Nidia Quillinan, PhD

Associate Professor, Anesthesiology


FacultyPhoto
Department
Anesthesiology

Publications

  • Quillinan N, Grewal H, Deng G, Shimizu K, Yonchek JC, Strnad F, Traystman RJ, Herson PS. Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia. Neuroscience. 2015 Jan 22;284:555-65. PubMed PMID: 25450957
  • Orfila JE, Shimizu K, Garske AK, Deng G, Maylie J, Traystman RJ, Quillinan N, Adelman JP, Herson PS. Increasing small conductance Ca2 -activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation. Eur J Neurosci. 2014 Oct;40(8):3179-88. PubMed PMID: 25080203
  • Quillinan N, Deng G, Grewal H, Herson PS. Androgens and stroke: good, bad or indifferent?. Exp Neurol. 2014 Sep;259:10-5. PubMed PMID: 24512750
  • Deng G, Yonchek JC, Quillinan N, Strnad FA, Exo J, Herson PS, Traystman RJ. A novel mouse model of pediatric cardiac arrest and cardiopulmonary resuscitation reveals age-dependent neuronal sensitivities to ischemic injury. J Neurosci Methods. 2014 Jan 30;222:34-41. PubMed PMID: 24192226
  • Bell MT, Puskas F, Bennett DT, Herson PS, Quillinan N, Fullerton DA, Reece TB. Dexmedetomidine, an a-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion. J Thorac Cardiovasc Surg. 2014 Jan;147(1):500-6. PubMed PMID: 24035379
  • Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion. Nidia Quillinan, Himmat Grewal, Jelena Klawitter, Paco S. Herson. eNeuro (2014) in press.
  • Shimizu K, Quillinan N, Orfila JE, Herson PS. Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels. Exp Neurol. 2016 Jan;275 Pt 1:78-83. PubMed PMID: 26522013
  • Quillinan N, Grewal H, Klawitter J, Herson PS. Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion(1,2,3). eNeuro. 2014 Nov-Dec;1(1). PubMed PMID: 26464961
  • Graber LC, Quillinan N, Marrotte EJ, McDonagh DL, Bartels K. Neurocognitive outcomes after extracorporeal membrane oxygenation. Best Pract Res Clin Anaesthesiol. 2015 Jun;29(2):125-35. PubMed PMID: 26060025
  • Quillinan N, Herson PS, Traystman RJ. Neuropathophysiology of Brain Injury. Anesthesiol Clin. 2016 Sep;34(3):453-64. PubMed PMID: 27521191
  • Shimizu T, Dietz RM, Cruz-Torres I, Strnad F, Garske AK, Moreno M, Venna VR, Quillinan N, Herson PS. Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia. Exp Neurol. 2016 Sep;283(Pt A):151-6. PubMed PMID: 27317297
  • Shimizu K, Quillinan N, Orfila JE, Herson PS. Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels. Exp Neurol. 2016 Jan;275 Pt 1:78-83. PubMed PMID: 26522013
  • Quillinan N, Deng G, Shimizu K, Cruz-Torres C, Schroeder C, Traystman RJ, Herson PS. Long-term depression in Purkinje neurons is persistently impaired following cardiac arrest and cardiopulmonary resuscitation in mice. JCBFM. 2016 (in press).
