Eric Poeschla, MD

Professional Titles

• Tim Gill Professor of Medicine, Division of Infectious Diseases

Recognitions

• Elected to American Association of Physicians, AAP (2016)
• Pfizer Scholars Award for New Faculty, Pfizer Scholars Program (1998)
• Peter F. Curran Research Prize, Yale Medical School (1988)

Research Interests

Eric M. Poeschla, M.D., is a Professor of Medicine (Infectious Diseases) at the University of Colorado School of Medicine. He graduated from Yale Medical School and completed his clinical residency in internal medicine at UC San Francisco, followed by a fellowship in infectious diseases and molecular virology at UC San Diego. Before joining the University of Colorado, he was on the faculty of the Department of Molecular Medicine at the Mayo Clinic College of Medicine. His research group investigates the roles that cellular proteins play in HIV-1 and other viral replication cycles, and innate immune system factors that mediate frontline antiviral defenses and prevent cross-species virus transmission. They are interested in cellular systems that sense and respond defensively to viral RNA (e.g., MDA5) and DNA and also prevent autoimmunity to self nucleic acids.

Publications

• Yang Q, Meyerson NR, Paige CL, Morrison JH, Clark SK, Fattor WT, Decker CJ, Steiner HR, Lian E, Larremore DB, Perera R, Poeschla EM, Parker R, Dowell RD, Sawyer SL. Human mRNA in saliva can correctly identify individuals harboring acute infection. mBio. 2023 Nov 9;14(6):e0171223. PubMed PMID: 37943059
• Morrison JH, Poeschla EM. The Feline Immunodeficiency Virus Envelope Signal Peptide Is a Tetherin Antagonizing Protein. mBio. 2023 Apr 25;14(2):e0016123. PubMed PMID: 36927083
• Singh PK, Li W, Bedwell GJ, Fadel HJ, Poeschla EM, Engelman AN. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 2022 Aug 26;14(9). PubMed PMID: 36146690
• Francis AC, Cereseto A, Singh PK, Shi J, Poeschla E, Engelman AN, Aiken C, Melikyan GB. Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles. PLoS Pathog. 2022 Aug;18(8):e1010754. PubMed PMID: 35951676
• Guo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203760119. PubMed PMID: 35867811
• Ballandras-Colas A, Chivukula V, Gruszka DT, Shan Z, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P. Multivalent interactions essential for lentiviral integrase function. Nat Commun. 2022 May 3;13(1):2416. PubMed PMID: 35504909
• Niemeyer BF, Miller CM, Ledesma-Feliciano C, Morrison JH, Jimenez-Valdes R, Clifton C, Poeschla EM, Benam KH. Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia. Nano Sel. 2022 Feb;3(2):437-449. PubMed PMID: 34541574
• Allison Ballandras-Colas, Vidya Chivukula, Dominika T. Gruszka, Zelin Shan, Parmit K. Singh, Valerie E. Pye, Rebecca K. McLean, Gregory J. Bedwell, Wen Li, Andrea Nans, Nicola J. Cook, Hind J. Fadel, Eric M. Poeschla, David J. Griffiths, Javier Vargas, Ian A. Taylor, Dmitry Lyumkis, Hasan Yardimci, Alan N. Engelman, and Peter Cherepanov. The hexadecameric intasome architecture is critical for MVV integration and infectivity. In final revision, 2022.
• Morrison JH, Poeschla EM. A lentiviral signal sequence is a Tetherin Antagonizing Protein. Submitted, Oct 2021, in revision 2022.
• Niemeyer BF, Miller CM, Ledesma-Feliciano C, Morrison JH, Jimenez-Valdes R, Clifton C, Poeschla EM, Benam KH. Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia. Nano Sel. 2021 Jun 30. [Epub ahead of print] PubMed PMID: 34541574
• Guo K, Barrett BS, Mickens KL, Vladar EK, Morrison JH, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon Resistance of Emerging SARS-CoV-2 Variants. bioRxiv. 2021 Dec 10. PubMed PMID: 33758840. (Published as pre-print; submitted to journal Feb 2022).
• Rebensburg SV, Wei G, Larue RC, Lindenberger J, Francis AC, Annamalai AS, Morrison J, Shkriabai N, Huang SW, KewalRamani V, Poeschla EM, Melikyan GB, Kvaratskhelia M. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nat Microbiol. 2021 Apr;6(4):435-444. PubMed PMID: 33649557
• Miller MA, Molina KC, Gutman JA, Scherger S, Lum JM, Mossad SB, Burgess M, Cheng MP, Chuang ST, Jacobs SE, Melendez DP, Shah DP, Zimmer A, Sohail MR, Syed S, Walker RC, Poeschla EM, Abidi MZ. Mucormycosis in Hematopoietic Cell Transplant Recipients and in Patients With Hematological Malignancies in the Era of New Antifungal Agents. Open Forum Infect Dis. 2021 Feb;8(2):ofaa646. PubMed PMID: 33575424
