My research is focused on understanding what regulates blood flow in the placenta, especially in cases of severe, early-onset growth restriction. Specifically, my long-term goal is to identify and target abnormalities that can lead to poor placental blood flow, which in turn, can result in adverse pregnancy outcomes such as poor fetal growth requiring early delivery.
Publications
Gumina DL, Ji S, Flockton A, McPeak K, Stich D, Moldovan R, Su EJ. Dysregulation of integrin avß3 and a5ß1 impedes migration of placental endothelial cells in fetal growth restriction. Development. 2022 Oct 1;149(19):dev200717. PubMed PMID: 36193846
Costantine MM, Sibai B, Bombard AT, Sarno M, West H, Haas DM, Tita AT, Paidas MJ, Clark EAS, Boggess K, Grotegut C, Grobman W, Su EJ, Burd I, Saade G, Chavez MR, Paglia MJ, Merriam A, Torres C, Habli M, Macones G, Wen T, Bofill J, Palatnik A, Edwards RK, Haeri S, Oberoi P, Mazloom A, Cooper M, Lockton S, Hankins GD. Performance of a Multianalyte 'Rule-Out' Assay in Pregnant Individuals With Suspected Preeclampsia. Hypertension. 2022 Jul;79(7):1515-1524. PubMed PMID: 35545947
Heath-Freudenthal A, Toledo-Jaldin L, von Alvensleben I, Lazo-Vega L, Mizutani R, Stalker M, Yasini H, Mendizabal F, Dorado Madera J, Mundo W, Castro-Monrroy M, Houck JA, Moreno-Aramayo A, Miranda-Garrido V, Su EJ, Giussani DA, Abman SH, Moore LG, Julian CG. Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations. Hypertension. 2022 Jun;79(6):1286-1296. PubMed PMID: 35437031
Tita AT, Szychowski JM, Boggess K, Dugoff L, Sibai B, Lawrence K, Hughes BL, Bell J, Aagaard K, Edwards RK, Gibson K, Haas DM, Plante L, Metz T, Casey B, Esplin S, Longo S, Hoffman M, Saade GR, Hoppe KK, Foroutan J, Tuuli M, Owens MY, Simhan HN, Frey H, Rosen T, Palatnik A, Baker S, August P, Reddy UM, Kinzler W, Su E, Krishna I, Nguyen N, Norton ME, Skupski D, El-Sayed YY, Ogunyemi D, Galis ZS, Harper L, Ambalavanan N, Geller NL, Oparil S, Cutter GR, Andrews WW. Treatment for Mild Chronic Hypertension during Pregnancy. N Engl J Med. 2022 May 12;386(19):1781-1792. PubMed PMID: 35363951
Ji S, Gumina D, McPeak K, Moldovan R, Post MD, Su EJ. Human placental villous stromal extracellular matrix regulates fetoplacental angiogenesis in severe fetal growth restriction. Clin Sci (Lond). 2021 May 14;135(9):1127-1143. PubMed PMID: 33904582
Ouyang Y, Bagalkot T, Fitzgerald W, Sadovsky E, Chu T, Martínez-Marchal A, Brieño-Enríquez M, Su EJ, Margolis L, Sorkin A, Sadovsky Y. Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin. mSphere. 2021 Apr 14;6(2). PubMed PMID: 33853873
Markenson GR, Saade GR, Laurent LC, Heyborne KD, Coonrod DV, Schoen CN, Baxter JK, Haas DM, Longo S, Grobman WA, Sullivan SA, Major CA, Wheeler SM, Pereira LM, Su EJ, Boggess KA, Hawk AF, Crockett AH, Fox AC, Polpitiya A, Fleischer TC, Critchfield GC, Burchard J, Boniface JJ, Lam GK. Performance of a proteomic preterm delivery predictor in a large independent prospective cohort. Am J Obstet Gynecol MFM. 2020 Aug;2(3):100140. PubMed PMID: 33345877
Ji S, Xin H, Su EJ. Overexpression of the aryl hydrocarbon receptor nuclear translocator partially rescues fetoplacental angiogenesis in severe fetal growth restriction. Clin Sci (Lond). 2019 Jun 28;133(12):1353-1365. PubMed PMID: 31189688
Ji S, Xin H, Li Y, Su EJ. FMS-like tyrosine kinase 1 (FLT1) is a key regulator of fetoplacental endothelial cell migration and angiogenesis. Placenta. 2018 Oct;70:7-14. PubMed PMID: 30316329
Li Y, Lorca RA, Su EJ. Molecular and cellular underpinnings of normal and abnormal human placental blood flows. J Mol Endocrinol. 2018 Jan;60(1):R9-R22. PubMed PMID: 29097590
Gumina DL, Su EJ. Endothelial Progenitor Cells of the Human Placenta and Fetoplacental Circulation: A Potential Link to Fetal, Neonatal, and Long-term Health. Front Pediatr. 2017;5:41. PubMed PMID: 28361046
Mestan KK, Gotteiner N, Porta N, Grobman W, Su EJ, Ernst LM. Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. J Pediatr. 2017 Jun;185:33-41. PubMed PMID: 28162769
Palatnik A, Xin H, Su EJ. Dichotomous effects of aryl hydrocarbon receptor (AHR) activation on human fetoplacental endothelial cell function. Placenta. 2016 Aug;44:61-8. PubMed PMID: 27452439
Blundell C, Tess ER, Schanzer AS, Coutifaris C, Su EJ, Parry S, Huh D. A microphysiological model of the human placental barrier. Lab Chip. 2016 Aug 2;16(16):3065-73. PubMed PMID: 27229450
Su EJ, Xin H, Yin P, Dyson M, Coon J, Farrow KN, Mestan KK, Ernst LM. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015 Jan;100(1):E30-40. PubMed PMID: 25343232
Su EJ. Role of the fetoplacental endothelium in fetal growth restriction with abnormal umbilical artery Doppler velocimetry. Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S123-30. PubMed PMID: 26428491
Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. ERß- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Mol Endocrinol. 2014 Aug;28(8):1304-15. PubMed PMID: 24992181
Mestan KK, Check J, Minturn L, Yallapragada S, Farrow KN, Liu X, Su E, Porta N, Gotteiner N, Ernst LM. Placental pathologic changes of maternal vascular underperfusion in bronchopulmonary dysplasia and pulmonary hypertension. Placenta. 2014 Aug;35(8):570-4. PubMed PMID: 24906549
Voller SB, Chock S, Ernst LM, Su E, Liu X, Farrow KN, Mestan KK. Cord blood biomarkers of vascular endothelial growth (VEGF and sFlt-1) and postnatal growth: a preterm birth cohort study. Early Hum Dev. 2014 Apr;90(4):195-200. PubMed PMID: 24480606
Care Philosophy
My goal is to deliver evidence-based and holistic care to pregnant women in a compassionate and thorough manner. I believe in presenting comprehensive information about the pregnancy to the patient and her family, empowering them to be part of the decision-making process while also providing them with evidence-based, medical recommendations. Pregnancy is a time of great joy but can also be stressful, and I feel fortunate to have the opportunity to care for women during this special time in their lives.
Public Speaking Yes
General Information
Medical Schools:
MD, University of Illinois College of Medicine
(2000)
Graduate Schools:
MS, Northwestern University
(2007)
Undergraduate Schools:
BA, Brown University (RI)
(1996)
Residency Programs:
McGaw Medical Center of Northwestern University Program, Chief Resident, Obstetrics and Gynecology (2004)
Fellowships:
McGaw Medical Center of Northwestern University Program, Maternal and Fetal Medicine
(2007)