Thomas Jansson, MD, PhD

Aye IL, Lager S, Ramirez VI, Gaccioli F, Dudley DJ, Jansson T, Powell TL. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014 Jun;90(6):129. PubMed PMID: 24759787

Lager S, Samulesson AM, Taylor PD, Poston L, Powell TL, Jansson T. Diet-induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling. Physiol Rep. 2014 Feb 1;2(2):e00242. PubMed PMID: 24744907

Aye IL, Gao X, Weintraub ST, Jansson T, Powell TL. Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis. Mol Endocrinol. 2014 Apr;28(4):512-24. PubMed PMID: 24606127

Abu Shehab M, Damerill I, Shen T, Rosario FJ, Nijland M, Nathanielsz PW, Kamat A, Jansson T, Gupta MB. Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction. Endocrinology. 2014 Apr;155(4):1327-39. PubMed PMID: 24437487

Kavitha JV, Rosario FJ, Nijland MJ, McDonald TJ, Wu G, Kanai Y, Powell TL, Nathanielsz PW, Jansson T. Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J. 2014 Mar;28(3):1294-305. PubMed PMID: 24334703

Malkani N, Biggar K, Shehab MA, Li S, Jansson T, Gupta MB. Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC. Mol Cell Endocrinol. 2015 Dec 27. [Epub ahead of print] PubMed PMID: 26733150

Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of Amino Acid Transporter Trafficking by mTORC1 in Primary Human Trophoblast cells is Mediated by the Ubiquitin Ligase Nedd4-2. Clin Sci (Lond). 2015 Nov 25. [Epub ahead of print] PubMed PMID: 26608079

Hu M, Richard JE, Maliqueo M, Kokosar M, Fornes R, Benrick A, Jansson T, Ohlsson C, Wu X, Skibicka KP, Stener-Victorin E. Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14348-53. PubMed PMID: 26578781

Aye IL, Jansson T, Powell TL. TNF-a stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling. Physiol Rep. 2015 Oct;3(10). PubMed PMID: 26508738

Díaz P, Harris J, Rosario FJ, Powell TL, Jansson T. Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1569-77. PubMed PMID: 26491104

Aye IL, Rosario FJ, Powell TL, Jansson T. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12858-63. PubMed PMID: 26417088

Chen YY, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond). 2015 Dec;129(12):1131-41. PubMed PMID: 26374858

Pantham P, Rosario FJ, Nijland M, Cheung A, Nathanielsz PW, Powell TL, Galan HL, Li C, Jansson T. Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon. Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R740-6. PubMed PMID: 26246504

Rosario FJ, Kanai Y, Powell TL, Jansson T. Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity (Silver Spring). 2015 Aug;23(8):1663-70. PubMed PMID: 26193061

Gaccioli F, Aye IL, Roos S, Lager S, Ramirez VI, Kanai Y, Powell TL, Jansson T. Expression and functional characterisation of System L amino acid transporters in the human term placenta. Reprod Biol Endocrinol. 2015 Jun 9;13:57. PubMed PMID: 26050671

Malkani N, Jansson T, Gupta MB. IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway. Mol Cell Endocrinol. 2015 Sep 5;412:182-95. PubMed PMID: 25957086

Barbaux S, Erwich JJ, Favaron PO, Gil S, Gallot D, Golos TG, Gonzalez-Bulnes A, Guibourdenche J, Heazell AE, Jansson T, Laprévote O, Lewis RM, Miller RK, Monk D, Novakovic B, Oudejans C, Parast M, Peugnet P, Pfarrer C, Pinar H, Roberts CT, Robinson W, Saffery R, Salomon C, Sexton A, Staff AC, Suter M, Tarrade A, Wallace J, Vaillancourt C, Vaiman D, Worton SA, Lash GE. IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction. Placenta. 2015 Apr;36 Suppl 1:S5-10. PubMed PMID: 25703592

Maliqueo M, Sundström Poromaa I, Vanky E, Fornes R, Benrick A, Åkerud H, Stridsklev S, Labrie F, Jansson T, Stener-Victorin E. Placental STAT3 signaling is activated in women with polycystic ovary syndrome. Hum Reprod. 2015 Mar;30(3):692-700. PubMed PMID: 25609240

