Brigitte Frohnert, MD, PhD

Publications

• Frohnert BI, Bernlohr DA. Glutathionylated products of lipid peroxidation: A novel mechanism of adipocyte to macrophage signaling. Adipocyte. 2014 Jul 1;3(3):224-9. PubMed PMID: 25068091
• Frohnert BI, Long EK, Hahn WS, Bernlohr DA. Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation. Diabetes. 2014 Jan;63(1):89-100. PubMed PMID: 24062247
• Simmons KM, McFann K, Taki I, Liu E, Klingensmith GJ, Rewers MJ, Frohnert BI. Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. J Pediatr. 2015 Nov 7. [Epub ahead of print] PubMed PMID: 26561381
• Frohnert BI, Rewers MJ. Metabolomics in childhood diabetes. Pediatr Diabetes. 2015 Sep 30. [Epub ahead of print] PubMed PMID: 26420304
• Frohnert BI, Alonso GT. Challenges in Delivering Smaller Doses of Insulin. Diabetes Technol Ther. 2015 Sep;17(9):597-9. PubMed PMID: 26317878
• Chahla SE, Frohnert BI, Thomas W, Kelly AS, Nathan BM, Polgreen LE. Higher daily physical activity is associated with higher osteocalcin levels in adolescents. Prev Med Rep. 2015;2:568-571. PubMed PMID: 26236583
• Jahansouz C, Serrot FJ, Frohnert BI, Foncea RE, Dorman RB, Slusarek B, Leslie DB, Bernlohr DA, Ikramuddin S. Roux-en-Y Gastric Bypass Acutely Decreases Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue. Obes Surg. 2015 May 15. [Epub ahead of print] PubMed PMID: 25975200
• Törn C, Hadley D, Lee HS, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler A, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Steck AK, Krischer J. Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. Diabetes. 2015 May;64(5):1818-29. PubMed PMID: 25422107
• Steck AK, Dong F, Waugh K, Frohnert BI, Yu L, Norris JM, Rewers MJ. Predictors of slow progression to diabetes in children with multiple islet autoantibodies. J Autoimmun. 2016 Aug;72:113-7. PubMed PMID: 27255734
• Simmons KM, McFann K, Taki I, Liu E, Klingensmith GJ, Rewers MJ, Frohnert BI. Reduced Bone Mineral Density Is Associated with Celiac Disease Autoimmunity in Children with Type 1 Diabetes. J Pediatr. 2016 Feb;169:44-8.e1. PubMed PMID: 26561381
• Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She J, Simell O, Akolkar B, Krischer J, Schatz D, Rewers MJ. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 2015 May;38(5):808-13. PubMed PMID: 25665818
• Frohnert BI, Rewers MJ. Metabolomics in childhood diabetes. Pediatr Diabetes. 2016 Feb;17(1):3-14. PubMed PMID: 26420304
• Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, Hummel M, Liu E, Koletzko S. Clinical features of celiac disease: a prospective birth cohort. Pediatrics. 2015 Apr;135(4):627-34. PubMed PMID: 25733751
• Törn C, Liu X, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler AG, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Sharma A, Steck A, Krischer J. Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. Sci Rep. 2016 Jun 16;6:27887. PubMed PMID: 27306948
• Lernmark B, Lynch K, Baxter J, Roth R, Simell T, Smith L, Swartling U, Johnson SB. Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing. J Diabetes Res. 2016;2016:2720650. PubMed PMID: 26682228
• Uusitalo U, Liu X, Yang J, Aronsson CA, Hummel S, Butterworth M, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer J, Norris JM, Virtanen SM. Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA Pediatr. 2016 Jan;170(1):20-8. PubMed PMID: 26552054
• Andrén Aronsson C, Lee HS, Koletzko S, Uusitalo U, Yang J, Virtanen SM, Liu E, Lernmark Å, Norris JM, Agardh D. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort. Clin Gastroenterol Hepatol. 2016 Mar;14(3):403-409.e3. PubMed PMID: 26453955
