Holm T, Raghavan CT, Nahomi R, Nagaraj RH, Kessel L. Effects of photobleaching on selected advanced glycation end products in the human lens. BMC Res Notes. 2015 Jan 16;8(1):5. [Epub ahead of print] PubMed PMID: 25592966
DiMauro MA, Nandi SK, Raghavan CT, Kar RK, Wang B, Bhunia A, Nagaraj RH, Biswas A. Acetylation of Gly1 and Lys2 promotes aggregation of human ?D-crystallin. Biochemistry. 2014 Nov 25;53(46):7269-82. PubMed PMID: 25393041
Nahomi RB, DiMauro MA, Wang B, Nagaraj RH. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. Biochem J. 2015 Jan 1;465(1):115-25. PubMed PMID: 25332102
Linetsky M, Raghavan CT, Johar K, Fan X, Monnier VM, Vasavada AR, Nagaraj RH. UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem. 2014 Jun 13;289(24):17111-23. PubMed PMID: 24798334
M.Smuda, C. Hennning, C. Raghavan, K. Johar, A. R. Vasavada, R.H. Nagaraj and M. Glomb. Comprehensive analysis of Maillard protein modifications in the human lens during aging and cataract formation Biochemistry, 54: 2500-2507, 2015.
T. Holm, C.T. Raghavan, R. Nahomi, R. H. Nagaraj, L. Kessel. Effects of photobleaching on advanced glycation end products in the human lens. BMC Ophthalmol. BMC Research Notes 8:5, 2015
R.H. Nagaraj, R. B. Nahomi, N. H. Mueller, C. T. Raghavan, D. A. Ammar and J. M. Petrash. Therapeutic Potential of a-Crystallin. Biochim. Biophys. Acta
A. K. Panda, S. K. Nandi, A. Chakraborty, R. H. Nagaraj and A. Biswas. Differential Role of Arginine Mutations on the Structure and Functions of a-crystallin. Biochim. Biophys. Acta, 2015 (in press)
R.H. Nagaraj, S. Sampathkumar and R. B. Nahomi. sHSP Peptides Inhibit Protein Aggregation and Apoptosis in the Eye. AOPT, Charleston, SC, 2015
R. H. Nagaraj, T.S. Kern, J.Tang, A. Lee, S. Sampthkumar and R.B. Nahomi. Identification of a new target to inhibit diabetic retinopathy in mice. 7th Ocular Drug Discovery Meeting, San Diego, 2015.
C.T. Raghavan , M. Smuda, A. J. Smith, A. Singh , P. Gupta , M. Glomb, M. Wormstone , R. H. Nagaraj. AGE levels are higher in capsules of human cataractous lenses than non-cataractous lenses: Relevance to TGFß2 induced EMT response in human lens epithelial cells. ARVO 2015
S.Rakete, H.Wang, M. Linetsky , R. H. Nagaraj. Identification of a novel fluorescent product from the reaction of 3OH-kynurenine and erythrulose: Relevance to lens aging. ARVO 2015
R. B. Nahomi, R. H. Nagaraj. The role of aB-crystallin in TGF-ß2 induced epithelial to mesenchymal transition of lens epithelial cells. ARVO 2015
S. Rakete and R. H. Nagaraj. Kynoxazine: a novel fluorescent compound in human lens derived from the Maillard reaction of 3-hydroxykynurenine and erythrulose. Maillard Meeting Tokyo, Japan, 2015
R. B. Nahomi, R. H. Nagaraj. aB-Crystallin is essential for the TGF-ß2-mediated epithelial to mesenchymal transition of lens epithelial cells. International Congress on lens, Hawaii, 2015
R. B. Nahomi, M. A. DiMauro, B. Wang and R. H. Nagaraj. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. Biochem. J. 465, 115-25, 2015
Nahomi RB, Palmer A, Green KM, Fort PE, Nagaraj RH. Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. Biochim Biophys Acta. 2014 Feb;1842(2):164-74. PubMed PMID: 24252613
Raghavan CT, Nagaraj RH. AGE-RAGE interaction in the TGFß2-mediated epithelial to mesenchymal transition of human lens epithelial cells. Glycoconj J. 2016 Aug;33(4):631-43. PubMed PMID: 27263094
Nahomi RB, Pantcheva MB, Nagaraj RH. aB-crystallin is essential for the TGF-ß2-mediated epithelial to mesenchymal transition of lens epithelial cells. Biochem J. 2016 May 15;473(10):1455-69. PubMed PMID: 26987815
Rakete S, Nagaraj RH. Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification. J Biol Chem. 2016 Apr 29;291(18):9596-609. PubMed PMID: 26941078
Rakete S, Nagaraj RH. UVA Light-mediated Ascorbate Oxidation in Human Lenses. Photochem Photobiol. 2017 Jul;93(4):1091-1095. PubMed PMID: 28084012
Flückiger R, Cocuzzi E, Nagaraj RH, Shoham M, Kern TS, Medof ME. DAF in diabetic patients is subject to glycation/inactivation at its active site residues. Mol Immunol. 2018 Jan;93:246-252. PubMed PMID: 28886871
Nam M, and Nagaraj RH. Matrix-bound AGEs enhance TGFß2-mediated mesenchymal transition of lens epithelial cells via the non-canonical pathway: Implications for secondary cataract formation. Biochem J. 2018 Apr 475(8): 1427-40. doi: 10.1042/BCJ20170856. PMID: 29588342.
