Elizabeth Redente, PhD

Associate Professor, Medicine-Pulmonary Sciences & Critical Care

FacultyPhoto
Graduate School
  • PhD, University of Colorado Health Sciences Center (2008)
Undergraduate School
  • BSc (Hons), Baylor University (TX) (2003)
Department
Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Associate Professor

Publications

  • Redente EF. ABC Transporters: An Overlooked Mechanism of Drug Failure in Our Preclinical Models?. Am J Respir Cell Mol Biol. 2020 Feb;62(2):130-131. PubMed PMID: 31469577
  • Aschner Y, Nelson M, Brenner M, Roybal H, Beke K, Meador C, Foster D, Correll KA, Reynolds PR, Anderson K, Redente EF, Matsuda J, Riches DWH, Groshong SD, Pozzi A, Sap J, Wang Q, Rajshankar D, McCulloch CAG, Zemans RL, Downey GP. Protein tyrosine phosphatase-a amplifies transforming growth factor-ß-dependent profibrotic signaling in lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol.. 2020 Aug 1;319(2):L294-L311. PubMed PMID: 32491951
  • Wollin L, Distler JHW, Redente EF, Riches DWH, Stowasser S, Schlenker-Herceg R, Maher TM, Kolb M. Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases. Eur Respir J. 2019 Sep;54(3). PubMed PMID: 31285305
  • Yuan T, Volckaert T, Redente EF, Hopkins S, Klinkhammer K, Wasnick R, Chao CM, Yuan J, Zhang JS, Yao C, Majka S, Stripp BR, Günther A, Riches DWH, Bellusci S, Thannickal VJ, De Langhe SP. FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury. Stem Cell Reports. 2019 May 14;12(5):1041-1055. PubMed PMID: 31056475
  • Allawzi A, Elajaili H, Redente EF, Nozik-Grayck E. Oxidative Toxicology of Bleomycin: Role of the Extracellular Redox Environment. Curr Opin Toxicol. 2019 Feb;13:68-73. PubMed PMID: 31289762
  • Correll KA, Edeen KE, Zemans RL, Redente EF, Serban KA, Curran-Everett D, Edelman BL, Mikels-Vigdal A, Mason RJ. Transitional human alveolar type II epithelial cells suppress extracellular matrix and growth factor gene expression in lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol.. 2019 Aug 1;317(2):L283-L294. PubMed PMID: 31166130
  • Tighe RM, Redente EF, Yu YR, Herold S, Sperling AI, Curtis JL, Duggan R, Swaminathan S, Nakano H, Zacharias WJ, Janssen WJ, Freeman CM, Brinkman RR, Singer BD, Jakubzick CV, Misharin AV. Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 Aug;61(2):150-161. PubMed PMID: 31368812
  • Bamberg A, Redente EF, Groshong SD, Tuder RM, Cool CD, Keith RC, Edelman BL, Black BP, Cosgrove GP, Wynes MW, Curran-Everett D, De Langhe S, Ortiz LA, Thorburn A, Riches DWH. Protein Tyrosine Phosphatase-N13 Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2018 Oct 1;198(7):914-927. PubMed PMID: 29727583
  • Atif SM, Gibbings SL, Redente EF, Camp FA, Torres RM, Kedl RM, Henson PM, Jakubzick CV. Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity. Am J Respir Cell Mol Biol. 2018 Nov;59(5):580-591. PubMed PMID: 29953261
  • Correll KA, Edeen KE, Zemans RL, Redente EF, Mikels-Vigdal A, Mason RJ. TGF beta inhibits expression of SP-A, SP-B, SP-C, but not SP-D in human alveolar type II cells. Biochem Biophys Res Commun. 2018 May 23;499(4):843-848. PubMed PMID: 29621540
  • Redente EF, Aguilar MA, Black BP, Edelman BL, Bahadur AN, Humphries SM, Lynch DA, Wollin L, Riches DWH. Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease. Am. J. Physiol. Lung Cell Mol. Physiol.. 2018 Jun 1;314(6):L998-L1009. PubMed PMID: 29543042
  • McCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJ. Deletion of c-FLIP from CD11b(hi) Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis. Am J Respir Cell Mol Biol. 2018 Jan;58(1):66-78. PubMed PMID: 28850249
  • Jansing NL, Patel N, McClendon J, Redente EF, Henson PM, Tuder RM, Hyde DM, Nyengaard JR, Zemans RL. Flow Cytometry Underestimates and Planimetry Overestimates Alveolar Epithelial Type 2 Cell Expansion after Lung Injury. Am J Respir Crit Care Med. 2018 Aug 1;198(3):390-392. PubMed PMID: 29533675
  • Correll KA, Edeen KE, Redente EF, Zemans RL, Edelman BL, Danhorn T, Curran-Everett D, Mikels-Vigdal A, Mason RJ. TGF beta inhibits HGF, FGF7, and FGF10 expression in normal and IPF lung fibroblasts. Physiol Rep. 2018 Aug;6(16):e13794. PubMed PMID: 30155985
  • Edelman BL, Redente EF. Isolation and Characterization of Mouse Fibroblasts. Methods Mol Biol. 2018;1809:59-67. PubMed PMID: 29987782
  • Redente EF. Macrophages and Fibrosis Resolution. Harnessing Wnt/ß-Catenin Signaling as the Way and the Means. Am J Respir Cell Mol Biol. 2017 Feb;56(2):150-151. PubMed PMID: 28145774
  • McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017 Aug;187(8):1772-1786. PubMed PMID: 28618253