Acosta O, Ramirez VI, Lager S, Gaccioli F, Dudley DJ, Powell TL, Jansson T. Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers. Am J Obstet Gynecol. 2015 Feb;212(2):227.e1-7. PubMed PMID: 25132463

Chen YY, Powell TL, Jansson T. 1,25-Dihydroxy vitamin D(3) stimulates system A amino acid transport in primary human trophoblast cells. Mol Cell Endocrinol. 2016 Dec 9;442:90-97. [Epub ahead of print] PubMed PMID: 27956114

Capobianco E, Fornes D, Roberti SL, Powell TL, Jansson T, Jawerbaum A. Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPAR? and mTOR signaling in female offspring developing gestational diabetes. J Nutr Biochem. 2017 Nov 27;53:39-47. [Epub ahead of print] PubMed PMID: 29190548

Dimasuay KG, Gong L, Rosario F, McBryde E, Spelman T, Glazier J, Rogerson SJ, Beeson JG, Jansson T, Devenish RJ, Boeuf P. Impaired placental autophagy in placental malaria. PLoS One. 2017;12(11):e0187291. PubMed PMID: 29125872

Holm MB, Bastani NE, Holme AM, Zucknick M, Jansson T, Refsum H, Mørkrid L, Blomhoff R, Henriksen T, Michelsen TM. Uptake and release of amino acids in the fetal-placental unit in human pregnancies. PLoS One. 2017;12(10):e0185760. PubMed PMID: 28982184

Díaz P, Dimasuay KG, Koele-Schmidt L, Jang B, Barbour LA, Jansson T, Powell TL. Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. Placenta. 2017 Sep;57:52-59. PubMed PMID: 28864019

Pantham P, Rosario FJ, Weintraub ST, Nathanielsz PW, Powell TL, Li C, Jansson T. Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons. Biol Reprod. 2016 Nov;95(5):98. PubMed PMID: 27605346

Jansson T. Placenta plays a critical role in maternal-fetal resource allocation. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11066-11068. PubMed PMID: 27660237

Rosario FJ, Powell TL, Jansson T. Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-a and the RFC. Sci Rep. 2016 Aug 26;6:31705. PubMed PMID: 27562465

Fornes R, Hu M, Maliqueo M, Kokosar M, Benrick A, Carr D, Billig H, Jansson T, Manni L, Stener-Victorin E. Maternal testosterone and placental function: Effect of electroacupuncture on placental expression of angiogenic markers and fetal growth. Mol Cell Endocrinol. 2016 Sep 15;433:1-11. PubMed PMID: 27208621

Lager S, Ramirez VI, Gaccioli F, Jang B, Jansson T, Powell TL. Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women. Placenta. 2016 Apr;40:60-6. PubMed PMID: 27016784

Dimasuay KG, Boeuf P, Powell TL, Jansson T. Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. Front Physiol. 2016 Jan 29;7:12. PubMed PMID: 26858656

Fornes R, Maliqueo M, Hu M, Hadi L, Jimenez-Andrade JM, Ebefors K, Nyström J, Labrie F, Jansson T, Benrick A, Stener-Victorin E. The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams. Sci Rep. 2017 Aug 14;7(1):8066. PubMed PMID: 28808352

Aye IL, Rosario FJ, Powell TL, Jansson T. Reply to Carbillon: Fetal/placental weight ratio and placental function. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E261. PubMed PMID: 26755612

Ferchaud-Roucher V, Rudolph MC, Jansson T, Powell TL. Fatty acid and lipid profiles in primary human trophoblast over 90h in culture. Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:14-20. PubMed PMID: 28651693

Rosario FJ, Nathanielsz PW, Powell TL, Jansson T. Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice. Sci Rep. 2017 Jun 21;7(1):3982. PubMed PMID: 28638048

Capobianco E, Fornes D, Linenberg I, Powell TL, Jansson T, Jawerbaum A. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol. 2016 Feb 15;422:221-32. PubMed PMID: 26747729

Silva E, Rosario FJ, Powell TL, Jansson T. Mechanistic Target of Rapamycin Is a Novel Molecular Mechanism Linking Folate Availability and Cell Function. J Nutr. 2017 Jul;147(7):1237-1242. PubMed PMID: 28592519

Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T. Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. Clin Sci (Lond). 2016 Apr 1;130(7):499-512. PubMed PMID: 26608079

