John Thompson, PhD

Professional Titles

• Associate Professor

Recognitions

• Boettcher Investigator Award, Webb-Waring Biomedical Research (2017)

Publications

• Thompson JA, Felsen G. Activity in mouse pedunculopontine tegmental nucleus reflects action and outcome in a decision-making task. J Neurophysiol. 2013 Dec;110(12):2817-29. PubMed PMID: 24089397
• Stratford JM, Thompson JA. Beta-galactosidase staining in the nucleus of the solitary tract of Fos-Tau-LacZ mice is unaffected by monosodium glutamate taste stimulation. PLoS One. 2014;9(9):e107238. PubMed PMID: 25192442
• Thompson JA, Lanctin D, Ince NF, Abosch A. Clinical implications of local field potentials for understanding and treating movement disorders. Stereotact Funct Neurosurg. 2014;92(4):251-63. PubMed PMID: 25170784
• Albrecht O, Dondzillo A, Mayer F, Thompson JA, Klug A. Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse. Front Neural Circuits. 2014;8:83. PubMed PMID: 25120436
• Stubblefield EA, Thompson JA, Felsen G. (2015) Optogenetic cholinergic modulation of the mouse superior colliculus in vivo. Journal of Neurophysiology 114:978-88
• Wolf AB, Lintz MJ, Costabile JD, Thompson JA, Stubblefield EA, Felsen G. (2015) An integrative role for the superior colliculus in selecting targets for movements. Journal of Neurophysiology 114(4):2118-31.
• Winter M, Thompson JA. Electrophysiological topography of the subthalamic nucleus in Parkinson's disease. American Association of Clinical Anatomists. 2015
• Tekriwal A, Kern DS, Tsai J, Ince NF, Wu J, Thompson JA, Abosch A. REM sleep behaviour disorder: prodromal and mechanistic insights for Parkinson's disease. J Neurol Neurosurg Psychiatry. 2016 Dec 13. [Epub ahead of print] PubMed PMID: 27965397
• Dondzillo A, Thompson JA, Klug A. Recurrent Inhibition to the Medial Nucleus of the Trapezoid Body in the Mongolian Gerbil (Meriones Unguiculatus). PLoS One. 2016 Aug 4;11(8):e0160241. PubMed PMID: 27489949
• Thompson JA, Costabile JD, Felsen G. Mesencephalic representations of recent experience influence decision making. Elife. 2016 Jul 25;5. PubMed PMID: 27454033
• Stratford JM, Thompson JA, Finger TE. Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice. J Comp Neurol. 2017 Feb 1;525(2):271-290. PubMed PMID: 27292295
• Stratford JM, Thompson JA. MSG-Evoked c-Fos Activity in the Nucleus of the Solitary Tract Is Dependent upon Fluid Delivery and Stimulation Parameters. Chem Senses. 2016 Mar;41(3):211-20. PubMed PMID: 26762887
• Liedtke EI, Zhang S, Thompson JA, Sillau S, Gault J. (2017) Correlated expression analysis of genes implicated in schizophrenia: identification of putative disease related pathways. New Horizons in Translational Medicine, 3 (5) 224-232
• Stratford JM, Thompson JA, Finger TE (2017) Immunocytochemical organization and sour taste activation in the rostral nuc. Solitary tract of mice. Journal of Comparative Neurology 525: 271-290
• Yin D, Thompson JA, Ojemann S, Pelak V, Drees C, Nagae L, Abosch A (2017) Optic radiation tractography and visual field deficits in laser interstitial thermal therapy for amygdalo-hippocampectomy in patients with mesial temporal lobe epilepsy. Stereotactic and Functional Neurosurgery 95:107-113
• Kolb R, Felsen G, Abosch A, Thompson JA (2017) Use of intraoperative local field potential spectral analysis to differentiate basal ganglia structures in Parkinson's disease patients. Physiological Reports, 5 (12), e13322
