Nathan Clendenen, MD

Professional Titles

• Assistant Professor

Publications

• Clendenen N, Cannon AD, Porter S, Robards CB, Parker AS, Clendenen SR. Whole-exome sequencing of a family with local anesthetic resistance. Minerva Anestesiol. 2016 Oct;82(10):1089-1097. PubMed PMID: 27243970
• Clendenen N, Tollefson A, Dzieciatkowska M, Cambiaghi A, Ferrario M, Kroehl M, Banerjee A, D'Alessandro A, Hansen KC, Weitzel N. Correlation of pre-operative plasma protein concentrations in cardiac surgery patients with bleeding outcomes using a targeted quantitative proteomics approach. Proteomics Clin Appl. 2017 Jul;11(7-8). PubMed PMID: 28176468
• Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Hansen K, Banerjee A, Moore HB, D'Alessandro A. Hemorrhagic shock and tissue injury drive distinct plasma metabolome derangements in swine. J Trauma Acute Care Surg. 2017 Oct;83(4):635-642. PubMed PMID: 28463938
• Clendenen N, Weitzel N. Predictors of Prolonged Mechanical Ventilation in Adults After Acute Type-A Aortic Dissection Repair-Implications for the Future. J Cardiothorac Vasc Anesth. 2017 Oct;31(5):1562-1563. PubMed PMID: 28864159
• Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562
• Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562
• Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J. TNF-a-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood. 2019 Aug 29;134(9):727-740. PubMed PMID: 31311815
• Schmitt LR, Henderson R, Barrett A, Darula Z, Issaian A, D'Alessandro A, Clendenen N, Hansen KC. Mass spectrometry-based molecular mapping of native FXIIIa cross-links in insoluble fibrin clots. J Biol Chem. 2019 May 31;294(22):8773-8778. PubMed PMID: 31028172
• Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB. Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus. 2019 Sep;17(5):347-356. PubMed PMID: 30747701
• Clendenen N, Ahlgren B. Lung Isolation Techniques in Patients With Early-Stage or Long-Term Tracheostomy: A Clear Path Down a Tough Road. J Cardiothorac Vasc Anesth. 2018 Aug 7. [Epub ahead of print] PubMed PMID: 30269887
• Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 Mar;95(3):590-610. PubMed PMID: 30709662
• Clendenen N, Ginde A. Efficacy of platelet-rich plasma as conservative treatment in orthopaedics. Blood Transfus. 2018 Nov;16(6):473-474. PubMed PMID: 30388071
• Clendenen N, Ginde A. Efficacy of platelet-rich plasma as conservative treatment in orthopaedics. Blood Transfus. 2018 Nov;16(6):473-474. PubMed PMID: 30388071
• Clendenen N, Ahlgren B. Lung Isolation Techniques in Patients With Early-Stage or Long-Term Tracheostomy: A Clear Path Down a Tough Road. J Cardiothorac Vasc Anesth. 2019 Feb;33(2):440-441. PubMed PMID: 30269887
• Clendenen N, D'Alessandro A. High Throughput Metabolomics in Clinical Studies: Review and New Applications to Remote Ischemic Preconditioning. Curr Top Med Chem. 2018;18(25):2143-2153. PubMed PMID: 30698107
• Bortot M, Sharifi A, Ashworth K, Walker F, Cox A, Ruegg K, Clendenen N, Neeves KB, Bark D Jr, Di Paola J. Pathologic Shear and Elongation Rates Do Not Cause Cleavage of Von Willebrand Factor by ADAMTS13 in a Purified System. Cell Mol Bioeng. 2020 Aug;13(4):379-390. PubMed PMID: 32952737
• Clendenen N, Abrams B, Morabito J, Grae L, Mosca MS, Weitzel N. Noteworthy Literature in Cardiac Anesthesia for 2019. Semin Cardiothorac Vasc Anesth. 2020 Jun;24(2):138-148. PubMed PMID: 32349616
• Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562
• Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J. TNF-a-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood. 2019 Aug 29;134(9):727-740. PubMed PMID: 31311815
• Schmitt LR, Henderson R, Barrett A, Darula Z, Issaian A, D'Alessandro A, Clendenen N, Hansen KC. Mass spectrometry-based molecular mapping of native FXIIIa cross-links in insoluble fibrin clots. J Biol Chem. 2019 May 31;294(22):8773-8778. PubMed PMID: 31028172
• Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB. Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus. 2019 Sep;17(5):347-356. PubMed PMID: 30747701
• Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 Mar;95(3):590-610. PubMed PMID: 30709662
• Clendenen N, Ahlgren B. Lung Isolation Techniques in Patients With Early-Stage or Long-Term Tracheostomy: A Clear Path Down a Tough Road. J Cardiothorac Vasc Anesth. 2019 Feb;33(2):440-441. PubMed PMID: 30269887
• Clendenen N, Ahlgren B, Robitaille MJ, Christensen E, Morabito J, Grae L, Lyman M, Weitzel N. Year in Review 2020: Noteworthy Literature in Cardiothoracic Anesthesiology. Semin Cardiothorac Vasc Anesth. 2021 Jun;25(2):94-106. PubMed PMID: 33938302
• Oyama Y, Shuff S, Davizon-Castillo P, Clendenen N, Eckle T. Intense light as anticoagulant therapy in humans. PLoS One. 2020;15(12):e0244792. PubMed PMID: 33382840
• Bortot M, Sharifi A, Ashworth K, Walker F, Cox A, Ruegg K, Clendenen N, Neeves KB, Bark D Jr, Di Paola J. Pathologic Shear and Elongation Rates Do Not Cause Cleavage of Von Willebrand Factor by ADAMTS13 in a Purified System. Cell Mol Bioeng. 2020 Aug;13(4):379-390. PubMed PMID: 32952737
• Clendenen N, Abrams B, Morabito J, Grae L, Mosca MS, Weitzel N. Noteworthy Literature in Cardiac Anesthesia for 2019. Semin Cardiothorac Vasc Anesth. 2020 Jun;24(2):138-148. PubMed PMID: 32349616
• Smoroda A, Douin D, Morabito J, Lyman M, Prin M, Ahlgren B, Young A, Christensen E, Abrams BA, Weitzel N, Clendenen N. Year in Review 2021: Noteworthy Literature in Cardiothoracic Anesthesia. Semin Cardiothorac Vasc Anesth. 2022 Jun;26(2):107-119. PubMed PMID: 35579926
• Clendenen N, Ahlgren B, Robitaille MJ, Christensen E, Morabito J, Grae L, Lyman M, Weitzel N. Year in Review 2020: Noteworthy Literature in Cardiothoracic Anesthesiology. Semin Cardiothorac Vasc Anesth. 2021 Jun;25(2):94-106. PubMed PMID: 33938302
• Christensen E, Morabito J, Kowalsky M, Tsai JP, Rooke D, Clendenen N. Year in Review 2022: Noteworthy Literature in Cardiac Anesthesiology. Semin Cardiothorac Vasc Anesth. 2023 Jun;27(2):123-135. PubMed PMID: 37126462
• Douin DJ, Pattee J, Scott B, Fernandez-Bustamante A, Prin M, Eckle T, Ginde AA, Clendenen N. Hyperoxemia During Cardiac Surgery Is Associated With Postoperative Pulmonary Complications. Crit Care Explor. 2023 Mar;5(3):e0878. PubMed PMID: 36875558
• Prin M, Clendenen N, Lum H, Kertai MD, Abrams BA. Challenging Paradigms and Trusting Evidence: New Approaches to Perioperative Care. Semin Cardiothorac Vasc Anesth. 2022 Dec;26(4):257-259. PubMed PMID: 36314083
• Smoroda A, Douin D, Morabito J, Lyman M, Prin M, Ahlgren B, Young A, Christensen E, Abrams BA, Weitzel N, Clendenen N. Year in Review 2021: Noteworthy Literature in Cardiothoracic Anesthesia. Semin Cardiothorac Vasc Anesth. 2022 Jun;26(2):107-119. PubMed PMID: 35579926
• Plaisted J, Christensen E, Kowalsky M, Rooke D, Clendenen N. Year in Review 2023: Noteworthy Literature in Cardiac Anesthesiology. Semin Cardiothorac Vasc Anesth. 2024 Jun;28(2):80-90. PubMed PMID: 38593818
• Christensen E, Morabito J, Kowalsky M, Tsai JP, Rooke D, Clendenen N. Year in Review 2022: Noteworthy Literature in Cardiac Anesthesiology. Semin Cardiothorac Vasc Anesth. 2023 Jun;27(2):123-135. PubMed PMID: 37126462
• Douin DJ, Pattee J, Scott B, Fernandez-Bustamante A, Prin M, Eckle T, Ginde AA, Clendenen N. Hyperoxemia During Cardiac Surgery Is Associated With Postoperative Pulmonary Complications. Crit Care Explor. 2023 Mar;5(3):e0878. PubMed PMID: 36875558

Practice Locations

Specialty Information

• Anesthesiology, Board Certification
• Adult Cardiothoracic Anesthesiology, Specialized Training (2018)
• Advanced Perioperative Transesophageal Echocardiography, Board Certification (2018)
• Anesthesiology, Board Certification (2016)