Shehab MA, Biggar K, Singal SS, Nygard K, Shun-Cheng Li S, Jansson T, Gupta MB. Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity. Mol Cell Endocrinol. 2017 Sep 5;452:1-14. PubMed PMID: 28435049

Rosario FJ, Powell TL, Jansson T. mTOR folate sensing links folate availability to trophoblast cell function. J Physiol. 2017 Jul 1;595(13):4189-4206. PubMed PMID: 28374905

Jones H, Jansson T. Preface. Placenta. 2017 Nov;59 Suppl 1:S1. PubMed PMID: 28214019

Rosario FJ, Powell TL, Jansson T. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R87-93. PubMed PMID: 26491103

Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017;145:217-251. PubMed PMID: 28110752

Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P. Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight. BMC Med. 2017 Jan 3;15(1):1. PubMed PMID: 28049467

Chen YY, Powell TL, Jansson T. 1,25-Dihydroxy vitamin D(3) stimulates system A amino acid transport in primary human trophoblast cells. Mol Cell Endocrinol. 2017 Feb 15;442:90-97. PubMed PMID: 27956114

Damerill I, Biggar KK, Abu Shehab M, Li SS, Jansson T, Gupta MB. Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition. Mol Endocrinol. 2016 Feb;30(2):201-16. PubMed PMID: 26714229

Ferchaud-Roucher V, Kramer A, Silva E, Pantham P, Weintraub ST, Jansson T, Powell TL. A potential role for lysophosphatidylcholine in the delivery of long chain polyunsaturated fatty acids to the fetal circulation. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Dec 17. [Epub ahead of print] PubMed PMID: 30572119

Jayabalan N, Lai A, Ormazabal V, Adam S, Guanzon D, Palma C, Scholz-Romero K, Lim R, Jansson T, McIntyre HD, Lappas M, Salomon C. Adipose tissue exosomal proteomic profile reveals a role on placenta glucose metabolism in gestational diabetes mellitus. J Clin Endocrinol Metab. 2018 Dec 3. [Epub ahead of print] PubMed PMID: 30517676

Gupta MB, Jansson T. Novel Roles of mTOR Signaling in Regulating Fetal Growth. Biol Reprod. 2018 Nov 21. [Epub ahead of print] PubMed PMID: 30476008

Paulsen ME, Rosario FJ, Wesolowski SR, Powell TL, Jansson T. Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. FASEB J. 2018 Oct 22;:fj201801015R. [Epub ahead of print] PubMed PMID: 30346829

Michelsen TM, Holme AM, Holm MB, Roland MC, Haugen G, Powell TL, Jansson T, Henriksen T. Uteroplacental glucose uptake and fetal glucose consumption: A quantitative study in human pregnancies. J Clin Endocrinol Metab. 2018 Oct 18. [Epub ahead of print] PubMed PMID: 30339207

Michelsen TM, Henriksen T, Reinhold D, Powell TL, Jansson T. The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling. FASEB J. 2018 Oct 18;:fj201801193R. [Epub ahead of print] PubMed PMID: 30335547

Nair S, Jayabalan N, Guanzon D, Palma C, Scholz-Romero K, Elfeky O, Zuñiga F, Ormazabal V, Diaz E, Rice GE, Duncombe G, Jansson T, McIntyre HD, Lappas M, Salomon C. Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity. Clin Sci (Lond). 2018 Nov 30;132(22):2451-2467. PubMed PMID: 30254065

Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T. IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1. J Clin Endocrinol Metab. 2018 Aug 16. [Epub ahead of print] PubMed PMID: 30124960

Chen YY, Gupta MB, Grattton R, Powell TL, Jansson T. Down-regulation of placental folate transporters in intrauterine growth restriction. J Nutr Biochem. 2018 Sep;59:136-141. PubMed PMID: 29986308

Grindler NM, Allshouse AA, Jungheim E, Powell TL, Jansson T, Polotsky AJ. OBGYN screening for environmental exposures: A call for action. PLoS One. 2018;13(5):e0195375. PubMed PMID: 29768418

Singal SS, Nygard K, Gratton R, Jansson T, Gupta MB. Increased Insulin-like Growth Factor Binding Protein-1 Phosphorylation in Decidualized Stromal Mesenchymal Cells in Human Intrauterine Growth Restriction Placentas. J Histochem Cytochem. 2018 Sep;66(9):617-630. PubMed PMID: 29718759

