Kevin Messacar, MD, PhD

Professional Titles

• Professor, Department of Pediatrics, Sections of Hospital Medicine and Infectious Diseases

Recognitions

• Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2025)
  Voted by licensed CO physicians
• Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2021)
  Voted by licensed CO physicians
• Young Investigator Award, Pediatric Infectious Disease Society (2021)
  Presented annually to a single physician whose independent and productive research during and after fellowship represents outstanding contributions in pediatric infectious diseases
• Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2020)
  Voted by licensed CO physicians
• Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2019)
  Voted by licensed CO physicians
• Acute Flaccid Myelitis Task Force, Centers for Disease Control and Prevention Board of Scientific Counselors (2018)
  https://www.cdc.gov/ddid/bsc/afm-task-force.html
• Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2018)
  Voted by licensed CO physicians
• Century Award, Children's Hospital Colorado (2018)
  Recognizes a staff member with five or fewer years of training who has made major contributions through committee work, leadership and/or advocacy.
• Top Doctor: Pediatric Infectious Diseases, 5280 Magazine (2017)
  Voted by licensed CO physicians
• Gary Way Award for Outstanding Teaching by a Faculty Member, University of Colorado Department of Pediatrics (2017)
  Elected by the University of Colorado pediatric residents
• Research Scholars Award, Children's Hospital Colorado Research Institute (2015)
• Astute Clinician Award, Colorado Department of Public Health and Environment (2014)
  For initial description of the association of Acute Flaccid Myelitis and Enterovirus D68 in CO in 2014
• Fellow Teaching Award, University of Colorado School of Medicine, Department of Pediatrics (2013)
  Voted by University of Colorado pediatric residents
• Outstanding Resident of the Year, University of Colorado NICU (2011)
• Resident Teaching Award, University of Colorado School of Medicine, Department of Pediatrics (2011)
  Voted by University of Colorado medical students
• Outstanding Intern of the Year, University of Colorado NICU (2009)
• MCAS Academic Achievement Award, University of Michigan Medical School (2008)
  Highest Academic Standing in the Graduating Class of 2008
• Alpha Omega Alpha Medical Honors Society, Alpha Omega Alpha, University of Michigan Chapter (2008)
• Dean’s Commendation for Excellence in Clinical Skills and the Art of Medicine, University of Michigan Medical School (2008)
• Distinction in Service, University of Michigan Medical School (2008)
• Dean’s Merit Scholarship, University of Michigan Medical School (2003)
• Highest Distinction and Highest Honors in Biochemistry, University of Michigan (2003)

Research Interests

My research interests include using new rapid tests to improve the care of children with infections. I am interested in learning more about what causes brain and spinal cord infections in children, as well as better ways to diagnose and treat them. I have been investigating the causes of acute flaccid myelitis, which causes paralysis in children, including enterovirus D68 and A71. I am seeking to improve our pandemic preparedness by studying ways to expedite the development of tools to predict, detect, and respond to emerging infectious diseases.