  • Quillinan N, Grewal H, Deng G, Shimizu K, Yonchek JC, Strnad F, Traystman RJ, Herson PS. Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia. Neuroscience. 2015 Jan 22;284:555-65. PubMed PMID: 25450957
  • Quillinan N, Deng G, Shimizu K, Cruz-Torres I, Schroeder C, Traystman RJ, Herson PS. Long-term depression in Purkinje neurons is persistently impaired following cardiac arrest and cardiopulmonary resuscitation in mice. J Cereb Blood Flow Metab. 2017 Aug;37(8):3053-3064. PubMed PMID: 28168893
  • Orfila JE, Shimizu K, Garske AK, Deng G, Maylie J, Traystman RJ, Quillinan N, Adelman JP, Herson PS. Increasing small conductance Ca2 -activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation. Eur J Neurosci. 2014 Oct;40(8):3179-88. PubMed PMID: 25080203
  • Quillinan N, Deng G, Grewal H, Herson PS. Androgens and stroke: good, bad or indifferent?. Exp Neurol. 2014 Sep;259:10-5. PubMed PMID: 24512750
  • Deng G, Orfila JE, Dietz RM, Moreno-Garcia M, Rodgers KM, Coultrap SJ, Quillinan N, Traystman RJ, Bayer KU, Herson PS. Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep. 2017 Jan 31;18(5):1109-1117. PubMed PMID: 28147268
  • Deng G, Yonchek JC, Quillinan N, Strnad FA, Exo J, Herson PS, Traystman RJ. A novel mouse model of pediatric cardiac arrest and cardiopulmonary resuscitation reveals age-dependent neuronal sensitivities to ischemic injury. J Neurosci Methods. 2014 Jan 30;222:34-41. PubMed PMID: 24192226
  • Orfila JE, McKinnon N, Moreno M, Deng G, Chalmers N, Dietz RM, Herson PS, Quillinan N. Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation. Neural Plast. 2018;2018:9275239. PubMed PMID: 29853851
  • Bell MT, Puskas F, Bennett DT, Herson PS, Quillinan N, Fullerton DA, Reece TB. Dexmedetomidine, an a-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion. J Thorac Cardiovasc Surg. 2014 Jan;147(1):500-6. PubMed PMID: 24035379
  • Dietz RM, Orfila JE, Rodgers KM, Patsos OP, Deng G, Chalmers N, Quillinan N, Traystman RJ, Herson PS. Juvenile cerebral ischemia reveals age-dependent BDNF-TrkB signaling changes: Novel mechanism of recovery and therapeutic intervention. J Cereb Blood Flow Metab. 2018 Apr 3;:271678X18766421. [Epub ahead of print] PubMed PMID: 29611441
  • Clevenger AC, Kim H, Salcedo E, Yonchek JC, Rodgers KM, Orfila JE, Dietz RM, Quillinan N, Traystman RJ, Herson PS. Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice. J Mol Neurosci. 2018 Mar;64(3):410-420. PubMed PMID: 29450697
  • Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. J Cereb Blood Flow Metab. 2017 Jan 1;:271678X17750761. [Epub ahead of print] PubMed PMID: 29283314
  • Quillinan N, Deng G, Shimizu K, Cruz-Torres I, Schroeder C, Traystman RJ, Herson PS. Long-term depression in Purkinje neurons is persistently impaired following cardiac arrest and cardiopulmonary resuscitation in mice. J Cereb Blood Flow Metab. 2017 Aug;37(8):3053-3064. PubMed PMID: 28168893
  • Deng G, Orfila JE, Dietz RM, Moreno-Garcia M, Rodgers KM, Coultrap SJ, Quillinan N, Traystman RJ, Bayer KU, Herson PS. Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep. 2017 Jan 31;18(5):1109-1117. PubMed PMID: 28147268
  • Chalmers NE, Yonchek J, Steklac KE, Ramsey M, Bayer KU, Herson PS, Quillinan N. Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice. Mol Neurobiol. 2019 Sep 13. [Epub ahead of print] PubMed PMID: 31520314
