Research Director, CU Neuromagnetic Laboratories (https://cuneuromag.org)
Associate Director of Research, Movement Disorders Center
Research Interests
I am a neurophysiologist with a unique scientific trajectory from lab bench to pre-clinical and clinical research. I have studied brain correlates of motor development, function and dysfunction using diverse models, ranging from single brain cells to neuronal networks, in both animals and humans with or without neurological disorders.
The focus of my current research is on the neurophysiology of motor dysfunction in movement disorders, particularly understanding the underlying neuropathophysiology and testing novel treatment approaches using diverse brain imaging techniques such as magnetoencephalography (MEG), electroencephalography (EEG) and magnetic resonance imaging (MRI). I am also investigating the use of transcranial magnetic stimulation (TMS) as a tool to modulate brain networks dynamic and assess excitation/inhibition (im)balance in cortical regions. Finally, I am integrating these state-of-the-art techniques with experimental paradigms relying on the neurophysiological analysis of sensorimotor control to provide an inclusive view of the neural control of movement.
Publications
Buard I, Yang X, Kaizer A, Lattanzio L, Kluger B, Enoka RM. Finger dexterity measured by the Grooved Pegboard test indexes Parkinson's motor severity in a tremor-independent manner. J Electromyogr Kinesiol. 2022 Oct;66:102695. PubMed PMID: 36030732
Buard I, Lopez-Esquibel N, Carey FJ, Brown MS, Medina LD, Kronberg E, Martin CS, Rogers S, Holden SK, Greher MR, Kluger BM. Does Prefrontal Glutamate Index Cognitive Changes in Parkinson's Disease?. Front Hum Neurosci. 2022;16:809905. PubMed PMID: 35496064
Buard I, Lopez-Esquibel N, Carey FJ, Brown MS, Medina LD, Kronberg E, Martin CS, Rogers S, Holden SK, Greher MR, Kluger BM. Does Prefrontal Glutamate Index Cognitive Changes in Parkinson's Disease?. Front Hum Neurosci. 2022;16:809905. PubMed PMID: 35496064
Simon OB, Rojas DC, Ghosh D, Yang X, Rogers SE, Martin CS, Holden SK, Kluger BM, Buard I. Profiling Parkinson's disease cognitive phenotypes via resting-state magnetoencephalography. J Neurophysiol. 2022 Jan 1;127(1):279-289. PubMed PMID: 34936515
Simon OB, Rojas DC, Ghosh D, Yang X, Rogers SE, Martin CS, Holden SK, Kluger BM, Buard I. Profiling Parkinson's disease cognitive phenotypes via resting-state magnetoencephalography. J Neurophysiol. 2022 Jan 1;127(1):279-289. PubMed PMID: 34936515
Grande M, Lattanzio L, Buard I, McKendrick AM, Chan YM, Pelak VS. A Study Protocol for an Open-Label Feasibility Treatment Trial of Visual Snow Syndrome With Transcranial Magnetic Stimulation. Front Neurol. 2021;12:724081. PubMed PMID: 34630299
Simon OB, Buard I, Rojas DC, Holden SK, Kluger BM, Ghosh D. A novel approach to understanding Parkinsonian cognitive decline using minimum spanning trees, edge cutting, and magnetoencephalography. Sci Rep. 2021 Oct 5;11(1):19704. PubMed PMID: 34611218
Buard I, Lattanzio L, Stewart R, Thompson S, Sjoberg K, Hookstadt K, Morrow M, Holden SK, Sillau S, Thaut M, Kluger B. Randomized controlled trial of neurologic music therapy in Parkinson's disease: research rehabilitation protocols for mechanistic and clinical investigations. Trials. 2021 Aug 28;22(1):577. PubMed PMID: 34454592
Lattanzio L, Seames A, Holden SK, Buard I. The emergent relationship between temporoparietal junction and anosognosia in Alzheimer's disease. J Neurosci Res. 2021 Sep;99(9):2091-2096. PubMed PMID: 34131953