Publications

• Nguyen-Tran H, Park SW, Vogt MR, Permaul P, Spaulding AB, Hernandez ML, Bohl JA, Godbole S, Ruckwardt TJ, Krug PW, Moss DL, Derrien-Colemyn A, Chowdhury A, Dziubla G, Wang L, Castro M, Narpala SR, Longtine ER, Henry AR, Ngo TB, Dzantiev L, Sigal GB, Metcalf CJ, Kimberlin DW, Dominguez SR, Mittelman A, McDermott AB, Serebryannyy LA, Grenfell B, Messacar K, Douek DC. Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022-23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study. Lancet Infect Dis. 2025 Aug 6. [Epub ahead of print] PubMed PMID: 40782819
• Howerton E, Williams TC, Casalegno JS, Dominguez S, Gunson R, Messacar K, Metcalf CJE, Park SW, Viboud C, Grenfell BT. Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions. Nat Commun. 2025 Aug 6;16(1):7261. PubMed PMID: 40770182
• Nguyen-Tran H, Butler M, Simmons D, Dominguez SR, Messacar K. Return of the Biennial Circulation of Enterovirus D68 in Colorado Children in 2024 Following the Large 2022 Outbreak. Viruses. 2025 May 5;17(5). PubMed PMID: 40431685
• Hoyt BM, Messacar K, Sick-Samuels AC, Jaggi P, Hamilton SL, Janelle S, Parker SK. Opportunities for collaboration: the synergy between antimicrobial and diagnostic stewardship in pediatrics. Antimicrob Steward Healthc Epidemiol. 2025;5(1):e32. PubMed PMID: 39950001
• Freeman MC, Messacar K. Enterovirus and Parechovirus Neurologic Infections in Children: Clinical Presentations and Neuropathogenesis. J Pediatric Infect Dis Soc. 2025 Jan 20;14(1). PubMed PMID: 39776161
• Park SW, Noble B, Howerton E, Nielsen BF, Lentz S, Ambroggio L, Dominguez S, Messacar K, Grenfell BT. Predicting the impact of non-pharmaceutical interventions against COVID-19 on Mycoplasma pneumoniae in the United States. Epidemics. 2024 Dec;49:100808. PubMed PMID: 39642758
• Nguyen-Tran H, Spaulding AB, Messacar K, Vogt MR, Permaul P, Douek DC, Mittelman A, Thompson C, Grubbs S, Magana C, Hernandez ML. Recruitment and retention of pediatric participants for pandemic preparedness research: Experience from the PREMISE EV-D68 Pilot Study. Contemp Clin Trials Commun. 2024 Oct;41:101351. PubMed PMID: 39252862
• Grizer CS, Messacar K, Mattapallil JJ. Enterovirus-D68 - A Reemerging Non-Polio Enterovirus that Causes Severe Respiratory and Neurological Disease in Children. Front Virol. 2024;4. PubMed PMID: 39246649
• Ho EC, Olson KE, Butler M, Birkholz M, Miller K, MacBrayne CE, Jung S, Messacar K, Asturias EJ, Dominguez SR. Clinical Impact of Pleural Fluid Streptococcus pneumoniae Polymerase Chain Reaction Testing in Children With Complicated Pneumonia. Clin Infect Dis. 2024 Dec 17;79(6):1487-1494. PubMed PMID: 39207213
• Helfferich J, Fall A, Pardo CA, Jacobs BC, Messacar K. Acute flaccid myelitis in low- to middle-income countries: diagnosis and surveillance. Brain Commun. 2024;6(4):fcae167. PubMed PMID: 39027410
• Messacar K, Matzinger S, Berg K, Weisbeck K, Butler M, Pysnack N, Nguyen-Tran H, Davizon ES, Bankers L, Jung SA, Birkholz M, Wheeler A, Dominguez SR. Multimodal Surveillance Model for Enterovirus D68 Respiratory Disease and Acute Flaccid Myelitis among Children in Colorado, USA, 2022. Emerg Infect Dis. 2024 Mar;30(3):423-431. PubMed PMID: 38407198
• Park SW, Messacar K, Douek DC, Spaulding AB, Metcalf CJE, Grenfell BT. Predicting the impact of COVID-19 non-pharmaceutical intervention on short- and medium-term dynamics of enterovirus D68 in the US. Epidemics. 2024 Mar;46:100736. PubMed PMID: 38118274
• Park SY, Coufal NG, Dominguez SR, Farnaes L, Messacar K, Goldman FD. Gaps in diagnosing suspected infection in immunocompromised children with cancer: A systematic review. Pediatr Blood Cancer. 2024 Feb;71(2):e30794. PubMed PMID: 38059641
• Nguyen-Tran H, Spaulding AB, Messacar K, Vogt MR, Permaul P, Douek DC, Mittelman A, Thompson C, Grubbs S, Magana C, Hernandez ML. Recruitment and retention of pediatric participants for pandemic preparedness research: Experience from the PREMISE EV-D68 Pilot Study. Contemp Clin Trials Commun. 2024 Oct;41:101351. PubMed PMID: 39252862
• Grizer CS, Messacar K, Mattapallil JJ. Enterovirus-D68 - A Reemerging Non-Polio Enterovirus that Causes Severe Respiratory and Neurological Disease in Children. Front Virol. 2024;4. PubMed PMID: 39246649
• Ho EC, Olson KE, Butler M, Birkholz M, Miller K, MacBrayne CE, Jung S, Messacar K, Asturias EJ, Dominguez SR. Clinical impact of pleural fluid Streptococcus pneumoniae PCR testing in children with complicated pneumonia. Clin Infect Dis. 2024 Aug 29. [Epub ahead of print] PubMed PMID: 39207213
• Helfferich J, Fall A, Pardo CA, Jacobs BC, Messacar K. Acute flaccid myelitis in low- to middle-income countries: diagnosis and surveillance. Brain Commun. 2024;6(4):fcae167. PubMed PMID: 39027410
• Messacar K, Matzinger S, Berg K, Weisbeck K, Butler M, Pysnack N, Nguyen-Tran H, Davizon ES, Bankers L, Jung SA, Birkholz M, Wheeler A, Dominguez SR. Multimodal Surveillance Model for Enterovirus D68 Respiratory Disease and Acute Flaccid Myelitis among Children in Colorado, USA, 2022. Emerg Infect Dis. 2024 Mar;30(3):423-431. PubMed PMID: 38407198
• Park SW, Messacar K, Douek DC, Spaulding AB, Metcalf CJE, Grenfell BT. Predicting the impact of COVID-19 non-pharmaceutical intervention on short- and medium-term dynamics of enterovirus D68 in the US. Epidemics. 2024 Mar;46:100736. PubMed PMID: 38118274
• Park SY, Coufal NG, Dominguez SR, Farnaes L, Messacar K, Goldman FD. Gaps in diagnosing suspected infection in immunocompromised children with cancer: A systematic review. Pediatr Blood Cancer. 2024 Feb;71(2):e30794. PubMed PMID: 38059641