  • Chastain-Potts SE, Tesic V, Tat QL, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum. Mol Neurobiol. 2019 Sep 12. [Epub ahead of print] PubMed PMID: 31512116
  • Cabrera OH, Tesic V, Tat QL, Chastain S, Quillinan N, Jevtovic-Todorovic V. Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain. Mol Neurobiol. 2019 Sep 6. [Epub ahead of print] PubMed PMID: 31493242
  • Dietz RM, Cruz-Torres I, Orfila JE, Patsos OP, Shimizu K, Chalmers N, Deng G, Tiemeier E, Quillinan N, Herson PS. Reversal of Global Ischemia-Induced Cognitive Dysfunction by Delayed Inhibition of TRPM2 Ion Channels. Transl Stroke Res. 2019 Jun 28. [Epub ahead of print] PubMed PMID: 31250378
  • Quillinan N, Dingman AL, Deng G, Tatum S, Orfila JE, Clevenger AC, Klawitter J, Traystman RJ, Herson PS. Single dose of 17ß-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation. Neurochem Int. 2019 Jul;127:80-86. PubMed PMID: 30471325
  • Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020 May;124(5):603-613. PubMed PMID: 32151384
  • Cabrera OH, Gulvezan T, Symmes B, Quillinan N, Jevtovic-Todorovic V. Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review. Br J Anaesth. 2020 Mar;124(3):e81-e91. PubMed PMID: 31980157
  • Buonarati OR, Cook SG, Goodell DJ, Chalmers NE, Rumian NL, Tullis JE, Restrepo S, Coultrap SJ, Quillinan N, Herson PS, Bayer KU. CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest. Cell Rep. 2020 Jan 7;30(1):1-8.e4. PubMed PMID: 31914378
  • Chalmers NE, Yonchek J, Steklac KE, Ramsey M, Bayer KU, Herson PS, Quillinan N. Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice. Mol Neurobiol. 2020 Jan;57(1):150-158. PubMed PMID: 31520314
  • Chastain-Potts SE, Tesic V, Tat QL, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum. Mol Neurobiol. 2020 Jan;57(1):11-22. PubMed PMID: 31512116
  • Cabrera OH, Tesic V, Tat QL, Chastain S, Quillinan N, Jevtovic-Todorovic V. Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):1-10. PubMed PMID: 31493242
  • Dietz RM, Cruz-Torres I, Orfila JE, Patsos OP, Shimizu K, Chalmers N, Deng G, Tiemeier E, Quillinan N, Herson PS. Reversal of Global Ischemia-Induced Cognitive Dysfunction by Delayed Inhibition of TRPM2 Ion Channels. Transl Stroke Res. 2020 Apr;11(2):254-266. PubMed PMID: 31250378
  • Dietz RM, Orfila JE, Chalmers N, Minjarez C, Vigil J, Deng G, Quillinan N, Herson PS. Functional Restoration following Global Cerebral Ischemia in Juvenile Mice following Inhibition of Transient Receptor Potential M2 (TRPM2) Ion Channels. Neural Plast. 2021;2021:8774663. PubMed PMID: 34659399
  • D'Souza A, Burch A, Dave KM, Sreeram A, Reynolds MJ, Dobbins DX, Kamte YS, Zhao W, Sabatelle C, Joy GM, Soman V, Chandran UR, Shiva SS, Quillinan N, Herson PS, Manickam DS. Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells. J Control Release. 2021 Oct 10;338:505-526. PubMed PMID: 34450196
  • Cabrera OH, Useinovic N, Maksimovic S, Near M, Quillinan N, Todorovic SM, Jevtovic-Todorovic V. Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons. Neurobiol Dis. 2022 Nov 10;175:105923. [Epub ahead of print] PubMed PMID: 36371060
  • Walrath T, McMahan RH, Idrovo JP, Quillinan N, Kovacs EJ. Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice. Exp Gerontol. 2022 Nov;169:111975. PubMed PMID: 36208823
  • Useinovic N, Maksimovic S, Liechty C, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. Br J Anaesth. 2022 Oct;129(4):555-566. PubMed PMID: 35701270
