Eric Poeschla, MD

Professional Titles

• Tim Gill Professor of Medicine, Division of Infectious Diseases

Recognitions

• Elected to American Association of Physicians, AAP (2016)
• Pfizer Scholars Award for New Faculty, Pfizer Scholars Program (1998)
• Peter F. Curran Research Prize, Yale Medical School (1988)

Research Interests

Eric M. Poeschla, M.D., is a Professor of Medicine (Infectious Diseases) at the University of Colorado School of Medicine. He graduated from Yale Medical School and completed his clinical residency in internal medicine at UC San Francisco, followed by a fellowship in infectious diseases and molecular virology at UC San Diego. Before joining the University of Colorado, he was on the faculty of the Department of Molecular Medicine at the Mayo Clinic College of Medicine. His research group investigates the roles that cellular proteins play in HIV-1 and other viral replication cycles, and innate immune system factors that mediate frontline antiviral defenses and prevent cross-species virus transmission. They are interested in cellular systems that sense and respond defensively to viral RNA (e.g., MDA5) and DNA and also prevent autoimmunity to self nucleic acids.

Publications

• Miller CM, Morrison JH, Bankers L, Dran R, Kendrick JM, Briggs E, Ferguson VL, Poeschla EM. ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy. mBio. 2025 Aug 13;16(8):e0149225. PubMed PMID: 40693792
• Miller CM, Morrison JH, Bankers L, Dran R, Kendrick JM, Briggs E, Ferguson VL, Poeschla EM. ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy. bioRxiv. 2025 May 28. PubMed PMID: 39896491
• Tedbury PR, Mahboubi D, Puray-Chavez M, Shah R, Ukah OB, Wahoski CC, Fadel HJ, Poeschla EM, Gao X, McFadden WM, Gaitanidou M, Kesesidis N, Kirby KA, Vanderford TH, Kvaratskhelia M, Achuthan V, Behrens RT, Engelman AN, Sarafianos SG. Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome. bioRxiv. 2024 Dec 6. PubMed PMID: 39677798
• Yang Q, Meyerson NR, Paige CL, Morrison JH, Clark SK, Fattor WT, Decker CJ, Steiner HR, Lian E, Larremore DB, Perera R, Poeschla EM, Parker R, Dowell RD, Sawyer SL. Human mRNA in saliva can correctly identify individuals harboring acute infection. mBio. 2023 Nov 9;14(6):e0171223. PubMed PMID: 37943059
• Morrison JH, Poeschla EM. The Feline Immunodeficiency Virus Envelope Signal Peptide Is a Tetherin Antagonizing Protein. mBio. 2023 Apr 25;14(2):e0016123. PubMed PMID: 36927083
• Allison Ballandras-Colas, Vidya Chivukula, Dominika T. Gruszka, Zelin Shan, Parmit K. Singh, Valerie E. Pye, Rebecca K. McLean, Gregory J. Bedwell, Wen Li, Andrea Nans, Nicola J. Cook, Hind J. Fadel, Eric M. Poeschla, David J. Griffiths, Javier Vargas, Ian A. Taylor, Dmitry Lyumkis, Hasan Yardimci, Alan N. Engelman, and Peter Cherepanov. The hexadecameric intasome architecture is critical for MVV integration and infectivity. In final revision, 2022.
• Singh PK, Li W, Bedwell GJ, Fadel HJ, Poeschla EM, Engelman AN. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 2022 Aug 26;14(9). PubMed PMID: 36146690
• Francis AC, Cereseto A, Singh PK, Shi J, Poeschla E, Engelman AN, Aiken C, Melikyan GB. Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles. PLoS Pathog. 2022 Aug;18(8):e1010754. PubMed PMID: 35951676
• Guo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203760119. PubMed PMID: 35867811
• Ballandras-Colas A, Chivukula V, Gruszka DT, Shan Z, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P. Multivalent interactions essential for lentiviral integrase function. Nat Commun. 2022 May 3;13(1):2416. PubMed PMID: 35504909