• Nguyen-Tran H, Thompson C, Butler M, Miller KR, Pyle L, Jung S, Rogers S, Ng TFF, Routh J, Dominguez SR, Messacar K. Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA. Emerg Infect Dis. 2023 Nov;29(11):2315-2324. PubMed PMID: 37877582
• Ku TSN, Al Mohajer M, Newton JA, Wilson MH, Monsees E, Hayden MK, Messacar K, Kisgen JJ, Diekema DJ, Morgan DJ, Sifri CD, Vaughn VM. Improving antimicrobial use through better diagnosis: The relationship between diagnostic stewardship and antimicrobial stewardship. Infect Control Hosp Epidemiol. 2023 Dec;44(12):1901-1908. PubMed PMID: 37665212
• Park SY, Chang EJ, Ledeboer N, Messacar K, Lindner MS, Venkatasubrahmanyam S, Wilber JC, Vaughn ML, Bercovici S, Perkins BA, Nolte FS. Plasma Microbial Cell-Free DNA Sequencing from over 15,000 Patients Identified a Broad Spectrum of Pathogens. J Clin Microbiol. 2023 Aug 23;61(8):e0185522. PubMed PMID: 37439686
• Nguyen-Tran H, Reno S, Mwangi E, Mentel M, Hengartner R, Dominguez SR, Messacar K, Jung SA. Qualitative detection of enterovirus D68 from PrimeStore® molecular transport medium: implications for home- and self-collection. Diagn Microbiol Infect Dis. 2023 Aug;106(4):115976. PubMed PMID: 37267740
• Rao S, Armistead I, Messacar K, Alden NB, Schmoll E, Austin E, Dominguez SR. Shifting Epidemiology and Severity of Respiratory Syncytial Virus in Children During the COVID-19 Pandemic. JAMA Pediatr. 2023 Jul 1;177(7):730-732. PubMed PMID: 37184852
• Le Maréchal M, Diaz-Arias LA, Beekmann SE, Polgreen P, Messacar K, Tunkel AR, Thakur KT, Venkatesan A. Perspectives on Diagnosis and Management of All-Cause Encephalitis: A National Survey of Adult Infectious Diseases Physicians. Open Forum Infect Dis. 2023 Apr;10(4):ofad132. PubMed PMID: 37125234
• Boster JM, Dominguez SR, Messacar K, Adams M, Weinberg A, Black JO, Feldman AG. Acute Liver Failure in a Child With Adenovirus Detected by PCR in the Explanted Liver. Pediatrics. 2023 Feb 1;151(2). PubMed PMID: 36691756
• Ku TSN, Al Mohajer M, Newton JA, Wilson MH, Monsees E, Hayden MK, Messacar K, Kisgen JJ, Diekema DJ, Morgan DJ, Sifri CD, Vaughn VM. Improving antimicrobial use through better diagnosis: The relationship between diagnostic stewardship and antimicrobial stewardship. Infect Control Hosp Epidemiol. 2023 Sep 4;:1-8. [Epub ahead of print] PubMed PMID: 37665212
• Park SY, Chang EJ, Ledeboer N, Messacar K, Lindner MS, Venkatasubrahmanyam S, Wilber JC, Vaughn ML, Bercovici S, Perkins BA, Nolte FS. Plasma Microbial Cell-Free DNA Sequencing from over 15,000 Patients Identified a Broad Spectrum of Pathogens. J Clin Microbiol. 2023 Aug 23;61(8):e0185522. PubMed PMID: 37439686
• Nguyen-Tran H, Reno S, Mwangi E, Mentel M, Hengartner R, Dominguez SR, Messacar K, Jung SA. Qualitative detection of enterovirus D68 from PrimeStore® molecular transport medium: implications for home- and self-collection. Diagn Microbiol Infect Dis. 2023 Aug;106(4):115976. PubMed PMID: 37267740
• Rao S, Armistead I, Messacar K, Alden NB, Schmoll E, Austin E, Dominguez SR. Shifting Epidemiology and Severity of Respiratory Syncytial Virus in Children During the COVID-19 Pandemic. JAMA Pediatr. 2023 Jul 1;177(7):730-732. PubMed PMID: 37184852
• Le Maréchal M, Diaz-Arias LA, Beekmann SE, Polgreen P, Messacar K, Tunkel AR, Thakur KT, Venkatesan A. Perspectives on Diagnosis and Management of All-Cause Encephalitis: A National Survey of Adult Infectious Diseases Physicians. Open Forum Infect Dis. 2023 Apr;10(4):ofad132. PubMed PMID: 37125234
• Boster JM, Dominguez SR, Messacar K, Adams M, Weinberg A, Black JO, Feldman AG. Acute Liver Failure in a Child With Adenovirus Detected by PCR in the Explanted Liver. Pediatrics. 2023 Feb 1;151(2). PubMed PMID: 36691756
• Nguyen-Tran H, Thompson C, Butler M, Miller KR, Pyle L, Jung S, Routh J, Dominguez SR, Messacar K. Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission Among Household Contacts. Emerging Infectious Diseases. 2023
• Messacar K, Baker RE, Park SW, Nguyen-Tran H, Cataldi JR, Grenfell B. Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption. Lancet. 2022 Nov 12;400(10364):1663-1665. PubMed PMID: 35843260
• Nguyen-Tran H, Messacar K. Preventing enterovirus A71 disease: another promising vaccine for children. Lancet. 2022 Apr 30;399(10336):1671-1673. PubMed PMID: 35427482
• Messacar K, Palmer C, Gregoire L, Elliott A, Ackley E, Perraillon MC, Tyler KL, Dominguez SR. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022 May;244:161-168.e1. PubMed PMID: 35150729
• Nguyen-Tran H, Park SW, Messacar K, Dominguez SR, Vogt MR, Permar S, Permaul P, Hernandez M, Douek DC, McDermott AB, Metcalf CJE, Grenfell B, Spaulding AB. Enterovirus D68: a test case for the use of immunological surveillance to develop tools to mitigate the pandemic potential of emerging pathogens. Lancet Microbe. 2022 Feb;3(2):e83-e85. PubMed PMID: 35036969
• Messacar K, Baker RE, Park SW, Nguyen-Tran H, Cataldi JR, Grenfell B. Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption. Lancet. 2022 Nov 12;400(10364):1663-1665. PubMed PMID: 35843260
• Nguyen-Tran H, Messacar K. Preventing enterovirus A71 disease: another promising vaccine for children. Lancet. 2022 Apr 30;399(10336):1671-1673. PubMed PMID: 35427482
• Messacar K, Palmer C, Gregoire L, Elliott A, Ackley E, Perraillon MC, Tyler KL, Dominguez SR. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022 May;244:161-168.e1. PubMed PMID: 35150729
• Nguyen-Tran H, Park SW, Messacar K, Dominguez SR, Vogt MR, Permar S, Permaul P, Hernandez M, Douek DC, McDermott AB, Metcalf CJE, Grenfell B, Spaulding AB. Enterovirus D68: a test case for the use of immunological surveillance to develop tools to mitigate the pandemic potential of emerging pathogens. Lancet Microbe. 2022 Feb;3(2):e83-e85. PubMed PMID: 35036969