• Frohnert BI, Laimighofer M, Krumsiek J, Theis FJ, Winkler C, Norris JM, Ziegler AG, Rewers MJ, Steck AK. Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2017 Jul 11. [Epub ahead of print] PubMed PMID: 28695611
• Alonso GT, Pyle L, Frohnert B. Change in hemoglobin A1c one year following the 2014 American Diabetes Association guideline update. Diabetes Res Clin Pract. 2017 Jul;129:169-172. PubMed PMID: 28528078
• Waugh K, Snell-Bergeon J, Michels A, Dong F, Steck AK, Frohnert BI, Norris JM, Rewers M. Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). PLoS One. 2017;12(4):e0174840. PubMed PMID: 28380011
• Frohnert BI, Ide L, Dong F, Barón AE, Steck AK, Norris JM, Rewers MJ. Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia. 2017 Jun;60(6):998-1006. PubMed PMID: 28314946
• Liu E, Dong F, Barón AE, Taki I, Norris JM, Frohnert BI, Hoffenberg EJ, Rewers M. High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes. Gastroenterology. 2017 May;152(6):1329-1336.e1. PubMed PMID: 28188747
• Webb-Robertson BJ, Bramer LM, Reehl SM, Metz TO, Zhang Q, Rewers MJ, Frohnert BI. ROFI - The Use of Repeated Optimization for Feature Interpretation. 2016 International Conference on Computational Science and Computational Intelligence (CSCI), IEEE Xplore: 20 March 2017.
• Sharma A, Liu X, Hadley D, Hagopian W, Chen W, Onengut-Gumuscu S, Törn C, Steck AK , Frohnert BI, Rewers M, Ziegler AG, Lernmark Å,6 Mykkänen J, Toppari J, Krischer JP, Akolkar B, Rich SS, She J; TEDDY Study Group. Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort. J Autoimmun. (in press)
• Jefferies C, Bidder C, Calliari LE, Commissariat PV, Agwu JC, Evans M, Frohnert B, Jasser-Nitsche H, Virmani A, Maahs DM. ISPAD Annual Conference 2016 Highlights. Pediatr Diabetes. 2017;18:249–252.
• Steck AK, Dong F, Frohnert BI, Waugh K, Hoffman M, Norris JM, Rewers MJ. Predicting progression to diabetes in islet autoantibody positive children. J Autoimmun. 2018 Jan 27. [Epub ahead of print] PubMed PMID: 29395739
• Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG. Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study. J Med Genet. 2018 Oct 4. [Epub ahead of print] PubMed PMID: 30287597
• Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG. Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children. PLoS Med. 2018 Apr;15(4):e1002548. PubMed PMID: 29614081
• Steck AK, Dong F, Frohnert BI, Waugh K, Hoffman M, Norris JM, Rewers MJ. Predicting progression to diabetes in islet autoantibody positive children. J Autoimmun. 2018 Jun;90:59-63. PubMed PMID: 29395739
• Sharma A, Liu X, Hadley D, Hagopian W, Chen WM, Onengut-Gumuscu S, Törn C, Steck AK, Frohnert BI, Rewers M, Ziegler AG, Lernmark Å, Toppari J, Krischer JP, Akolkar B, Rich SS, She JX. Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort. J Autoimmun. 2018 May;89:90-100. PubMed PMID: 29310926
• Frohnert BI, Laimighofer M, Krumsiek J, Theis FJ, Winkler C, Norris JM, Ziegler AG, Rewers MJ, Steck AK. Prediction of type 1 diabetes using a genetic risk model in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2018 Mar;19(2):277-283. PubMed PMID: 28695611
• Berget C, Messer LH, Vigers T, Frohnert BI, Pyle L, Wadwa RP, Driscoll KA, Forlenza GP. Six months of Hybrid Closed Loop in the Real-World: An Evaluation of Children and Young Adults using the 670G System. Pediatr Diabetes. 2019 Dec 13. [Epub ahead of print] PubMed PMID: 31837064
• Frohnert BI, Webb-Robertson BJ, Bramer LM, Reehl SM, Waugh K, Steck AK, Norris JM, Rewers M. Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources. Diabetes. 2019 Nov 18. [Epub ahead of print] PubMed PMID: 31740441