• Franco-Paredes C, Ghandnoosh N, Latif H, Krsak M, Henao-Martinez AF, Robins M, Vargas Barahona L, Poeschla EM. Decarceration and community re-entry in the COVID-19 era. Lancet Infect Dis. 2021 Jan;21(1):e11-e16. PubMed PMID: 33007225
• Miller MA, Molina KC, Gutman JA, Scherger S, Lum JM, Mossad SB, Burgess M, Cheng MP, Chuang ST, Jacobs SE, Melendez DP, Shah DP, Zimmer A, Sohail MR, Syed S, Walker RC, Poeschla EM, Abidi MZ. Mucormycosis in Hematopoietic Cell Transplant Recipients and in Patients With Hematological Malignancies in the Era of New Antifungal Agents. Open Forum Infect Dis. 2021 Feb;8(2):ofaa646. PubMed PMID: 33575424
• Franco-Paredes C, Ghandnoosh N, Latif H, Krsak M, Henao-Martinez AF, Robins M, Vargas Barahona L, Poeschla EM. Decarceration and community re-entry in the COVID-19 era. Lancet Infect Dis. 2021 Jan;21(1):e11-e16. PubMed PMID: 33007225
• Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. mBio. 2020 Sep 29;11(5). PubMed PMID: 32994325
• Morrison JH, Miller C, Bankers L, Crameri G, Wang LF, Poeschla EM. A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat. mBio. 2020 Sep 15;11(5). PubMed PMID: 32934084
• Bonfiglio G, Rosal K, Henao-Martínez A, Franco-Paredes C, Poeschla EM, Moo-Young J, Seefeldt T, Dunlevy H, Haas M, Young J. The long journey inside immigration detention centres in the USA. J Travel Med. 2020 Nov 9;27(7). PubMed PMID: 32463091
• Krsak M, Johnson SC, Poeschla EM. COVID-19 Serosurveillance May Facilitate Return-to-Work Decisions. Am J Trop Med Hyg. 2020 Jun;102(6):1189-1190. PubMed PMID: 32329432
• Bankers L, Miller C, Liu G, Thongkittidilok C, Morrison J, Poeschla EM. Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation. J Immunol. 2020 May 15;204(10):2791-2807. PubMed PMID: 32277054
• Krsak M, Morrisette T, Miller M, Molina K, Huang M, Damioli L, Pisney L, Wong M, Poeschla E. Advantages of Outpatient Treatment with Long-Acting Lipoglycopeptides for Serious Gram-Positive Infections: A Review. Pharmacotherapy. 2020 May;40(5):469-478. PubMed PMID: 32239771
• Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease. J Virol. 2020 Apr 16;94(9). PubMed PMID: 32051266
• Poeschla M, Valenzano DR. The turquoise killifish: a genetically tractable model for the study of aging. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1). PubMed PMID: 32034047
• Chand S, Thapa S, Kon S, Johnson SC, Poeschla EM, Franco-Paredes C, Rodríguez-Morales AJ, Mattar S, Henao-Martínez AF. Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019. Emerg Infect Dis. 2020 Feb;26(2):383-385. PubMed PMID: 31961310
• Godavarthy A, Kelly R, Jimah J, Beckford M, Caza T, Fernandez D, Huang N, Duarte M, Lewis J, Fadel HJ, Poeschla EM, Banki K, Perl A. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. JCI Insight. 2020 Jan 16;5(1). PubMed PMID: 31805010
• Poeschla E. Neutralizing SARS-CoV-2. Elife. 2020 Dec 15;9. PubMed PMID: 33320086
• Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 Oct 16;370(6514):360-364. PubMed PMID: 33060363
• Bester S, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble V, Francis A, Annamalai A, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman A, Melikyan G, Griffin P, Fuchs JR, Asturias F, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science, vol. 370 (6514):360-364), 2020.
• Poeschla, E. (2020). Neutralizing SARS-CoV-2. eLife 9. 9:e64496. doi: 10.7554/eLife.64496.
• Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease. J Virol. 2020 Feb 12. [Epub ahead of print] PubMed PMID: 32051266
• Poeschla M, Valenzano DR. The turquoise killifish: a genetically tractable model for the study of aging. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1). PubMed PMID: 32034047
• Chand S, Thapa S, Kon S, Johnson SC, Poeschla EM, Franco-Paredes C, Rodríguez-Morales AJ, Mattar S, Henao-Martínez AF. Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019. Emerg Infect Dis. 2020 Feb;26(2):383-385. PubMed PMID: 31961310
• Godavarthy A, Kelly R, Jimah J, Beckford M, Caza T, Fernandez D, Huang N, Duarte M, Lewis J, Fadel HJ, Poeschla EM, Banki K, Perl A. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. JCI Insight. 2020 Jan 16;5(1). PubMed PMID: 31805010
• Decker CJ, Steiner HR, Hoon-Hanks LL, Morrison JH, Haist KC, Stabell AC, Poeschla EM, Morrison TE, Stenglein MD, Sawyer SL, Parker R. dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA. Viruses. 2019 Oct 14;11(10). PubMed PMID: 31615058
