Kristen Nowak, PhD

Professional Titles

• Associate Professor

Recognitions

• Rising Star, University of Colorado Department of Medicine (2020)

Research Interests

I am trained as a physiologist with an interest in lifestyle interventions to reduce risk of cardiovascular disease and kidney disease progression in patients with kidney diseases, including autosomal dominant polycystic kidney disease (ADPKD) and chronic kidney disease (CKD). I conduct research on the mechanisms of vascular dysfunction in kidney diseases, as well as on novel therapeutics to alleviate such dysfunction. I have unique expertise in identifying integrative physiological mechanisms mediating vascular dysfunction, as well as in epidemiology (Master of Public Health). I direct the clinical vascular physiology laboratory for the Division of Renal Diseases and Hypertension. I also became recently interested in the role of diet and metabolic dysfunction in ADPKD progression. I have a recently completed NIH R03 grant evaluating the feasibility of two weight loss interventions, daily caloric restriction and intermittent fasting, and also have an active PKD Foundation Research grant evaluating the feasibility of time restricted feeding, both in a population of adults with overweight/obesity and ADPKD. I have a recently awarded R01 for a clinical trial evaluating weight loss via daily caloric restriction to slow cyst growth in ADPKD. Additionally, I have a multi-PI R01 assessing the efficacy of inspiratory muscle strength training to lower blood pressure and improve vascular function in CKD.

Publications

• Jablonski KL, Decker E, Perrenoud L, Kendrick J, Chonchol M, Seals DR, Jalal D. Assessment of vascular function in patients with chronic kidney disease. J Vis Exp. 2014 Jun 16;(88). PubMed PMID: 24962357
• Jovanovich AJ, Ginde AA, Holmen J, Jablonski K, Allyn RL, Kendrick J, Chonchol M. Vitamin D level and risk of community-acquired pneumonia and sepsis. Nutrients. 2014 Jun 10;6(6):2196-205. PubMed PMID: 24918697
• Miyazaki-Anzai S, Masuda M, Demos-Davies KM, Keenan AL, Saunders SJ, Masuda R, Jablonski K, Cavasin MA, Kendrick J, Chonchol M, McKinsey TA, Levi M, Miyazaki M. Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification. J Am Heart Assoc. 2014 Jun 24;3(3):e000949. PubMed PMID: 24963104
• Jovanovich AJ, Chonchol M, Brady CB, Kaufman JD, Kendrick J, Cheung AK, Jablonski KL. 25-vitamin D, 1,25-vitamin D, parathyroid hormone, fibroblast growth factor-23 and cognitive function in men with advanced CKD: a veteran population. Clin Nephrol. 2014 Nov;82(5):296-303. PubMed PMID: 25208315
• Jablonski KL, Chonchol M. Chronic Renal Disease. 1st ed. San Diego: Academic Press; c2015. Chapter 53, Management of mineral and bone disorders in CKD patients; p. 646-662.
