Isabelle Buard, PhD

Professional Titles

• Research Director, CU Neuromagnetic Laboratories (https://cuneuromag.org)
• Associate Director of Research, Movement Disorders Center

Research Interests

I am a neurophysiologist with a unique scientific trajectory from lab bench to pre-clinical and clinical research. I have studied brain correlates of motor development, function and dysfunction using diverse models, ranging from single brain cells to neuronal networks, in both animals and humans with or without neurological disorders. The focus of my current research is on the neurophysiology of motor dysfunction in movement disorders, particularly understanding the underlying neuropathophysiology and testing novel treatment approaches using diverse brain imaging techniques such as magnetoencephalography (MEG), electroencephalography (EEG) and magnetic resonance imaging (MRI). I am also investigating the use of transcranial magnetic stimulation (TMS) as a tool to modulate brain networks dynamic and assess excitation/inhibition (im)balance in cortical regions. Finally, I am integrating these state-of-the-art techniques with experimental paradigms relying on the neurophysiological analysis of sensorimotor control to provide an inclusive view of the neural control of movement.

Publications

• Buard I, Kronberg E, Steinmetz S, Hepburn S, Rojas DC. Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism. Autism Res Treat. 2018;2018:9035793. PubMed PMID: 30147953
• Jones W, Silkworth W, Dusto N, Pelak VS, Berliner J, Buard I, Kluger B. Central Visual Oscillopsia: Case Report and Review of the Literature. Cogn Behav Neurol. 2018 Jun;31(2):86-95. PubMed PMID: 29927799
• Buard I, Berliner JM, Kluger BM. Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes. Brain Stimul. 2018 May - Jun;11(3):653-655. PubMed PMID: 29500042
• Buard I, Dewispelaere WB, Teale P, Rojas DC, Kronberg E, Thaut MH, Kluger BM. Auditory entrainment of motor responses in older adults with and without Parkinson's disease: An MEG study. Neurosci Lett. 2019 Aug 24;708:134331. PubMed PMID: 31226362
• Braunlich K, Seger CA, Jentink KG, Buard I, Kluger BM, Thaut MH. Rhythmic auditory cues shape neural network recruitment in Parkinson's disease during repetitive motor behavior. Eur J Neurosci. 2019 Mar;49(6):849-858. PubMed PMID: 30375083
• Buard I, Dewispelaere WB, Thaut M, Kluger BM. Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease. Front Neurosci. 2019;13:105. PubMed PMID: 30837830
• Buard I, Kronberg E, Steinmetz S, Hepburn S, Rojas DC. Neuromagnetic Beta-Band Oscillations during Motor Imitation in Youth with Autism. Autism Res Treat. 2018;2018:9035793. PubMed PMID: 30147953
• Buard I, Berliner JM, Kluger BM. Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes. Brain Stimul. 2018 May - Jun;11(3):653-655. PubMed PMID: 29500042
• Buard I, Sciacca DM, Martin CS, Rogers S, Sillau SH, Greher MR, Chen R, Kluger BM. Transcranial magnetic stimulation does not improve mild cognitive impairment in Parkinson's disease. Mov Disord. 2018 Mar;33(3):489-491. PubMed PMID: 29178298
• Buard I, Lopez-Esquibel N, Schoeneberger S, Berliner JM, Kluger BM. Transcranial Magnetic Stimulation as Treatment for Mal de Debarquement Syndrome: Case Report and Literature Review. Cogn Behav Neurol. 2020 Jun;33(2):145-153. PubMed PMID: 32496300
• Grande M, Lattanzio L, Buard I, McKendrick AM, Chan YM, Pelak VS. A Study Protocol for an Open-Label Feasibility Treatment Trial of Visual Snow Syndrome With Transcranial Magnetic Stimulation. Front Neurol. 2021;12:724081. PubMed PMID: 34630299
• Simon OB, Buard I, Rojas DC, Holden SK, Kluger BM, Ghosh D. A novel approach to understanding Parkinsonian cognitive decline using minimum spanning trees, edge cutting, and magnetoencephalography. Sci Rep. 2021 Oct 5;11(1):19704. PubMed PMID: 34611218
• Buard I, Lattanzio L, Stewart R, Thompson S, Sjoberg K, Hookstadt K, Morrow M, Holden SK, Sillau S, Thaut M, Kluger B. Randomized controlled trial of neurologic music therapy in Parkinson's disease: research rehabilitation protocols for mechanistic and clinical investigations. Trials. 2021 Aug 28;22(1):577. PubMed PMID: 34454592
• Lattanzio L, Seames A, Holden SK, Buard I. The emergent relationship between temporoparietal junction and anosognosia in Alzheimer's disease. J Neurosci Res. 2021 Sep;99(9):2091-2096. PubMed PMID: 34131953
• Buard I, Lopez-Esquibel N, Carey FJ, Brown MS, Medina LD, Kronberg E, Martin CS, Rogers S, Holden SK, Greher MR, Kluger BM. Does Prefrontal Glutamate Index Cognitive Changes in Parkinson's Disease?. Front Hum Neurosci. 2022;16:809905. PubMed PMID: 35496064
