Nam MH, Stankowska DL, Johnson GA, Nahomi RB, Pantcheva MB, Nagaraj RH. Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma. Cell Death Dis. 2022 Nov 15;13(11):958. PubMed PMID: 36379926
Nam MH, Nahomi RB, Pantcheva MB, Dhillon A, Chiodo VA, Smith WC, Nagaraj RH. AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension. Transl Vis Sci Technol. 2022 Nov 1;11(11):8. PubMed PMID: 36355386
Rajeswaren V, Wong JO, Yabroudi D, Nahomi RB, Rankenberg J, Nam MH, Nagaraj RH. Small Heat Shock Proteins in Retinal Diseases. Front Mol Biosci. 2022;9:860375. PubMed PMID: 35480891
109. S.K. Nandi, J. Rankenberg, S. Rakete, R.B. Nahomi, M. A. Glomb, M.D. Linetsky and R.H. Nagaraj. Glycation-mediated protein crosslinking and stiffening in mouse lenses are inhibited by carboxitin in vitro. Glycoconj. J. 38: 347–359, 2021
110. M. Nam, M. Pantcheva and R.H. Nagaraj. Transforming growth factor-ß2-mediated mesenchymal transition of lens epithelial cells is repressed in the absence of RAGE Biochem. J. 478: 2285-2296, 2021
111. J. Rankenberg, B. D. Wagner, J. Patnaik, S. Rakete, M. A. Glomb, A, C. Henning, A. Lynch and R. H. Nagaraj. Advanced glycation endproducts in human diabetic lens capsules Exp. Eye Res. 210: 108704, 2021
Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFß2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. PubMed PMID: 31815277
Nahomi RB, Nandi SK, Rakete S, Michel C, Fritz KS, Nagaraj RH. Lysine malonylation and propionylation are prevalent in human lens proteins. Exp Eye Res. 2020 Jan;190:107864. PubMed PMID: 31678036
R.B. Nahomi, S. K. Nandi, S. Rakete, C. Michel, K.S. Fritz and R. H. Nagaraj. Lysine malonylation and propionylation are prevalent in human lens protein. Exp. Eye Res. 190: Article 107864, 2020.PMID: 31678036, PMCID: PMC6957740
M. Nam, K. A.J.O Smit, M.B. Pantcheva, K.U. Park, J.A. Brzezinski, J.J. Galligan, K.S. Fritz, I.M. Wormstone and R.H. Nagaraj. Aspirin inhibits TGF-ß2 mediated epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem. J. 477, 75-97, 2020. PMID: 31815277
R.B. Nahomi, M. Nam, J. Rankenberg, S. Rakete, J. Houck, G.C. Johnson, D. Stankowska, M.P. Pantcheva, P.S. McLean and R.H. Nagaraj. Kynurenic acid protects against ischemia-reperfusion-induced retinal ganglion cell death in mice Int. J. Mol. Sci. 21, 1795, 2020.PMID: 32151061 PMCID: PMC7084183
S.K. Nandi, R. Nahomi, J. Rankenberg, M. A. Glomb and R.H. Nagaraj. Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of a-crystallin: Implications for lens aging and presbyopia. J. Biol. Chem. 295, 5701–5716, 2020. PMID: 32184356 PMCID: PMC7186181
S. K. Nandi, J. Rankenberg, M.A. Glomb and R.H. Nagaraj. Transient elevation of temperature promotes cross-linking of a-crystallin-client proteins through AGE formation: A potential role in presbyopia and cataracts. Biochem. Biophys. Res. Commun. 533: 1352-1358, 2020.PMID: 33081971 PMCID: PMC7744422
S.K. Nandi, J. Rankenberg, S. Rakete, R.B. Nahomi, M. A. Glomb, M.D. Linetsky and R.H. Nagaraj. Carboxitin inhibits glycation-mediated protein crosslinking and stiffening in mouse lenses (In press, Glycoconj. J.). PMID: 33245448
Stankowska DL, Nam MH, Nahomi RB, Chaphalkar RM, Nandi SK, Fudala R, Krishnamoorthy RR, Nagaraj RH. Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma. Cell Death Discov. 2019;5:122. PubMed PMID: 31372242
Nandi SK, Nahomi RB, Harris PS, Michel CR, Fritz KS, Nagaraj RH. The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of a-crystallin in mouse lenses. Exp Eye Res. 2019 May;182:1-9. PubMed PMID: 30849386
Nandi SK, Rakete S, Nahomi RB, Michel C, Dunbar A, Fritz KS, Nagaraj RH. Succinylation Is a Gain-of-Function Modification in Human Lens aB-Crystallin. Biochemistry. 2019 Mar 5;58(9):1260-1274. PubMed PMID: 30758948
Nahomi RB, Nandi SK, Nagaraj RH. A monoclonal antibody targeted to the functional peptide of aB-crystallin inhibits the chaperone and anti-apoptotic activities. J Immunol Methods. 2019 Apr;467:37-47. PubMed PMID: 30738041
Flückiger R, Cocuzzi E, Nagaraj RH, Shoham M, Kern TS, Medof ME. DAF in diabetic patients is subject to glycation/inactivation at its active site residues. Mol Immunol. 2018 Jan;93:246-252. PubMed PMID: 28886871
Rakete S, Nagaraj RH. UVA Light-mediated Ascorbate Oxidation in Human Lenses. Photochem Photobiol. 2017 Jul;93(4):1091-1095. PubMed PMID: 28084012
Raghavan CT, Nagaraj RH. AGE-RAGE interaction in the TGFß2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 Aug;33(4):631-43. PubMed PMID: 27263094
Nahomi RB, Pantcheva MB, Nagaraj RH. aB-crystallin is essential for the TGF-ß2-mediated epithelial to mesenchymal transition of lens epithelial cells. Biochem J. 2016 May 15;473(10):1455-69. PubMed PMID: 26987815
Rakete S, Nagaraj RH. Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification. J Biol Chem. 2016 Apr 29;291(18):9596-609. PubMed PMID: 26941078
Nahomi RB, DiMauro MA, Wang B, Nagaraj RH. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. Biochem J. 2015 Jan 1;465(1):115-25. PubMed PMID: 25332102
Holm T, Raghavan CT, Nahomi R, Nagaraj RH, Kessel L. Effects of photobleaching on selected advanced glycation end products in the human lens. BMC Res Notes. 2015 Jan 16;8(1):5. [Epub ahead of print] PubMed PMID: 25592966
Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH. UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem. 2014 Jun 13;289(24):17111-23. PubMed PMID: 24798334
Nahomi RB, Palmer A, Green KM, Fort PE, Nagaraj RH. Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. Biochim Biophys Acta. 2014 Feb;1842(2):164-74. PubMed PMID: 24252613
DiMauro MA, Nandi SK, Raghavan CT, Kar RK, Wang B, Bhunia A, Nagaraj RH, Biswas A. Acetylation of Gly1 and Lys2 promotes aggregation of human ?D-crystallin. Biochemistry. 2014 Nov 25;53(46):7269-82. PubMed PMID: 25393041
S. Panja, H. Gaikwad, J. Rankenberg, M. Nam and R.H. Nagaraj. Promotion of Protein Solubility and Reduction of Stiffness in Human Lenses by Aggrelyte-1: Implications for Reversing Presbyopia. (In Press, IJMS)