• Jovanovich AJ, Chonchol MB, Sobhi A, Kendrick JB, Cheung AK, Kaufman JS, Smits G, Jablonski KL. Mineral Metabolites, Angiotensin II Inhibition and Outcomes in Advanced Chronic Kidney Disease. Am J Nephrol. 2015 Nov 25;42(5):361-368. [Epub ahead of print] PubMed PMID: 26606453
• Nowak KL, Farmer H, Cadnapaphornchai MA, Gitomer B, Chonchol M. Vascular Dysfunction in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Nephrol Dial Transplant. 2016 Mar 21. [Epub ahead of print] PubMed PMID: 27001648
• Nowak KL, Cadnapaphornchai MA, Chonchol MB, Schrier RW, Gitomer B. Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2016;44(3):171-8. PubMed PMID: 27548646
• Nowak KL, Chonchol M, Ikizler TA, Farmer-Bailey H, Salas N, Chaudhry R, Wang W, Smits G, Tengesdal I, Dinarello CA, Hung AM. IL-1 Inhibition and Vascular Function in CKD. J Am Soc Nephrol. 2016 Sep 19. [Epub ahead of print] PubMed PMID: 27647856
• Kendrick J, Andrews E, You Z, Moreau K, Nowak KL, Farmer-Bailey H, Seals DR, Chonchol M. Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial. Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1438-1446. PubMed PMID: 28784657
• Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2016 Sep 12. [Epub ahead of print] PubMed PMID: 27620990
• Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nat Immunol. 2017 Jul 19;18(8):826-831. PubMed PMID: 28722720
• Nowak KL, Chonchol M, You Z, Gupta M, Gitomer B. Affected parent sex and severity of autosomal dominant polycystic kidney disease: a retrospective cohort study?. Clin Nephrol. 2017 Oct 16. [Epub ahead of print] PubMed PMID: 29035198
• Nowak KL, You Z, Gitomer B, Brosnahan G, Torres VE, Chapman AB, Perrone RD, Steinman TI, Abebe KZ, Rahbari-Oskoui FF, Yu ASL, Harris PC, Bae KT, Hogan M, Miskulin D, Chonchol M. Overweight and obesity are predictors of progression in early autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2017 Nov 8. [Epub ahead of print] PubMed PMID: 29118087
• Andrews ES, Perrenoud L, Nowak KL, You Z, Pasch A, Chonchol M, Kendrick J, Jalal D. Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial. PLoS One. 2018;13(10):e0205831. PubMed PMID: 30356327
• Nowak KL and Brosnahan G. Current Progress in the Understanding of ADPKD.J Am Soc Nephrol. In RK Visweswaran and C Ponticelli (Eds), Current Progress in Nephrology. Tree Life Media. 2016;1:159-180
• Kendrick J, Shah P, Andrews E, You Z, Nowak K, Pasch A, Chonchol M. Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study. Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1463-1470. PubMed PMID: 30237219
• Nowak KL, Wang W, Farmer-Bailey H, Gitomer B, Malaczewski M, Klawitter J, Jovanovich A, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1493-1501. PubMed PMID: 30228110
• Nowak KL, Gitomer B, Farmer-Bailey H, Wang W, Malaczewski M, Klawitter J, You Z, George D, Patel N, Jovanovich A, Chonchol M. Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial. Am J Kidney Dis. 2019 Aug;74(2):213-223. PubMed PMID: 30803706
• Jovanovich A, You Z, Isakova T, Nowak K, Cheung A, Wolf M, Chonchol M, Kendrick J. Fibroblast Growth Factor 23 Trajectories in Chronic Hemodialysis Patients: Lessons from the HEMO Study. Am J Nephrol. 2019;49(4):263-270. PubMed PMID: 30820005
• Nowak KL, Hopp K. Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential. Clin J Am Soc Nephrol. 2020 Apr 7;15(4):577-584. PubMed PMID: 32086281
• Hung AM, Tsuchida Y, Nowak KL, Sarkar S, Chonchol M, Whitfield V, Salas N, Dikalova A, Yancey PG, Huang J, Linton MF, Ikizler TA, Kon V. IL-1 Inhibition and Function of the HDL-Containing Fraction of Plasma in Patients with Stages 3 to 5 CKD. Clin J Am Soc Nephrol. 2019 May 7;14(5):702-711. PubMed PMID: 31015261
• Nowak KL, Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cell Signal. 2020 Apr;68:109518. PubMed PMID: 31881325
• Nowak KL, Chonchol M, Jovanovich A, You Z, Bates J, Foy C, Glasser S, Killeen AA, Kostis J, Rodriguez CJ, Segal M, Simmons DL, Taylor A, Lovato LC, Ambrosius WT, Supiano MA. Serum Sodium and Pulse Pressure in SPRINT. Am J Hypertens. 2019 Jun 11;32(7):649-656. PubMed PMID: 30977767
• Nowak KL and Chonchol M. Management of mineral and bone disorders in CKD patients (2019). In PL Kimmel and M Rosenberg (Eds), Chronic Renal Disease. Elsevier/Academic Press. Elsevier/Academic Press. 2:1013-1033.