Grindler NM, Vanderlinden L, Karthikraj R, Kannan K, Teal S, Polotsky AJ, Powell TL, Yang IV, Jansson T. Exposure to Phthalate, an Endocrine Disrupting Chemical, Alters the First Trimester Placental Methylome and Transcriptome in Women. Sci Rep. 2018 Apr 17;8(1):6086. PubMed PMID: 29666409

Roberti SL, Higa R, White V, Powell TL, Jansson T, Jawerbaum A. Critical role of mTOR, PPAR? and PPARd signaling in regulating early pregnancy decidual function, embryo viability and feto-placental growth. Mol Hum Reprod. 2018 Jun 1;24(6):327-340. PubMed PMID: 29538677

Chassen SS, Ferchaud-Roucher V, Gupta MB, Jansson T, Powell TL. Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction. Clin Sci (Lond). 2018 Mar 15;132(5):595-607. PubMed PMID: 29463583

Capobianco E, Gomez Ribot D, Fornes D, Powell TL, Levieux C, Jansson T, Jawerbaum A. Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming. Mol Nutr Food Res. 2018 Oct;62(19):e1800263. PubMed PMID: 29939470

Singal SS, Nygard K, Dhruv MR, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB. Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2ß, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay. Am J Pathol. 2018 Jan;188(1):111-124. PubMed PMID: 29037858

James-Allan LB, Powell TL and Jansson T 2018 Placental Nutrient Transport. In M. K. Skinner (Ed.), Encyclopedia of Reproduction. vol. 2, pp. 537–543. Academic Press: Elsevier. http://dx.doi.org/10.1016/B978-0-12-801238-3.64683-4 ISBN: 9780128118993

Jansson T 2018 Placental Transfer In M. K. Skinner (Ed.), Encyclopedia of Reproduction. vol. 2, pp. 530–536. Academic Press: Elsevier. http://dx.doi.org/10.1016/B978-0-12-801238-3.64682-2 ISBN: 9780128118993

Rosario FJ, Gupta MB, Myatt L, Powell, TL, Glenn JP, Cox L. Jansson T. 2018. Control of the Trophoblast Transcriptome by Mechanistic Target of Rapamycin (mTOR): mTOR Complex 1 is a positive regulator of mitochondrial respiration. Sci Rep, in press

Chassen S, Jansson T 2018 Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in intrauterine growth restriction. BBA - Molecular Basis of Disease

Jessel RH, Rosario FJ, Chen YY, Erickson K, Teal SB, Kramer A, Cotton E, Ryan S, Jansson T, Powell TL. Decreased placental folate transporter expression and activity in first and second trimester in obese mothers. J Nutr Biochem. 2019 Nov 25;77:108305. [Epub ahead of print] PubMed PMID: 31926453

Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 Jan 1;128(1):127-133. PubMed PMID: 31804891

Vyas V, Guerra DD, Bok R, Powell T, Jansson T, Hurt KJ. Adiponectin links maternal metabolism to uterine contractility. FASEB J. 2019 Dec;33(12):14588-14601. PubMed PMID: 31665924

Castillo-Castrejon M, Jansson T, Powell TL. No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in maternal obesity and gestational diabetes mellitus. Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1037-E1049. PubMed PMID: 31573844

Vaughan OR, Powell TL, Jansson T. Glucocorticoid regulation of amino acid transport in primary human trophoblast cells. J Mol Endocrinol. 2019 Nov;63(4):239-248. PubMed PMID: 31505460

Ramzan AA, Bitler BG, Hicks D, Barner K, Qamar L, Behbakht K, Powell T, Jansson T, Wilson H. Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells. Mol Cell Biochem. 2019 Nov;461(1-2):37-46. PubMed PMID: 31292831

James-Allan LB, Arbet J, Teal SB, Powell TL, Jansson T. Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta. J Clin Endocrinol Metab. 2019 May 21. [Epub ahead of print] PubMed PMID: 31112275

Vaughan OR, Rosario FJ, Powell TL, Jansson T. Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring. Int J Obes (Lond). 2019 May 10. [Epub ahead of print] PubMed PMID: 31076636

Vaughan OR, Powell TL, Jansson T. Apelin is a novel regulator of human trophoblast amino acid transport. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E810-E816. PubMed PMID: 30835509

