Yubin Miao, PhD
Professor, Radiology

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Graduate School :
  • PhD, Beijing Normal University (1997)
Undergraduate School:
  • BS, Beijing Normal University (1992)
Languages: English
Department: Radiology

Recognition & Awards

  • Distinguished Investigator Award, The Academy for Radiology & Biomedical Imaging Research (2019)
  • Innovation Award, STC.UNM (2014)
  • Top Newsmaker, New Mexico Business Weekly (2011)
  • Breast Cancer Research Program Award, Department of Defense (2008)
  • New Investigator Award, American Association of Colleges of Pharmacy (2007)
  • Radiopharmaceutical Science Young Investigator Award, Society of Nuclear Medicine (2002)

Research Interests

The research interests in Dr. Miao‘s laboratory focus on developing novel radiolabeled peptides for cancer (melanoma, breast and prostate cancers) diagnosis and treatment. Specifically, we are using radiolabeled peptides to target G protein-coupled receptors (GPCRs) that are over-expressed on cancer cells for cancer detection and therapy. Radiolabeled peptides are attractive probes for cancer imaging and therapy due to their specific nanomolar binding with the GPCRs on cancer cells. Radiolabeled peptides can selectively deliver diagnostic and therapeutic radionuclides to cancer cells through peptide-receptor interactions for imaging and therapy. Hence, malignant tumors can be detected non-invasively by imaging modalities (SPECT or PET) through the collection of photons generated from diagnostic radionuclides. Moreover, malignant tumors can be effectively treated by targeted radiation yielded from therapeutic radionuclides delivered by peptides.