• Thompson JA, Yin D, Ojemann S, Abosch A (2017) Use of the putamen as a surrogate anatomical marker for the internal segment of globus pallidus in deep brain stimulation surgery. Stereotactic and Functional Neurosurgery, 95 (2), 229-235
• Tekriwal A, Kern D, Tsai J, Ince NF, Wu J, Thompson JA, Abosch A (2017) REM sleep behavior disorder: prodromal and mechanistic insights for Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry 88:445-451
• Ormond DR, D’Souza S, Thompson JA (2017) Global and targeted pathway impact of gliomas on white matter integrity based on lobar localization, Cureus 9 (9)
• Correlated expression analysis of genes implicated in schizophrenia: identification of putative disease-related pathways Erin I. Liedtke · Sirey Zhang · John A. Thompson · [...] · Judith Gault Article · Dec 2016 New Horizons in Translational Medicine
• 4. Yin D, Thompson JA, Ojemann S, Pelak V, Drees C, Nagae L, Abosch A (2016) Optic radiation tractography and visual field deficits in laser interstitial thermal therapy for amygdalo-hippocampectomy in patients with mesial temporal lobe epilepsy. Stereotactic and Functional Neurosurgery
• Kern DS, Picillo M, Thompson JA, Sammartino F, di Biase L, Munhoz RP, Fasano A. Interleaving Stimulation in Parkinson's Disease, Tremor, and Dystonia. Stereotact Funct Neurosurg. 2019 Jan 17;:1-13. [Epub ahead of print] PubMed PMID: 30654368
• Christensen E, Abosch A, Thompson JA, Zylberberg J. Inferring sleep stage from local field potentials recorded in the subthalamic nucleus of Parkinson's patients. J Sleep Res. 2018 Dec 13;:e12806. [Epub ahead of print] PubMed PMID: 30549130
• Winter M, Costabile JD, Abosch A, Thompson JA. Method for localizing intraoperative recordings from deep brain stimulation surgery using post-operative structural MRI. Neuroimage Clin. 2018;20:1123-1128. PubMed PMID: 30380519
• Weinkle LJ, Hoyt B, Thompson JA, Sillau S, Tanabe J, Honce J, Klepitskaya O. Association of MRI Measurements with Cognitive Outcomes After STN-DBS in Parkinson's Disease. Mov Disord Clin Pract. 2018 Jul-Aug;5(4):417-426. PubMed PMID: 30363383
• Thompson JA, Oukal S, Bergman H, Ojemann S, Hebb AO, Hanrahan S, Israel Z, Abosch A. Semi-automated application for estimating subthalamic nucleus boundaries and optimal target selection for deep brain stimulation implantation surgery. J Neurosurg. 2018 May 1;:1-10. [Epub ahead of print] PubMed PMID: 29775152
• Tekriwal A, Felsen G, Thompson JA. Modular auditory decision-making behavioral task designed for intraoperative use in humans. J Neurosci Methods. 2018 Jul 1;304:162-167. PubMed PMID: 29746889
• Kern DS, Picillo M, Thompson JA, et al. Interleaving Stimulation in Parkinson's Disease, Tremor, and Dystonia. Stereotact Funct Neurosurg. 2018;96(6):379–391. doi:10.1159/000494983
• Christensen E, Abosch A, Thompson JA, Zylberberg J. Inferring sleep stage from local field potentials recorded in the subthalamic nucleus of Parkinson's patients. J Sleep Res. 2019;28(4):e12806. doi:10.1111/jsr.12806
• Costabile JD, Alaswad E, D'Souza S, Thompson JA, Ormond DR. Current Applications of Diffusion Tensor Imaging and Tractography in Intracranial Tumor Resection. Front Oncol. 2019;9:426. Published 2019 May 29. doi:10.3389/fonc.2019.00426
• Winter M, Costabile JD, Abosch A, Thompson JA. Method for localizing intraoperative recordings from deep brain stimulation surgery using post-operative structural MRI. Neuroimage Clin. 2018;20:1123–1128. doi:10.1016/j.nicl.2018.10.016
• Lora Kahn, Aviva Abosch, Drew S. Kern, Clete A. Kushida, Casey H. Halpern, John A. Thompson, Chapter 49 - Rapid Eye Movement Sleep Behavior Disorder: Pathological Neural Circuits and Association with Parkinson's Disease, Editor(s): Hans C. Dringenberg, Handbook of Behavioral Neuroscience, Elsevier, Volume 30, 2019, Pages 723-730