Ferchaud-Roucher V, Barner K, Jansson T, Powell TL. Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties. FASEB J. 2019 May;33(5):6643-6654. PubMed PMID: 30811959

Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T. IUGR Is Associated With Marked Hyperphosphorylation of Decidual and Maternal Plasma IGFBP-1. J Clin Endocrinol Metab. 2019 Feb 1;104(2):408-422. PubMed PMID: 30124960

Rosario FJ, Powell TL, Gupta MB, Cox L, Jansson T. mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells. Front Cell Dev Biol. 2020;8:583801. PubMed PMID: 33324640

Powell TL, Barner K, Madi L, Armstrong M, Manke J, Uhlson C, Jansson T, Ferchaud-Roucher V. Sex-specific responses in placental fatty acid oxidation, esterification and transfer capacity to maternal obesity. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec 13;1866(3):158861. [Epub ahead of print] PubMed PMID: 33321178

Kelly AC, Kramer A, Rosario FJ, Powell TL, Jansson T. Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta. Clin Sci (Lond). 2020 Dec 11;134(23):3123-3136. PubMed PMID: 33215629

Kakadia JH, Jain BB, Biggar K, Sutherland A, Nygard K, Li C, Nathanielsz PW, Jansson T, Gupta MB. Hyperphosphorylation of fetal liver IGFBP-1 precedes slowing of fetal growth in nutrient-restricted baboons and may be a mechanism underlying IUGR. Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E614-E628. PubMed PMID: 32744097

Francis EC, Dabelea D, Boyle KE, Jansson T, Perng W. Maternal diet quality is associated with placental proteins in the placental insulin/ growth factor, environmental stress, inflammation, and mTOR signaling pathways: The Healthy Start ECHO Cohort. J Nutr. 2021 Nov 26. [Epub ahead of print] PubMed PMID: 34850052

Roeca C, Silva E, Barentsen C, Powell TL, Jansson T. Effects of vitrification and the superovulated environment on placental function and fetal growth in an IVF mouse model. Mol Hum Reprod. 2020 Aug 1;26(8):624-635. PubMed PMID: 32618997

Abu Shehab M, Biggar K, Kakadia JH, Dhruv M, Jain B, Nandi P, Nygard K, Jansson T, Gupta MB. Inhibition of decidual IGF-1 signaling in response to hypoxia and leucine deprivation is mediated by mTOR and AAR pathways and increased IGFBP-1 phosphorylation. Mol Cell Endocrinol. 2020 Jul 15;512:110865. PubMed PMID: 32502935

Chassen SS, Ferchaud-Roucher V, Palmer C, Li C, Jansson T, Nathanielsz PW, Powell TL. Placental fatty acid transport across late gestation in a baboon model of intrauterine growth restriction. J Physiol. 2020 Jun;598(12):2469-2489. PubMed PMID: 32338384

Rosario FJ, Kelly AC, Gupta MB, Powell TL, Cox L, Jansson T. Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome. Front Cell Dev Biol. 2021;9:670980. PubMed PMID: 34805133

Rosario FJ, Pardo S, Michelsen TM, Erickson K, Moore L, Powell TL, Weintraub ST, Jansson T. Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture. Front Cell Dev Biol. 2021;9:704781. PubMed PMID: 34595166

Nandi P, Jang CE, Biggar K, Halari CD, Jansson T, Gupta MB. Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells. Biomolecules. 2021 Sep 18;11(9). PubMed PMID: 34572595

Aye ILMH, Rosario FJ, Kramer A, Kristiansen O, Michelsen TM, Powell TL, Jansson T. Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity. J Clin Endocrinol Metab. 2022 Jan 1;107(1):53-66. PubMed PMID: 34519830

Rosario FJ, Kramer A, Li C, Galan HL, Powell TL, Nathanielsz PW, Jansson T. Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-Human Primate. Nutrients. 2021 Aug 23;13(8). PubMed PMID: 34445051

Kakadia J, Biggar K, Jain B, Chen AW, Nygard K, Li C, Nathanielsz PW, Jansson T, Gupta MB. Mechanisms linking hypoxia to phosphorylation of insulin-like growth factor binding protein-1 in baboon fetuses with intrauterine growth restriction and in cell culture. FASEB J. 2021 Sep;35(9):e21788. PubMed PMID: 34425031