R. B. Nahomi, S. Sampathkumar, A. M. Myers, D. G. Smith, J. Tang, C. Allen Lee, T. S. Kern, R. H. Nagaraj and P. E. Fort. The absence of indoleamine 2,3-dioxygenase inhibits retinal capillary degeneration in diabetic mice. Invest. Ophthalmol. Vis. Sci. 59: 2042–2053, 2018.
R. Nahomi and R. H. Nagaraj. Role of HIF-1a in TGF2-mediated epithelial to mesenchymal transition of lens epithelial cells. J. Cell. Biochem. 1: 1-14, 2018.
R. Flückiger, E. Cocuzzi, R. H. Nagaraj, M. Shoham, T. S. Kern and M.E. Medof. DAF in diabetic patients is subject to glycation/inactivation at its active site residues. Mol. Immunol. 93:246-252, 2018.
Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGFß2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 Jan 17;477(1):75-97. PubMed PMID: 31815277
Nahomi RB, Nandi SK, Rakete S, Michel C, Fritz KS, Nagaraj RH. Lysine malonylation and propionylation are prevalent in human lens proteins. Exp Eye Res. 2020 Jan;190:107864. PubMed PMID: 31678036
Stankowska DL, Nam MH, Nahomi RB, Chaphalkar RM, Nandi SK, Fudala R, Krishnamoorthy RR, Nagaraj RH. Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma. Cell Death Discov. 2019;5:122. PubMed PMID: 31372242
Nandi SK, Nahomi RB, Harris PS, Michel CR, Fritz KS, Nagaraj RH. The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of a-crystallin in mouse lenses. Exp Eye Res. 2019 May;182:1-9. PubMed PMID: 30849386
Nandi SK, Rakete S, Nahomi RB, Michel C, Dunbar A, Fritz KS, Nagaraj RH. Succinylation Is a Gain-of-Function Modification in Human Lens aB-Crystallin. Biochemistry. 2019 Mar 5;58(9):1260-1274. PubMed PMID: 30758948
Nahomi RB, Nandi SK, Nagaraj RH. A monoclonal antibody targeted to the functional peptide of aB-crystallin inhibits the chaperone and anti-apoptotic activities. J Immunol Methods. 2019 Apr;467:37-47. PubMed PMID: 30738041
A. I. Marin, J. Brzezinski, R. H. Nagaraj, J. K. Singh. Biology of the Eye”, A Novel Multi-Format Translational Elective for Medical Students Interested in Learning More About the Eye and Ophthalmology. J. Acad. Ophthalmol. 11(01): e30-e35, 2019.
