Melanie Cree-Green, MD, PhD

Professional Titles

• Director, Multi-Disciplinary PCOS clinic

Recognitions

• Fellow's Clinical Research Award, Society for Pediatric Research (2014)
  
• Fellows Travel Award, Pediatric Endocrine Society (2014)
  
• Scholar, Western Region of the American Federation for Medical Research (2013)
  
• Women's Health Fellowship, Endocrine Society (2013)
  
• Research Fellowship, Pediatric Endocrine Society (2013)
  
• Junior Faculty Outstanding Abstract Award, Endocrine Society (2015)
• 1st annual Carmel Prize for Academic Excellence, Western Society for Pediatric Medicine (2016)
• Early Investigator Award, Endocrine Society (2016)
• Highest Patient Satisfaction Award, Children's Hospital Colorado (2017)
• “Best of 2017” article selection, Endocrine Society (2017)

Research Interests

Publications

• Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal Function Is Associated With Peak Exercise Capacity in Adolescents With Type 1 Diabetes. Diabetes Care. 2014 Nov 20. [Epub ahead of print] PubMed PMID: 25414156
• Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2014 Aug 25. [Epub ahead of print] PubMed PMID: 25157095
• Messacar K, Cree-Green M, Lovell M, Anderson MS, Dominguez SR. Severe Neuroinvasive West Nile Virus Infection in a Child with Undiagnosed Addison's Disease. IDCases. 2014;1(3):29-31. PubMed PMID: 25133095
• Bjornstad P, Maahs DM, Cherney DZ, Cree-Green M, West A, Pyle L, Nadeau KJ. Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes. Diabetes Care. 2014 Nov;37(11):3033-9. PubMed PMID: 25071077
• Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2015 Jun 17. [Epub ahead of print] PubMed PMID: 26080650
• Cree-Green M, Newcomer BR, Coe G, Newnes L, Baumgartner A, Brown MS, Pyle L, Reusch JE, Nadeau KJ. Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids. Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E726-33. PubMed PMID: 25714677
• Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan;38(1):126-31. PubMed PMID: 25414156
• Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2015 Feb;64(2):383-92. PubMed PMID: 25157095
• Ohman-Hanson R, Cree-Green M, Kelsey MM, Bessesen DH, Sharp TA, Pyle L, Pereira RI, Nadeau KJ. Ethnic and sex differences in adiponectin: from childhood to adulthood. J Clin Endocrinol Metab. 2016 Sep 7;:jc20161137. [Epub ahead of print] PubMed PMID: 27603898
• Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2016 Aug 9. [Epub ahead of print] PubMed PMID: 27503277
• Poppy A, Retamal-Munoz C, Cree-Green M, Wood C, Davis S, Clements SA, Majidi S, Steck AK, Alonso GT, Chambers C, Rewers A. Reduction of Insulin Related Preventable Severe Hypoglycemic Events in Hospitalized Children. Pediatrics. 2016 Jul;138(1). PubMed PMID: 27317577
• Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 Aug;30(6):1103-10. PubMed PMID: 27133451
• Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18;5(3):e002804. PubMed PMID: 26994128
• Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined. Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E323-31. PubMed PMID: 26714848
• Cree-Green M, Maahs DM, Ferland A, Hokanson JE, Wang H, Pyle L, Kinney GL, King M, Eckel RH, Nadeau KJ. Lipoprotein subfraction cholesterol distribution is more atherogenic in insulin resistant adolescents with type 1 diabetes. Pediatr Diabetes. 2016 Jun;17(4):257-65. PubMed PMID: 26080650
• Cree-Green M, Newcomer BR, Coe G, Newnes L, Baumgartner A, Brown MS, Pyle L, Reusch JE, Nadeau KJ. Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids. Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E726-33. PubMed PMID: 25714677
• Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan;38(1):126-31. PubMed PMID: 25414156
• Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2015 Feb;64(2):383-92. PubMed PMID: 25157095
• Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ. Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance. Obesity (Silver Spring). 2016 Nov;24(11):2399-2406. PubMed PMID: 27804265
• Melanie Cree-Green, Abhinav Gupta,Gregory V. Coe, Amy D. Baumgartner, Laura Pyle, Jane E.B. Reusch,Mark S. Brown, Bradley R. Newcomer, Kristen J. Nadeaua;Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J diabetes and it's complications. In Press, Accepted Manuscript
• Sonali S. Patel, Uyen Truong, Martina King, Annie Ferland, Kerrie L. Moreau, Jennifer Dorosz7, John E. Hokanson, Hong Wang, Gregory L. Kinney, David M. Maahs, Robert H. Eckel, Kristen J. Nadeau, Melanie Cree-Green;Obese Adolescents with Polycystic Ovarian Syndrome have Elevated Cardiovascular Disease Risk Markers. Journal of Vascular Medicine. In Press
• Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2017 Oct 30. [Epub ahead of print] PubMed PMID: 29082640
• Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940557
• Cree-Green M. Worldwide Dissatisfaction With the Diagnostic Process and Initial Treatment of PCOS. J Clin Endocrinol Metab. 2017 Feb 1;102(2):375-378. PubMed PMID: 28359108
• Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schafer M, Pyle L, Regensteiner JG, Reusch JEB, Nadeau KJ. Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study. J Diabetes Complications. 2017 May;31(5):850-853. PubMed PMID: 28336216
• Cree-Green M, Cai N, Pyle L, Ringham B, Brown MS, Newcomer BR, Nadeau KJ, Dabelea D. Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction. J Clin Endocrinol Metab. 2017 May 1;102(5):1652-1660. PubMed PMID: 28204552
• Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M. Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers. Vasc Med. 2017 Apr;22(2):85-95. PubMed PMID: 28095749
• Cree-Green M, Gupta A, Coe GV, Baumgartner AD, Pyle L, Reusch JE, Brown MS, Newcomer BR, Nadeau KJ. Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J Diabetes Complications. 2017 Jan;31(1):141-148. PubMed PMID: 27839922
• Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2017 Sep;18(6):470-477. PubMed PMID: 27503277
• 5. M. Cree-Green; H. Rahat; B.R. Newcomer; B.C. Bergman; M.S. Brown; G.V. Coe; L. Newnes; Y. Garcia-Reyes; S. Bacon; J.E. Thurston; L. Pyle; A. Scherzinger; K. J. Nadeau. Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome. J. Endocrine Society. 2017. 1(7):931–944.
• Bjornstad P, Schäfer M, Truong U, Cree-Green M, Pyle L, Baumgartner A, Garcia Reyes Y, Maniatis A, Nayak S, Wadwa RP, Browne LP, Reusch JEB, Nadeau KJ. Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus. Circulation. 2018 Dec 18;138(25):2895-2907. PubMed PMID: 30566007
• Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with Type 2 Diabetes Have Hepatic, Peripheral and Adipose Insulin Resistance. Am J Physiol Endocrinol Metab. 2018 Dec 18. [Epub ahead of print] PubMed PMID: 30562061
• Simon SL, Behn CD, Cree-Green M, Kaar JL, Pyle L, Hawkins SMM, Rahat H, Garcia-Reyes Y, Wright KP Jr, Nadeau KJ. Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity. J Pediatr. 2018 Nov 19. [Epub ahead of print] PubMed PMID: 30497764
• Jensen T, Wieland A, Cree-Green M, Nadeau K, Sullivan S. Clinical workup of fatty liver for the primary care provider. Postgrad Med. 2018 Nov 29;:1-12. [Epub ahead of print] PubMed PMID: 30496690
• Cree-Green M, Cai N, Thurston JE, Coe GV, Newnes L, Garcia-Reyes Y, Baumgartner AD, Pyle L, Nadeau KJ. Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome. Pediatr Diabetes. 2018 Dec;19(8):1370-1378. PubMed PMID: 30246333
• Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3647-3657. PubMed PMID: 30020457
• Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ. Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls. J Endocr Soc. 2018 Jun 1;2(6):547-562. PubMed PMID: 29942919
• Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, McClatchey PM, Bauer TA, Regensteiner JG, Reusch JEB. Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes. 2018 Jul;67(7):1369-1379. PubMed PMID: 29643061
• Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2018 May;19(3):436-442. PubMed PMID: 29082640
• Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 1;596(1):67-82. PubMed PMID: 28940557
• RISE Consortium. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp. Diabetes Care. 2018 Aug;41(8):1696-1706. PubMed PMID: 29941497
• RISE Consortium. Impact of Insulin and Metformin Versus Metformin Alone on ß-Cell Function in Youth With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2018 Aug;41(8):1717-1725. PubMed PMID: 29941500
• Cree-Green M. Postglucose Hyperinsulinemia in Black Women Is Not What We Thought. J Clin Endocrinol Metab. 2019 Feb 1;104(2):266-268. PubMed PMID: 30371868
• Simon S, Rahat H, Carreau AM, Garcia-Reyes Y, Halbower A, Pyle L, Nadeau KJ, Cree-Green M. Poor Sleep is Related to Metabolic Syndrome Severity in Adolescents with PCOS and Obesity. J Clin Endocrinol Metab. 2020 Jan 4. [Epub ahead of print] PubMed PMID: 31901092
• RISE Consortium. Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test. Diabetes Care. 2018 Aug;41(8):1707-1716. PubMed PMID: 29941498
• McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2019 Nov 26;:883073819886244. [Epub ahead of print] PubMed PMID: 31769329
• Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018 May;68(5):1063-1075. PubMed PMID: 29408694
• P. Price, KJ Nadeau, M Cree-Green. Chapter 4: Diabetes and Obesity in Adolescence. Diabetes in Women, 4th edition, Reece (Ed.), Wolters Kluwer Publishers, In Press.
• M Cree-Green, A.M. Carreau. “Polycystic Ovarian Syndrome” in Endocrine Secrets. In Press.
• Simens J., Cree-Green M., Bergman B.C., Nadeau K.J., and Diniz Behn C. Structural identifiability analysis of a labeled oral minimal model for quantifying hepatic insulin resistance, In:, Manore C, et al., eds. Advances in the Mathematical Sciences: Research from the 2017 Association for Women in Mathematics Symposium. New York: Springer, In Press.
• Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism. Obesity (Silver Spring). 2019 Dec;27(12):2046-2054. PubMed PMID: 31659873
• Cree-Green M. Understanding cardiovascular disease risk in women with polycystic ovary syndrome. Trends Cardiovasc Med. 2019 Sep 24. [Epub ahead of print] PubMed PMID: 31607636
• Diniz Behn C, Jin ES, Bubar K, Malloy C, Parks EJ, Cree-Green M. Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling. J Investig Med. 2020 Jan;68(1):3-10. PubMed PMID: 31554675
• Carreau AM, Pyle L, Garcia-Reyes Y, Rahat H, Vigers T, Jensen T, Scherzinger A, Nadeau KJ, Cree-Green M. Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index). Clin Endocrinol (Oxf). 2019 Oct;91(4):544-552. PubMed PMID: 31301251
• Simon SL, Diniz Behn C, Laikin A, Kaar JL, Rahat H, Cree-Green M, Wright KP Jr, Nadeau KJ. Sleep & Circadian Health are Associated with Mood & Behavior in Adolescents with Overweight/Obesity. Behav Sleep Med. 2019 Jun 20;:1-10. [Epub ahead of print] PubMed PMID: 31218887
• Scalzo RL, Rafferty D, Schauer I, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG. Sitagliptin improves diastolic cardiac function but not cardiorespiratory fitness in adults with type 2 diabetes. J Diabetes Complications. 2019 Aug;33(8):561-566. PubMed PMID: 31182338
• Ravi SJ, Cree-Green M. Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report. J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619850215. PubMed PMID: 31113263
• Carreau AM, Jin ES, Garcia-Reyes Y, Rahat H, Nadeau KJ, Malloy CR, Cree-Green M. A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R134-R142. PubMed PMID: 31042400
• Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
• Cree-Green M, Bergman BC, Cengiz E, Fox LA, Hannon TS, Miller K, Nathan B, Pyle L, Kahn D, Tansey M, Tichy E, Tsalikian E, Libman I, Nadeau KJ. Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3265-3278. PubMed PMID: 30938764
• Simon SL, McWhirter L, Diniz Behn C, Bubar KM, Kaar JL, Pyle L, Rahat H, Garcia-Reyes Y, Carreau AM, Wright KP, Nadeau KJ, Cree-Green M. Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3525-3534. PubMed PMID: 30888398
• Cree-Green M, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Pyle L, Nadeau KJ. Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E707-E718. PubMed PMID: 30753112
• Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E186-E195. PubMed PMID: 30562061
• Simon SL, Behn CD, Cree-Green M, Kaar JL, Pyle L, Hawkins SMM, Rahat H, Garcia-Reyes Y, Wright KP Jr, Nadeau KJ. Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity. J Pediatr. 2019 Feb;205:257-264.e1. PubMed PMID: 30497764
• Jensen T, Wieland A, Cree-Green M, Nadeau K, Sullivan S. Clinical workup of fatty liver for the primary care provider. Postgrad Med. 2019 Jan;131(1):19-30. PubMed PMID: 30496690
• Cree-Green M. Postglucose Hyperinsulinemia in Black Women Is Not What We Thought. J Clin Endocrinol Metab. 2019 Feb 1;104(2):266-268. PubMed PMID: 30371868
• . Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults. Pediatr Diabetes. 2019 Nov;20(7):849-860. PubMed PMID: 31301210
• . Lack of Durable Improvements in ß-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. Diabetes Care. 2019 Sep;42(9):1742-1751. PubMed PMID: 31178434
• Temple KA, Tjaden AH, Atkinson KM, Barengolts E, Hannon TS, Mather KJ, Utzschneider KM, Edelstein SL, Ehrmann DA, Mokhlesi B. Association of Habitual Daily Physical Activity With Glucose Tolerance and ß-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2019 Aug;42(8):1521-1529. PubMed PMID: 31177181
• . Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on ß-Cell Function: Comparison of Responses In Youth And Adults. Diabetes. 2019 Aug;68(8):1670-1680. PubMed PMID: 31178433
• Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Utzschneider KM, Nadeau KJ, Hannon TS, Sam S, Barengolts E, Manchanda S, Ehrmann DA, Van Cauter E. Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes. Diabetes Care. 2019 Jul;42(7):1326-1332. PubMed PMID: 31048411
• 24. Cree-Green M, Ravi S*, Carreau AM*, Sewell R*, Baumgartner A, Coe GV, Bergman B, Scherzinger A, Jensen T, Pyle L, Nadeau KJ, Non-alcoholic Fatty Liver Disease in Obese Adolescent Females is Associated with Multi-Tissue Insulin Resistance and Visceral Adiposity Markers, Metabolism Open. Vol 2. Article 100011. June 2019.
• Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389543
• Tommerdahl KL, Bjornstad P, Kendrick J, Cree-Green M, Baumgartner AD, Pyle L, Reusch JEB, Nadeau KJ. Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes. Diabetes Obes Metab. 2020 Nov 25. [Epub ahead of print] PubMed PMID: 33236509
• Tommerdahl KL, Brinton JT, Vigers T, Cree-Green M, Zeitler PS, Nadeau KJ, Chan CL. Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index. J Cyst Fibros. 2020 Sep 11;:2111. [Epub ahead of print] PubMed PMID: 32928701
• Buyers E, Sass AE, Severn CD, Pyle L, Cree-Green M. Twelve-month Continuation of the Etonogestrel Implant in Adolescents With Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2020 Sep 9. [Epub ahead of print] PubMed PMID: 32919086
• Utzschneider KM, Tripputi MT, Kozedub A, Mather KJ, Nadeau KJ, Edelstein SL, Hannon TS, Arslanian SA, Cree-Green M, Buchanan TA, Caprio S, Mari A. ß-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults. Pediatr Diabetes. 2020 Dec;21(8):1421-1429. PubMed PMID: 32902875
