Kimberley Bruce, PhD

Professional Titles

• Associate Professor

Research Interests

Lipid and Lipoprotein Metabolism. Brain Metabolism. Microglia Metabolism and Function. Neurodegenerative diseases, Alzheimer's Disease, and Multiple Sclerosis. Lipoprotein Lipase (LPL) Biology and Function. Fatty Liver disease. Sex Differences in Brain Metabolism and Disease

Publications

• Yamada R, Deshpande SA, Bruce KD, Mak EM, Ja WW. Microbes Promote Amino Acid Harvest to Rescue Undernutrition in Drosophila. Cell Rep. 2015 Feb 12. [Epub ahead of print] PubMed PMID: 25683709
• Bruce KD, Szczepankiewicz D, Sihota KK, Ravindraanandan M, Thomas H, Lillycrop KA, Burdge GC, Hanson MA, Byrne CD, Cagampang FR. Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH. Biochim Biophys Acta. 2016 Jul;1861(7):584-93. PubMed PMID: 27040510
• Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH. Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition. Metabolism. 2016 Jul;65(7):987-97. PubMed PMID: 27282869
• Taha DA, Zgair A, Lee JB, de Moor CH, Barrett DA, Bruce KD, Sungelo M, Eckel RH, Gershkovich P. Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. Eur J Pharm Sci. 2017 Jan 16;100:163-175. [Epub ahead of print] PubMed PMID: 28104473
• Taha DA, Zgair A, Lee JB, de Moor CH, Barrett DA, Bruce KD, Sungelo M, Eckel RH, Gershkovich P. Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. Eur J Pharm Sci. 2017 Mar 30;100:163-175. PubMed PMID: 28104473
• Bruce KD, Zsombok A, Eckel RH. Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism. Front Endocrinol (Lausanne). 2017;8:60. PubMed PMID: 28421037
• Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Prévot V, Tschöp MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia. 2017 Jul;60(7):1314-1324. PubMed PMID: 28456865
• Carvalho GB, Drago I, Hoxha S, Yamada R, Mahneva O, Bruce KD, Soto Obando A, Conti B, Ja WW. The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9737-9742. PubMed PMID: 28827349
• Bruce KD, Jonscher KR. Assessment of Fatty Liver in Models of Disease Programming. Methods Mol Biol. 2018;1735:251-266. PubMed PMID: 29380318
• Kimberley D. Bruce1*, Sachi Gorkhali1, Katherine Given2, Alison M. Coates3, Kristen E. Boyle4, Wendy B. Macklin2 and Robert H. Eckel1Lipoprotein Lipase is a feature of alternatively-activated microglia and may facilitate lipid uptake in the CNS during demyelination Front. Mol. Neurosci. | doi: 10.3389/fnmol.2018.00057
• Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018;11:57. PubMed PMID: 29599706
• Series Title : Adv Exp Med Biol Volume Number : 1134 Book Title : Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders ISBN : 978-3-030-12667-4 Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions
• Cleal JK, Bruce KD, Shearer JL, Thomas H, Plume J, Gregory L, Shepard JN, Spiers-Fitzgerald KL, Mani R, Lewis RM, Lillycrop KA, Hanson MA, Byrne CD, Cagampang FR. Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring. Int J Mol Sci. 2019 Oct 30;20(21). PubMed PMID: 31671625
• Jonscher KR, Bruce KD. Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions. Adv Exp Med Biol. 2019;1134:33-58. PubMed PMID: 30919331
• Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, Bruce KD. Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation. Cells. 2021 Jan 20;10(2). PubMed PMID: 33498265
• Joshi M, Kim J, D'Alessandro A, Monk E, Bruce K, Elajaili H, Nozik-Grayck E, Goodspeed A, Costello JC, Schlaepfer IR. CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer. Cancers (Basel). 2020 Nov 18;12(11). PubMed PMID: 33218188