• Bispham NZ, Nowak KL. Drinking Water: The Saltier The Better?. J Am Heart Assoc. 2019 May 7;8(9):e012758. PubMed PMID: 31060416
• Hanudel MR, Salusky IB, Pereira RC, Wang W, You Z, Nowak KL, Brosnahan GM, Torres VE, Chapman AB, Perrone RD, Steinman TI, Bae KT, Gitomer BY, Chonchol MB. Erythropoietin and Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney Disease Patients. Kidney Int Rep. 2019 Dec;4(12):1742-1748. PubMed PMID: 31844811
• Nowak KL, Rossman MJ, Chonchol M, Seals DR. Strategies for Achieving Healthy Vascular Aging. Hypertension. 2018 Mar;71(3):389-402. PubMed PMID: 29311256
• Nowak KL, Yaffe K, Orwoll ES, Ix JH, You Z, Barrett-Connor E, Hoffman AR, Chonchol M. Serum Sodium and Cognition in Older Community-Dwelling Men. Clin J Am Soc Nephrol. 2018 Mar 7;13(3):366-374. PubMed PMID: 29439092
• Nowak KL, Chonchol M, You Z, Gupta M, Gitomer B. Affected parent sex and severity of autosomal dominant polycystic kidney disease: a retrospective cohort study?. Clin Nephrol. 2018 Mar;89(3):196-204. PubMed PMID: 29035198
• Nowak KL, Chonchol M. Does inflammation affect outcomes in dialysis patients?. Semin Dial. 2018 Jul;31(4):388-397. PubMed PMID: 29513906
• Nowak KL, You Z, Gitomer B, Brosnahan G, Torres VE, Chapman AB, Perrone RD, Steinman TI, Abebe KZ, Rahbari-Oskoui FF, Yu ASL, Harris PC, Bae KT, Hogan M, Miskulin D, Chonchol M. Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2018 Feb;29(2):571-578. PubMed PMID: 29118087
• Nowak KL, Fried L, Jovanovich A, Ix J, Yaffe K, You Z, Chonchol M. Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices. Am J Nephrol. 2018;47(1):57-65. PubMed PMID: 29393090
• Nowak KL, Hung A, Ikizler TA, Farmer-Bailey H, Salas-Cruz N, Sarkar S, Hoofnagle A, You Z, Chonchol M. Interleukin-1 inhibition, chronic kidney disease-mineral and bone disorder, and physical function?. Clin Nephrol. 2017 Sep;88(9):132-143. PubMed PMID: 28699886
• Nowak KL, Chonchol M, Ikizler TA, Farmer-Bailey H, Salas N, Chaudhry R, Wang W, Smits G, Tengesdal I, Dinarello CA, Hung AM. IL-1 Inhibition and Vascular Function in CKD. J Am Soc Nephrol. 2017 Mar;28(3):971-980. PubMed PMID: 27647856
• Nowak KL, Farmer H, Cadnapaphornchai MA, Gitomer B, Chonchol M. Vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2017 Feb 1;32(2):342-347. PubMed PMID: 28186577
• Nowak KL, Bartz TM, Dalrymple L, de Boer IH, Kestenbaum B, Shlipak MG, Garimella PS, Ix JH, Chonchol M. Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. J Am Soc Nephrol. 2017 Apr;28(4):1239-1246. PubMed PMID: 28122946
• Jablonski KL, Chonchol M. Posthemodialysis weights and mortality: another narrow range target?. Clin J Am Soc Nephrol. 2015 May 7;10(5):729-31. PubMed PMID: 25862780
• Jablonski KL, Klawitter J, Chonchol M, Bassett CJ, Racine ML, Seals DR. Effect of dietary sodium restriction on human urinary metabolomic profiles. Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1227-34. PubMed PMID: 25901092
• Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR. Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor ? B signalling. J Hypertens. 2015 Dec;33(12):2477-82. PubMed PMID: 26378681
• Jablonski KL, Kendrick JB. Renal outcomes and dietary potassium: the overshadowed electrolyte?. Kidney Int. 2014 Dec;86(6):1077-8. PubMed PMID: 25427082