• Krsak M, Patel NU, Poeschla EM. Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. Am J Trop Med Hyg. 2019 Mar;100(3):588-590. PubMed PMID: 30628571
• Krsak M, Patel NU, Poeschla EM. Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. Am J Trop Med Hyg. 2019 Jan 7. [Epub ahead of print] PubMed PMID: 30628571
• Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. PubMed PMID: 30173955
• Kumar S, Morrison JH, Dingli D, Poeschla E. HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. J Virol. 2018 Aug 15;92(16). PubMed PMID: 29769349
• Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. PubMed PMID: 26858452
• Painter MM, Morrison JH, Zoecklein LJ, Rinkoski TA, Watzlawik JO, Papke LM, Warrington AE, Bieber AJ, Matchett WE, Turkowski KL, Poeschla EM, Rodriguez M. Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. PLoS Pathog. 2016: 11(12):e1005311. PubMed PMID: 26633895
• Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. PubMed PMID: 26858452
• Painter MM, Morrison JH, Zoecklein LJ, Rinkoski TA, Watzlawik JO, Papke LM, Warrington AE, Bieber AJ, Matchett WE, Turkowski KL, Poeschla EM*, Rodriguez M. Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. PLoS Pathog. 2015 Dec;11(12):e1005311. PubMed PMID: 26633895. *Sole corresponding author. Wrote paper.
• Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL. LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev. 2015 Nov 1;29(21):2287-97. PubMed PMID: 26545813
• Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy DN, Lesbats P, Saïb A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration. Retrovirology. 2015 Mar 12;12:24. PubMed PMID: 25808736
• Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb;185(2):496-512. PubMed PMID: 25499974
• Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy D, Lesbats P, Saib A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase Inhibitor Reversal Dynamics Indicate Unintegrated HIV-1 DNA Initiates De Novo Integration. Retrovirology, in press.
• Poeschla EM. Hemingway's Last Letter. Southwest Review, 100th Anniversary Edition
• Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb;185(2):496-512. PubMed PMID: 25499974
• Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of N ¿ -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25;11(1):100. [Epub ahead of print] PubMed PMID: 25421939
• Abidi MZ, Sohail MR, Cummins N, Wilhelm M, Wengenack N, Brumble L, Shah H, Jane Hata D, McCullough A, Wendel A, Vikram HR, Kusne S, Litzow M, Letendre L, Lahr BD, Poeschla E, Walker RC. Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: a comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies. Mycoses. 2014 Nov;57(11):687-98. PubMed PMID: 25040241
• Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014 Sep 1;88(17):9704-17. PubMed PMID: 24942577
• Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014 May;10(5):e1004171. PubMed PMID: 24874515
• Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014 Feb;10(2):e1003969. PubMed PMID: 24586169
• Morrison JH, Guevara RB, Marcano AC, Saenz DT, Fadel HJ, Rogstad DK, Poeschla EM. Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation. J Virol. 2014 Mar;88(6):3255-72. PubMed PMID: 24390322
• Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol Carcinog. 2014 Apr;53(4):300-13. PubMed PMID: 23138933
• Kumar S, Morrison J, Dingli D, Poeschla E. HIV-1 activation of innate immunity depends strongly on the intracellular level of TREX1 and sensing of incomplete reverse transcription products. Journal of Virology, 2018
• Vasudevan A, Jill M. Perreira3, Sowd G, Puray-Chavez M, Paulucci-Holthauzen A, Wu X, Fadel H, Poeschla EM, Multani A, Hughes S, Sarafianos SG, Brass A, Engelman A. Pan-Nuclear Distribution of HIV-1 Preintegration Complexes for Viral DNA Integration . In Press, Cell Host and Microbe, 2018
• Liu G, Morisson J, Poeschla E.

Professional Memberships

• Association of American Physicians (AAP), Elected 2016
• Editorial Boards, Journal of Virology, Viruses, Member
• American Society of Virology (ASV), Member
• Association of American Immunologists (AAI), Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Infectious Disease, Board Certification
• Internal Medicine, Board Certification
• ABIM, Board Certification (0001)