• Messacar K, Palmer C, Gregoire L, Elliott A, Ackley E, Perraillon MC, Tyler KL, Dominguez SR. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022 May;244:161-168.e1. PubMed PMID: 35150729
• Nguyen-Tran H, Park SW, Messacar K, Dominguez SR, Vogt MR, Permar S, Permaul P, Hernandez M, Douek DC, McDermott AB, Metcalf CJE, Grenfell B, Spaulding AB. Enterovirus D68: a test case for the use of immunological surveillance to develop tools to mitigate the pandemic potential of emerging pathogens. Lancet Microbe. 2022 Feb;3(2):e83-e85. PubMed PMID: 35036969
• Nguyen-Tran H, Messacar K. Preventing enterovirus A71 disease: another promising vaccine for children. Lancet. 2022 Apr 30;399(10336):1671-1673. PubMed PMID: 35427482
• Messacar K, Baker RE, Park SW, Nguyen-Tran H, Cataldi JR, Grenfell B. Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption. Lancet. 2022 Jul 14. [Epub ahead of print] PubMed PMID: 35843260
• Dehority W, Janowski AB, Messacar K, Polgreen PM, Beekmann SE. Variability in the Use of Novel Diagnostic Technology in Children With Suspected Encephalitis and in the Management of Emerging Encephalitides by Pediatric Infectious Disease Providers. J Pediatric Infect Dis Soc. 2021 Apr 30;10(4):529-532. PubMed PMID: 33347568
• Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, Dean J, DeBiasi R, Desai J, Elrick MJ, Farias-Moeller R, Gombolay GY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda VK, Helfferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA. Acute flaccid myelitis: cause, diagnosis, and management. Lancet. 2021 Jan 23;397(10271):334-346. PubMed PMID: 33357469
• Park SW, Pons-Salort M, Messacar K, Cook C, Meyers L, Farrar J, Grenfell BT. Epidemiological dynamics of enterovirus D68 in the United States and implications for acute flaccid myelitis. Sci Transl Med. 2021 Mar 10;13(584). PubMed PMID: 33692131
• Ackley ER, Tchou MJ, Press CA, Parker SK, Dominguez SR, Gaensbauer J, Messacar K. AKI In Suspected Meningitis/Encephalitis May Be "Avoidable Kidney Injury". Hosp Pediatr. 2021 Aug;11(8):e167-e169. PubMed PMID: 34244336
• Schubert RD, Hawes IA, Ramachandran PS, Ramesh A, Crawford ED, Pak JE, Wu W, Cheung CK, O'Donovan BD, Tato CM, Lyden A, Tan M, Sit R, Sowa GM, Sample HA, Zorn KC, Banerji D, Khan LM, Bove R, Hauser SL, Gelfand AA, Johnson-Kerner BL, Nash K, Krishnamoorthy KS, Chitnis T, Ding JZ, McMillan HJ, Chiu CY, Briggs B, Glaser CA, Yen C, Chu V, Wadford DA, Dominguez SR, Ng TFF, Marine RL, Lopez AS, Nix WA, Soldatos A, Gorman MP, Benson L, Messacar K, Konopka-Anstadt JL, Oberste MS, DeRisi JL, Wilson MR. Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis. Nat Med. 2021 Oct;27(10):1849. PubMed PMID: 34548659
• Graff K, Dominguez SR, Messacar K. Metagenomic Next-Generation Sequencing for Diagnosis of Pediatric Meningitis and Encephalitis: A Review. J Pediatric Infect Dis Soc. 2021 Dec 24;10(Supplement_4):S78-S87. PubMed PMID: 34951470
• Graff K, Dominguez SR, Messacar K. Metagenomic Next-Generation Sequencing for Diagnosis of Pediatric Meningitis and Encephalitis: A Review. J Pediatric Infect Dis Soc. 2021 Dec 24;10(Supplement_4):S78-S87. PubMed PMID: 34951470
• Schubert RD, Hawes IA, Ramachandran PS, Ramesh A, Crawford ED, Pak JE, Wu W, Cheung CK, O'Donovan BD, Tato CM, Lyden A, Tan M, Sit R, Sowa GM, Sample HA, Zorn KC, Banerji D, Khan LM, Bove R, Hauser SL, Gelfand AA, Johnson-Kerner BL, Nash K, Krishnamoorthy KS, Chitnis T, Ding JZ, McMillan HJ, Chiu CY, Briggs B, Glaser CA, Yen C, Chu V, Wadford DA, Dominguez SR, Ng TFF, Marine RL, Lopez AS, Nix WA, Soldatos A, Gorman MP, Benson L, Messacar K, Konopka-Anstadt JL, Oberste MS, DeRisi JL, Wilson MR. Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis. Nat Med. 2021 Oct;27(10):1849. PubMed PMID: 34548659
• Ackley ER, Tchou MJ, Press CA, Parker SK, Dominguez SR, Gaensbauer J, Messacar K. AKI In Suspected Meningitis/Encephalitis May Be "Avoidable Kidney Injury". Hosp Pediatr. 2021 Aug;11(8):e167-e169. PubMed PMID: 34244336
• Park SW, Pons-Salort M, Messacar K, Cook C, Meyers L, Farrar J, Grenfell BT. Epidemiological dynamics of enterovirus D68 in the United States and implications for acute flaccid myelitis. Sci Transl Med. 2021 Mar 10;13(584). PubMed PMID: 33692131
• Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, Dean J, DeBiasi R, Desai J, Elrick MJ, Farias-Moeller R, Gombolay GY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda VK, Helfferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA. Acute flaccid myelitis: cause, diagnosis, and management. Lancet. 2021 Jan 23;397(10271):334-346. PubMed PMID: 33357469
• Dehority W, Janowski AB, Messacar K, Polgreen PM, Beekmann SE. Variability in the Use of Novel Diagnostic Technology in Children With Suspected Encephalitis and in the Management of Emerging Encephalitides by Pediatric Infectious Disease Providers. J Pediatric Infect Dis Soc. 2021 Apr 30;10(4):529-532. PubMed PMID: 33347568
• Gould CV, Messacar K, Dominguez SR, Panella A, Tobolowsky F, Fischer M. EVALUATION FOR ARBOVIRAL INFECTION AMONG CHILDREN HOSPITALIZED IN COLORADO WITH ASEPTIC MENINGITIS AND ENCEPHALITIS. Pediatr Infect Dis J. 2020 Aug 5. [Epub ahead of print] PubMed PMID: 32773665
• Park SW, Farrar J, Messacar K, Meyers L, Pons-Salort M, Grenfell BT. Epidemiological dynamics of enterovirus D68 in the US: implications for acute flaccid myelitis. medRxiv. 2020 Jul 29. PubMed PMID: 32766605