• Halper-Stromberg E, Gallo T, Champakanath A, Taki I, Rewers M, Snell-Bergeon J, Frohnert BI, Shah VN. Bone Mineral Density across the Life-Span in Patients with Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Nov 2. [Epub ahead of print] PubMed PMID: 31676897
• Steck AK, Dong F, Taki I, Hoffman M, Simmons K, Frohnert BI, Rewers MJ. Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3337-3344. PubMed PMID: 30844073
• Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG. Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study. J Med Genet. 2019 Sep;56(9):602-605. PubMed PMID: 30287597
• Frohnert BI, Chase HP, Rewers M. Chapter 35: Diabetes Mellitus. In Current Diagnosis and Treatment Pediatrics, 25th Edition. Eds: William Hay, Myron Levin, Robin Deterding, Mark Abzug. McGraw-Hill, New York, NY.
• Onengut-Gumuscu S, Paila U, Chen WM, Ratan A, Zhu Z, Steck AK, Frohnert BI, Waugh KC, Webb-Robertson BM, Norris JM, Lange LA, Rewers MJ, Rich SS. Novel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes. Sci Rep. 2020 Nov 5;10(1):19193. PubMed PMID: 33154504
• Webb-Robertson BM, Bramer LM, Stanfill BA, Reehl SM, Nakayasu ES, Metz TO, Frohnert BI, Norris JM, Johnson RK, Rich SS, Rewers MJ. Prediction of the Development of Islet Autoantibodies through Integration of Environmental, Genetic, and Metabolic Markers. J Diabetes. 2020 Jul 22. [Epub ahead of print] PubMed PMID: 33124145
• Stahl MG, Geno Rasmussen C, Dong F, Waugh K, Norris JM, Baxter J, Yu L, Steck AK, Frohnert BI, Liu E, Rewers MJ. Mass Screening for Celiac Disease: The Autoimmunity Screening for Kids Study. Am J Gastroenterol. 2020 Jul 22. [Epub ahead of print] PubMed PMID: 32701732
• Gardner JA, Johnson RK, Dong F, Hoffman M, Steck AK, Frohnert BI, Rewers M, Norris JM. Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY). Endocrine. 2020 Nov;70(2):331-337. PubMed PMID: 32651851
• Cree-Green M, Carreau AM, Davis SM, Frohnert BI, Kaar JL, Ma NS, Nokoff NJ, Reusch JEB, Simon SL, Nadeau KJ. Peer mentoring for professional and personal growth in academic medicine. J Investig Med. 2020 Aug;68(6):1128-1134. PubMed PMID: 32641352
• McQueen RB, Geno Rasmussen C, Waugh K, Frohnert BI, Steck AK, Yu L, Baxter J, Rewers M. Cost and Cost-effectiveness of Large-scale Screening for Type 1 Diabetes in Colorado. Diabetes Care. 2020 Jul;43(7):1496-1503. PubMed PMID: 32327420
• Kwon BC, Anand V, Severson KA, Ghosh S, Sun Z, Frohnert BI, Lundgren M, Ng K. DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways. IEEE Trans Vis Comput Graph. 2020 Apr 7. [Epub ahead of print] PubMed PMID: 32275600
• Johnson RK, Vanderlinden LA, Dong F, Carry PM, Seifert J, Waugh K, Shorrosh H, Fingerlin T, Frohnert BI, Yang IV, Kechris K, Rewers M, Norris JM. Longitudinal DNA methylation differences precede type 1 diabetes. Sci Rep. 2020 Feb 28;10(1):3721. PubMed PMID: 32111940
• Carry PM, Vanderlinden LA, Johnson RK, Dong F, Steck AK, Frohnert BI, Rewers M, Yang IV, Kechris K, Norris JM. DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young. Pediatr Diabetes. 2020 Jun;21(4):597-605. PubMed PMID: 32061050
• Ng K, Stavropoulos H, Anand V, Veijola R, Toppari J, Maziarz M, Lundgren M, Waugh K, Frohnert BI, Martin F, Hagopian W, Achenbach P. Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children. Diabetes Care. 2021 Nov 10. [Epub ahead of print] PubMed PMID: 34758977
