Fredrick Joseph, PhD
Assistant Professor, Ob/Gyn-Basic Repro Science

Publications

  • Aye ILMH, Rosario FJ, Kramer A, Kristiansen O, Michelsen TM, Powell TL, Jansson T. Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity. J Clin Endocrinol Metab. 2022 Jan 1;107(1):53-66. PubMed PMID: 34519830
  • Rosario FJ, Kelly AC, Gupta MB, Powell TL, Cox L, Jansson T. Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome. Front Cell Dev Biol. 2021;9:670980. PubMed PMID: 34805133
  • Rosario FJ, Pardo S, Michelsen TM, Erickson K, Moore L, Powell TL, Weintraub ST, Jansson T. Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture. Front Cell Dev Biol. 2021;9:704781. PubMed PMID: 34595166
  • Rosario FJ, Kramer A, Li C, Galan HL, Powell TL, Nathanielsz PW, Jansson T. Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate. Nutrients. 2021 Aug 23;13(8). PubMed PMID: 34445051
  • Vaughan OR, Maksym K, Silva E, Barentsen K, Anthony RV, Brown TL, Hillman SL, Spencer R, David AL, Rosario FJ, Powell TL, Jansson T. Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice. Clin Sci (Lond). 2021 Sep 17;135(17):2049-2066. PubMed PMID: 34406367
  • Higa R, Rosario FJ, Powell TL, Jansson T, Jawerbaum A. Inhibition of MTOR signaling impairs rat embryo organogenesis by affecting folate availability. Reproduction. 2021 Apr;161(4):365-373. PubMed PMID: 33528379
  • Rosario FJ, Powell TL, Gupta MB, Cox L, Jansson T. mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells. Front Cell Dev Biol. 2020;8:583801. PubMed PMID: 33324640
  • Kelly AC, Kramer A, Rosario FJ, Powell TL, Jansson T. Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta. Clin Sci (Lond). 2020 Dec 11;134(23):3123-3136. PubMed PMID: 33215629
  • James-Allan LB, Rosario FJ, Barner K, Lai A, Guanzon D, McIntyre HD, Lappas M, Powell TL, Salomon C, Jansson T. Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB J. 2020 Apr;34(4):5724-5739. PubMed PMID: 32154621
  • Jessel RH, Rosario FJ, Chen YY, Erickson K, Teal SB, Kramer A, Cotton E, Ryan S, Jansson T, Powell TL. Decreased placental folate transporter expression and activity in first and second trimester in obese mothers. J Nutr Biochem. 2020 Mar;77:108305. PubMed PMID: 31926453
  • Jansson T, Castillo-Castrejon M, Gupta MB, Powell TL, Rosario FJ. Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction. Clin Sci (Lond). 2020 Jan 17;134(1):53-70. PubMed PMID: 31825077
  • Vaughan OR, Rosario FJ, Powell TL, Jansson T. Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring. Int J Obes (Lond). 2020 Feb;44(2):488-499. PubMed PMID: 31076636
  • Vaughan OR, Rosario FJ, Powell TL, Jansson T. Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring. Int J Obes (Lond). 2019 May 10. [Epub ahead of print] PubMed PMID: 31076636
  • Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2019 Feb;33(2):2899-2909. PubMed PMID: 30346829
  • Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017;145:217-251. PubMed PMID: 28110752
  • Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P. Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight. BMC Med. 2017 Jan 3;15(1):1. PubMed PMID: 28049467
  • Dimasuay KG, Gong L, Rosario F, McBryde E, Spelman T, Glazier J, Rogerson SJ, Beeson JG, Jansson T, Devenish RJ, Boeuf P. Impaired placental autophagy in placental malaria. PLoS One. 2017;12(11):e0187291. PubMed PMID: 29125872
  • Lager S, Ramirez VI, Acosta O, Meireles C, Miller E, Gaccioli F, Rosario FJ, Gelfond JAL, Hakala K, Weintraub ST, Krummel DA, Powell TL. Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women. J Clin Endocrinol Metab. 2017 Dec 1;102(12):4557-4567. PubMed PMID: 29053802
  • Rosario FJ, Nathanielsz PW, Powell TL, Jansson T. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep. 2017 Jun 21;7(1):3982. PubMed PMID: 28638048
  • Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P. Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight. BMC Med. 2017 Jan 3;15(1):1. PubMed PMID: 28049467
  • Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017;145:217-251. PubMed PMID: 28110752
  • Rosario FJ, Powell TL, Jansson T. mTOR folate sensing links folate availability to trophoblast cell function. J Physiol. 2017 Jul 1;595(13):4189-4206. PubMed PMID: 28374905
  • Silva E, Rosario FJ, Powell TL, Jansson T. Mechanistic Target of Rapamycin Is a Novel Molecular Mechanism Linking Folate Availability and Cell Function. J Nutr. 2017 Jul;147(7):1237-1242. PubMed PMID: 28592519
  • Aye IL, Rosario FJ, Powell TL, Jansson T. Reply to Carbillon: Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E261. PubMed PMID: 26755612
  • Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R87-93. PubMed PMID: 26491103
  • Pantham P, Rosario FJ, Weintraub ST, Nathanielsz PW, Powell TL, Li C, Jansson T. Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons. Biol Reprod. 2016 Nov;95(5):98. PubMed PMID: 27605346
  • Rosario FJ, Powell TL, Jansson T. Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-a and the RFC. Sci Rep. 2016 Aug 26;6:31705. PubMed PMID: 27562465
  • Aye IL, Rosario FJ, Powell TL, Jansson T. Reply to Carbillon: Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E261. PubMed PMID: 26755612
  • Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. Clin Sci (Lond). 2016 Apr 1;130(7):499-512. PubMed PMID: 26608079
  • Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R87-93. PubMed PMID: 26491103
  • Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of Amino Acid Transporter Trafficking by mTORC1 in Primary Human Trophoblast cells is Mediated by the Ubiquitin Ligase Nedd4-2. Clin Sci (Lond). 2015 Nov 25. [Epub ahead of print] PubMed PMID: 26608079
  • Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1569-77. PubMed PMID: 26491104
  • Aye IL, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12858-63. PubMed PMID: 26417088
  • Chen YY, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond). 2015 Dec;129(12):1131-41. PubMed PMID: 26374858
  • Pantham P, Rosario FJ, Nijland M, Cheung A, Nathanielsz PW, Powell TL, Galan HL, Li C, Jansson T. Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon. Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R740-6. PubMed PMID: 26246504
  • Rosario FJ, Kanai Y, Powell TL, Jansson T. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity (Silver Spring). 2015 Aug;23(8):1663-70. PubMed PMID: 26193061
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General Information

Department: Ob/Gyn-Basic Repro Science
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