  • Moreno M, Minjarez C, Vigil J, Orfila JE, Schmidt R, Burch A, Carter DJ, Kubesh M, Yonchek J, Dietz RM, Quillinan N. Differences in hippocampal plasticity and memory outcomes in anterior versus posterior cerebellar stroke. Neurobiol Dis. 2022 Jun 15;168:105701. PubMed PMID: 35337949
  • Maksimovic S, Useinovic N, Quillinan N, Covey DF, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action. Int J Mol Sci. 2022 Feb 8;23(3). PubMed PMID: 35163810
  • Useinovic N, Maksimovic S, Near M, Quillinan N, Jevtovic-Todorovic V. Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?. Int J Mol Sci. 2022 Jan 20;23(3). PubMed PMID: 35163060
  • Garcia JD, Wolfe SE, Stewart AR, Tiemeier E, Gookin SE, Guerrero MB, Quillinan N, Smith KR. Distinct mechanisms drive sequential internalization and degradation of GABA(A)Rs during global ischemia and reperfusion injury. iScience. 2023 Oct 20;26(10):108061. PubMed PMID: 37860758
  • Walrath T, Najarro KM, Giesy LE, Khair S, Frank DN, Robertson CE, Orlicky DJ, Quillinan N, Idrovo JP, McMahan RH, Kovacs EJ. REMOTE BURN INJURY IN AGED MICE INDUCES COLONIC LYMPHOID AGGREGATE EXPANSION AND DYSBIOSIS OF THE FECAL MICROBIOME WHICH CORRELATES WITH NEUROINFLAMMATION. Shock. 2023 Oct 1;60(4):585-593. PubMed PMID: 37548929
  • Useinovic N, Near M, Cabrera OH, Boscolo A, Milosevic A, Harvey R, Newson A, Chastain-Potts S, Quillinan N, Jevtovic-Todorovic V. Neonatal sevoflurane exposure induces long-term changes in dendritic morphology in juvenile rats and mice. Exp Biol Med (Maywood). 2023 Apr;248(7):641-655. PubMed PMID: 37309741
  • Moreno M, Minjarez C, Todorovic SM, Quillinan N. Distinct excitability of thalamocortical neurons correlates with the presence of cerebellar afferents. bioRxiv. 2023 May 26. PubMed PMID: 37292810
  • Basak JM, Falk M, Mitchell DN, Coakley KA, Quillinan N, Orfila JE, Herson PS. Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. J Cereb Blood Flow Metab. 2023 Nov;43(2_suppl):66-77. PubMed PMID: 37150606
  • Rumian NL, Brown CN, Hendry-Hofer TB, Rossetti T, Orfila JE, Tullis JE, Dwoskin LP, Buonarati OR, Lisman JE, Quillinan N, Herson PS, Bebarta VS, Bayer KU. Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs. J Biol Chem. 2023 May;299(5):104693. PubMed PMID: 37037305
  • Frazier AP, Mitchell DN, Given KS, Hunn G, Burch AM, Childs CR, Moreno-Garcia M, Corigilano MR, Quillinan N, Macklin WB, Herson PS, Dingman AL. Chronic changes in oligodendrocyte sub-populations after middle cerebral artery occlusion in neonatal mice. Glia. 2023 Jun;71(6):1429-1450. PubMed PMID: 36794545
  • Rumian NL, Brown CN, Hendry-Hofer TB, Rossetti T, Orfila JE, Tullis JE, Dwoskin LP, Buonarati OR, Lisman JE, Quillinan N, Herson PS, Bebarta VS, Bayer KU. Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents. bioRxiv. 2023 Jan 23. PubMed PMID: 36747773
  • Cabrera OH, Useinovic N, Maksimovic S, Near M, Quillinan N, Todorovic SM, Jevtovic-Todorovic V. Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons. Neurobiol Dis. 2022 Dec;175:105923. PubMed PMID: 36371060
  • Walrath T, McMahan RH, Idrovo JP, Quillinan N, Kovacs EJ. Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice. Exp Gerontol. 2022 Nov;169:111975. PubMed PMID: 36208823
  • Useinovic N, Maksimovic S, Liechty C, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. Br J Anaesth. 2022 Oct;129(4):555-566. PubMed PMID: 35701270
