My research interests are focused on how insulin works in youth with polycystic ovarian syndrome or diabetes. We are trying to better understand how high insulin levels cause disease, so that we can prevent related conditions such as fatty liver disease or heart disease and develop new therapies.
Publications
Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389543
Cung S, Pyle L, Nadeau K, Dabelea D, Cree-Green M, Davis SM. In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome. J Investig Med. 2021 Sep 7. [Epub ahead of print] PubMed PMID: 34493629
Utzschneider KM, Tripputi MT, Kozedub A, Barengolts E, Caprio S, Cree-Green M, Edelstein SL, El Ghormli L, Hannon TS, Mather KJ, Palmer J, Nadeau KJ. Differential loss of ß-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study. Diabetes Res Clin Pract. 2021 Aug;178:108948. PubMed PMID: 34274407
Moore JM, Waldrop SW, Cree-Green M. Weight Management in Adolescents with Polycystic Ovary Syndrome. Curr Obes Rep. 2021 Sep;10(3):311-321. PubMed PMID: 34043216
Xiang AH, Martinez MP, Trigo E, Utzschneider KM, Cree-Green M, Arslanian SA, Ehrmann DA, Caprio S, Mohamed PHIH, Hwang DH, Katkhouda N, Nayak KS, Buchanan TA. Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ß-Cell Function. Obesity (Silver Spring). 2021 Jul;29(7):1155-1163. PubMed PMID: 34038037
Hudnut-Beumler J, Kaar JL, Taylor A, Kelsey MM, Nadeau KJ, Zeitler P, Snell-Bergeon J, Pyle L, Cree-Green M. Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity. Pediatr Diabetes. 2021 Aug;22(5):699-706. PubMed PMID: 33870630
Torres-Zegarra C, Sundararajan D, Benson J, Seagle H, Witten M, Walders-Abramson N, Simon SL, Huguelet P, Nokoff NJ, Cree-Green M. Care for Adolescents With Polycystic Ovary Syndrome: Development and Prescribing Patterns of a Multidisciplinary Clinic. J Pediatr Adolesc Gynecol. 2021 Oct;34(5):617-625. PubMed PMID: 33794340
Pyle L, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Nadeau KJ, Cree-Green M. Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity. Metabol Open. 2021 Mar;9:100085. PubMed PMID: 33665598
Mather KJ, Tjaden AH, Hoehn A, Nadeau KJ, Buchanan TA, Kahn SE, Arslanian SA, Caprio S, Atkinson KM, Cree-Green M, Utzschneider KM, Edelstein SL. Precision and accuracy of hyperglycemic clamps in a multicenter study. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E797-E807. PubMed PMID: 33645253
Andrisse S, Garcia-Reyes Y, Pyle L, Kelsey MM, Nadeau KJ, Cree-Green M. Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome. J Endocr Soc. 2021 Apr 1;5(4):bvab008. PubMed PMID: 33644620
Scalzo RL, Schauer IE, Rafferty D, Knaub LA, Kvaratskhelia N, Johnson TK, Pott GB, Abushamat LA, Whipple MO, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG. Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes. J Physiol. 2021 Feb 10. [Epub ahead of print] PubMed PMID: 33569797
Bartlette K, Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Pyle L, Nadeau KJ, Cree-Green M, Diniz Behn C. Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration. Metabol Open. 2021 Mar;9:100078. PubMed PMID: 33511337
Jobira B, Frank DN, Silveira LJ, Pyle L, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome. PLoS One. 2021;16(1):e0245219. PubMed PMID: 33465100
Tommerdahl KL, Baumgartner K, Schäfer M, Bjornstad P, Melena I, Hegemann S, Baumgartner AD, Pyle L, Cree-Green M, Truong U, Browne L, Regensteiner JG, Reusch JEB, Nadeau KJ. Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes. Diabetes Care. 2021 Mar;44(3):795-803. PubMed PMID: 33402367
Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 Jun;22(2):351-366. PubMed PMID: 33389543
Huguelet PS, Olson E, Sass A, Bartz S, Hsu S, Cree-Green M. Application of a Standard Cross-Specialty Workup for Diagnosis and Metabolic Screening of Obese Adolescents With Polycystic Ovary Syndrome. J Adolesc Health. 2021 Mar;68(3):589-595. PubMed PMID: 32819830
Buyers E, Sass AE, Severn CD, Pyle L, Cree-Green M. Twelve-month Continuation of the Etonogestrel Implant in Adolescents With Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2021 Feb;34(1):33-39. PubMed PMID: 32919086
