Kejun Guo, PhD

Publications

• Guo K, Halemano K, Schmitt K, Katuwal M, Wang Y, Harper MS, Heilman KJ, Kuwata T, Stephens EB, Santiago ML. Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques. Immunogenetics. 2015 May; 67(7);DOI: 10.1007/s00251-015-0844-3
• Wang Y, Schmitt K, Guo K, Santiago ML, Stephens EB. The role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancer. Journal of General Virology. 10/20/2015; Doi:10.1099/jgv.0.000320
• Harper MS, Guo K, Gibbert K, Lee EJ, Dillon SM, Barrett BS, McCarter MD, Hasendrug KJ, Dittmer U, Wilson CC, Santiago ML. Interferon-a subtypes in an ex vivo model of acute HIV-1 infection: expression, potency and effectors. PLoS Pathogens, 11(11): e1005254. doi:10.1371/journal.ppat.1005254
• Dillon SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, Wilson CC. Enhancement of HIV-1 infection and intestinal CD4 T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. 2016 Jan 14;13:5. PubMed PMID: 26762145
• Miller SM, Miles B, Guo K, Folkvord J, Meditz AL, McCarter MD, Levy DN, MaWhinney S, Santiago ML, Connick E. Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1. J Virol. 2017 Sep 1;91(17). PubMed PMID: 28615202
• Barrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago ML. Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction. Retrovirology. 2017 Apr 17;14(1):25. PubMed PMID: 28415995
• Yoder AC, Guo K, Dillon SM, Phang T, Lee EJ, Harper MS, Helm K, Kappes JC, Ochsenbauer C, McCarter MD, Wilson CC, Santiago ML. The transcriptome of HIV-1 infected intestinal CD4 T cells exposed to enteric bacteria. PLoS Pathog. 2017 Feb;13(2):e1006226. PubMed PMID: 28241075
• Li SX, Barrett BS, Guo K, Kassiotis G, Hasenkrug KJ, Dittmer U, Gibbert K, Santiago ML. Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection. Sci Rep. 2016 Feb 5;6:20425. PubMed PMID: 26846717
• Lavender KJ, Gibbert K, Peterson KE, Van Dis E, Francois S, Woods T, Messer RJ, Gawanbacht A, Müller JA, Münch J, Phillips K, Race B, Harper MS, Guo K, Lee EJ, Trilling M, Hengel H, Piehler J, Verheyen J, Wilson CC, Santiago ML, Hasenkrug KJ, Dittmer U. Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo. J Virol. 2016 Jul 1;90(13):6001-13. PubMed PMID: 27099312
• Dillon SM, Kibbie J, Lee EJ, Guo K, Santiago ML, Austin GL, Gianella S, Landay AL, Donovan AM, Frank DN, McCarter MD, Wilson CC. Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation. AIDS. 2016 Dec 19. [Epub ahead of print] PubMed PMID: 28002063
• Dillon SM, Guo K, Austin GL, Gianella S, Engen PA, Mutlu EA, Losurdo J, Swanson G, Chakradeo P, Keshavarzian A, Landay AL, Santiago ML, Wilson CC. A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis. AIDS. 2018 Jul 31;32(12):1599-1611. PubMed PMID: 29762170
• Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D. Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. J Virol. 2018 Apr 1;92(7). PubMed PMID: 29367246
• Agazio A, Cimons J, Shotts KM, Guo K, Santiago ML, Pelanda R, Torres RM. Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1. Front Immunol. 2020;11:1565. PubMed PMID: 32849530
