Yael Aschner, MD

Publications

• Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-ß responsiveness. Am J Pathol. 2014 May;184(5):1489-502. PubMed PMID: 24650563
• Yamashita CM, Radisky DC, Aschner Y, Downey GP. The importance of matrix metalloproteinase-3 in respiratory disorders. Expert Rev Respir Med. 2014 Aug;8(4):411-21. PubMed PMID: 24869454
• Aschner Y, Zemans RL, Yamashita CM, Downey GP. Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS. Chest. 2014 Oct;146(4):1081-91. PubMed PMID: 25287998
• Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time?. Ann Am Thorac Soc. 2017 Jan;14(1):14-16. PubMed PMID: 28035871
• Downey GP, Aschner Y. Chasing the Lymph: New Clues for the Management of Idiopathic Plastic Bronchitis. Ann Am Thorac Soc. 2016 Oct;13(10):1671-1673. PubMed PMID: 27726438
• Aschner Y, Downey GP. Transforming Growth Factor-ß: Master Regulator of the Respiratory System in Health and Disease. Am J Respir Cell Mol Biol. 2016 May;54(5):647-55. PubMed PMID: 26796672
• Downey GP, Aschner Y. Taking It Off: New Insights into the Role of Tyrosine Phosphorylation-dependent Pathways in the Pathogenesis of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2017 Feb 15;195(4):418-420. PubMed PMID: 28199155
• Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time?. Ann Am Thorac Soc. 2017 Jan;14(1):14-16. PubMed PMID: 28035871
• Aschner Y, Davidson JA. Early Plasma Matrix Metalloproteinase Profiles Offer New Insight into the Biology and Prognosis of Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Aug 30. [Epub ahead of print] PubMed PMID: 30160977
• Aschner Y, Downey GP. The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not. Am J Respir Cell Mol Biol. 2018 Nov;59(5):535-547. PubMed PMID: 29812954
• Downey GP, Aschner Y. Taking It Off: New Insights into the Role of Tyrosine Phosphorylation-dependent Pathways in the Pathogenesis of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2017 Feb 15;195(4):418-420. PubMed PMID: 28199155
• Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time?. Ann Am Thorac Soc. 2017 Jan;14(1):14-16. PubMed PMID: 28035871
• Aschner Y, Nelson M, Brenner M, Roybal H, Beke K, Meador C, Foster D, Correll KA, Reynolds PR, Anderson K, Redente EF, Matsuda J, Riches DWH, Groshong SD, Pozzi A, Sap J, Wang Q, Rajshankar D, McCulloch CAG, Zemans RL, Downey GP. Protein tyrosine phosphatase-a amplifies transforming growth factor-ß-dependent profibrotic signaling in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L294-L311. doi: 10.1152/ajplung.00235.2019. Epub 2020 Jun 3. PMID: 32491951; PMCID: PMC7473933.
• Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 Dec 15;206(12):1463-1479. PubMed PMID: 35998281
• Urban JA, Zirille F, Kiser TH, Aschner Y. Why So Salty? Transient Diabetes Insipidus After Discontinuation of Vasopressin. Ann Intern Med Clin Cases. 2022;1. PubMed PMID: 35782522
• Aschner Y, Correll KA, Beke KM, Foster DG, Roybal HM, Nelson MR, Meador CL, Strand M, Anderson KC, Moore CM, Reynolds PR, Kopf KW, Burnham EL, Downey GP. PTPa promotes fibroproliferative responses after acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L69-L83. PubMed PMID: 35670474
• Aschner Y, Downey GP. Proteinases in the pathogenesis of lymphangioleiomyomatosis lung disease: nibbling or chewing up the lung?. Eur Respir J. 2022 Apr;59(4). PubMed PMID: 35422429
• Sendo S, Kiosses WB, Yang S, Wu DJ, Lee DWK, Liu L, Aschner Y, Vela AJ, Downey GP, Santelli E, Bottini N. Clustering of phosphatase RPTPa promotes Src signaling and the arthritogenic action of synovial fibroblasts. Sci Signal. 2023 Jul 4;16(792):eabn8668. PubMed PMID: 37402225

Practice Locations

UCHealth Pulmonology Clinic - Anschutz Medical Campus
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0748

UCHealth Interstitial Lung Disease Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 7th Fl
Aurora, CO 80045
720-848-0748

Hospital Affiliation

• University of Colorado Hospital
• Veterans Affairs Medical Center

Specialty Information

Specialties

• Pulmonary Disease, Board Certification
• Critical Care Medicine, Board Certification