• Shah PV, Wathen J, Keyes J, Osborne C, Messacar K, Stence N, Kothari K. Foreign Body Esophageal Perforation Leading to Multifocal Brain Abscesses: A Case Report. J Emerg Med. 2020 Jul 18. [Epub ahead of print] PubMed PMID: 32694010
• Murphy OC, Messacar K, Benson L, Bove R, Carpenter J, Crawford T, Dean J, Debiasi R, Desai J, Ellrick MJ, Farias-Moeller R, Gombolay RY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda KK, Hlefferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA. Acute Flaccid Myelitis: Etiology, diagnosis and management. The Lancet 2020 (accepted, in press)
• Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber SI, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2020 Feb;20(2):230-239. PubMed PMID: 31859216
• Tran P, Dowell E, Hamilton S, Dolan SA, Messacar K, Dominguez SR, Todd J. Two Blood Cultures With Age-Appropriate Volume Enhance Suspected Sepsis Decision-Making. Open Forum Infect Dis. 2020 Feb;7(2):ofaa028. PubMed PMID: 32055641
• Rao S, Martin J, Ahearn MA, Osborne C, Moss A, Dempsey A, Dominguez SR, Weinberg A, Messacar KB. Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016-2017 Season. J Pediatric Infect Dis Soc. 2020 Feb 28;9(1):71-74. PubMed PMID: 30590598
• Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber SI, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2020 Feb;20(2):230-239. PubMed PMID: 31859216
• Messacar K, Gaensbauer JT, Birkholz M, Palmer C, Todd JK, Tyler KL, Dominguez SR. Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period. Diagn Microbiol Infect Dis. 2020 Aug;97(4):115085. PubMed PMID: 32559588
• Gould CV, Messacar K, Dominguez SR, Panella A, Tobolowsky F, Fischer M. Evaluation for Arboviral Infection Among Children Hospitalized in Colorado With Aseptic Meningitis and Encephalitis. Pediatr Infect Dis J. 2020 Nov;39(11):e382-e384. PubMed PMID: 32773665
• Fall A, Ndiaye N, Messacar K, Kebe O, Jallow MM, Harouna H, Kiori DE, Sy S, Goudiaby D, Dia M, Niang MN, Ndiaye K, Dia N. Enterovirus D68 Subclade B3 in Children with Acute Flaccid Paralysis in West Africa, 2016. Emerg Infect Dis. 2020 Sep;26(9):2227-2230. PubMed PMID: 32818390
• Messacar K, Hamilton SL, Prinzi AM, Mitchell JC, Beil ED, Dowell EB, Dominguez SR. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2019 Jan;93(1):22-23. PubMed PMID: 30213466
• Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber I, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical Characteristics of Enterovirus A71 Neurologic Disease During an Outbreak in Children in Colorado, 2018: An Observational Cohort Study. Accepted, In-Press 2019 The Lancet Infectious Diseases
• Messacar K, Pretty K, Reno S, Dominguez SR. Continued biennial circulation of enterovirus D68 in Colorado. J Clin Virol. 2019 Apr;113:24-26. PubMed PMID: 30825833
• Messacar K, Tyler KL. Enterovirus D68-Associated Acute Flaccid Myelitis: Rising to the Clinical and Research Challenges. JAMA. 2019 Mar 5;321(9):831-832. PubMed PMID: 30768149
• Messacar K, Abzug MJ, Dominguez SR. Acute Flaccid Myelitis Surveillance: A Signal Through the Noise. Pediatrics. 2019 Nov;144(5). PubMed PMID: 31591134
• Gaensbauer JT, Todd J, Grubenhoff JA, Soranno DE, Scudamore D, Cheetham A, Messacar K. A Resident-Based, Educational Program to Drive Individual and Institutional Improvement in a Pediatric Training Hospital. J Pediatr. 2019 Nov;214:4-7.e1. PubMed PMID: 31655703
• Kirkley MJ, Robinson C, Dominguez SR, Messacar K. Neonatal parechovirus infection mimicking a surgical abdomen. BMJ Case Rep. 2019 Jun 26;12(6). PubMed PMID: 31248894
• Olson CA, Dominguez SR, Miller S, Chiu CY, Messacar K. Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing. J Pediatr. 2019 Sep;212:228-231. PubMed PMID: 31208781
• Christy A, Messacar K. Acute Flaccid Myelitis Associated With Enterovirus D68: A Review. J Child Neurol. 2019 Aug;34(9):511-516. PubMed PMID: 31014167
• Kane MS, Sonne C, Zhu S, Malhotra A, Van Haren K, Messacar K, Glaser CA. Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016. Pediatr Infect Dis J. 2019 Jul;38(7):667-672. PubMed PMID: 30985511
• Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, Weinshenker BG, Shosha E, Lucchinetti CF, Fryer JP, Lopez-Chiriboga AS, Chen JC, Jitprapaikulsan J, McKeon A, Gadoth A, Keegan BM, Tillema JM, Naddaf E, Patterson MC, Messacar K, Tyler KL, Flanagan EP. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody. JAMA Neurol. 2019 Mar 1;76(3):301-309. PubMed PMID: 30575890
• Elrick MJ, Gordon-Lipkin E, Crawford TO, Van Haren K, Messacar K, Thornton N, Dee E, Voskertchian A, Nance JR, Muñoz LS, Gorman MP, Benson LA, Thomas DL, Pardo CA, Milstone AM, Duggal P. Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016. JAMA Pediatr. 2019 Feb 1;173(2):134-139. PubMed PMID: 30500056
• Hopkins SE, Elrick MJ, Messacar K. Acute Flaccid Myelitis-Keys to Diagnosis, Questions About Treatment, and Future Directions. JAMA Pediatr. 2019 Feb 1;173(2):117-118. PubMed PMID: 30500054
• Schubert RD, Hawes IA, Ramachandran PS, Ramesh A, Crawford ED, Pak JE, Wu W, Cheung CK, O'Donovan BD, Tato CM, Lyden A, Tan M, Sit R, Sowa GA, Sample HA, Zorn KC, Banerji D, Khan LM, Bove R, Hauser SL, Gelfand AA, Johnson-Kerner BL, Nash K, Krishnamoorthy KS, Chitnis T, Ding JZ, McMillan HJ, Chiu CY, Briggs B, Glaser CA, Yen C, Chu V, Wadford DA, Dominguez SR, Ng TFF, Marine RL, Lopez AS, Nix WA, Soldatos A, Gorman MP, Benson L, Messacar K, Konopka-Anstadt JL, Oberste MS, DeRisi JL, Wilson MR. Pan-viral serology implicates enteroviruses in acute flaccid myelitis. Nat Med. 2019 Nov;25(11):1748-1752. PubMed PMID: 31636453