Publications

  • Qiao Z, Xu J, Fisher DR, Gonzalez R, Miao, Y. Introduction of a polyethylene glycol linker improves uptake of 67Cu-NOTA-conjugated lactam-cyclized alpha-melanocyte-stimulating hormone peptide in melanoma. Cancers 2023,15 (10):2755.
  • Qiao Z, Xu J, Gonzalez R, Miao Y. Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [(99m)Tc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized a-MSH Peptides. Bioconjug Chem. 2023 May 17;34(5):934-940. PubMed PMID: 37140963
  • Xu J, Gallazzi F, Fisher DR, Gonzalez R, Miao Y. The Effect of Albumin-Binding Moiety on Tumor Targeting and Biodistribution Properties of (67)Ga-Labeled Albumin Binder-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Cancer Biother Radiopharm. 2022;37:47-55. PubMed PMID: 34762521
  • Qiao Z, Xu J, Gonzalez R, Miao Y. Novel Al(18)F-NOTA-Conjugated Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptides with Enhanced Melanoma Uptake. Bioconjug Chem. 2022 May 18;33(5):982-990. PubMed PMID: 35475603
  • Qiao Z, Xu J, Gonzalez R, Miao Y. Novel (64)Cu-Labeled NOTA-Conjugated Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptides with Enhanced Tumor to Kidney Uptake Ratios. Mol Pharm. 2022 Jul 4;19(7):2535-2541. PubMed PMID: 35486894
  • Bernardes E, Caravan P, van Dam RM, Deuther-Conrad W, Ellis B, Furumoto S, Guillet B, Huang YY, Jia H, Laverman P, Li Z, Liu Z, Lodi F, Miao Y, Perk L, Schirrmacher R, Vercoullie J, Yang H, Yang M, Yang X, Zhang J, Zhang MR, Zhu H. Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharm Chem. 2022 Apr 26;7(1):9. PubMed PMID: 35471681
  • Miao Y, Quinn TP. Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy. J Nucl Med. 2021 Mar;62(3):313-318. PubMed PMID: 33277401
  • Qiao Z, Xu J, Gonzalez R, Miao Y. Novel [(99m)Tc]-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized Alpha-MSH Peptide with Enhanced Melanoma Uptake and Reduced Renal Uptake. Mol Pharm. 2020 Sep 8;17(9):3581-3588. PubMed PMID: 32663011
  • Xu J, Qiao Z, Gonzalez R, Miao Y. Facile preparation of a novel Ga-67-labeled NODAGA-conjugated lactam-cyclized alpha-MSH peptide at room temperature for melanoma targeting. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127627. PubMed PMID: 33141072
  • Xu J, Yang J, Gonzalez R, Fisher DR, Miao Y. Melanoma-Targeting Property of Y-90-Labeled Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptide. Cancer Biother Radiopharm. 2019 Nov;34(9):597-603. PubMed PMID: 31644317
  • Yang J, Xu J, Cheuy L, Gonzalez R, Fisher DR, Miao Y. Evaluation of a Novel Pb-203-Labeled Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptide for Melanoma Targeting. Mol Pharm. 2019 Apr 1;16(4):1694-1702. PubMed PMID: 30763112
  • Yang J, Xu J, Gonzalez R, Lindner T, Kratochwil C, Miao Y. (68)Ga-DOTA-GGNle-CycMSH(hex) targets the melanocortin-1 receptor for melanoma imaging. Sci Transl Med. 2018 Nov 7;10(466). PubMed PMID: 30404861
  • Bandara N, Stott Reynolds TJ, Schehr R, Bandari RP, Diebolder PJ, Krieger S, Xu J, Miao Y, Rogers BE, Smith CJ. Matched-pair, (86)Y/(90)Y-labeled, bivalent RGD/bombesin antagonist, [RGD-Glu-[DO3A]-6-Ahx-RM2], as a potential theranostic agent for prostate cancer. Nucl Med Biol. 2018 Jul - Aug;62-63:71-77. PubMed PMID: 29929115
  • Li J, Zheng H, Wang W, Miao Y, Sheng Y, Feng C. Role of an isoform-specific residue at the calmodulin-heme (NO synthase) interface in the FMN - heme electron transfer. FEBS Lett. 2018 Jul;592(14):2425-2431. PubMed PMID: 29904908
  • Astashkin AV, Li J, Zheng H, Miao Y, Feng C. A docked state conformational dynamics model to explain the ionic strength dependence of FMN - heme electron transfer in nitric oxide synthase. J Inorg Biochem. 2018 Jul;184:146-155. PubMed PMID: 29751215
  • Berman BD, Pollard RT, Shelton E, Karki R, Smith-Jones PM, Miao Y. GABA(A) Receptor Availability Changes Underlie Symptoms in Isolated Cervical Dystonia. Front Neurol. 2018;9:188. PubMed PMID: 29670567
  • Liu L, Xu J, Yang J, Feng C, Miao Y. Metastatic melanoma imaging using a novel Tc-99m-labeled lactam-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2017 Nov 15;27(22):4952-4955. PubMed PMID: 29054361
  • Xu J, Feng C, Miao Y. Evaluation of novel (111)In-labeled gonadotropin-releasing hormone peptides for human prostate cancer imaging. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4647-4651. PubMed PMID: 28917649
  • Chen L, Zheng H, Li W, Li W, Miao Y, Feng C. Role of a Conserved Tyrosine Residue in the FMN-Heme Interdomain Electron Transfer in Inducible Nitric Oxide Synthase. J Phys Chem A. 2016 Oct 6;120(39):7610-7616. PubMed PMID: 27633182
  • Liu L, Xu J, Yang J, Feng C, Miao Y. Imaging human melanoma using a novel Tc-99m-labeled lactam bridge-cyclized alpha-MSH peptide. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4724-8. PubMed PMID: 27568083
  • Zongrui Jiang, Rajendra P. Bandari, Tamila J. Stott Reynolds, Jingli Xu, Yubin Miao, Tammy L. Rold, Ashley F. Szczodroski, Silvia S. Jurisson, Charles J. Smith. Molecular imaging investigations of a 67Ga/64Cu labeled bivalent ligand, [RGD-Glu-(DO3A)-6-Ahx-RM2], targeting GRPR/avß3 biomarkers: a comparative study. Radiochimica Acta 2016;104:499-512.
  • Wu Z, Hu CA, Wu G, Zhaorigetu S, Chand H, Sun K, Ji Y, Wang B, Dai Z, Walton B, Miao Y, Hou Y. Intimacy and a deadly feud: the interplay of autophagy and apoptosis mediated by amino acids. Amino Acids. 2015 Oct;47(10):2089-99. PubMed PMID: 26354329
  • Astashkin AV, Chen L, Elmore BO, Kunwar D, Miao Y, Li H, Poulos TL, Roman LJ, Feng C. Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance. J Phys Chem A. 2015 Jun 25;119(25):6641-9. PubMed PMID: 26035438
  • Xu J, Yang J, Miao Y. Dual receptor-targeting 99mTc-labeled Arg-Gly-Asp-conjugated Alpha-Melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nucl Med Biol. 2015 Apr;42(4):369-74. PubMed PMID: 25577037
  • Yang J, Hu CA, Miao Y. Tc-99m-labeled RGD-conjugated alpha-melanocyte stimulating hormone hybrid peptides with reduced renal uptake. Amino Acids. 2015 Apr;47(4):813-23. PubMed PMID: 25557051
  • Stott Reynolds TJ, Schehr R, Liu D, Xu J, Miao Y, Hoffman TJ, Rold TL, Lewis MR, Smith CJ. Characterization and evaluation of DOTA-conjugated Bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy. Nucl Med Biol. 2015 Feb;42(2):99-108. PubMed PMID: 25459113
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Graduate Schools:
  • PhD, Beijing Normal University (1997)
Undergraduate Schools:
  • BS, Beijing Normal University (1992)
Languages: English
Department: Radiology
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