• Simon OB, Rojas DC, Ghosh D, Yang X, Rogers SE, Martin CS, Holden SK, Kluger BM, Buard I. Profiling Parkinson's disease cognitive phenotypes via resting-state magnetoencephalography. J Neurophysiol. 2022 Jan 1;127(1):279-289. PubMed PMID: 34936515
• Allen CH, Kluger BM, Buard I. Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature. Pediatr Neurol. 2017 Mar;68:3-17. PubMed PMID: 28216033
• Buard I, Pfrieger FW. Relevance of neuronal and glial NPC1 for synaptic input to cerebellar Purkinje cells. Mol Cell Neurosci. 2014 Jul;61:65-71. PubMed PMID: 24910948
• Buard I, Yang X, Kaizer A, Lattanzio L, Kluger B, Enoka RM. Finger dexterity measured by the Grooved Pegboard test indexes Parkinson's motor severity in a tremor-independent manner. J Electromyogr Kinesiol. 2022 Oct;66:102695. PubMed PMID: 36030732
• Buard I, Lopez-Esquibel N, Carey FJ, Brown MS, Medina LD, Kronberg E, Martin CS, Rogers S, Holden SK, Greher MR, Kluger BM. Does Prefrontal Glutamate Index Cognitive Changes in Parkinson's Disease?. Front Hum Neurosci. 2022;16:809905. PubMed PMID: 35496064
• Barcomb K, Buard I, Coultrap SJ, Kulbe JR, O'Leary H, Benke TA, Bayer KU. Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength. FASEB J. 2014 Aug;28(8):3810-9. PubMed PMID: 24843070
• Simon OB, Rojas DC, Ghosh D, Yang X, Rogers SE, Martin CS, Holden SK, Kluger BM, Buard I. Profiling Parkinson's disease cognitive phenotypes via resting-state magnetoencephalography. J Neurophysiol. 2022 Jan 1;127(1):279-289. PubMed PMID: 34936515
• Buard I, Rogers SJ, Hepburn S, Kronberg E, Rojas DC. Altered oscillation patterns and connectivity during picture naming in autism. Front Hum Neurosci. 2013;7:742. PubMed PMID: 24265611
• Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU. CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem. 2010 Jun 4;285(23):17930-7. PubMed PMID: 20353941
• Wylie KP, Kluger BM, Medina LD, Holden SK, Kronberg E, Tregellas JR, Buard I. Hippocampal, basal ganglia and olfactory connectivity contribute to cognitive impairments in Parkinson's disease. Eur J Neurosci. 2023 Feb;57(3):511-526. PubMed PMID: 36516060
• Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU. CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci. 2010 Jun 16;30(24):8214-20. PubMed PMID: 20554872
• Jarrar R, Monahan C, Shattuck J, Teale P, Kronberg E, Kluger BM, Buard I. Spatiotemporal dynamics of selective attention and visual conflict monitoring using a Stroop task. Cogn Neurosci. 2023 Jan-Oct;14(4):127-136. PubMed PMID: 37707299
• Alem O, Hughes KJ, Buard I, Cheung TP, Maydew T, Griesshammer A, Holloway K, Park A, Lechuga V, Coolidge C, Gerginov M, Quigg E, Seames A, Kronberg E, Teale P, Knappe S. An integrated full-head OPM-MEG system based on 128 zero-field sensors. Front Neurosci. 2023;17:1190310. PubMed PMID: 37389367
• Lucas Lattanzio, Isabelle Buard, A.M. McKendrick, Y.M. Chan, Victoria Pelak Repetitive TMS pilot trial for visual snow syndrome: Adverse event report Brain Stimulation 16(4):5-6 July 2023
• Claudepierre T, Paques M, Simonutti M, Buard I, Sahel J, Maue RA, Picaud S, Pfrieger FW. Lack of Niemann-Pick type C1 induces age-related degeneration in the mouse retina. Mol Cell Neurosci. 2010 Jan;43(1):164-76. PubMed PMID: 19883762
• Buard I, Steinmetz CC, Claudepierre T, Pfrieger FW. Glial cells promote dendrite formation and the reception of synaptic input in Purkinje cells from postnatal mice. Glia. 2010 Apr;58(5):538-45. PubMed PMID: 19908290
• Göritz C, Thiebaut R, Tessier LH, Nieweg K, Moehle C, Buard I, Dupont JL, Schurgers LJ, Schmitz G, Pfrieger FW. Glia-induced neuronal differentiation by transcriptional regulation. Glia. 2007 Aug 15;55(11):1108-22. PubMed PMID: 17582617
• Steinmetz CC, Buard I, Claudepierre T, Nägler K, Pfrieger FW. Regional variations in the glial influence on synapse development in the mouse CNS. J Physiol. 2006 Nov 15;577(Pt 1):249-61. PubMed PMID: 16959855

Professional Memberships

• American Congress of Rehabilitation Medicine, Member

Practice Locations

Center Affiliations

• University of Colorado Movement Disorders Center
• Marcus Institute for Brain Health

Specialty Information

Conditions & Treatments

• Complementary and Alternative Therapies
• Brain and Nervous System - Huntington's Disease
• Brain and Nervous System
• Brain and Nervous System - Parkinson's Disease
• Brain and Nervous System - Parkinson's Disease Dementia
• Brain and Nervous System - Traumatic Brain Injury (TBI)