Tommerdahl KL, Brinton JT, Vigers T, Cree-Green M, Zeitler PS, Nadeau KJ, Chan CL. Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index. J Cyst Fibros. 2021 Mar;20(2):339-345. PubMed PMID: 32928701
Tommerdahl KL, Bjornstad P, Kendrick J, Cree-Green M, Baumgartner AD, Pyle L, Reusch JEB, Nadeau KJ. Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes. Diabetes Obes Metab. 2021 Mar;23(3):844-849. PubMed PMID: 33236509
Simon S, Rahat H, Carreau AM, Garcia-Reyes Y, Halbower A, Pyle L, Nadeau KJ, Cree-Green M. Poor Sleep is Related to Metabolic Syndrome Severity in Adolescents with PCOS and Obesity. J Clin Endocrinol Metab. 2020 Jan 4. [Epub ahead of print] PubMed PMID: 31901092
Diniz Behn C, Jin ES, Bubar K, Malloy C, Parks EJ, Cree-Green M. Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling. J Investig Med. 2020 Jan;68(1):3-10. PubMed PMID: 31554675
Tommerdahl KL, Bjornstad P, Kendrick J, Cree-Green M, Baumgartner AD, Pyle L, Reusch JEB, Nadeau KJ. Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes. Diabetes Obes Metab. 2020 Nov 25. [Epub ahead of print] PubMed PMID: 33236509
Tommerdahl KL, Brinton JT, Vigers T, Cree-Green M, Zeitler PS, Nadeau KJ, Chan CL. Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index. J Cyst Fibros. 2020 Sep 11;:2111. [Epub ahead of print] PubMed PMID: 32928701
Buyers E, Sass AE, Severn CD, Pyle L, Cree-Green M. Twelve-month Continuation of the Etonogestrel Implant in Adolescents With Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2020 Sep 9. [Epub ahead of print] PubMed PMID: 32919086
Utzschneider KM, Tripputi MT, Kozedub A, Mather KJ, Nadeau KJ, Edelstein SL, Hannon TS, Arslanian SA, Cree-Green M, Buchanan TA, Caprio S, Mari A. ß-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults. Pediatr Diabetes. 2020 Dec;21(8):1421-1429. PubMed PMID: 32902875
Benson J, Severn C, Hudnut-Beumler J, Simon SL, Abramson N, Shomaker LB, Gulley LD, Taylor A, Kelsey MM, Nadeau KJ, Zeitler PS, Pyle L, Cree-Green M. Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes. Can J Diabetes. 2020 Aug;44(6):507-513. PubMed PMID: 32792104
Cree-Green M, Carreau AM, Davis SM, Frohnert BI, Kaar JL, Ma NS, Nokoff NJ, Reusch JEB, Simon SL, Nadeau KJ. Peer mentoring for professional and personal growth in academic medicine. J Investig Med. 2020 Aug;68(6):1128-1134. PubMed PMID: 32641352
Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Bartlette K, Behn CD, Pyle L, Nadeau KJ, Cree-Green M. Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents. Pediatr Diabetes. 2020 Jun 26. [Epub ahead of print] PubMed PMID: 32592269
Davis SM, Soares K, Howell S, Cree-Green M, Buyers E, Johnson J, Tartaglia NR. Diminished Ovarian Reserve in Girls and Adolescents with Trisomy X Syndrome. Reprod Sci. 2020 Nov;27(11):1985-1991. PubMed PMID: 32578162
Cree-Green M, Cree J, Urban K, Bunik M, Sass AE, Rosenberg A. A Structured Neonatal Parenting Elective: An Approach for Parenting Leave During Residency. Acad Pediatr. 2020 Jul;20(5):595-599. PubMed PMID: 32045680
Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota. J Clin Endocrinol Metab. 2020 Jun 1;105(6). PubMed PMID: 31970418
Simon S, Rahat H, Carreau AM, Garcia-Reyes Y, Halbower A, Pyle L, Nadeau KJ, Cree-Green M. Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity. J Clin Endocrinol Metab. 2020 Apr 1;105(4). PubMed PMID: 31901092
McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2020 Mar;35(3):215-220. PubMed PMID: 31769329
Cree-Green M. Editoral commentary: Understanding cardiovascular disease risk in women with polycystic ovary syndrome. Trends Cardiovasc Med. 2020 Oct;30(7):405-406. PubMed PMID: 31607636
Diniz Behn C, Jin ES, Bubar K, Malloy C, Parks EJ, Cree-Green M. Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling. J Investig Med. 2020 Jan;68(1):3-10. PubMed PMID: 31554675
Simon SL, Diniz Behn C, Laikin A, Kaar JL, Rahat H, Cree-Green M, Wright KP Jr, Nadeau KJ. Sleep & Circadian Health are Associated with Mood & Behavior in Adolescents with Overweight/Obesity. Behav Sleep Med. 2020 Jul-Aug;18(4):550-559. PubMed PMID: 31218887