Vaughan OR, Maksym K, Silva E, Barentsen K, Anthony RV, Brown TL, Hillman SL, Spencer R, David AL, Rosario FJ, Powell TL, Jansson T. Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice. Clin Sci (Lond). 2021 Sep 17;135(17):2049-2066. PubMed PMID: 34406367

Chen AW, Biggar K, Nygard K, Singal S, Zhao T, Li C, Nathanielsz PW, Jansson T, Gupta MB. IGFBP-1 hyperphosphorylation in response to nutrient deprivation is mediated by activation of protein kinase Ca (PKCa). Mol Cell Endocrinol. 2021 Oct 1;536:111400. PubMed PMID: 34314739

Castillo-Castrejon M, Yamaguchi K, Rodel RL, Erickson K, Kramer A, Hirsch NM, Rolloff K, Jansson T, Barbour LA, Powell TL. Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity. Mol Cell Endocrinol. 2021 Jul 15;532:111319. PubMed PMID: 33989714

Keleher MR, Erickson K, Kechris K, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort. Int J Obes (Lond). 2020 Nov;44(11):2203-2212. PubMed PMID: 32327723

Kelly AC, Powell TL, Jansson T. Placental function in maternal obesity. Clin Sci (Lond). 2020 Apr 30;134(8):961-984. PubMed PMID: 32313958

James-Allan LB, Rosario FJ, Barner K, Lai A, Guanzon D, McIntyre HD, Lappas M, Powell TL, Salomon C, Jansson T. Regulation of glucose homeostasis by small extracellular vesicles in normal pregnancy and in gestational diabetes. FASEB J. 2020 Apr;34(4):5724-5739. PubMed PMID: 32154621

Dumolt JH, Powell TL, Jansson T. Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction. Obstet Gynecol Clin North Am. 2021 Jun;48(2):247-266. PubMed PMID: 33972064

James-Allan LB, Teal S, Powell TL, Jansson T. Changes in Placental Nutrient Transporter Protein Expression and Activity Across Gestation in Normal and Obese Women. Reprod Sci. 2020 Sep;27(9):1758-1769. PubMed PMID: 32072607

Kristiansen O, Zucknick M, Reine TM, Kolset SO, Jansson T, Powell TL, Haugen G, Henriksen T, Michelsen TM. Mediators Linking Maternal Weight to Birthweight and Neonatal Fat Mass in Healthy Pregnancies. J Clin Endocrinol Metab. 2021 Jun 16;106(7):1977-1993. PubMed PMID: 33713406

Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na( ) K( ) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825

Higa R, Rosario FJ, Powell TL, Jansson T, Jawerbaum A. Inhibition of MTOR signaling impairs rat embryo organogenesis by affecting folate availability. Reproduction. 2021 Apr;161(4):365-373. PubMed PMID: 33528379

Keleher MR, Erickson K, Smith HA, Kechris KJ, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Placental Insulin/IGF-1 Signaling, PGC-1a, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4-6 Years of Age: The ECHO Healthy Start Cohort. Diabetes. 2021 Mar;70(3):745-751. PubMed PMID: 33414248

Powell TL, Barner K, Madi L, Armstrong M, Manke J, Uhlson C, Jansson T, Ferchaud-Roucher V. Sex-specific responses in placental fatty acid oxidation, esterification and transfer capacity to maternal obesity. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Mar;1866(3):158861. PubMed PMID: 33321178

Jansson T, Castillo-Castrejon M, Gupta MB, Powell TL, Rosario FJ. Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction. Clin Sci (Lond). 2020 Jan 17;134(1):53-70. PubMed PMID: 31825077

Chassen S, Jansson T. Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR. Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165373. PubMed PMID: 30684642

James-Allan LB, Rosario FJ, Madi L, Barner K, Nair S, Lai A, Carrion F, Powell TL, Salomon C, Jansson T. A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice. Clin Sci (Lond). 2022 Nov 11;136(21):1535-1549. PubMed PMID: 36239315

Kelly AC, J Rosario F, Chan J, Cox LA, Powell TL, Jansson T. Transcriptomic responses are sex-dependent in the skeletal muscle and liver in offspring of obese mice. Am J Physiol Endocrinol Metab. 2022 Oct 1;323(4):E336-E353. PubMed PMID: 35858246