• Benson J, Severn C, Hudnut-Beumler J, Simon SL, Abramson N, Shomaker LB, Gulley LD, Taylor A, Kelsey MM, Nadeau KJ, Zeitler PS, Pyle L, Cree-Green M. Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes. Can J Diabetes. 2020 Aug;44(6):507-513. PubMed PMID: 32792104
• Cree-Green M, Carreau AM, Davis SM, Frohnert BI, Kaar JL, Ma NS, Nokoff NJ, Reusch JEB, Simon SL, Nadeau KJ. Peer mentoring for professional and personal growth in academic medicine. J Investig Med. 2020 Aug;68(6):1128-1134. PubMed PMID: 32641352
• Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Bartlette K, Behn CD, Pyle L, Nadeau KJ, Cree-Green M. Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents. Pediatr Diabetes. 2020 Jun 26. [Epub ahead of print] PubMed PMID: 32592269
• Davis SM, Soares K, Howell S, Cree-Green M, Buyers E, Johnson J, Tartaglia NR. Diminished Ovarian Reserve in Girls and Adolescents with Trisomy X Syndrome. Reprod Sci. 2020 Nov;27(11):1985-1991. PubMed PMID: 32578162
• Pereira-Eshraghi CF, Chiuzan C, Zhang Y, Tao RH, McCann M, Neugut YD, Printz A, Fennoy I, Cree-Green M, Oberfield SE, Sopher AB. Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women. Horm Res Paediatr. 2019;92(6):365-371. PubMed PMID: 32348991
• Cree-Green M, Cree J, Urban K, Bunik M, Sass AE, Rosenberg A. A Structured Neonatal Parenting Elective: An Approach for Parenting Leave During Residency. Acad Pediatr. 2020 Jul;20(5):595-599. PubMed PMID: 32045680
• Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota. J Clin Endocrinol Metab. 2020 Jun 1;105(6). PubMed PMID: 31970418
• Simon S, Rahat H, Carreau AM, Garcia-Reyes Y, Halbower A, Pyle L, Nadeau KJ, Cree-Green M. Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity. J Clin Endocrinol Metab. 2020 Apr 1;105(4). PubMed PMID: 31901092
• McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2020 Mar;35(3):215-220. PubMed PMID: 31769329
• Cree-Green M. Editoral commentary: Understanding cardiovascular disease risk in women with polycystic ovary syndrome. Trends Cardiovasc Med. 2020 Oct;30(7):405-406. PubMed PMID: 31607636
• Diniz Behn C, Jin ES, Bubar K, Malloy C, Parks EJ, Cree-Green M. Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling. J Investig Med. 2020 Jan;68(1):3-10. PubMed PMID: 31554675
• Simon SL, Diniz Behn C, Laikin A, Kaar JL, Rahat H, Cree-Green M, Wright KP Jr, Nadeau KJ. Sleep & Circadian Health are Associated with Mood & Behavior in Adolescents with Overweight/Obesity. Behav Sleep Med. 2020 Jul-Aug;18(4):550-559. PubMed PMID: 31218887
• Avery J, Ottey S, Morman R, Cree-Green M, Gibson-Helm M. Polycystic Ovary Syndrome support groups and their role in awareness, advocacy and peer-support: a systematic search and narrative review. Current Opinion in Endo and Met Research. Volume 12, June 2020, Pages 98-104
• S HP, Emily O, Amy S, Sarah B, Stephanie H, Melanie CG. Application of a Standard Cross-Specialty Workup for Diagnosis and Metabolic Screening of Obese Adolescents With Polycystic Ovary Syndrome. J Adolesc Health. 2020 Aug 17. [Epub ahead of print] PubMed PMID: 32819830
• Cung S, Pyle L, Nadeau K, Dabelea D, Cree-Green M, Davis SM. In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome. J Investig Med. 2021 Sep 7. [Epub ahead of print] PubMed PMID: 34493629
• Utzschneider KM, Tripputi MT, Kozedub A, Barengolts E, Caprio S, Cree-Green M, Edelstein SL, El Ghormli L, Hannon TS, Mather KJ, Palmer J, Nadeau KJ. Differential loss of ß-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study. Diabetes Res Clin Pract. 2021 Aug;178:108948. PubMed PMID: 34274407
• Moore JM, Waldrop SW, Cree-Green M. Weight Management in Adolescents with Polycystic Ovary Syndrome. Curr Obes Rep. 2021 Sep;10(3):311-321. PubMed PMID: 34043216