Avery J, Ottey S, Morman R, Cree-Green M, Gibson-Helm M. Polycystic Ovary Syndrome support groups and their role in awareness, advocacy and peer-support: a systematic search and narrative review. Current Opinion in Endo and Met Research. Volume 12, June 2020, Pages 98-104
S HP, Emily O, Amy S, Sarah B, Stephanie H, Melanie CG. Application of a Standard Cross-Specialty Workup for Diagnosis and Metabolic Screening of Obese Adolescents With Polycystic Ovary Syndrome. J Adolesc Health. 2020 Aug 17. [Epub ahead of print] PubMed PMID: 32819830
Utzschneider KM, Tripputi MT, Kozedub A, Mather KJ, Nadeau KJ, Edelstein SL, Hannon TS, Arslanian SA, Cree-Green M, Buchanan TA, Caprio S, Mari A. ß-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults. Pediatr Diabetes. 2020 Dec;21(8):1421-1429. PubMed PMID: 32902875
Cree-Green M. Postglucose Hyperinsulinemia in Black Women Is Not What We Thought. J Clin Endocrinol Metab. 2019 Feb 1;104(2):266-268. PubMed PMID: 30371868
McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2019 Nov 26;:883073819886244. [Epub ahead of print] PubMed PMID: 31769329
Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism. Obesity (Silver Spring). 2019 Dec;27(12):2046-2054. PubMed PMID: 31659873
Cree-Green M. Understanding cardiovascular disease risk in women with polycystic ovary syndrome. Trends Cardiovasc Med. 2019 Sep 24. [Epub ahead of print] PubMed PMID: 31607636
Carreau AM, Pyle L, Garcia-Reyes Y, Rahat H, Vigers T, Jensen T, Scherzinger A, Nadeau KJ, Cree-Green M. Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index). Clin Endocrinol (Oxf). 2019 Oct;91(4):544-552. PubMed PMID: 31301251
Simon SL, Diniz Behn C, Laikin A, Kaar JL, Rahat H, Cree-Green M, Wright KP Jr, Nadeau KJ. Sleep & Circadian Health are Associated with Mood & Behavior in Adolescents with Overweight/Obesity. Behav Sleep Med. 2019 Jun 20;:1-10. [Epub ahead of print] PubMed PMID: 31218887
Scalzo RL, Rafferty D, Schauer I, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG. Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes. J Diabetes Complications. 2019 Aug;33(8):561-566. PubMed PMID: 31182338
Ravi SJ, Cree-Green M. Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report. J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619850215. PubMed PMID: 31113263
Carreau AM, Jin ES, Garcia-Reyes Y, Rahat H, Nadeau KJ, Malloy CR, Cree-Green M. A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R134-R142. PubMed PMID: 31042400
Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
Cree-Green M, Bergman BC, Cengiz E, Fox LA, Hannon TS, Miller K, Nathan B, Pyle L, Kahn D, Tansey M, Tichy E, Tsalikian E, Libman I, Nadeau KJ. Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3265-3278. PubMed PMID: 30938764
Simon SL, McWhirter L, Diniz Behn C, Bubar KM, Kaar JL, Pyle L, Rahat H, Garcia-Reyes Y, Carreau AM, Wright KP, Nadeau KJ, Cree-Green M. Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3525-3534. PubMed PMID: 30888398
Cree-Green M, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Pyle L, Nadeau KJ. Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E707-E718. PubMed PMID: 30753112
Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E186-E195. PubMed PMID: 30562061
Simon SL, Behn CD, Cree-Green M, Kaar JL, Pyle L, Hawkins SMM, Rahat H, Garcia-Reyes Y, Wright KP Jr, Nadeau KJ. Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity. J Pediatr. 2019 Feb;205:257-264.e1. PubMed PMID: 30497764
Jensen T, Wieland A, Cree-Green M, Nadeau K, Sullivan S. Clinical workup of fatty liver for the primary care provider. Postgrad Med. 2019 Jan;131(1):19-30. PubMed PMID: 30496690
Cree-Green M. Postglucose Hyperinsulinemia in Black Women Is Not What We Thought. J Clin Endocrinol Metab. 2019 Feb 1;104(2):266-268. PubMed PMID: 30371868
. Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults. Pediatr Diabetes. 2019 Nov;20(7):849-860. PubMed PMID: 31301210
. Lack of Durable Improvements in ß-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2019 Sep;42(9):1742-1751. PubMed PMID: 31178434