• Hixon AM, Frost J, Rudy MJ, Messacar K, Clarke P, Tyler KL. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review. Viruses. 2019 Sep 4;11(9). PubMed PMID: 31487952
• Wilson MR, Sample HA, Zorn KC, Arevalo S, Yu G, Neuhaus J, Federman S, Stryke D, Briggs B, Langelier C, Berger A, Douglas V, Josephson SA, Chow FC, Fulton BD, DeRisi JL, Gelfand JM, Naccache SN, Bender J, Dien Bard J, Murkey J, Carlson M, Vespa PM, Vijayan T, Allyn PR, Campeau S, Humphries RM, Klausner JD, Ganzon CD, Memar F, Ocampo NA, Zimmermann LL, Cohen SH, Polage CR, DeBiasi RL, Haller B, Dallas R, Maron G, Hayden R, Messacar K, Dominguez SR, Miller S, Chiu CY. Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis. N Engl J Med. 2019 Jun 13;380(24):2327-2340. PubMed PMID: 31189036
• Abedi GR, Messacar K, Luong W, Nix WA, Rogers S, Queen K, Tong S, Oberste MS, Watt J, Rothrock G, Dominguez S, Gerber SI, Watson JT. Picornavirus etiology of acute infections among hospitalized infants. J Clin Virol. 2019 Jul;116:39-43. PubMed PMID: 31100674
• Miller S, Naccache SN, Samayoa E, Messacar K, Arevalo S, Federman S, Stryke D, Pham E, Fung B, Bolosky WJ, Ingebrigtsen D, Lorizio W, Paff SM, Leake JA, Pesano R, DeBiasi R, Dominguez S, Chiu CY. Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid. Genome Res. 2019 May;29(5):831-842. PubMed PMID: 30992304
• Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 Apr 30;92(18):e2118-e2126. PubMed PMID: 30413631
• Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2019 Jul 1;8(3):282-283. PubMed PMID: 30299497
• Messacar K, Robinson CC, Dominguez SR. Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis. Future Microbiol. 2018 Nov;13:1553-1554. PubMed PMID: 30421966
• Messacar K, Dominguez SR. Blood PCR testing for enteroviruses in young children. Lancet Infect Dis. 2018 Dec;18(12):1299-1301. PubMed PMID: 30389483
• Rao S, Martin J, Ahearn MA, Osborne C, Moss A, Dempsey A, Dominguez SR, Weinberg A, Messacar KB. Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016-2017 Season. J Pediatric Infect Dis Soc. 2018 Dec 27. [Epub ahead of print] PubMed PMID: 30590598
• Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2018 Oct 9. [Epub ahead of print] PubMed PMID: 30299497
• Messacar K, Hamilton SL, Prinzi AM, Mitchell JC, Beil ED, Dowell EB, Dominguez SR. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2018 Jul 31. [Epub ahead of print] PubMed PMID: 30213466
• Saporta-Keating SR, Simões EAF, Yu G, Federman S, Mirsky D, Dominguez SR, Chiu CY, Messacar K. A Child With Intermittent Headaches and Eosinophilic Meningitis. J Pediatric Infect Dis Soc. 2018 Feb 9. [Epub ahead of print] PubMed PMID: 29438532
• Messacar K, Burakoff A, Nix WA, Rogers S, Oberste MS, Gerber SI, Spence-Davizon E, Herlihy R, Dominguez SR. Notes from the Field: Enterovirus A71 Neurologic Disease in Children - Colorado, 2018. MMWR Morb Mortal Wkly Rep. 2018 Sep 14;67(36):1017-1018. PubMed PMID: 30212441
• Messacar K. Narrow-spectrum, compared with broad-spectrum, antibiotics equally effective with less adverse events. J Pediatr. 2018 May;196:324-327. PubMed PMID: 29703366
• Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
• Saporta-Keating SR, Simões EAF, Yu G, Federman S, Mirsky D, Dominguez SR, Chiu CY, Messacar K. A Child With Intermittent Headaches and Eosinophilic Meningitis. J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):355-357. PubMed PMID: 29438532
• Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 Mar;32(1):145-162. PubMed PMID: 29224854
• Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
• Messacar K, Parker SK, Todd JK, Dominguez SR. Reply to "Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship)". J Clin Microbiol. 2017 Nov;55(11):3308. PubMed PMID: 29066568
• Martin JA, Messacar K, Yang ML, Maloney JA, Lindwall J, Carry T, Kenyon P, Sillau SH, Oleszek J, Tyler KL, Dominguez SR, Schreiner TL. Outcomes of Colorado children with acute flaccid myelitis at 1 year. Neurology. 2017 Jul 11;89(2):129-137. PubMed PMID: 28615421
• Messacar K, Robinson CC, Pretty K, Yuan J, Dominguez SR. Surveillance for enterovirus D68 in colorado children reveals continued circulation. J Clin Virol. 2017 Jul;92:39-41. PubMed PMID: 28521212
• Alvarez E, Seppa M, Rivas S, Fuentes L, Valverde P, Antillón-Klussmann F, Castellanos M, Sweet-Cordero EA, Messacar K, Kurap J, Bustamante M, Howard SC, Efron B, Luna-Fineman S. Improvement in treatment abandonment in pediatric patients with cancer in Guatemala. Pediatr Blood Cancer. 2017 Oct;64(10). PubMed PMID: 28423236
• Messacar K, Campbell K, Pearce K, Pyle L, Hurst AL, Child J, Parker SK. A Handshake From Antimicrobial Stewardship Opens Doors for Infectious Disease Consultations. Clin Infect Dis. 2017 May 15;64(10):1449-1452. PubMed PMID: 28186533
• Messacar K, Parker SK, Todd JK, Dominguez SR. Implementation of Rapid Molecular Infectious Disease Diagnostics: the Role of Diagnostic and Antimicrobial Stewardship. J Clin Microbiol. 2017 Mar;55(3):715-723. PubMed PMID: 28031432
• Messacar K, Hurst AL, Child J, Campbell K, Palmer C, Hamilton S, Dowell E, Robinson CC, Parker SK, Dominguez SR. Clinical Impact and Provider Acceptability of Real-Time Antimicrobial Stewardship Decision Support for Rapid Diagnostics in Children With Positive Blood Culture Results. J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):267-274. PubMed PMID: 27543412
• Phan TG, Messacar K, Dominguez SR, da Costa AC, Deng X, Delwart E. A new densovirus in cerebrospinal fluid from a case of anti-NMDA-receptor encephalitis. Arch Virol. 2016 Nov;161(11):3231-5. PubMed PMID: 27522586