Gupta MB, Biggar KK, Li C, Nathanielsz PW, Jansson T. Increased Colocalization and Interaction Between Decidual Protein Kinase A and Insulin-like Growth Factor-Binding Protein-1 in Intrauterine Growth Restriction. J Histochem Cytochem. 2022 Jul;70(7):515-530. PubMed PMID: 35801847

Degnes ML, Westerberg AC, Zucknick M, Powell TL, Jansson T, Henriksen T, Roland MCP, Michelsen TM. Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function?. BMC Med. 2022 Jul 1;20(1):227. PubMed PMID: 35773701

Dumolt J, Powell TL, Jansson T, Rosario FJ. Normalization of maternal adiponectin in obese pregnant mice prevents programming of impaired glucose metabolism in adult offspring. FASEB J. 2022 Jul;36(7):e22383. PubMed PMID: 35670755

Vaughan OR, Rosario FJ, Chan J, Cox LA, Ferchaud-Roucher V, Zemski-Berry KA, Reusch JEB, Keller AC, Powell TL, Jansson T. Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice. J Physiol. 2022 Jul;600(13):3169-3191. PubMed PMID: 35545608

Schreiner C, Powell TL, Palmer C, Jansson T. Placental proteins with predicted roles in fetal development decrease in premature infants. Pediatr Res. 2022 Nov;92(5):1316-1324. PubMed PMID: 35132128

Francis EC, Dabelea D, Boyle KE, Jansson T, Perng W. Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort. J Nutr. 2022 Mar 3;152(3):816-825. PubMed PMID: 34850052

Aye ILMH, Rosario FJ, Kramer A, Kristiansen O, Michelsen TM, Powell TL, Jansson T. Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity. J Clin Endocrinol Metab. 2022 Jan 1;107(1):53-66. PubMed PMID: 34519830

Powell TL, Barentsen K, Vaughan O, Uhlson C, Zemski Berry K, Erickson K, Faer K, Chassen SS, Jansson T. Knockdown of Placental Major Facilitator Superfamily Domain Containing 2a in Pregnant Mice Reduces Fetal Brain Growth and Phospholipid Docosahexaenoic Acid Content. Nutrients. 2023 Nov 29;15(23). PubMed PMID: 38068814

Waldrop SW, Niemiec S, Wood C, Gyllenhammer LE, Jansson T, Friedman JE, Tryggestad JB, Borengasser SJ, Davidson EJ, Yang IV, Kechris K, Dabelea D, Boyle KE. Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity. Obesity (Silver Spring). 2024 Jan;32(1):187-199. PubMed PMID: 37869908

Rosario FJ, Urschitz J, Powell TL, Brown TL, Jansson T. Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling. Clin Sci (Lond). 2023 Nov 15;137(21):1651-1664. PubMed PMID: 37861075

Kramer AC, Jansson T, Bale TL, Powell TL. Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism. Development. 2023 Oct 15;150(20). PubMed PMID: 37831056

Powell TL, Uhlson C, Madi L, Berry KZ, Chassen SS, Jansson T, Ferchaud-Roucher V. Fetal sex differences in placental LCPUFA ether and plasmalogen phosphatidylethanolamine and phosphatidylcholine contents in pregnancies complicated by obesity. Biol Sex Differ. 2023 Sep 28;14(1):66. PubMed PMID: 37770949

Kelly A, Chan J, Powell TL, Cox LA, Jansson T, Rosario FJ. Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner. Front Cell Dev Biol. 2023;11:1178533. PubMed PMID: 37397247

Rosario FJ, Chopra A, Biggar K, Powell TL, Gupta MB, Jansson T. Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability. Int J Mol Sci. 2023 Apr 14;24(8). PubMed PMID: 37108437

Dumolt JH, Rosario FJ, Kramer AC, Horwitz S, Powell TL, Jansson T. Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity. Clin Sci (Lond). 2023 Apr 26;137(8):663-678. PubMed PMID: 37014924

Francis EC, Kechris K, Jansson T, Dabelea D, Perng W. Novel Metabolic Subtypes in Pregnant Women and Risk of Early Childhood Obesity in Offspring. JAMA Netw Open. 2023 Apr 3;6(4):e237030. PubMed PMID: 37014638

Professor, OB-GYN-Basic Repro Science

Department

Publications

School of Medicine

CU Anschutz

Fitzsimons Building