  • Moreno M, Minjarez C, Vigil J, Orfila JE, Schmidt R, Burch A, Carter DJ, Kubesh M, Yonchek J, Dietz RM, Quillinan N. Differences in hippocampal plasticity and memory outcomes in anterior versus posterior cerebellar stroke. Neurobiol Dis. 2022 Jun 15;168:105701. PubMed PMID: 35337949
  • Maksimovic S, Useinovic N, Quillinan N, Covey DF, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action. Int J Mol Sci. 2022 Feb 8;23(3). PubMed PMID: 35163810
  • Useinovic N, Maksimovic S, Near M, Quillinan N, Jevtovic-Todorovic V. Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?. Int J Mol Sci. 2022 Jan 20;23(3). PubMed PMID: 35163060
  • Burch AM, Garcia JD, O'Leary H, Haas A, Orfila JE, Tiemeier E, Chalmers N, Smith KR, Quillinan N, Herson PS. TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia. J Neurosci. 2024 May 8;44(19). PubMed PMID: 38565288
  • Oshima K, Siddiqui N, Orfila JE, Carter D, Laing J, Han X, Zakharevich I, Iozzo RV, Ghasabyan A, Moore H, Zhang F, Linhardt RJ, Moore EE, Quillinan N, Schmidt EP, Herson PS, Hippensteel JA. A role for decorin in improving motor deficits after traumatic brain injury. Matrix Biol. 2024 Jan;125:88-99. PubMed PMID: 38135163
  • Garcia JD, Wolfe SE, Stewart AR, Tiemeier E, Gookin SE, Guerrero MB, Quillinan N, Smith KR. Distinct mechanisms drive sequential internalization and degradation of GABA(A)Rs during global ischemia and reperfusion injury. iScience. 2023 Oct 20;26(10):108061. PubMed PMID: 37860758
  • Walrath T, Najarro KM, Giesy LE, Khair S, Frank DN, Robertson CE, Orlicky DJ, Quillinan N, Idrovo JP, McMahan RH, Kovacs EJ. REMOTE BURN INJURY IN AGED MICE INDUCES COLONIC LYMPHOID AGGREGATE EXPANSION AND DYSBIOSIS OF THE FECAL MICROBIOME WHICH CORRELATES WITH NEUROINFLAMMATION. Shock. 2023 Oct 1;60(4):585-593. PubMed PMID: 37548929
  • Useinovic N, Near M, Cabrera OH, Boscolo A, Milosevic A, Harvey R, Newson A, Chastain-Potts S, Quillinan N, Jevtovic-Todorovic V. Neonatal sevoflurane exposure induces long-term changes in dendritic morphology in juvenile rats and mice. Exp Biol Med (Maywood). 2023 Apr;248(7):641-655. PubMed PMID: 37309741
  • Moreno M, Minjarez C, Todorovic SM, Quillinan N. Distinct excitability of thalamocortical neurons correlates with the presence of cerebellar afferents. bioRxiv. 2023 May 26. PubMed PMID: 37292810
  • Basak JM, Falk M, Mitchell DN, Coakley KA, Quillinan N, Orfila JE, Herson PS. Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. J Cereb Blood Flow Metab. 2023 Nov;43(2_suppl):66-77. PubMed PMID: 37150606
  • Rumian NL, Brown CN, Hendry-Hofer TB, Rossetti T, Orfila JE, Tullis JE, Dwoskin LP, Buonarati OR, Lisman JE, Quillinan N, Herson PS, Bebarta VS, Bayer KU. Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs. J Biol Chem. 2023 May;299(5):104693. PubMed PMID: 37037305
  • Frazier AP, Mitchell DN, Given KS, Hunn G, Burch AM, Childs CR, Moreno-Garcia M, Corigilano MR, Quillinan N, Macklin WB, Herson PS, Dingman AL. Chronic changes in oligodendrocyte sub-populations after middle cerebral artery occlusion in neonatal mice. Glia. 2023 Jun;71(6):1429-1450. PubMed PMID: 36794545
  • Rumian NL, Brown CN, Hendry-Hofer TB, Rossetti T, Orfila JE, Tullis JE, Dwoskin LP, Buonarati OR, Lisman JE, Quillinan N, Herson PS, Bebarta VS, Bayer KU. Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents. bioRxiv. 2023 Jan 23. PubMed PMID: 36747773