• Rao S, Messacar K, Torok MR, Rick AM, Holzberg J, Montano A, Bagdure D, Curtis DJ, Oberste MS, Nix WA, de Masellis G, Robinson CC, Dominguez SR. Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza. Pediatr Crit Care Med. 2016 Nov;17(11):1023-1031. PubMed PMID: 27505715
• Aliabadi N, Messacar K, Pastula DM, Robinson CC, Leshem E, Sejvar JJ, Nix WA, Oberste MS, Feikin DR, Dominguez SR. Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014. Emerg Infect Dis. 2016 Aug;22(8):1387-94. PubMed PMID: 27434186
• Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL, Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Ann Neurol. 2016 Sep;80(3):326-38. PubMed PMID: 27422805
• Bagdure D, Custer JW, Rao S, Messacar K, Dominguez S, Beam BW, Bhutta A. Hospitalized Children With Encephalitis in the United States: A Pediatric Health Information System Database Study. Pediatr Neurol. 2016 Aug;61:58-62. PubMed PMID: 27353693
• White A, Olson D, Messacar K. A state-wide assessment of the association between epidural analgesia, maternal fever and neonatal antibiotics in Colorado, 2007-2012. Arch Dis Child Fetal Neonatal Ed. 2016 Jun 24. [Epub ahead of print] PubMed PMID: 27343198
• Messacar K, Breazeale G, Robinson CC, Dominguez SR. Potential clinical impact of the film array meningitis encephalitis panel in children with suspected central nervous system infections. Diagn Microbiol Infect Dis. 2016 Sep;86(1):118-20. PubMed PMID: 27342782
• Messacar K, Abzug MJ, Dominguez SR. The Emergence of Enterovirus-D68. Microbiol Spectr. 2016 Jun;4(3). PubMed PMID: 27337448
• Messacar K, Hawkins SM, Baker J, Pearce K, Tong S, Dominguez SR, Parker S. Resource Burden During the 2014 Enterovirus D68 Respiratory Disease Outbreak at Children's Hospital Colorado: An Unexpected Strain. JAMA Pediatr. 2016 Mar;170(3):294-7. PubMed PMID: 26783716
• Messacar K, Abzug MJ, Dominguez SR. 2014 outbreak of enterovirus D68 in North America. J Med Virol. 2016 May;88(5):739-45. PubMed PMID: 26489019
• Messacar K, Abzug MJ “Congenital, Perinatal, and Neonatal Enterovirus and Parechovirus Infections” in Congenital and Perinatal Infections, ed. Schleiss M, 2016
• Messacar K, Modlin JF, Abzug MJ “Enteroviruses and Parechoviruses” in Principles and Practice of Pediatric Infectious Diseases, Fifth Edition, ed. Long SS, Prober CG, and Fischer M. Elsevier, Inc, 2016 (in-press)
• Messacar K, Modlin JF, Abzug MJ “Introduction to Picornaviruses” in Principles and Practice of Pediatric Infectious Diseases, Fifth Edition, ed. Long SS, Prober CG, and Fischer M. Elsevier, Inc, 2016 (in-press)
• Messacar K, Abzug MJ, Dominguez SR “Enterovirus D68” in Emerging Infections, Tenth Edition, ed. Scheld WM, Hughes JM, Whitley RJ. American Society of Microbiology Press, 2016.
• Messacar K, Parker SK, Todd JK, Dominguez SR. Implementation of Rapid Molecular Infectious Disease Diagnostics: The Role of Diagnostic and Antimicrobial Stewardship. J Clin Microbiol. 2016 Dec 28. [Epub ahead of print] PubMed PMID: 28031432
• Messacar K, Hurst AL, Child J, Campbell K, Palmer C, Hamilton S, Dowell E, Robinson CC, Parker SK, Dominguez SR. Clinical Impact and Provider Acceptability of Real-Time Antimicrobial Stewardship Decision Support for Rapid Diagnostics in Children With Positive Blood Culture Results. J Pediatric Infect Dis Soc. 2016 Aug 19. [Epub ahead of print] PubMed PMID: 27543412
• Messacar K, Schreiner TL, Van Haren K, Yang M, Tyler KL, Glaser C, Dominguez SR. Acute Flaccid Myelitis: A Clinical Review.
• Messacar K, Abzug MJ, Dominguez SR. 2014 outbreak of enterovirus D68 in North America. J Med Virol. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26489019
• Messacar K, Schreiner TL, Maloney JA, Wallace A, Ludke J, Oberste MS, Nix WA, Robinson CC, Glodé MP, Abzug MJ, Dominguez SR. A cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA. Lancet. 2015 Apr 25;385(9978):1662-71. PubMed PMID: 25638662
• Messacar K, Breazeale G, Wei Q, Robinson CC, Dominguez SR. Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus. J Med Virol. 2015 May;87(5):829-35. PubMed PMID: 25650069
• Messacar K, Dunn J, Khan TZ, Etcheverry A, McFarland EJ, Dominguez SR. Diffuse Nodular Lung Infiltrates in a Well Appearing Three-Year-Old Boy With Recurrent Sinopulmonary Infections and Parotitis. J Pediatric Infect Dis Soc. 2015 Mar;4(1):74-7. PubMed PMID: 26407362
• Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI findings in children with acute flaccid paralysis and cranial nerve dysfunction occurring during the 2014 enterovirus D68 outbreak. AJNR Am J Neuroradiol. 2015 Feb;36(2):245-50. PubMed PMID: 25414005
• Notes from the field: acute flaccid myelitis among persons aged =21 years - United States, August 1-November 13, 2014. MMWR Morb Mortal Wkly Rep. 2015 Jan 9;63(53):1243-4. PubMed PMID: 25577990
• Greninger AL, Naccache SN, Messacar K, Clayton A, Yu G, Somasekar S, Federman S, Stryke D, Anderson C, Yagi S, Messenger S, Wadford D, Xia D, Watt JP, Van Haren K, Dominguez SR, Glaser C, Aldrovandi G, Chiu CY. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study. Lancet Infect Dis. 2015 Jun;15(6):671-82. PubMed PMID: 25837569
• Greninger AL*, Messacar K*, Dunnebacke T, Naccache SN, Federman S, Bouquet J, Mirsky D, Nomura Y, Yagi S, Glaser C, Vollmer M, Press CA, Klenschmidt-DeMasters BK, Dominguez SR, Chiu CY. Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing. Genome Med. 2015 Dec 1;7(1):113. PubMed PMID: 26620704
• Good RJ, Messacar K, Stence NV, Press CA, Carpenter TC. Abnormal Neuroimaging in a Case of Infantile Botulism. Frontiers in Pediatrics. 2015.