• Jablonski KL, Chonchol M. Recent advances in the management of hemodialysis patients: a focus on cardiovascular disease. F1000Prime Rep. 2014;6:72. PubMed PMID: 25165571
• Jablonski KL, Chonchol M. Vascular calcification in end-stage renal disease. Hemodial Int. 2013 Oct;17 Suppl 1:S17-21. PubMed PMID: 24134325
• Jablonski KL, Fedorova OV, Racine ML, Geolfos CJ, Gates PE, Chonchol M, Fleenor BS, Lakatta EG, Bagrov AY, Seals DR. Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clin J Am Soc Nephrol. 2013 Nov;8(11):1952-9. PubMed PMID: 23929930
• DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, Seals DR. Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clin Sci (Lond). 2013 Mar;124(5):325-31. PubMed PMID: 23025811
• Jablonski KL, Chonchol M. Chronic kidney disease: Cystatin-C-based eGFR: what is it telling us?. Nat Rev Nephrol. 2013 Jun;9(6):318-9. PubMed PMID: 23591444
• Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. J Am Coll Cardiol. 2013 Jan 22;61(3):335-43. PubMed PMID: 23141486
• Pierce GL, Jablonski KL, Walker AE, Seibert SM, DeVan AE, Black SM, Sharma S, Seals DR. Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. Am J Hypertens. 2012 Oct;25(10):1050-4. PubMed PMID: 22673017
• Jablonski KL, Chonchol M. Frequent hemodialysis: a way to improve physical function?. Clin J Am Soc Nephrol. 2012 May;7(5):707-10. PubMed PMID: 22516284
• Jalal DI, Jablonski KL, McFann K, Chonchol MB, Seals DR. Vascular endothelial function is not related to serum uric acid in healthy adults. Am J Hypertens. 2012 Apr;25(4):407-13. PubMed PMID: 22237152
• Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011 May;120(9):357-75. PubMed PMID: 21244363
• Jablonski KL, Gates PE, Pierce GL, Seals DR. Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure. Ther Adv Cardiovasc Dis. 2009 Oct;3(5):347-56. PubMed PMID: 19723834
• Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR. Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H425-32. PubMed PMID: 19465546
• Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR. Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. J Appl Physiol (1985). 2008 Oct;105(4):1359-63. PubMed PMID: 18669935
• Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell. 2008 Dec;7(6):805-12. PubMed PMID: 18782346
• Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J Appl Physiol (1985). 2007 Nov;103(5):1715-21. PubMed PMID: 17965239
• Nowak KL, Hopp K. Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential. Clin J Am Soc Nephrol. 2020 Apr 7;15(4):577-584. PubMed PMID: 32086281
• Nowak KL, Chonchol M, Jovanovich A, You Z, Ambrosius WT, Cho ME, Glasser S, Lash J, Simmons DL, Taylor A, Weiner D, Rastogi A, Oparil S, Supiano MA. Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial?. Clin Nephrol. 2020 Jul;94(1):26-35. PubMed PMID: 32449678
• Wang W, Chonchol M, Seals DR, Nowak KL. Dietary sodium restriction decreases urinary NGAL in older adults with moderately elevated systolic blood pressure free from chronic kidney disease. J Investig Med. 2020 Oct;68(7):1271-1275. PubMed PMID: 32699180
• Nowak KL, Kakkar R, Devalaraja M, Lo L, Park W, Gobburu J, Kling D, Davidson M, Chonchol M. A phase 1 randomized, double-blind, placebo-controlled, cohort dose-escalation study of a human monoclonal antibody to IL-6 in patients with CKD. Kidney 360, 2:224-235, 2021.