• Berget C, Messer LH, Vigers T, Frohnert BI, Pyle L, Wadwa RP, Driscoll KA, Forlenza GP. Six months of hybrid closed loop in the real-world: An evaluation of children and young adults using the 670G system. Pediatr Diabetes. 2020 Mar;21(2):310-318. PubMed PMID: 31837064
• Frohnert BI, Webb-Robertson BJ, Bramer LM, Reehl SM, Waugh K, Steck AK, Norris JM, Rewers M. Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources. Diabetes. 2020 Feb;69(2):238-248. PubMed PMID: 31740441
• Nakayasu ES, Gritsenko M, Piehowski PD, Gao Y, Orton DJ, Schepmoes AA, Fillmore TL, Frohnert BI, Rewers M, Krischer JP, Ansong C, Suchy-Dicey AM, Evans-Molina C, Qian WJ, Webb-Robertson BM, Metz TO. Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation. Nat Protoc. 2021 Aug;16(8):3737-3760. PubMed PMID: 34244696
• Halper-Stromberg E, Gallo T, Champakanath A, Taki I, Rewers M, Snell-Bergeon J, Frohnert BI, Shah VN. Bone Mineral Density across the Lifespan in Patients with Type 1 Diabetes. J Clin Endocrinol Metab. 2020 Mar 1;105(3). PubMed PMID: 31676897
• Stahl MG, Geno Rasmussen C, Dong F, Waugh K, Norris JM, Baxter J, Yu L, Steck AK, Frohnert BI, Liu E, Rewers MJ. Mass Screening for Celiac Disease: The Autoimmunity Screening for Kids Study. Am J Gastroenterol. 2021 Jan 1;116(1):180-187. PubMed PMID: 32701732
• Webb-Robertson BM, Bramer LM, Stanfill BA, Reehl SM, Nakayasu ES, Metz TO, Frohnert BI, Norris JM, Johnson RK, Rich SS, Rewers MJ. Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers. J Diabetes. 2021 Feb;13(2):143-153. PubMed PMID: 33124145
• Rydin AA, Spiegel G, Frohnert BI, Kaess A, Oswald L, Owen D, Simmons KM. Medical management of children with type 1 diabetes on low-carbohydrate or ketogenic diets. Pediatr Diabetes. 2021 May;22(3):448-454. PubMed PMID: 33470021
• Buckner T, Vanderlinden LA, DeFelice BC, Carry PM, Kechris K, Dong F, Fiehn O, Frohnert BI, Clare-Salzler M, Rewers M, Norris JM. The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia. 2021 Aug;64(8):1785-1794. PubMed PMID: 33893822
• Anand V, Li Y, Liu B, Ghalwash M, Koski E, Ng K, Dunne JL, Jönsson J, Winkler C, Knip M, Toppari J, Ilonen J, Killian MB, Frohnert BI, Lundgren M, Ziegler AG, Hagopian W, Veijola R, Rewers M. Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes: Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S. Diabetes Care. 2021 Jun 23. [Epub ahead of print] PubMed PMID: 34162665
• Kwon BC, Anand V, Severson KA, Ghosh S, Sun Z, Frohnert BI, Lundgren M, Ng K. DPVis: Visual Analytics With Hidden Markov Models for Disease Progression Pathways. IEEE Trans Vis Comput Graph. 2021 Sep;27(9):3685-3700. PubMed PMID: 32275600
• Kwon BC, Achenbach P, Dunne JL, Hagopian W, Lundgren M, Ng K, Veijola R, Frohnert BI, Anand V. Modeling Disease Progression Trajectories from Longitudinal Observational Data. AMIA Annu Symp Proc. 2020;2020:668-676. PubMed PMID: 33936441
• Bonifacio E, Weiß A, Winkler C, Hippich M, Rewers MJ, Toppari J, Lernmark Å, She JX, Hagopian WA, Krischer JP, Vehik K, Schatz DA, Akolkar B, Ziegler AG. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood. Diabetes Care. 2021 Feb 24. [Epub ahead of print] PubMed PMID: 33627366
• Ng K, Anand V, Stavropoulos H, Veijola R, Toppari J, Maziarz M, Lundgren M, Waugh K, Frohnert BI, Martin F, Lou O, Hagopian W, Achenbach P. Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children. Diabetologia. 2022 Oct 5. [Epub ahead of print] PubMed PMID: 36195673
• Melin J, Lynch KF, Lundgren M, Aronsson CA, Larsson HE, Johnson SB. Is staff consistency important to parents' satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study. BMC Endocr Disord. 2022 Jan 10;22(1):19. PubMed PMID: 35012530
