Research Interests
Anna Dondzillo, PhD is a neuroscientist interested in signal processing in the aging auditory system. Specifically, how different cell types and network connectivity define neuronal processing. Dr. Dondzillo’s expertise in auditory brainstem synaptic and neuronal network anatomy as well as synaptic physiology developed during her doctoral training in the Max Planck Institute in Heidelberg, and the postdoctoral training at the Universities of Heidelberg and Colorado. Her studies of auditory brainstem in rodent, using stereotaxic brain injections, and single cell recordings have shown involvement of inhibitory circuits in the synaptic processing of neurons in a major auditory brainstem nucleus, known as MNTB. The MNTB, itself consisting of inhibitory neurons, is important in sound source localization. Using single cell neuronal tracing, she found that the inhibitory signal that arrives to MNTB comes not only from outside source but also from the inside collateral neurons. Interestingly, the outside source of inhibition to MNTB, a small auditory brainstem nucleus in the medial olivocochlear center projects to the inner ear hair cells, where it too provides inhibition. This system of auditory brainstem – hair cells innervation changes within a life span. To further understand the role the medial olivocochlear center might have in age related hearing loss, Dr. Dondzillo research is focused on the inner ear hair cells and their synapses.