• Xiang AH, Martinez MP, Trigo E, Utzschneider KM, Cree-Green M, Arslanian SA, Ehrmann DA, Caprio S, Mohamed PHIH, Hwang DH, Katkhouda N, Nayak KS, Buchanan TA. Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ß-Cell Function. Obesity (Silver Spring). 2021 Jul;29(7):1155-1163. PubMed PMID: 34038037
• Hudnut-Beumler J, Kaar JL, Taylor A, Kelsey MM, Nadeau KJ, Zeitler P, Snell-Bergeon J, Pyle L, Cree-Green M. Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity. Pediatr Diabetes. 2021 Aug;22(5):699-706. PubMed PMID: 33870630
• Torres-Zegarra C, Sundararajan D, Benson J, Seagle H, Witten M, Walders-Abramson N, Simon SL, Huguelet P, Nokoff NJ, Cree-Green M. Care for Adolescents With Polycystic Ovary Syndrome: Development and Prescribing Patterns of a Multidisciplinary Clinic. J Pediatr Adolesc Gynecol. 2021 Oct;34(5):617-625. PubMed PMID: 33794340
• Pyle L, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Nadeau KJ, Cree-Green M. Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity. Metabol Open. 2021 Mar;9:100085. PubMed PMID: 33665598
• Mather KJ, Tjaden AH, Hoehn A, Nadeau KJ, Buchanan TA, Kahn SE, Arslanian SA, Caprio S, Atkinson KM, Cree-Green M, Utzschneider KM, Edelstein SL. Precision and accuracy of hyperglycemic clamps in a multicenter study. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E797-E807. PubMed PMID: 33645253
• Andrisse S, Garcia-Reyes Y, Pyle L, Kelsey MM, Nadeau KJ, Cree-Green M. Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome. J Endocr Soc. 2021 Apr 1;5(4):bvab008. PubMed PMID: 33644620
• Scalzo RL, Schauer IE, Rafferty D, Knaub LA, Kvaratskhelia N, Johnson TK, Pott GB, Abushamat LA, Whipple MO, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG. Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes. J Physiol. 2021 Feb 10. [Epub ahead of print] PubMed PMID: 33569797
• Bartlette K, Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Pyle L, Nadeau KJ, Cree-Green M, Diniz Behn C. Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration. Metabol Open. 2021 Mar;9:100078. PubMed PMID: 33511337
• Jobira B, Frank DN, Silveira LJ, Pyle L, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome. PLoS One. 2021;16(1):e0245219. PubMed PMID: 33465100
• Tommerdahl KL, Baumgartner K, Schäfer M, Bjornstad P, Melena I, Hegemann S, Baumgartner AD, Pyle L, Cree-Green M, Truong U, Browne L, Regensteiner JG, Reusch JEB, Nadeau KJ. Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes. Diabetes Care. 2021 Mar;44(3):795-803. PubMed PMID: 33402367
• Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 Jun;22(2):351-366. PubMed PMID: 33389543
• Huguelet PS, Olson E, Sass A, Bartz S, Hsu S, Cree-Green M. Application of a Standard Cross-Specialty Workup for Diagnosis and Metabolic Screening of Obese Adolescents With Polycystic Ovary Syndrome. J Adolesc Health. 2021 Mar;68(3):589-595. PubMed PMID: 32819830
• Utzschneider KM, Tripputi MT, Kozedub A, Mather KJ, Nadeau KJ, Edelstein SL, Hannon TS, Arslanian SA, Cree-Green M, Buchanan TA, Caprio S, Mari A. ß-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults. Pediatr Diabetes. 2020 Dec;21(8):1421-1429. PubMed PMID: 32902875
• Buyers E, Sass AE, Severn CD, Pyle L, Cree-Green M. Twelve-month Continuation of the Etonogestrel Implant in Adolescents With Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2021 Feb;34(1):33-39. PubMed PMID: 32919086
• Tommerdahl KL, Brinton JT, Vigers T, Cree-Green M, Zeitler PS, Nadeau KJ, Chan CL. Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index. J Cyst Fibros. 2021 Mar;20(2):339-345. PubMed PMID: 32928701
• Bjornstad P, Chao LC, Cree-Green M, Dart AB, King M, Looker HC, Magliano DJ, Nadeau KJ, Pinhas-Hamiel O, Shah AS, van Raalte DH, Pavkov ME, Nelson RG. Youth-onset type 2 diabetes mellitus: an urgent challenge. Nat Rev Nephrol. 2023 Mar;19(3):168-184. PubMed PMID: 36316388