• Vasquez CA, Thompson JA, Youssef AS. The Tentorial Bridge to Deep Skull Base Exposure: Anatomic Morphometric Study. World Neurosurg. 2018 Jun;114:e588-e596. PubMed PMID: 29551719
• Gault JM, Davis R, Cascella NG, Saks ER, Corripio-Collado I, Anderson WS, Olincy A, Thompson JA, Pomarol-Clotet E, Sawa A, Daskalakis ZJ, Lipsman N, Abosch A. Approaches to neuromodulation for schizophrenia. J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):777-787. PubMed PMID: 29242310
• Brown MG, Drees C, Nagae LM, Thompson JA, Ojemann S, Abosch A. Curative and palliative MRI-guided laser ablation for drug-resistant epilepsy. J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):425-433. PubMed PMID: 29084870
• Thompson JA, Tekriwal A, Felsen G, Ozturk M, Telkes I, Wu J, Ince NF, Abosch A. Sleep patterns in Parkinson's disease: direct recordings from the subthalamic nucleus. J Neurol Neurosurg Psychiatry. 2018 Jan;89(1):95-104. PubMed PMID: 28866626
• Kern DS, Fasano A, Thompson JA, Abosch A, Ojemann S, Munhoz RP. Constant Current versus Constant Voltage: Clinical Evidence Supporting a Fundamental Difference in the Modalities. Stereotact Funct Neurosurg. 2020 Nov 23;:1-5. [Epub ahead of print] PubMed PMID: 33227781
• Kern DS, Uy D, Rhoades R, Ojemann S, Abosch A, Thompson JA. Discrete changes in brain volume after deep brain stimulation in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):928-937. PubMed PMID: 32651244
• Youssef AS, Arnone GD, Farell NF, Thompson JA, Ramakrishnan VR, Gubbels S, Cohen-Gadol AA, Cass S, Labib MA. The Combined Endoscopic Endonasal Far Medial and Open Postauricular Transtemporal Approaches As a Lesser Invasive Approach to the Jugular Foramen: Anatomic Morphometric Study With Case Illustration. Oper Neurosurg (Hagerstown). 2020 Sep 15;19(4):471-479. PubMed PMID: 32510567
• George DD, Ojemann SG, Drees C, Thompson JA. Stimulation Mapping Using Stereoelectroencephalography: Current and Future Directions. Front Neurol. 2020;11:320. PubMed PMID: 32477236
• Gault JM, Thompson JA, Maharajh K, Hosokawa P, Stevens KE, Olincy A, Liedtke EI, Ojemann A, Ojemann S, Abosch A. Striatal and Thalamic Auditory Response During Deep Brain Stimulation for Essential Tremor: Implications for Psychosis. Neuromodulation. 2020 Jun;23(4):478-488. PubMed PMID: 32022409
• Pang Y, Christenson J, Jiang F, Lei T, Rhoades R, Kern D, Thompson JA, Liu C. Automatic detection and quantification of hand movements toward development of an objective assessment of tremor and bradykinesia in Parkinson's disease. J Neurosci Methods. 2020 Mar 1;333:108576. PubMed PMID: 31923452
• Hirt L, Grassia F, Feuerstein J, Thompson JA, Ojemann S, Kern DS. Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Writer's Cramp: A Case Report. Tremor Other Hyperkinet Mov (N Y). 2021;11:46. PubMed PMID: 34824889
• Baumgartner AJ, Kushida CA, Summers MO, Kern DS, Abosch A, Thompson JA. Basal Ganglia Local Field Potentials as a Potential Biomarker for Sleep Disturbance in Parkinson's Disease. Front Neurol. 2021;12:765203. PubMed PMID: 34777232
• Ung TH, Kahn L, Hirt L, Chatain G, Humes E, David-Gerecht P, Drees C, Thompson JA, Ojemann S, Abosch A. Using a Robotic-Assisted Approach for Stereotactic Laser Ablation Corpus Callosotomy: A Technical Report. Stereotact Funct Neurosurg. 2021 Aug 17;:1-6. [Epub ahead of print] PubMed PMID: 34515241