• Guo K, Shen G, Kibbie J, Gonzalez T, Dillon SM, Smith HA, Cooper EH, Lavender K, Hasenkrug KJ, Sutter K, Dittmer U, Kroehl M, Kechris K, Wilson CC, Santiago ML. Qualitative Differences Between the IFNa subtypes and IFNß Influence Chronic Mucosal HIV-1 Pathogenesis. PLoS Pathog. 2020 Oct;16(10):e1008986. PubMed PMID: 33064743
• Guo K, Barrett BS, Mickens KL, Hasenkrug KJ, Santiago ML. Interferon Resistance of Emerging SARS-CoV-2 Variants. bioRxiv. 2021 Mar 21. PubMed PMID: 33758840
• Hasenkrug KJ, Feldmann F, Myers L, Santiago ML, Guo K, Barrett BS, Mickens KL, Carmody A, Okumura A, Rao D, Collins MM, Messer RJ, Lovaglio J, Shaia C, Rosenke R, van Doremalen N, Clancy C, Saturday G, Hanley P, Smith B, Meade-White K, Shupert WL, Hawman DW, Feldmann H. Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques. bioRxiv. 2021 Apr 4. PubMed PMID: 33821272
• Barrett B, Nguyen DH, Xu J, Guo K, Shetty S, Jones ST, Mickens KL, Shepard C, Roers A, Behrendt R, Wu L, Kim B, Santiago ML. SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide. J Immunol. 2021 Dec 10. [Epub ahead of print] PubMed PMID: 34893529
• Windsor WJ, Knight V, Merkel PA, Lamb MM, Tucker HR, Carson K, Howard KM, Yates JL, Santiago ML, McCarthy MK, Morrison TE, Kedl RM, Frazer-Abel A, Guo K, Andersen G, Huey L, Barrett BS, Colón-Franco JM, Lee WT, Chu MC. COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method. Am J Trop Med Hyg. 2022 Jan 7;106(2):562-565. PubMed PMID: 34996045
• Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JM. Specialized interferon action in COVID-19. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11). PubMed PMID: 35217532
• Iwamoto C, Lesteberg KE, Lamb MM, Calvimontes DM, Guo K, Barrett BS, Mickens KL, Duca LM, Monzon J, Chard AN, Guzman G, Barrios E, Rojop N, Arias K, Gomez M, Paiz C, Bolanos GA, Edwards KM, Zielinski Gutierrez E, Azziz-Baumgartner E, Asturias EJ, Santiago ML, Beckham JD, Olson D. High SARS-CoV-2 Seroprevalence and Rapid Neutralizing Antibody Decline among Agricultural Workers in Rural Guatemala, June 2020-March 2021. Vaccines (Basel). 2022 Jul 21;10(7). PubMed PMID: 35891324
• Jones ST, Guo K, Cooper EH, Dillon SM, Wood C, Nguyen DH, Shen G, Barrett BS, Frank DN, Kroehl M, Janoff EN, Kechris K, Wilson CC, Santiago ML. Altered Immunoglobulin Repertoire and Decreased IgA Somatic Hypermutation in the Gut during Chronic HIV-1 Infection. J Virol. 2022 Sep 14;96(17):e0097622. PubMed PMID: 35938870
• Guo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203760119. PubMed PMID: 35867811
• Dillon SM, Mickens KL, Thompson TA, Cooper EH, Nesladek S, Christians AJ, Castleman M, Guo K, Wood C, Frank DN, Kechris K, Santiago ML, Wilson CC. Granzyme B( ) CD4 T cells accumulate in the colon during chronic HIV-1 infection. Gut Microbes. 2022 Jan-Dec;14(1):2045852. PubMed PMID: 35258402
• Pasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen L, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EB. Regulation of human interferon signaling by transposon exonization. bioRxiv. 2023 Sep 15. PubMed PMID: 37745311
• Dopkins N, Fei T, Michael S, Liotta N, Guo K,Mickens KL, Barrett BS, Bendall ML, Dillon SM, Wilson CC, Santiago ML, and Nixon DF, Endogenous Retroelement Expression in the Gut Microenvironment of People Living with HIV-1, medRxiv, 2023, Nov. 07, doi: https://doi.org/10.1101/2023.11.06.23298166