• Kwon BC, Achenbach P, Anand V, Frohnert BI, Hagopian W, Hu J, Koski E, Lernmark Å, Lou O, Martin F, Ng K, Toppari J, Veijola R. Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes. Diabetes. 2022 Dec 1;71(12):2632-2641. PubMed PMID: 36112006
• Karpen SR, Dunne JL, Frohnert BI, Marinac M, Richard C, David SE, O'Doherty IM. Consortium-based approach to receiving an EMA qualification opinion on the use of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies. Diabetologia. 2022 Jul 22. [Epub ahead of print] PubMed PMID: 35867129
• Webb-Robertson BM, Nakayasu ES, Frohnert BI, Bramer LM, Akers SM, Norris JM, Vehik K, Ziegler AG, Metz TO, Rich SS, Rewers MJ. Integration of Infant Metabolite, Genetic, and Islet Autoimmunity Signatures to Predict Type 1 Diabetes by Age 6 Years. J Clin Endocrinol Metab. 2022 Jul 14;107(8):2329-2338. PubMed PMID: 35468213
• Kwon BC, Anand V, Achenbach P, Dunne JL, Hagopian W, Hu J, Koski E, Lernmark Å, Lundgren M, Ng K, Toppari J, Veijola R, Frohnert BI. Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories. Nat Commun. 2022 Mar 21;13(1):1514. PubMed PMID: 35314671
• Li Z, Toppari J, Lundgren M, Frohnert BI, Achenbach P, Veijola R, Anand V. Imputing Longitudinal Growth Data in International Pediatric Studies: Does CDC Reference Suffice?. AMIA Annu Symp Proc. 2021;2021:754-762. PubMed PMID: 35308906
• He L, Jia X, Rasmussen CG, Waugh K, Miao D, Dong F, Frohnert B, Steck AK, Simmons KM, Rewers M, Yu L. High-Throughput Multiplex Electrochemiluminescence Assay Applicable to General Population Screening for Type 1 Diabetes and Celiac Disease. Diabetes Technol Ther. 2022 Jul;24(7):502-509. PubMed PMID: 35238620
• Krischer JP, Liu X, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Diabetes Care. 2022 Oct 1;45(10):2271-2281. PubMed PMID: 36150053
• Steck AK, Dong F, Geno Rasmussen C, Bautista K, Sepulveda F, Baxter J, Yu L, Frohnert BI, Rewers MJ, Rewers M, Barbour A, Bautista K, Baxter J, Felipe-Morales D, Dong F, Dormond-Brooks P, Driscoll K, Frohnert B, Rasmussen CG, Gesualdo P, Hoffman M, Karban R, Sepulveda F, Shorrosh H, Simmons K, Steck A, Taki I, Waugh K, Yu L, Liu E, Gallant M, McQueen RB, Norris JM. CGM Metrics Predict Imminent Progression to Type 1 Diabetes: Autoimmunity Screening for Kids (ASK) Study. Diabetes Care. 2022 Feb 1;45(2):365-371. PubMed PMID: 34880069
• Ng K, Stavropoulos H, Anand V, Veijola R, Toppari J, Maziarz M, Lundgren M, Waugh K, Frohnert BI, Martin F, Hagopian W, Achenbach P. Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children. Diabetes Care. 2022 Jan 1;45(1):160-168. PubMed PMID: 34758977
• Vehik K, Boulware D, Killian M, Rewers M, McIndoe R, Toppari J, Lernmark Å, Akolkar B, Ziegler AG, Rodriguez H, Schatz DA, Krischer JP, Hagopian W. Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Diabetes Care. 2022 Oct 1;45(10):2342-2349. PubMed PMID: 36150054
• Törn C, Liu X, Onengut-Gumuscu S, Counts KM, Moreno JL, Remedios CL, Chen WM, LeFaive J, Butterworth MD, Akolkar B, Krischer JP, Lernmark Å, Rewers M, She JX, Toppari J, Ziegler AG, Ratan A, Smith AV, Hagopian WA, Rich SS, Parikh HM. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022 Mar 16;12(1):4516. PubMed PMID: 35296692
• Jacobsen LM, Vehik K, Veijola R, Warncke K, Toppari J, Steck AK, Gesualdo P, Akolkar B, Lundgren M, Hagopian WA, She JX, Rewers M, Ziegler AG, Krischer JP, Larsson HE, Haller MJ. Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022 Mar 1;45(3):624-633. PubMed PMID: 35043162