• Tommerdahl KL, Bjornstad P, Kendrick J, Cree-Green M, Baumgartner AD, Pyle L, Reusch JEB, Nadeau KJ. Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes. Diabetes Obes Metab. 2021 Mar;23(3):844-849. PubMed PMID: 33236509
• Tjaden AH, Edelstein SL, Arslanian S, Barengolts E, Caprio S, Cree-Green M, Lteif A, Mather KJ, Savoye M, Xiang AH, Kahn SE. Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study. J Clin Endocrinol Metab. 2023 Sep 18;108(10):e1125-e1133. PubMed PMID: 36938582
• Roy MK, Wilkerson RB, Alexander K, Nokoff NJ, Cree-Green M, D'Alessandro A. Longitudinal metabolic study of red blood cells from patients undergoing gender-affirming testosterone therapy. Blood Adv. 2023 Aug 22;7(16):4269-4277. PubMed PMID: 36001490
• Breslow E, Taylor A, Chan CL, Severn C, Pyle L, Torchen L, Sisk R, Legro R, Turcu AF, Auchus RJ, Dunaif A, Kelsey MM, Cree-Green M. 11-Oxygenated Androgen Metabolite Concentrations Are Affected by Pubertal Progression and Obesity. Horm Res Paediatr. 2023;96(4):412-422. PubMed PMID: 36446347
• Ware MA, Kaar JL, Diniz Behn C, Bartlette K, Carreau AM, Lopez-Paniagua D, Scherzinger A, Xie D, Rahat H, Garcia-Reyes Y, Nadeau KJ, Cree-Green M. Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity. Obesity (Silver Spring). 2022 Jan;30(1):191-200. PubMed PMID: 34932884
• Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, Gerszten R, Schoen J, Cree-Green M, Bergman BC. Quantifying the inflammatory secretome of human intermuscular adipose tissue. Physiol Rep. 2022 Aug;10(16):e15424. PubMed PMID: 35980018
• Simon SL, Phimphasone-Brady P, McKenney KM, Gulley LD, Bonny AE, Moore JM, Torres-Zegarra C, Cree MG. Comprehensive transition of care for polycystic ovary syndrome from adolescence to adulthood. Lancet Child Adolesc Health. 2024 Jun;8(6):443-455. PubMed PMID: 38552655
• Rydin AA, Severn C, Pyle L, Morelli N, Shoemaker AH, Chung ST, Yanovski JA, Han JC, Higgins JA, Nadeau KJ, Fox C, Kelly AS, Cree MG. Prediction of resting energy expenditure for adolescents with severe obesity: A multi-centre analysis. Pediatr Obes. 2024 Jul;19(7):e13123. PubMed PMID: 38658523
• Gottlieb D, Abushamat LA, Nadeau KJ, Regensteiner JG, Reusch JEB, Tommerdahl KL, Rice J, Knaub LA, Monaco CMF, Hawke TJ, Perry CGR, Cree MG, Schauer IE. Muscle mitochondrial function is impaired in adults with type 1 diabetes. J Diabetes Complications. 2024 Aug;38(8):108798. PubMed PMID: 38991492
• Ha J, Chung ST, Springer M, Kim JY, Chen P, Chhabra A, Cree MG, Diniz Behn C, Sumner AE, Arslanian SA, Sherman AS. Estimating insulin sensitivity and ß-cell function from the oral glucose tolerance test: validation of a new insulin sensitivity and secretion (ISS) model. Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E454-E471. PubMed PMID: 38054972
• Fordham TM, Morelli NS, Garcia-Reyes Y, Ware MA, Rahat H, Sundararajan D, Fuller KNZ, Severn C, Pyle L, Malloy CR, Jin ES, Parks EJ, Wolfe RR, Cree MG. Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity. Obesity (Silver Spring). 2024 Apr;32(4):678-690. PubMed PMID: 38439205
• Jin ES, Malloy CR, Sharma G, Finn E, Fuller KNZ, Reyes YG, Lovell MA, Derderian SC, Schoen JA, Inge TH, Cree MG. Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver. Redox Biol. 2023 Jul;63:102749. PubMed PMID: 37224695

Professional Memberships

• Endocrine Society, Member
• Pediatric Endocrine Society (PES), Member
• American Diabetes Association (ADA), Member
• American Physiological Society (APS), Member
• American Heart Association (AHA), Member
• Obesity Society, Member
• AE-PCOS Society, Member

Practice Locations

• Children's Hospital Colorado

• Center for Women's Health Research

Specialty Information

• Pediatrics, Board Certification (2012)
• Pediatric Endocrinology, Board Certification (2015)

• Child and Teen Health - Pediatric Diseases and Conditions
• Child and Teen Health
• Endocrine System (Hormones)