• Nowak KL, Steele C, Gitomer B, Wang W, Ouyang J, Chonchol MB. Overweight and Obesity and Progression of ADPKD. Clin J Am Soc Nephrol. 2021 Jun;16(6):908-915. PubMed PMID: 34117082
• Nowak KL, Farmer-Bailey H, Cadnapaphornchai MA, You Z, George D, Wang W, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: Design and baseline characteristics of participants. Contemp Clin Trials Commun. 2020 Sep;19:100635. PubMed PMID: 33294724
• Nowak KL, Murray K, You Z, Gitomer B, Brosnahan G, Abebe KZ, Braun W, Chapman A, Harris PC, Miskulin D, Perrone R, Torres V, Steinman T, Yu A, Chonchol M. Pain and Obesity in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis of the Halt Progression of Polycystic Kidney Disease (HALT-PKD) Studies. Kidney Med. 2021 Jul-Aug;3(4):536-545.e1. PubMed PMID: 34401721
• Nowak KL, Jovanovich A, Farmer-Bailey H, Bispham N, Struemph T, Malaczewski M, Wang W, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Chronic Kidney Disease. Kidney360. 2020 Jun;1(6):501-509. PubMed PMID: 33305290
• Grau L, Gitomer B, McNair B, Wolf M, Harris P, Brosnahan G, Torres V, Steinman T, Yu A, Chapman A, Chonchol M, Nowak KL. Interactions between FGF23 and Genotype in Autosomal Dominant Polycystic Kidney Disease. Kidney360. 2020 Jul;1(7):648-656. PubMed PMID: 33305291
• Brosnahan GM, Wang W, Gitomer B, Struemph T, George D, You Z, Nowak KL, Klawitter J, Chonchol M. Feasibility of metformin therapy in autosomal dominant polycystic kidney disease. Am J Kidney Dis, doi: 10.1053/j.ajkd.2021.06.026. [Epub ahead of print] PMID: 34391872. PMC Journal – in process
• Pengshung M, Bispham N, You Z, Oh E, Supiano M, Chonchol M, Nowak KL*, Jovanovich A*. Arterial stiffness independently predicts acute kidney injury in SPRINT. Clin J Am Soc Nephrol, doi: 10.2215/CJN.06420521 [Epub ahead of print]. *equal contributions
• Nowak KL, Murray K, You Z, Gitomer B, Brosnahan G, Abebe KZ, Braun W, Chapman A, Harris PC, Miskulin D, Perrone R, Torres V, Steinman T, Yu A, Chonchol M. Pain and Obesity in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis of the Halt Progression of Polycystic Kidney Disease (HALT-PKD) Studies. Kidney Med. 2021 Jul-Aug;3(4):536-545.e1. PubMed PMID: 34401721
• Pengshung MH, Bispham NZ, You Z, Oh E, Supiano MA, Chonchol MB, Nowak KL*, Jovanovich AJ*. Arterial Stiffness Is Independently Associated with Acute Kidney Injury in SPRINT. Clin J Am Soc Nephrol. 2021 Oct;16(10):1560-1561. PubMed PMID: 34452880. * equal contributions
• Nowak KL, Steele C, Gitomer B, Wang W, Ouyang J, Chonchol MB. Overweight and Obesity and Progression of ADPKD. Clin J Am Soc Nephrol. 2021 Jun;16(6):908-915. PubMed PMID: 34117082
• Steele CN, You Z, Gitomer BY, Brosnahan GM, Abebe K, Braun WE, Chapman A, Harris PC, Perrone RD, Steinman TI, Torres VE, Yu AS, Chonchol M, Nowak KL. PKD1 Compared to PKD2 genotype and cardiac hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies. KI Reports, DOI: 10.1016/j.ekir.2021.09.013 [Epub ahead of print].