Temple KA, Tjaden AH, Atkinson KM, Barengolts E, Hannon TS, Mather KJ, Utzschneider KM, Edelstein SL, Ehrmann DA, Mokhlesi B. Association of Habitual Daily Physical Activity With Glucose Tolerance and ß-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2019 Aug;42(8):1521-1529. PubMed PMID: 31177181
. Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on ß-Cell Function: Comparison of Responses In Youth And Adults. Diabetes. 2019 Aug;68(8):1670-1680. PubMed PMID: 31178433
Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Utzschneider KM, Nadeau KJ, Hannon TS, Sam S, Barengolts E, Manchanda S, Ehrmann DA, Van Cauter E. Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes. Diabetes Care. 2019 Jul;42(7):1326-1332. PubMed PMID: 31048411
Pereira-Eshraghi CF, Chiuzan C, Zhang Y, Tao RH, McCann M, Neugut YD, Printz A, Fennoy I, Cree-Green M, Oberfield SE, Sopher AB. Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women. Horm Res Paediatr. 2019;92(6):365-371. PubMed PMID: 32348991
Bjornstad P, Schäfer M, Truong U, Cree-Green M, Pyle L, Baumgartner A, Garcia Reyes Y, Maniatis A, Nayak S, Wadwa RP, Browne LP, Reusch JEB, Nadeau KJ. Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus. Circulation. 2018 Dec 18;138(25):2895-2907. PubMed PMID: 30566007
Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with Type 2 Diabetes Have Hepatic, Peripheral and Adipose Insulin Resistance. Am J Physiol Endocrinol Metab. 2018 Dec 18. [Epub ahead of print] PubMed PMID: 30562061
Simon SL, Behn CD, Cree-Green M, Kaar JL, Pyle L, Hawkins SMM, Rahat H, Garcia-Reyes Y, Wright KP Jr, Nadeau KJ. Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity. J Pediatr. 2018 Nov 19. [Epub ahead of print] PubMed PMID: 30497764
Jensen T, Wieland A, Cree-Green M, Nadeau K, Sullivan S. Clinical workup of fatty liver for the primary care provider. Postgrad Med. 2018 Nov 29;:1-12. [Epub ahead of print] PubMed PMID: 30496690
Cree-Green M, Cai N, Thurston JE, Coe GV, Newnes L, Garcia-Reyes Y, Baumgartner AD, Pyle L, Nadeau KJ. Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome. Pediatr Diabetes. 2018 Dec;19(8):1370-1378. PubMed PMID: 30246333
Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3647-3657. PubMed PMID: 30020457
Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ. Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls. J Endocr Soc. 2018 Jun 1;2(6):547-562. PubMed PMID: 29942919
Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, McClatchey PM, Bauer TA, Regensteiner JG, Reusch JEB. Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes. 2018 Jul;67(7):1369-1379. PubMed PMID: 29643061
Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2018 May;19(3):436-442. PubMed PMID: 29082640
Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 1;596(1):67-82. PubMed PMID: 28940557
Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018 May;68(5):1063-1075. PubMed PMID: 29408694
Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2017 Oct 30. [Epub ahead of print] PubMed PMID: 29082640
Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940557
Cree-Green M. Worldwide Dissatisfaction With the Diagnostic Process and Initial Treatment of PCOS. J Clin Endocrinol Metab. 2017 Feb 1;102(2):375-378. PubMed PMID: 28359108
Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schafer M, Pyle L, Regensteiner JG, Reusch JEB, Nadeau KJ. Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study. J Diabetes Complications. 2017 May;31(5):850-853. PubMed PMID: 28336216
Cree-Green M, Cai N, Pyle L, Ringham B, Brown MS, Newcomer BR, Nadeau KJ, Dabelea D. Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction. J Clin Endocrinol Metab. 2017 May 1;102(5):1652-1660. PubMed PMID: 28204552
Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M. Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers. Vasc Med. 2017 Apr;22(2):85-95. PubMed PMID: 28095749
Cree-Green M, Gupta A, Coe GV, Baumgartner AD, Pyle L, Reusch JE, Brown MS, Newcomer BR, Nadeau KJ. Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J Diabetes Complications. 2017 Jan;31(1):141-148. PubMed PMID: 27839922
Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2017 Sep;18(6):470-477. PubMed PMID: 27503277
