021-22 among patients with peripheral artery disease. Vasc Med. 2023 Jun;28(3):233-235. PubMed PMID: 36847166
• Hess CN, Capell WH, Bristow MR, Ruf W, Szarek M, Morrow DA, Nicolau JC, Graybill CA, Marshall D, Hsia J, Bonaca MP. Rationale and design of a study to assess the safety and efficacy of rNAPc2 in COVID-19: the Phase 2b ASPEN-COVID-19 trial. Am Heart J. 2022 Apr;246:136-143. PubMed PMID: 34986394
• Hess CN, Bonaca MP. Guideline-Directed Medical Therapy in PAD: Time to Step on the Gas. JACC Cardiovasc Interv. 2023 Feb 13;16(3):344-346. PubMed PMID: 36792258
• Govsyeyev N, Nehler M, Conte MS, Debus S, Chung J, Dorigo W, Gudz I, Krievins D, Mills J, Moll F, Norgren L, Piffaretti G, Powell R, Szalay D, Sillesen H, Wohlauer M, Szarek M, Bauersachs RM, Anand SS, Patel MR, Capell WH, Jaeger N, Hess CN, Muehlhofer E, Haskell LP, Berkowitz SD, Bonaca MP. Rivaroxaban in patients with symptomatic peripheral artery disease after lower extremity bypass surgery with venous and prosthetic conduits. J Vasc Surg. 2023 Apr;77(4):1107-1118.e2. PubMed PMID: 36470531
• Bonaca MP, Hess C, Beckman JA. Telmisartan and Walking Performance in Peripheral Artery Disease. JAMA. 2022 Oct 4;328(13):1302-1303. PubMed PMID: 36194236
• Altin SE, Gitto M, Secemsky EA, Rao SV, Hess CN. Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention. Circ Cardiovasc Interv. 2022 Aug;15(8):e011768. PubMed PMID: 35938403
• Hess CN, Szarek M, Anand SS, Bauersachs RM, Patel MR, Debus ES, Nehler MR, Capell WH, Beckman JA, Piazza G, Henkin S, Bura-Rivière A, Lawall H, Roztocil K, Hsia J, Muehlhofer E, Berkowitz SD, Haskell LP, Bonaca MP. Rivaroxaban and Risk of Venous Thromboembolism in Patients With Symptomatic Peripheral Artery Disease After Lower Extremity Revascularization. JAMA Netw Open. 2022 Jun 1;5(6):e2215580. PubMed PMID: 35731517
• Hess CN, Bonaca MP. Risk of remnants and remnant risk in peripheral artery disease. Eur Heart J. 2022 Sep 7;43(34):3270-3272. PubMed PMID: 34888625
• Hess CN, Bonaca MP. Risk of remnants and remnant risk in peripheral artery disease. Eur Heart J. 2022 Sep 7;43(34):3270-3272. PubMed PMID: 34888625
• Hess CN, Capell WH, Bristow MR, Ruf W, Szarek M, Morrow DA, Nicolau JC, Graybill CA, Marshall D, Hsia J, Bonaca MP. Rationale and design of a study to assess the safety and efficacy of rNAPc2 in COVID-19: the Phase 2b ASPEN-COVID-19 trial. Am Heart J. 2022 Apr;246:136-143. PubMed PMID: 34986394
• Morrison JT, Govsyeyev N, Hess CN, Bonaca MP. Vorapaxar for Prevention of Major Adverse Cardiovascular and Limb Events in Peripheral Artery Disease. J Cardiovasc Pharmacol Ther. 2022 Jan-Dec;27:10742484211056115. PubMed PMID: 35006035
• Berkowitz SD, Bauersachs RM, Szarek M, Nehler MR, Debus ES, Patel MR, Anand SS, Capell WH, Hess CN, Hsia J, Leeper NJ, Brasil D, Mátyás L, Diaz R, Brodmann M, Muehlhofer E, Haskell LP, Bonaca MP. Prevention of arterial and venous thrombotic events in symptomatic peripheral arterial disease patients after lower extremity revascularization in the VOYAGER PAD trial: Dual anticoagulant/antiplatelet regimen vs antiplatelet therapy alone. J Thromb Haemost. 2022 May;20(5):1193-1205. PubMed PMID: 35170216
• Pabon M, Cheng S, Altin SE, Sethi SS, Nelson MD, Moreau KL, Hamburg N, Hess CN. Sex Differences in Peripheral Artery Disease. Circ Res. 2022 Feb 18;130(4):496-511. PubMed PMID: 35175843
• Bonaca MP, Hess C, Beckman JA. Telmisartan and Walking Performance in Peripheral Artery Disease. JAMA. 2022 Oct 4;328(13):1302-1303. PubMed PMID: 36194236
• Szarek M, Hess C, Patel MR, Jones WS, Berger JS, Baumgartner I, Katona B, Mahaffey KW, Norgren L, Blomster J, Rockhold FW, Hsia J, Fowkes FGR, Bonaca MP. Total Cardiovascular and Limb Events and the Impact of Polyvascular Disease in Chronic Symptomatic Peripheral Artery Disease. J Am Heart Assoc. 2022 Jun 7;11(11):e025504. PubMed PMID: 35621222
• Hogan SE, Nehler MR, Anand S, Patel MR, Debus S, Jackson MT, Buchanan C, King RW, Hess C, Muehlhofer E, Haskell LP, Bauersachs RM, Berkowitz SD, Hsia J, Bonaca MP. Improvement in walking impairment following surgical and endovascular revascularization: Insights from VOYAGER PAD. Vasc Med. 2022 Aug;27(4):343-349. PubMed PMID: 35467452
• Hogan SE, Nehler MR, Anand S, Patel MR, Debus S, Jackson MT, Buchanan C, King RW, Hess C, Muehlhofer E, Haskell LP, Bauersachs RM, Berkowitz SD, Hsia J, Bonaca MP. Improvement in walking impairment following surgical and endovascular revascularization: Insights from VOYAGER PAD. Vasc Med. 2022 Aug;27(4):343-349. PubMed PMID: 35467452
• Szarek M, Hess C, Patel MR, Jones WS, Berger JS, Baumgartner I, Katona B, Mahaffey KW, Norgren L, Blomster J, Rockhold FW, Hsia J, Fowkes FGR, Bonaca MP. Total Cardiovascular and Limb Events and the Impact of Polyvascular Disease in Chronic Symptomatic Peripheral Artery Disease. J Am Heart Assoc. 2022 Jun 7;11(11):e025504. PubMed PMID: 35621222
• Hess CN, Baumgartner I, Anand SS, Nehler MR, Patel MR, Debus ES, Szarek M, Capell W, Muehlhofer E, Berkowitz SD, Haskell LP, Bauersachs RM, Bonaca MP, Hsia J. Sex-Based Differences in Outcomes Following Peripheral Artery Revascularization: Insights From VOYAGER PAD. J Am Heart Assoc. 2022 Jun 21;11(12):e024655. PubMed PMID: 35699170

Practice Locations

UCHealth Heart & Vascular Center - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Cardiology, Board Certification
• Interventional Cardiology, Board Certification

Conditions & Treatments

• Heart and Circulation