V. Miller, J. Patnaik, A. Lynch, M. Taravella, A. Palestine and R. Nagaraj. Risk Factors Predisposing to Early Nd:YAG Capsulotomy in a Colorado Cohort. ARVO 2018
D. Stankowska, R. Nahomi, R. Chaphalkar, R. Krishnamoorthy and R. Nagaraj. The neuroprotective potential of a small, blood-retinal barrier permeable peptide in glaucoma. ARVO 2018
R.B. Nahomi, S. K. Nandi, S. Rakete, C. Michel, K.S. Fritz and R. H. Nagaraj. Lysine malonylation and propionylation are prevalent in human lens protein. Exp. Eye Res. 190: Article 107864, 2020.PMID: 31678036, PMCID: PMC6957740
M. Nam, K. A.J.O Smit, M.B. Pantcheva, K.U. Park, J.A. Brzezinski, J.J. Galligan, K.S. Fritz, I.M. Wormstone and R.H. Nagaraj. Aspirin inhibits TGF-ß2 mediated epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem. J. 477, 75-97, 2020. PMID: 31815277
R.B. Nahomi, M. Nam, J. Rankenberg, S. Rakete, J. Houck, G.C. Johnson, D. Stankowska, M.P. Pantcheva, P.S. McLean and R.H. Nagaraj. Kynurenic acid protects against ischemia-reperfusion-induced retinal ganglion cell death in mice Int. J. Mol. Sci. 21, 1795, 2020.PMID: 32151061 PMCID: PMC7084183
S.K. Nandi, R. Nahomi, J. Rankenberg, M. A. Glomb and R.H. Nagaraj. Glycation-mediated inter-protein cross-linking is promoted by chaperone-client complexes of a-crystallin: Implications for lens aging and presbyopia. J. Biol. Chem. 295, 5701–5716, 2020. PMID: 32184356 PMCID: PMC7186181
R. Nagaraj and M. Nam. AGEs promote TGFß2-mediated EMT response through the non-canonical pathway. ARVO 2018
R. H. Nagaraj. Carbonyl stress as a driver of fibrosis.19th international workshop- enzymology and molecular biology of carbonyl metabolism, Breckenridge, 2018
M. Nam, D. Stankowska, R. B. Nahomi, R. R. Krishnamoorthy and R. H. Nagaraj. Retinal Neuroprotection by Peptain-1. CU Ophthalmology Research Day, 2018
M. Nam and R. H. Nagaraj. AGEs in extracellular matrix enhance the TGFß2-mediated mesenchymal transition of lens epithelial cells. IMARS Meeting, Montreal, 2018
S. K. Nandi, J. Rankenberg, M.A. Glomb and R.H. Nagaraj. Transient elevation of temperature promotes cross-linking of a-crystallin-client proteins through AGE formation: A potential role in presbyopia and cataracts. Biochem. Biophys. Res. Commun. 533: 1352-1358, 2020.PMID: 33081971 PMCID: PMC7744422
S.K. Nandi, J. Rankenberg, S. Rakete, R.B. Nahomi, M. A. Glomb, M.D. Linetsky and R.H. Nagaraj. Carboxitin inhibits glycation-mediated protein crosslinking and stiffening in mouse lenses (In press, Glycoconj. J.). PMID: 33245448
R. H. Nagaraj, S. K. Nandi, S. Rakete, R. B. Nahomi, C. Michel, A. Dunbar and K. Fritz. Acylation of lens proteins improves the chaperone activity of a-crystallin. ICER, Belfast, 2018.
D.L. Stankowska, M. Nam, R.B. Nahomi, R.M. Chaphalkar, R. R. Krishnamoorthy and R.H.Nagaraj. Neuroprotective Potential of Peptain-1 for Glaucoma.ICER, Belfast, 2018.