• Tekriwal A, Lintz MJ, Thompson JA, Felsen G. Disrupted basal ganglia output during movement preparation in hemiparkinsonian mice is consistent with behavioral deficits. J Neurophysiol. 2021 Oct 1;126(4):1248-1264. PubMed PMID: 34406873
• Fringuello A, Tatman PD, Wroblewski T, Thompson JA, Yu X, Lillehei KO, Kowalski RG, Graner MW. Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident. Int J Mol Sci. 2021 Jul 22;22(15). PubMed PMID: 34360613
• Belanger K, Grassia F, Kortz MW, Thompson JA, DeStefano S, Ojemann S. Management of post-operative delirium following stereoelectroencephalography electrode placement for drug resistant epilepsy: Lessons learned from two case reports. Epilepsy Behav Rep. 2021;16:100438. PubMed PMID: 33997756
• Thaker AA, Reddy KM, Thompson JA, Gerecht PD, Brown MS, Abosch A, Ojemann SG, Kern DS. Coronal Gradient Echo MRI to Visualize the Zona Incerta for Deep Brain Stimulation Targeting in Parkinson's Disease. Stereotact Funct Neurosurg. 2021;99(5):443-450. PubMed PMID: 33902054
• Kahn L, Sutton B, Winston HR, Abosch A, Thompson JA, Davis RA. Deep Brain Stimulation for Obsessive-Compulsive Disorder: Real World Experience Post-FDA-Humanitarian Use Device Approval. Front Psychiatry. 2021;12:568932. PubMed PMID: 33868034
• D'Souza S, Hirt L, Ormond DR, Thompson JA. Retrospective analysis of hemispheric structural network change as a function of location and size of glioma. Brain Commun. 2021;3(1):fcaa216. PubMed PMID: 33501423
• Kern DS, Fasano A, Thompson JA, Abosch A, Ojemann S, Munhoz RP. Constant Current versus Constant Voltage: Clinical Evidence Supporting a Fundamental Difference in the Modalities. Stereotact Funct Neurosurg. 2021;99(2):171-175. PubMed PMID: 33227781
• Chee K, Razmara A, Geller AS, Harris WB, Restrepo D, Thompson JA, Kramer DR. The role of the piriform cortex in temporal lobe epilepsy: A current literature review. Front Neurol. 2022;13:1042887. PubMed PMID: 36479052
• Duffy KA, Fenstermacher EA, Thompson JA, Tanabe J, Patel MS, Ojemann S, Davis RA. Case report: Clinical efficacy of deep brain stimulation contacts corresponds to local field potential signals in a patient with obsessive-compulsive disorder. Front Psychiatry. 2023;14:1279972. PubMed PMID: 38076699
• Tekriwal A, Baker S, Christensen E, Petersen-Jones H, Tien RN, Ojemann SG, Kern DS, Kramer DR, Felsen G, Thompson JA. Quantifying neuro-motor correlations during awake deep brain stimulation surgery using markerless tracking. Sci Rep. 2022 Oct 27;12(1):18120. PubMed PMID: 36302865
• Baker S, Tekriwal A, Felsen G, Christensen E, Hirt L, Ojemann SG, Kramer DR, Kern DS, Thompson JA. Automatic extraction of upper-limb kinematic activity using deep learning-based markerless tracking during deep brain stimulation implantation for Parkinson's disease: A proof of concept study. PLoS One. 2022;17(10):e0275490. PubMed PMID: 36264986
• Serva SN, Bernstein J, Thompson JA, Kern DS, Ojemann SG. An update on advanced therapies for Parkinson's disease: From gene therapy to neuromodulation. Front Surg. 2022;9:863921. PubMed PMID: 36211256
• Thompson JA, Hirt L, David-Gerecht P, Fasano A, Kramer DR, Ojemann SG, Kern DS. Comparison of Monopolar Review to Fixed Parameter Fractionation in Deep Brain Stimulation. Mov Disord Clin Pract. 2023 Jun;10(6):987-991. PubMed PMID: 37332654
• Kern D, Korsmo M, Baumgartner AJ, Kramer D, Ojemann S, Case M, Holt-Becker AB, Raike R, Thompson JA. Methylphenidate effects on a clinically informative oscillatory signal within the subthalamic nucleus in Parkinson's disease during deep brain stimulation programming. Brain Stimul. 2022 May-Jun;15(3):747-749. PubMed PMID: 35526817
