Vitaly Kheyfets, PhD

Publications

• Kheyfets VO, Sweatt AJ, Zhang H, Nemkov T, Heerdt P, Dzieciatkowska M, Stephenson D, LaCroix IS, D'Alessandro A, Oldham WM, Hansen K, Zamanian RT, Stenmark KR. Identification of candidate biomarkers and molecular networks associated with Pulmonary Arterial Hypertension using machine learning and plasma multi-Omics analysis. medRxiv. 2024 Dec 20. PubMed PMID: 39763543
• Laudenschlager S, Schofield S, Drysdale N, Stone M, Romanowicz J, Frank B, DiMaria M, Kheyfets VO, Hedjazi-Moghari M. Estimation of pulmonary vascular resistance for Glenn physiology. PLoS One. 2024;19(7):e0307890. PubMed PMID: 39058711
• Heerdt PM, Kheyfets VO, Oakland HT, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis-Clinical Relevance and Future Directions. J Cardiothorac Vasc Anesth. 2024 Oct;38(10):2433-2445. PubMed PMID: 39025682
• Ichimura K, Boehm M, Andruska AM, Zhang F, Schimmel K, Bonham S, Kabiri A, Kheyfets VO, Ichimura S, Reddy S, Mao Y, Zhang T, Wang GX, Santana EJ, Tian X, Essafri I, Vinh R, Tian W, Nicolls MR, Yajima S, Shudo Y, MacArthur JW, Woo YJ, Metzger RJ, Spiekerkoetter E. 3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension. Circ Res. 2024 Jun 21;135(1):60-75. PubMed PMID: 38770652
• Tuder RM, Gandjeva A, Williams S, Kumar S, Kheyfets VO, Hatton-Jones KM, Starr JR, Yun J, Hong J, West NP, Stenmark KR. Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2024 Aug 1;210(3):329-342. PubMed PMID: 38568479
• Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease. Alzheimers Dement. 2024 Jan;20(1):301-315. PubMed PMID: 37610059
• Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease. Alzheimers Dement. 2023 Aug 23. [Epub ahead of print] PubMed PMID: 37610059
• Hu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KR. The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 Jul;69(1):73-86. PubMed PMID: 36944195
• Kheyfets VO, Kumar S, Heerdt PM, Ichimura K, Brown RD, Lucero M, Essafri I, Williams S, Stenmark KR, Spiekerkoetter E. Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. Int J Mol Sci. 2023 Jun 5;24(11). PubMed PMID: 37298696
• Ichimura K, Santana EJ, Kuznetsova T, Cauwenberghs N, Sabovcik F, Chun L, Francisco NLC, Kheyfets VO, Salerno M, Zamanian RT, Spiekerkoetter E, Haddad F. Novel left ventricular mechanical index in pulmonary arterial hypertension. Pulm Circ. 2023 Apr;13(2):e12216. PubMed PMID: 37063750
• Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H804-H820. PubMed PMID: 36961489
• Kheyfets VO, Sweatt AJ, Gomberg-Maitland M, Ivy DD, Condliffe R, Kiely DG, Lawrie A, Maron BA, Zamanian RT, Stenmark KR. Computational platform for doctor-artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study. ERJ Open Res. 2023 Jan;9(1). PubMed PMID: 36776484
• Gu S, Goel K, Forbes LM, Kheyfets VO, Yu YA, Tuder RM, Stenmark KR. Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension. Compr Physiol. 2023 Jan 30;13(1):4295-4319. PubMed PMID: 36715285
• Walter R, Hunter K, Stenmark K, Kheyfets VO. Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study. J Biomech Eng. 2022 Feb 1;144(2). PubMed PMID: 34251418
• Mickael C, Kheyfets VO, Langouët-Astrié C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM. Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform. Am J Respir Cell Mol Biol. 2022 May;66(5):580-581. PubMed PMID: 35486078
• Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure-based estimation of right ventricular ejection fraction. ESC Heart Fail. 2022 Apr;9(2):1436-1443. PubMed PMID: 35150211
• Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L58-L68. PubMed PMID: 35608266
• McConnell BV, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Sillau SH, Pulver RL, Bettcher BM. The Rise and Fall of Slow Wave Tides: Vacillations in Coupled Slow Wave/Spindle Pairing Shift the Composition of Slow Wave Activity in Accordance With Depth of Sleep. Front Neurosci. 2022;16:915934. PubMed PMID: 35812239
• Javadi E, Laudenschlager S, Kheyfets V, Di Maria M, Stone M, Jamali S, Powell AJ, Moghari MH. Predicting Hemodynamic Performance of Fontan Operation for Glenn Physiology using Computational Fluid Dynamics: Ten Patient-specific Cases. J Clin Images Med Case Rep. 2022 Jun;3(6). PubMed PMID: 36339935
• V.O. Kheyfets, A.J. Sweatt, M. Gomberg-Maitland, D.D. Ivy, R. Condliffe, D.G. Kiely, A. Lawrie, B.A. Maron, R.T. Zamanian, K. Stenmark. Computational Platform for Doctor-AI Cooperation in PAH Prognostication. European Respiratory Journal Open Research
• S. Gu, K. Goel, L. M. Forbes, V.O. Kheyfets, Y. A. Yu, R. M. Tuder, K. R. Stenmark. Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiological Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension. Comprehensive Physiology