A. I. Marin, J. Brzezinski, R. Nagaraj, J. K. Singh. "Biology of the Eye”, A Novel Multi-Format Translational Elective for Medical Students Interested in Learning More About the Eye and Ophthalmology
109. S.K. Nandi, J. Rankenberg, S. Rakete, R.B. Nahomi, M. A. Glomb, M.D. Linetsky and R.H. Nagaraj. Glycation-mediated protein crosslinking and stiffening in mouse lenses are inhibited by carboxitin in vitro. Glycoconj. J. 38: 347–359, 2021
110. M. Nam, M. Pantcheva and R.H. Nagaraj. Transforming growth factor-ß2-mediated mesenchymal transition of lens epithelial cells is repressed in the absence of RAGE Biochem. J. 478: 2285-2296, 2021
111. J. Rankenberg, B. D. Wagner, J. Patnaik, S. Rakete, M. A. Glomb, A, C. Henning, A. Lynch and R. H. Nagaraj. Advanced glycation endproducts in human diabetic lens capsules Exp. Eye Res. 210: 108704, 2021
Nam MH, Stankowska DL, Johnson GA, Nahomi RB, Pantcheva MB, Nagaraj RH. Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma. Cell Death Dis. 2022 Nov 15;13(11):958. PubMed PMID: 36379926
Nam MH, Nahomi RB, Pantcheva MB, Dhillon A, Chiodo VA, Smith WC, Nagaraj RH. AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension. Transl Vis Sci Technol. 2022 Nov 1;11(11):8. PubMed PMID: 36355386
Rajeswaren V, Wong JO, Yabroudi D, Nahomi RB, Rankenberg J, Nam MH, Nagaraj RH. Small Heat Shock Proteins in Retinal Diseases. Front Mol Biosci. 2022;9:860375. PubMed PMID: 35480891
S. Panja, H. Gaikwad, J. Rankenberg, M. Nam and R.H. Nagaraj. Promotion of Protein Solubility and Reduction of Stiffness in Human Lenses by Aggrelyte-1: Implications for Reversing Presbyopia. (In Press, IJMS)
Panja S, Nahomi RB, Rankenberg J, Michel CR, Gaikwad H, Nam MH, Nagaraj RH. Aggrelyte-2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia. Aging Cell. 2023 Apr;22(4):e13797. PubMed PMID: 36823285
Panja S, Gaikwad H, Rankenberg J, Nam MH, Nagaraj RH. Promotion of Protein Solubility and Reduction in Stiffness in Human Lenses by Aggrelyte-1: Implications for Reversing Presbyopia. Int J Mol Sci. 2023 Jan 22;24(3). PubMed PMID: 36768517
S. Panja, M. Nam, H. Gaikwad, RJ. Rankenberg and R.H. Nagaraj. Topical ocular application of aggrelyte-2A reduces lens stiffness in mice. Front. Ophthalmol. DOI 10.3389/fopht.2023.1274825, 2023.
J.C. Portillo, A. Pfaff, S. Vos, M. Weng, R.H. Nagaraj and C.S. Subauste. Advanced glycation end products upregulate CD40 in retinal endothelial and Muller cells: Relevance to diabetic retinopathy. Cells.13(5):429. doi: 10.3390/cells13050429, 2024.
G. Johnson, B. Kodati, R. B. Nahomi, J. Pham, R. Phillips, R.R. Krishnamoorthy, R. H. Nagaraj, D.L. Stankowska. On the Mechanism of Inhibition of Retinal Ganglion Cell Death by Peptain-1 under Glaucomatous Stress. 2024. Revised submitted to Cell Death and Discovery 10:305, https://doi.org/10.1038/s41420-024-02070-8, 2024
S. Panja, R.B. Nahomi, J. Rankenberg, M. Cole and R.H. Nagaraj. Thiol-mediated Enhancement of N?-acetyllysine Formation in Lens Proteins. ACS Chem Biol. 19: 1495–1505, 2024.
G. Cooksley, M. Nam, R.B. Nahomi, J. Rankenberg, Y. Wormstone, I.M. Wormstone and R.H. Nagaraj. Lens capsule advanced glycation end products induce senescence in epithelial cells: Implications for secondary cataracts. Aging Cell. 00:e14249, 2024.
C. Michel, R. B. Nahomi, M. A. Assiri, K.Henriksen, D.Orlicky, R. Reisdorph, P.S. Harris, M. Levi, A. Rosenberg, R. H. Nagaraj, K. S. Fritz. Quantifying Protein Acetylation in Diabetic Nephropathy from Formalin-fixed Paraffin-embedded Tissue. Proteomics - Clin Applicat. un 24:e202400018. doi: 10.1002/prca.202400018, 2024.
M. Nam, A. Dhillon and R.H. Nagaraj. Peptain-1 inhibits ischemia/reperfusion-mediated retinal capillary degeneration in mice. Front Cell Neurosci.18: https://doi.org/10.3389/fncel.2024.1441924, 2024.