• Simmons K, Frohnert B, O'Donnell H, Bautista K, Geno Rasmussen C, Gerard Gonzalez A, Steck A, Rewers MJ. Historical Insights and Current Perspectives on the Diagnosis and Management of Pre-Symptomatic Type 1 Diabetes. Diabetes Technol Ther. 2023 Sep 11. [Epub ahead of print] PubMed PMID: 37695674
• O'Donnell HK, Rasmussen CG, Dong F, Simmons KM, Steck AK, Frohnert BI, Bautista K, Rewers MJ, Baxter J. Anxiety and Risk Perception in Parents of Children Identified by Population Screening as High Risk for Type 1 Diabetes. Diabetes Care. 2023 Sep 6. [Epub ahead of print] PubMed PMID: 37673098
• Frost HM, Geno Rasmussen C, Shorrosh H, Pyle L, Bautista K, Frohnert BI, Stahl M, Simmons K, Steck AK, Jia X, Yu L, Rewers M. Prevalence of SARS-CoV-2 Antibodies Among Healthy Children From Colorado From 2020 to 2021: A Brief Report. J Prim Care Community Health. 2023 Jan-Dec;14:21501319231189147. PubMed PMID: 37501515
• Nakayasu ES, Bramer LM, Ansong C, Schepmoes AA, Fillmore TL, Gritsenko MA, Clauss TR, Gao Y, Piehowski PD, Stanfill BA, Engel DW, Orton DJ, Moore RJ, Qian WJ, Sechi S, Frohnert BI, Toppari J, Ziegler AG, Lernmark Å, Hagopian W, Akolkar B, Smith RD, Rewers MJ, Webb-Robertson BM, Metz TO. Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity. Cell Rep Med. 2023 Jul 18;4(7):101093. PubMed PMID: 37390828
• Karpen SR, Dunne JL, Frohnert BI, Marinac M, Richard C, David SE, O'Doherty IM. Consortium-based approach to receiving an EMA qualification opinion on the use of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies. Diabetologia. 2023 Mar;66(3):415-424. PubMed PMID: 35867129
• Ng K, Anand V, Stavropoulos H, Veijola R, Toppari J, Maziarz M, Lundgren M, Waugh K, Frohnert BI, Martin F, Lou O, Hagopian W, Achenbach P. Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children. Diabetologia. 2023 Jan;66(1):93-104. PubMed PMID: 36195673
• Buckner T, Johnson RK, Vanderlinden LA, Carry PM, Romero A, Onengut-Gumuscu S, Chen WM, Fiehn O, Frohnert BI, Crume T, Perng W, Kechris K, Rewers M, Norris JM. An Oxylipin-Related Nutrient Pattern and Risk of Type 1 Diabetes in the Diabetes Autoimmunity Study in the Young (DAISY). Nutrients. 2023 Feb 14;15(4). PubMed PMID: 36839302
• Frohnert BI, Ghalwash M, Li Y, Ng K, Dunne JL, Lundgren M, Hagopian W, Lou O, Winkler C, Toppari J, Veijola R, Anand V. Refining the Definition of Stage 1 Type 1 Diabetes: An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity. Diabetes Care. 2023 Oct 1;46(10):1753-1761. PubMed PMID: 36862942
• Alonso GT, Triolo TM, Akturk HK, Pauley ME, Sobczak M, Forlenza GP, Sakamoto C, Pyle L, Frohnert BI. Increased Technology Use Associated With Lower A1C in a Large Pediatric Clinical Population. Diabetes Care. 2023 Jun 1;46(6):1218-1222. PubMed PMID: 37023293
• Buckner T, Johnson RK, Vanderlinden LA, Carry PM, Romero A, Onengut-Gumuscu S, Chen WM, Kim S, Fiehn O, Frohnert BI, Crume T, Perng W, Kechris K, Rewers M, Norris JM. Genome-wide analysis of oxylipins and oxylipin profiles in a pediatric population. Front Nutr. 2023;10:1040993. PubMed PMID: 37057071

Practice Locations

Barbara Davis Center for Diabetes Pediatric Clinic - CU Anschutz Medical Campus
1775 Aurora Ct
Suite A140
Aurora, CO 80045
303-724-2323

Children's Colorado Health Pavilion
860 N Potomac Cir
Aurora, CO 80111
720-777-1234

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• University of Colorado Hospital
• Children's Hospital Colorado

Center Affiliations

• Barbara Davis Center for Childhood Diabetes

Specialty Information

Specialties

• Pediatric Endocrinology, Board Certification
• Pediatrics, Board Certification