Buard I, Lopez-Esquibel N, Schoeneberger S, Berliner JM, Kluger BM. Transcranial Magnetic Stimulation as Treatment for Mal de Debarquement Syndrome: Case Report and Literature Review. Cogn Behav Neurol. 2020 Jun;33(2):145-153. PubMed PMID: 32496300
Buard I, Dewispelaere WB, Teale P, Rojas DC, Kronberg E, Thaut MH, Kluger BM. Auditory entrainment of motor responses in older adults with and without Parkinson's disease: An MEG study. Neurosci Lett. 2019 Aug 24;708:134331. PubMed PMID: 31226362
Braunlich K, Seger CA, Jentink KG, Buard I, Kluger BM, Thaut MH. Rhythmic auditory cues shape neural network recruitment in Parkinson's disease during repetitive motor behavior. Eur J Neurosci. 2019 Mar;49(6):849-858. PubMed PMID: 30375083
Buard I, Dewispelaere WB, Thaut M, Kluger BM. Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease. Front Neurosci. 2019;13:105. PubMed PMID: 30837830
Buard I, Kronberg E, Steinmetz S, Hepburn S, Rojas DC. Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism. Autism Res Treat. 2018;2018:9035793. PubMed PMID: 30147953
Jones W, Silkworth W, Dusto N, Pelak VS, Berliner J, Buard I, Kluger B. Central Visual Oscillopsia: Case Report and Review of the Literature. Cogn Behav Neurol. 2018 Jun;31(2):86-95. PubMed PMID: 29927799
Buard I, Berliner JM, Kluger BM. Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes. Brain Stimul. 2018 May - Jun;11(3):653-655. PubMed PMID: 29500042
Buard I, Kronberg E, Steinmetz S, Hepburn S, Rojas DC. Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism. Autism Res Treat. 2018;2018:9035793. PubMed PMID: 30147953
Buard I, Berliner JM, Kluger BM. Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes. Brain Stimul. 2018 May - Jun;11(3):653-655. PubMed PMID: 29500042
Buard I, Sciacca DM, Martin CS, Rogers S, Sillau SH, Greher MR, Chen R, Kluger BM. Transcranial magnetic stimulation does not improve mild cognitive impairment in Parkinson's disease. Mov Disord. 2018 Mar;33(3):489-491. PubMed PMID: 29178298
Allen CH, Kluger BM, Buard I. Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature. Pediatr Neurol. 2017 Mar;68:3-17. PubMed PMID: 28216033
Buard I, Pfrieger FW. Relevance of neuronal and glial NPC1 for synaptic input to cerebellar Purkinje cells. Mol Cell Neurosci. 2014 Jul;61:65-71. PubMed PMID: 24910948
Barcomb K, Buard I, Coultrap SJ, Kulbe JR, O'Leary H, Benke TA, Bayer KU. Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength. FASEB J. 2014 Aug;28(8):3810-9. PubMed PMID: 24843070
Buard I, Rogers SJ, Hepburn S, Kronberg E, Rojas DC. Altered oscillation patterns and connectivity during picture naming in autism. Front Hum Neurosci. 2013;7:742. PubMed PMID: 24265611
Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU. CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem. 2010 Jun 4;285(23):17930-7. PubMed PMID: 20353941
Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16;30(24):8214-20. PubMed PMID: 20554872
Claudepierre T, Paques M, Simonutti M, Buard I, Sahel J, Maue RA, Picaud S, Pfrieger FW. Lack of Niemann-Pick type C1 induces age-related degeneration in the mouse retina. Mol Cell Neurosci. 2010 Jan;43(1):164-76. PubMed PMID: 19883762
Buard I, Steinmetz CC, Claudepierre T, Pfrieger FW. Glial cells promote dendrite formation and the reception of synaptic input in Purkinje cells from postnatal mice. Glia. 2010 Apr;58(5):538-45. PubMed PMID: 19908290
Steinmetz CC, Buard I, Claudepierre T, Nägler K, Pfrieger FW. Regional variations in the glial influence on synapse development in the mouse CNS. J Physiol. 2006 Nov 15;577(Pt 1):249-61. PubMed PMID: 16959855