Ohman-Hanson R, Cree-Green M, Kelsey MM, Bessesen DH, Sharp TA, Pyle L, Pereira RI, Nadeau KJ. Ethnic and sex differences in adiponectin: from childhood to adulthood. J Clin Endocrinol Metab. 2016 Sep 7;:jc20161137. [Epub ahead of print] PubMed PMID: 27603898
Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2016 Aug 9. [Epub ahead of print] PubMed PMID: 27503277
Poppy A, Retamal-Munoz C, Cree-Green M, Wood C, Davis S, Clements SA, Majidi S, Steck AK, Alonso GT, Chambers C, Rewers A. Reduction of Insulin Related Preventable Severe Hypoglycemic Events in Hospitalized Children. Pediatrics. 2016 Jul;138(1). PubMed PMID: 27317577
Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 Aug;30(6):1103-10. PubMed PMID: 27133451
Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18;5(3):e002804. PubMed PMID: 26994128
Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined. Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E323-31. PubMed PMID: 26714848
Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Jun;17(4):257-65. PubMed PMID: 26080650
Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ. Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring). 2016 Nov;24(11):2399-2406. PubMed PMID: 27804265
Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2015 Jun 17. [Epub ahead of print] PubMed PMID: 26080650
Cree-Green M, Newcomer BR, Coe G, Newnes L, Baumgartner A, Brown MS, Pyle L, Reusch JE, Nadeau KJ. Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids. Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E726-33. PubMed PMID: 25714677
Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan;38(1):126-31. PubMed PMID: 25414156
Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2015 Feb;64(2):383-92. PubMed PMID: 25157095
Cree-Green M, Newcomer BR, Coe G, Newnes L, Baumgartner A, Brown MS, Pyle L, Reusch JE, Nadeau KJ. Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids. Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E726-33. PubMed PMID: 25714677
Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan;38(1):126-31. PubMed PMID: 25414156
Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2015 Feb;64(2):383-92. PubMed PMID: 25157095
Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal Function Is Associated With Peak Exercise Capacity in Adolescents With Type 1 Diabetes. Diabetes Care. 2014 Nov 20. [Epub ahead of print] PubMed PMID: 25414156
Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2014 Aug 25. [Epub ahead of print] PubMed PMID: 25157095
Messacar K, Cree-Green M, Lovell M, Anderson MS, Dominguez SR. Severe Neuroinvasive West Nile Virus Infection in a Child with Undiagnosed Addison's Disease. IDCases. 2014;1(3):29-31. PubMed PMID: 25133095
Bjornstad P, Maahs DM, Cherney DZ, Cree-Green M, West A, Pyle L, Nadeau KJ. Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes. Diabetes Care. 2014 Nov;37(11):3033-9. PubMed PMID: 25071077
Child and Teen Health - Pediatric Diseases and Conditions
Child and Teen Health
Endocrine System (Hormones)
Clinical Interests
I see most pediatric endocrine conditions. I have a special interest in polycystic ovarian syndrome and oversee a special clinic for girls with this condition who are also overweight, to try to offer a complete treatment plan in 1-2 visits.
Care Philosophy
My overall philosophy is try to practice personalized medicine as much as possible, and make sure my recommended therapies are right for the medical condition, the patient and the family.
Personal Interests
In my spare time, I enjoy spending time with my family, running, snowboarding, gardening and photography.
Volunteer Activities
I spend time supporting activities in the schools and for children's health.
General Information
Medical Schools:
MD, University of Texas Medical Branch School of Medicine
(2007)
Graduate Schools:
PhD, University of Texas Medical Branch
(2007)
Undergraduate Schools:
AB, Bryn Mawr College (PA)
(1999)
Internships:
University of Colorado (Children's Hospital Colorado) Program
(2009)
Residency Programs:
University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2011)
Fellowships:
University of Colorado (Children's Hospital Colorado) Program, Pediatric Endocrinology
(2014)