• Hopp K, Catenacci V, Dwivedi N, Kline TL, Wang W, You Z, Nguyen DT, Bing K, Poudyal B, Johnson G, Jackman MR, Miller M, Steele C, MacLean P, Nemenoff RA, Gitomer B, Chonchol M, Nowak KL. Weight loss to slow cyst growth in autosomal dominant polycystic kidney disease. iScience, accepted
• Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai M, Klawitter J, Patel N, George D, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: A randomized controlled trial. Clin J Am Soc Nephrol, accepted
• Steele C, You Z, Gitomer BY, Brosnahan GM, Abebe KZ, Braun WE, Chapman AB, Harris PC, Perrone RD, Steinman TI, Torres VE, Yu ASL, Chonchol M, Nowak KL. PKD1 Compared With PK D2 Genotype and Cardiac Hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies. Kidney Int Rep. 2022 Jan;7(1):117-120. PubMed PMID: 35005320
• Hopp K, Catenacci V, Dwivedi N, Kline TL, Wang W, You Z, Nguyen DT, Bing K, Poudyal B, Johnson G, Jackman MR, Miller M, Steele C, MacLean P, Nemenoff RA, Gitomer B, Chonchol M, Nowak KL. Weight loss to slow cyst growth in autosomal dominant polycystic kidney disease. iScience, 25, 103697.
• Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai M, Klawitter J, Patel N, George D, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: A randomized controlled trial. Clin J Am Soc Nephrol, 2022, CJN.08950621; DOI: https://doi.org/10.2215/CJN.08950621 [Epub ahead of print]
• Oh ES, You Z, Nowak KL, Jovanovich AJ. Association of Monocyte Count and Monocyte/Lymphocyte Ratio with the Risk of Cardiovascular Outcomes in Patients with CKD. Kidney360. 2022 Apr 28;3(4):657-665. PubMed PMID: 35721602
• Steele C, Nowak K. Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease. Kidney Dial. 2022 Mar;2(1):106-122. PubMed PMID: 35350649
• Oh ES, Steele CN, You ZY, Nowak KL*, Jovanovich AJ.* Sex hormone levels and the risk of cardiovascular disease and mortality in men and women with chronic kidney disease: A systematic review and meta-analysis. Physiological Reports, accepted. *equal contributions
• Steele CN and Nowak KL. Non-pharmacological management of autosomal dominant polycystic kidney disease. Advances in Chronic Kidney Disease, accepted.
• Steele CN and Nowak KL. Targeting glycosphingolipid metabolism in ADPKD – Another roadblock for treatment. Am J Kidney Dis, accepted.
• Steele CN and Nowak KL. A step ahead towards measuring pain with ADPKD. Clin J Am Soc Nephrol, in press.
• Oh ES*, Freeberg KA*, Steele CN, Wang W, Farmer-Bailey H, Coppock ME, Seals DR, Chonchol M, Rossman MJ, Craighead D*, Nowak KL*. Cerebrovascular pulsatility index is higher in patients with chronic kidney disease. Physiological Reports, accepted. *equal contributions.
• Chebib FT, Nowak KL, Chonchol MB, Bing K, Ghanem A, Rahbari-Oskoui FF, Dahl NK, Mrug M. Polycystic Kidney Disease Diet: What is Known and What is Safe. Clin J Am Soc Nephrol. 2023 Sep 20. [Epub ahead of print] PubMed PMID: 37729939
• Oh ES, You Z, Nowak KL*, Jovanovich AJ*. Sex Differences in Cardiovascular and All-Cause Mortality in Adults with and without CKD: NHANES 1999-2018. Kidney360. 2023 Oct 1;4(10):1467-1471. PubMed PMID: 37548954 *equal contributions
• Steele CN, Oh ES, Wang W, Farmer-Bailey H, Gitomer BY, Chonchol M, Nowak KL. Cerebrovascular Pulsatility Index Is Reduced in Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2023;54(5-6):165-174. PubMed PMID: 37231790