• Messacar K, Modlin JF, Abzug MJ “Enteroviruses and Parechoviruses” in Principles and Practice of Pediatric Infectious Diseases, Fifth Edition, ed. Long SS, Prober CG, and Fischer M. Elsevier, Inc, 2015.
• Messacar K, Modlin JF, Abzug MJ “Introduction to Picornaviruses” in Principles and Practice of Pediatric Infectious Diseases, Fifth Edition, ed. Long SS, Prober CG, and Fischer M. Elsevier, Inc, 2015
• Messacar K, Dominguez SR, Levin MJ “Infections: Parasitic and Mycotic” in Current Diagnosis and Treatment Pediatrics, Twenty-Third Edition, ed. Hay, WM, Levin, MJ, Deterding, RD, Abzug, M. McGraw-Hill, Inc, 2015.
• Messacar K, Abzug MJ, Dominguez SR “Enterovirus D68” in Emerging Infections, Tenth Edition, ed. Scheld WM, Hughes JM, Whitley RJ. American Society of Microbiology, 2015 (in press).
• Messacar K, Abzug MJ. “Enterovirus Infections in Children” in Visual Dx, 2015.
• Aliabadi N, Messacar K, Pastula DM, Robinson CC, Leshem E, Sejvar JJ, Nix WA, Oberste MS, Feikin DR, Dominguez SR. Enterovirus D68 and Acute Flaccid Myelitis among Children: a Case-Control Study in Colorado, 2014. IDWeek 2015, San Diego, CA. Oral Presentation.
• Messacar K, Hawkins S, Rao S, Baker J, Pearce K, Mistry RD, DeMasellis G, Tong S, Milton J, Dominguez SR, Parker S. An Unexpected Strain: Resource Burden During the 2014 Enterovirus D68 Respiratory Disease Outbreak at Children’s Hospital Colorado. IDWeek 2015, San Diego, CA. Poster Presentation.
• Nomura Y, Greninger AL, Messacar K, Dunnebacke T, Naccache SN, Federman S, Bouquet J, Mirsky D, Tagi S, Glaser C, Vollmer M, Press CA, Kleinschmidt-DeMasters BK, Dominguez SR, Chiu C. Balamuthia mandrillaris Encephalitis Diagnosed by Metagenomic Sequencing of Cerebrospinal Fluid. IDWeek 2015, San Diego, CA. Poster Presentation.
• Rao S, Holzberg J, Rick A, Messacar K, Torok M, Montano A, Bagdure D, Curtis DJ, Dominguez SR. Enterovirus D68 is Critically-ill Children: a Comparison to Pandemic H1N1 Influenza. IDWeek 2015, San Diego, CA. Poster Presentation.
• Cataldi J, Olson D, Messacar K, Robinson CC, Dominguez SR, Gaensbauer J. Mycoplasma Pneumoniae as a Cause of Severe Bronchiolitis-like Syndrome among Children Under Two Years of Age. IDWeek 2015, San Diego, CA. Poster Presentation.
• White A, Olson D, Messacar K. A Statewide Assessment of the Association between Maternal Epidural Analgesia, Maternal Fever, and Newborn Receipt of Antibiotics in Colorado 2007-2012. Pediatric Academic Society National Meeting 2015, San Diego, CA. Oral Presentation
• Bagdure D, Messacar K¸ Rao S, Dominguez SR. Burden of Encephalitis on Pediatric Hospitals: Query of a National Database. Abstract submitted to Pediatric Academic Society National Meeting 2015, San Diego, CA. Poster Presentation
• Gaensbauer JT, Lindsey NP, Messacar K, Staples JE, Fischer M. Neuroinvasive arboviral disease in the United States: 2003 to 2012. Pediatrics. 2014 Sep;134(3):e642-50. PubMed PMID: 25113294
• Messacar K, Cree-Green M, Lovell M, Anderson MS, Dominguez SR. Severe Neuroinvasive West Nile Virus Infection in a Child with Undiagnosed Addison's Disease. IDCases. 2014;1(3):29-31. PubMed PMID: 25133095
• Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI Findings in Children with Acute Flaccid Paralysis and Cranial Nerve Dysfunction Occurring during the 2014 Enterovirus D68 Outbreak. AJNR Am J Neuroradiol. 2014 Nov 20. [Epub ahead of print] PubMed PMID: 25414005
• Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L, Centers for Disease Control and Prevention (CDC). Acute neurologic illness of unknown etiology in children - Colorado, August-September 2014. MMWR Morb Mortal Wkly Rep. 2014 Oct 10;63(40):901-2. PubMed PMID: 25299607
• Alvarez E, Seppa M, Messacar K, Kurap J, Sweet-Cordero A, Rivas S, Bustamante M, Howard S, Efron B, Luna-Fineman, S. Improvement of Abandonment and Refusal of Therapy in Pediatric Patients with Cancer in Guatemala at Unidad Nacional de Oncología Pediátrica (UNOP). 46th Congress of the International Society of Paediatric Oncology (SIOP).
• LaGreca J, Hotchkiss M, Carry P, Messacar K, Nyquist AC, Erickson MA, Garg S. Bacteriology and Risk Factors for Development of Late (Greater Than One Year) Deep Infection Following Spinal Fusion Instrumentation. Spine Deformity 2014; 2(3): 186-190.
• Messacar K, Dunn J, Dominguez,SR, Khan T, McFarland EJ. Diffuse Nodular Lung Infiltrates in a Three-Year-Old Boy with Recurrent Sinopulmonary Infections and Parotitis Journal of the Pediatric Infectious Disease Society 2014, doi 10.1093/jpids/piu016.
• Messacar K, Dominguez SR, Levin MJ “Infections: Parasitic and Mycotic” in Current Diagnosis and Treatment Pediatrics, Twenty-Second Edition, ed. Hay, WM, Levin, MJ, Deterding, RD, Abzug, M. McGraw-Hill, Inc, 2014.

Professional Memberships

• American Academy of Pediatrics (AAP), Member
• Pediatric Infectious Disease Society, Member
• Infectious Disease Society of America, Member
• Society of Pediatric Research, Member
• Colorado Chapter of the Infectious Disease Society of America, Board Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado

Specialty Information

Specialties

• Pediatric Infectious Diseases, Board Certification (2015)
• Pediatrics, Board Certification (2011)

Conditions & Treatments

• Brain and Nervous System
• Brain and Nervous System - Meningitis
• Child and Teen Health
• Infections
• Child and Teen Health - Pediatric Diseases and Conditions
• Infections - Bacterial Infections
• Infections - Viral Infections
• Brain and Nervous System - Autoimmune encephalitis and myelitis
• Brain and Nervous System - Paralysis
• Brain and Nervous System - Encephalitis
• Brain and Nervous System - Transverse Myelitis