• West LC, Summers M, Tang S, Hirt L, Halpern CH, Maroni D, Das R, Gliske SV, Abosch A, Kushida CA, Thompson JA. Evaluation of consensus sleep stage scoring of dysregulated sleep in Parkinson's disease. Sleep Med. 2023 Jul;107:236-242. PubMed PMID: 37257366
• Baumgartner AJ, Thompson JA, Kern DS, Ojemann SG. Novel targets in deep brain stimulation for movement disorders. Neurosurg Rev. 2022 Aug;45(4):2593-2613. PubMed PMID: 35511309
• Ung TH, Freeman L, Hirt L, Kortz M, Belanger K, Baird-Daniel E, Hosokawa P, Thaker A, Thompson JA, Youssef AS. Surgical outcomes in large vestibular schwannomas: should cerebellopontine edema be considered in the grading systems?. Acta Neurochir (Wien). 2023 Jul;165(7):1749-1755. PubMed PMID: 37204532
• Hirt L, Kern DS, Ojemann S, Grassia F, Kramer D, Thompson JA. Use of Three-Dimensional Printed Brain Models During Deep Brain Stimulation Surgery Consultation for Patient Health Literacy: A Randomized Controlled Investigation. World Neurosurg. 2022 Jun;162:e526-e533. PubMed PMID: 35306197
• Tekriwal A, Felsen G, Ojemann SG, Abosch A, Thompson JA. Motor context modulates substantia nigra pars reticulata spike activity in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2022 Apr;93(4):386-394. PubMed PMID: 35193951
• Murcia D, D'Souza S, Abozeid M, Thompson JA, Djoyum TD, Ormond DR. Investigation of Asleep versus Awake Motor Mapping in Resective Brain Surgery. World Neurosurg. 2022 Jan;157:e129-e136. PubMed PMID: 34619401
• Ung TH, Kahn L, Hirt L, Chatain G, Humes E, David-Gerecht P, Drees C, Thompson JA, Ojemann S, Abosch A. Using a Robotic-Assisted Approach for Stereotactic Laser Ablation Corpus Callosotomy: A Technical Report. Stereotact Funct Neurosurg. 2022;100(1):61-66. PubMed PMID: 34515241
• Radcliffe EM, Baumgartner AJ, Kern DS, Al Borno M, Ojemann S, Kramer DR, Thompson JA. Oscillatory beta dynamics inform biomarker-driven treatment optimization for Parkinson's disease. J Neurophysiol. 2023 Jun 1;129(6):1492-1504. PubMed PMID: 37198135
• Gault JM, Hosokawa P, Kramer D, Saks ER, Appelbaum PS, Thompson JA, Olincy A, Cascella N, Sawa A, Goodman W, Moukaddam N, Sheth SA, Anderson WS, Davis RA. Postsurgical morbidity and mortality favorably informs deep brain stimulation for new indications including schizophrenia and schizoaffective disorder. Front Surg. 2023;10:958452. PubMed PMID: 37066004
• Chee K, Razmara A, Geller AS, Harris WB, Restrepo D, Thompson JA, Kramer DR. Corrigendum: The role of the piriform cortex in temporal lobe epilepsy: A current literature review. Front Neurol. 2023;14:1148230. PubMed PMID: 36908616
• Lewis S, Radcliffe E, Ojemann S, Kramer DR, Hirt L, Case M, Holt-Becker AB, Raike R, Kern DS, Thompson JA. Pilot Study to Investigate the Use of In-Clinic Sensing to Identify Optimal Stimulation Parameters for Deep Brain Stimulation Therapy in Parkinson's Disease. Neuromodulation. 2023 Feb 14. [Epub ahead of print] PubMed PMID: 36797194
• McDermott D, Darwin ML, Fetrow K, Coulter I, Biesecker K, Thompson JA. Cannabis use patterns in drug-resistant and pharmacoresponsive epilepsy: Single tertiary referral center survey investigation. PLoS One. 2023;18(1):e0281040. PubMed PMID: 36706124

Professional Memberships

• Society for Neuroscience, Member
• American Society for Stereotactic and Functional Neurosurgery, Member

Practice Locations

• University of Colorado Hospital

• University of Colorado Movement Disorders Center
• Neurotechnology Center