• Kendrick J, You Z, Andrews E, Farmer-Bailey H, Moreau K, Chonchol M, Steele C, Wang W, Nowak KL, Patel N. Sodium Bicarbonate Treatment and Vascular Function in CKD: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Soc Nephrol. 2023 Aug 1;34(8):1433-1444. PubMed PMID: 37228030
• Steele CN, Nowak KL. Nonpharmacological Management of Autosomal Dominant Polycystic Kidney Disease. Adv Kidney Dis Health. 2023 May;30(3):220-227. PubMed PMID: 37088524
• Steele CN, Nowak KL. Targeting Glycosphingolipid Metabolism in ADPKD: Another Roadblock for Treatment. Am J Kidney Dis. 2023 May;81(5):504-506. PubMed PMID: 36863942
• Steele CN, Nowak KL. A Step Ahead toward Measuring Pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Clin J Am Soc Nephrol. 2023 Feb 1;18(2):160-162. PubMed PMID: 36754004
• Oh ES, Freeberg KA, Steele CN, Wang W, Farmer-Bailey H, Coppock ME, Seals DR, Chonchol M, Rossman MJ, Craighead DH, Nowak KL. Cerebrovascular pulsatility index is higher in chronic kidney disease. Physiol Rep. 2023 Jan;11(1):e15561. PubMed PMID: 36636757
• Nowak KL, Moretti F, Bussola N, Steele CN, Gregory AV, Kline TL, Ramanathan S, Trapletti G, Furlanello C, McCormick L, Chonchol M. Visceral Adiposity and Progression of ADPKD: A Cohort Study of Patients From the TEMPO 3:4 Trial. Am J Kidney Dis. 2024 Sep;84(3):275-285.e1. PubMed PMID: 38608748
• Bjornstad P, Richard G, Choi YJ, Nowak KL, Steele C, Chonchol MB, Nadeau KJ, Vigers T, Pyle L, Tommerdahl K, van Raalte DH, Hilkin A, Driscoll L, Birznieks C, Hopp K, Wang W, Edelstein C, Nelson RG, Gregory AV, Kline TL, Blondin D, Gitomer B. Kidney Energetics and Cyst Burden in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study. Am J Kidney Dis. 2024 Sep;84(3):286-297.e1. PubMed PMID: 38621633
• Jovanovich A, Struemph T, You Z, Wang W, Farmer-Bailey H, Bispham N, Levi M, Schwartz GG, Nowak KL, Chonchol M. Effect of Lanthanum Carbonate on Serum Phosphate, Oxidative Stress, and Vascular Dysfunction in CKD: A Mechanistic Randomized Controlled Trial. Kidney360. 2024 Jul 1;5(7):959-966. PubMed PMID: 38781013
• Wang W, You Z, Steele CN, Gitomer B, Chonchol M, Nowak KL. Changes in tubular biomarkers with dietary intervention and metformin in patients with autosomal dominant polycystic kidney disease: a post-hoc analysis of two clinical trials. BMC Nephrol. 2024 Jun 25;25(1):206. PubMed PMID: 38918734
• Nowak KL, Ostrow A, Oh ES, You Z, Chonchol M. Acute kidney injury, mild cognitive impairment, and dementia: A cohort study of patients from SPRINT. Kidney Medicine, accepted.
• Mortaji P, Cai X, Oh E, Frazier R, Srivastra A, Fischer M, Ricardo A, He J, Mills K, Wolfrum K, Anderson A, Feldman HI, Miyazaki M, Chonchol M, Kruella Tamura M, Nowak KL*, Isakova T, Jovanovich A, and CRIC Study Investigators. Deoxycholic acid and cognitive impairment and decline in the chronic renal insufficiency cohort. Kidney Medicine, accepted
• Chonchol M, Ha Gu JH, Hoffman C, Miyazaki M, Miyazaki-Anzai S, Nowak KL, Jovanovich A. Deoxycholic acid and the risk of death and cardiovascular events among patients with advanced chronic kidney disease. J Nephrol, accepted
• Nowak KL, Copeland T, Ku E, Sarnak MJ, Gitomer B, Abebe KZ, Chapman A, Perrone R, Rahbari-Oskoui FF, Steinman T, Yu A, Chonchol M. Overweight and obesity and progression to end-stage kidney disease in patients with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol, accepted.

Professional Memberships

• American Society of Nephrology, member
• American Heart Association, member
• American Physiological Society, member

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties

• Nephrology