• Bruce KD, Dobrinskikh E, Wang H, Rudenko I, Gao H, Libby AE, Gorkhali S, Yu T, Zsombok A, Eckel RH. Neuronal Lipoprotein Lipase Deficiency Alters Neuronal Function and Hepatic Metabolism. Metabolites. 2020 Sep 28;10(10). PubMed PMID: 32998280
• Coughlan C, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, Königshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 Sep;88(1):e110. PubMed PMID: 32633898
• Loving BA, Bruce KD. Lipid and Lipoprotein Metabolism in Microglia. Front Physiol. 2020;11:393. PubMed PMID: 32411016
• Bruce KD, Yassine HN, Fonteh AN. Editorial: Lipid Metabolism and Transport in CNS Health and Disease. Front Physiol. 2021;12:768417. PubMed PMID: 34721089
• Cleland NRW, Al-Juboori SI, Dobrinskikh E, Bruce KD. Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging. J Neuroinflammation. 2021 Oct 28;18(1):248. PubMed PMID: 34711251
• Guttenplan KA, Weigel MK, Prakash P, Wijewardhane PR, Hasel P, Rufen-Blanchette U, Münch AE, Blum JA, Fine J, Neal MC, Bruce KD, Gitler AD, Chopra G, Liddelow SA, Barres BA. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature. 2021 Nov;599(7883):102-107. PubMed PMID: 34616039
• Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, Bruce KD. Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation. Cells. 2021 Jan 20;10(2). PubMed PMID: 33498265
• Lightbourne M, Startzell M, Bruce KD, Brite B, Muniyappa R, Skarulis M, Shamburek R, Gharib AM, Ouwerkerk R, Walter M, Eckel RH, Brown RJ. Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy. J Clin Lipidol. 2022 Nov-Dec;16(6):850-862. PubMed PMID: 36195542
• Cleland NRW, Bruce KD. Fatty acid sensing in the brain: The role of glial-neuronal metabolic crosstalk and horizontal lipid flux. Biochimie. 2022 Aug 20. [Epub ahead of print] PubMed PMID: 35998849
• Oldham D, Wang H, Mullen J, Lietzke E, Sprenger K, Reigan P, Eckel RH, Bruce KD. Using Synthetic ApoC-II Peptides and nAngptl4 Fragments to Measure Lipoprotein Lipase Activity in Radiometric and Fluorescent Assays. Front Cardiovasc Med. 2022;9:926631. PubMed PMID: 35911520
• Eckel RH, Bruce KD. Statins, gut microbiome, LDL-C, glucose intolerance: Personalized medicine timely?. Med (N Y). 2022 Jun 10;3(6):355-357. PubMed PMID: 35690054
• Merrill NJ, Davidson WS, He Y, Díaz Ludovico I, Sarkar S, Berger MR, McDermott JE, Van Eldik LJ, Wilcock DM, Monroe ME, Kyle JE, Bruce KD, Heinecke JW, Vaisar T, Raber J, Quinn JF, Melchior JT. Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health. Sci Adv. 2023 Sep;9(35):eadi5571. PubMed PMID: 37647397
• Bruce KD, Eckel RH. Can DNA Methylation Predict the Lipid Response to Dietary Intervention? There's a Fat Chance. J Clin Endocrinol Metab. 2023 Nov 17;108(12):e1747-e1748. PubMed PMID: 37191137
• Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain Res. 2024 Jan 18;:148772. [Epub ahead of print] PubMed PMID: 38244754
• Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging. bioRxiv. 2023 Nov 30. PubMed PMID: 38076915
• Tobeh NS, Bruce KD. Emerging Alzheimer's disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions. Front Aging Neurosci. 2023;15:1259012. PubMed PMID: 38020773
• Merrill NJ, Davidson WS, He Y, Díaz Ludovico I, Sarkar S, Berger MR, McDermott JE, Van Eldik LJ, Wilcock DM, Monroe ME, Kyle JE, Bruce KD, Heinecke JW, Vaisar T, Raber J, Quinn JF, Melchior JT. Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health. Sci Adv. 2023 Sep;9(35):eadi5571. PubMed PMID: 37647397
• Bruce KD, Eckel RH. Can DNA Methylation Predict the Lipid Response to Dietary Intervention? There's a Fat Chance. J Clin Endocrinol Metab. 2023 Nov 17;108(12):e1747-e1748. PubMed PMID: 37191137

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000