  • McCubbrey AL, Barthel L, Mould KJ, Mohning MP, Redente EF, Janssen WJ. Selective and inducible targeting of CD11b+ mononuclear phagocytes in the murine lung with hCD68-rtTA transgenic systems. Am. J. Physiol. Lung Cell Mol. Physiol.. 2016 Jul 1;311(1):L87-L100. PubMed PMID: 27190063
  • Riches DW, Backos DS, Redente EF. ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis. Am J Pathol. 2015 Apr;185(4):909-12. PubMed PMID: 25687558
  • Fritz JM, Tennis MA, Orlicky DJ, Yin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD. Corrigendum: depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas. Front Immunol. 2015;6:88. PubMed PMID: 25784911
  • Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-ß responsiveness. Am J Pathol. 2014 May;184(5):1489-502. PubMed PMID: 24650563
  • Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor necrosis factor-a accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 2014 Apr;50(4):825-37. PubMed PMID: 24325577
  • Fritz JM, Tennis MA, Orlicky DJ, Lin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD. Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas. Front Immunol. 2014;5:587. PubMed PMID: 25505466
  • Keith RC, Sokolove J, Edelman BL, Lahey L, Redente EF, Holers VM, Sakaguchi S, Robinson WH, Riches DW. Testosterone is protective in the sexually dimorphic development of arthritis and lung disease in SKG mice. Arthritis Rheum. 2013 Jun;65(6):1487-93. PubMed PMID: 23529475
  • Cook RS, Jacobsen KM, Wofford AM, DeRyckere D, Stanford J, Prieto AL, Redente E, Sandahl M, Hunter DM, Strunk KE, Graham DK, Earp HS 3rd. MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis. J Clin Invest. 2013 Aug;123(8):3231-42. PubMed PMID: 23867499
  • Keith RC, Powers JL, Redente EF, Sergew A, Martin RJ, Gizinski A, Holers VM, Sakaguchi S, Riches DW. A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice. Exp Lung Res. 2012 Mar;38(2):55-66. PubMed PMID: 22185348
  • Trivedi R, Redente EF, Thakur A, Riches DW, Kompella UB. Local delivery of biodegradable pirfenidone nanoparticles ameliorates bleomycin-induced pulmonary fibrosis in mice. Nanotechnology. 2012 Dec 21;23(50):505101. PubMed PMID: 23186914
  • Redente EF, Jacobsen KM, Solomon JJ, Lara AR, Faubel S, Keith RC, Henson PM, Downey GP, Riches DW. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol.. 2011 Oct;301(4):L510-8. PubMed PMID: 21743030
  • Walter ND, Rice PL, Redente EF, Kauvar EF, Lemond L, Aly T, Wanebo K, Chan ED. Wound healing after trauma may predispose to lung cancer metastasis: review of potential mechanisms. Am J Respir Cell Mol Biol. 2011 May;44(5):591-6. PubMed PMID: 21177982
  • Wynes MW, Edelman BL, Kostyk AG, Edwards MG, Coldren C, Groshong SD, Cosgrove GP, Redente EF, Bamberg A, Brown KK, Reisdorph N, Keith RC, Frankel SK, Riches DW. Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol. 2011 Jul 1;187(1):527-37. PubMed PMID: 21632719
  • Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol. 2010 Sep;177(3):1549-61. PubMed PMID: 20671265
  • Redente EF, Dwyer-Nield LD, Merrick DT, Raina K, Agarwal R, Pao W, Rice PL, Shroyer KR, Malkinson AM. Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization. Am J Pathol. 2010 Jun;176(6):2972-85. PubMed PMID: 20431028
  • Redente EF, Higgins DM, Dwyer-Nield LD, Orme IM, Gonzalez-Juarrero M, Malkinson AM. Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation. J Leukoc Biol. 2010 Jul;88(1):159-68. PubMed PMID: 20360403
  • Tyagi A, Singh RP, Ramasamy K, Raina K, Redente EF, Dwyer-Nield LD, Radcliffe RA, Malkinson AM, Agarwal R. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila). 2009 Jan;2(1):74-83. PubMed PMID: 19139021
  • Redente EF, Dwyer-Nield LD, Barrett BS, Riches DW, Malkinson AM. Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice. Anticancer Res. 2009 Dec;29(12):5095-101. PubMed PMID: 20044622
  • Zerbe LK, Dwyer-Nield LD, Fritz JM, Redente EF, Shroyer RJ, Conklin E, Kane S, Tucker C, Eckhardt SG, Gustafson DL, Iwata KK, Malkinson AM. Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice. Cancer Chemother Pharmacol. 2008 Sep;62(4):605-20. PubMed PMID: 18030469
  • Redente EF, Orlicky DJ, Bouchard RJ, Malkinson AM. Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice. Am J Pathol. 2007 Feb;170(2):693-708. PubMed PMID: 17255336
  • Redente EF, Massengale RD. A systematic analysis of the effect of corn, wheat, and poultry dusts on interleukin-8 production by human respiratory epithelial cells. J Immunotoxicol. 2006 Jan 1;3(1):31-7. PubMed PMID: 18958683

Professional Memberships

  • American Thoracic Society, Member
Public Speaking
Yes



School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

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