• Niemeyer BF, Miller CM, Ledesma-Feliciano C, Morrison JH, Jimenez-Valdes R, Clifton C, Poeschla EM, Benam KH. Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia. Nano Sel. 2022 Feb;3(2):437-449. PubMed PMID: 34541574
• Morrison JH, Poeschla EM. A lentiviral signal sequence is a Tetherin Antagonizing Protein. Submitted, Oct 2021, in revision 2022.
• Niemeyer BF, Miller CM, Ledesma-Feliciano C, Morrison JH, Jimenez-Valdes R, Clifton C, Poeschla EM, Benam KH. Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia. Nano Sel. 2021 Jun 30. [Epub ahead of print] PubMed PMID: 34541574
• Guo K, Barrett BS, Mickens KL, Vladar EK, Morrison JH, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon Resistance of Emerging SARS-CoV-2 Variants. bioRxiv. 2021 Dec 10. PubMed PMID: 33758840. (Published as pre-print; submitted to journal Feb 2022).
• Rebensburg SV, Wei G, Larue RC, Lindenberger J, Francis AC, Annamalai AS, Morrison J, Shkriabai N, Huang SW, KewalRamani V, Poeschla EM, Melikyan GB, Kvaratskhelia M. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nat Microbiol. 2021 Apr;6(4):435-444. PubMed PMID: 33649557
• Miller MA, Molina KC, Gutman JA, Scherger S, Lum JM, Mossad SB, Burgess M, Cheng MP, Chuang ST, Jacobs SE, Melendez DP, Shah DP, Zimmer A, Sohail MR, Syed S, Walker RC, Poeschla EM, Abidi MZ. Mucormycosis in Hematopoietic Cell Transplant Recipients and in Patients With Hematological Malignancies in the Era of New Antifungal Agents. Open Forum Infect Dis. 2021 Feb;8(2):ofaa646. PubMed PMID: 33575424
• Franco-Paredes C, Ghandnoosh N, Latif H, Krsak M, Henao-Martinez AF, Robins M, Vargas Barahona L, Poeschla EM. Decarceration and community re-entry in the COVID-19 era. Lancet Infect Dis. 2021 Jan;21(1):e11-e16. PubMed PMID: 33007225
• Franco-Paredes C, Ghandnoosh N, Latif H, Krsak M, Henao-Martinez AF, Robins M, Vargas Barahona L, Poeschla EM. Decarceration and community re-entry in the COVID-19 era. Lancet Infect Dis. 2021 Jan;21(1):e11-e16. PubMed PMID: 33007225
• Miller MA, Molina KC, Gutman JA, Scherger S, Lum JM, Mossad SB, Burgess M, Cheng MP, Chuang ST, Jacobs SE, Melendez DP, Shah DP, Zimmer A, Sohail MR, Syed S, Walker RC, Poeschla EM, Abidi MZ. Mucormycosis in Hematopoietic Cell Transplant Recipients and in Patients With Hematological Malignancies in the Era of New Antifungal Agents. Open Forum Infect Dis. 2021 Feb;8(2):ofaa646. PubMed PMID: 33575424
• Poeschla E. Neutralizing SARS-CoV-2. Elife. 2020 Dec 15;9. PubMed PMID: 33320086
• Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 Oct 16;370(6514):360-364. PubMed PMID: 33060363
• Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. mBio. 2020 Sep 29;11(5). PubMed PMID: 32994325
• Morrison JH, Miller C, Bankers L, Crameri G, Wang LF, Poeschla EM. A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat. mBio. 2020 Sep 15;11(5). PubMed PMID: 32934084
• Bonfiglio G, Rosal K, Henao-Martínez A, Franco-Paredes C, Poeschla EM, Moo-Young J, Seefeldt T, Dunlevy H, Haas M, Young J. The long journey inside immigration detention centres in the USA. J Travel Med. 2020 Nov 9;27(7). PubMed PMID: 32463091
• Krsak M, Johnson SC, Poeschla EM. COVID-19 Serosurveillance May Facilitate Return-to-Work Decisions. Am J Trop Med Hyg. 2020 Jun;102(6):1189-1190. PubMed PMID: 32329432
• Bankers L, Miller C, Liu G, Thongkittidilok C, Morrison J, Poeschla EM. Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation. J Immunol. 2020 May 15;204(10):2791-2807. PubMed PMID: 32277054
• Krsak M, Morrisette T, Miller M, Molina K, Huang M, Damioli L, Pisney L, Wong M, Poeschla E. Advantages of Outpatient Treatment with Long-Acting Lipoglycopeptides for Serious Gram-Positive Infections: A Review. Pharmacotherapy. 2020 May;40(5):469-478. PubMed PMID: 32239771
• Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease. J Virol. 2020 Apr 16;94(9). PubMed PMID: 32051266
• Poeschla M, Valenzano DR. The turquoise killifish: a genetically tractable model for the study of aging. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1). PubMed PMID: 32034047
• Chand S, Thapa S, Kon S, Johnson SC, Poeschla EM, Franco-Paredes C, Rodríguez-Morales AJ, Mattar S, Henao-Martínez AF. Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019. Emerg Infect Dis. 2020 Feb;26(2):383-385. PubMed PMID: 31961310
• Godavarthy A, Kelly R, Jimah J, Beckford M, Caza T, Fernandez D, Huang N, Duarte M, Lewis J, Fadel HJ, Poeschla EM, Banki K, Perl A. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. JCI Insight. 2020 Jan 16;5(1). PubMed PMID: 31805010
• Bester S, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble V, Francis A, Annamalai A, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman A, Melikyan G, Griffin P, Fuchs JR, Asturias F, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science, vol. 370 (6514):360-364), 2020.
• Poeschla, E. (2020). Neutralizing SARS-CoV-2. eLife 9. 9:e64496. doi: 10.7554/eLife.64496.
• Miller CM, Barrett BS, Chen J, Morrison JH, Radomile C, Santiago ML, Poeschla EM. Systemic Expression of a Viral RdRP Protects Against Retrovirus Infection and Disease. J Virol. 2020 Feb 12. [Epub ahead of print] PubMed PMID: 32051266
• Poeschla M, Valenzano DR. The turquoise killifish: a genetically tractable model for the study of aging. J Exp Biol. 2020 Feb 7;223(Pt Suppl 1). PubMed PMID: 32034047
• Chand S, Thapa S, Kon S, Johnson SC, Poeschla EM, Franco-Paredes C, Rodríguez-Morales AJ, Mattar S, Henao-Martínez AF. Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019. Emerg Infect Dis. 2020 Feb;26(2):383-385. PubMed PMID: 31961310
• Godavarthy A, Kelly R, Jimah J, Beckford M, Caza T, Fernandez D, Huang N, Duarte M, Lewis J, Fadel HJ, Poeschla EM, Banki K, Perl A. Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. JCI Insight. 2020 Jan 16;5(1). PubMed PMID: 31805010
• Decker CJ, Steiner HR, Hoon-Hanks LL, Morrison JH, Haist KC, Stabell AC, Poeschla EM, Morrison TE, Stenglein MD, Sawyer SL, Parker R. dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA. Viruses. 2019 Oct 14;11(10). PubMed PMID: 31615058
• Krsak M, Patel NU, Poeschla EM. Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. Am J Trop Med Hyg. 2019 Mar;100(3):588-590. PubMed PMID: 30628571
• Krsak M, Patel NU, Poeschla EM. Case Report: Hepatic Fascioliasis in a Young Afghani Woman with Severe Wheezing, High-Grade Peripheral Eosinophilia, and Liver Lesions: A Brief Literature Review. Am J Trop Med Hyg. 2019 Jan 7. [Epub ahead of print] PubMed PMID: 30628571
• Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. PubMed PMID: 30173955
• Kumar S, Morrison JH, Dingli D, Poeschla E. HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. J Virol. 2018 Aug 15;92(16). PubMed PMID: 29769349
• Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. PubMed PMID: 26858452
• Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. PubMed PMID: 26858452
• Painter MM, Morrison JH, Zoecklein LJ, Rinkoski TA, Watzlawik JO, Papke LM, Warrington AE, Bieber AJ, Matchett WE, Turkowski KL, Poeschla EM, Rodriguez M. Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. PLoS Pathog. 2016: 11(12):e1005311. PubMed PMID: 26633895
• Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy D, Lesbats P, Saib A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase Inhibitor Reversal Dynamics Indicate Unintegrated HIV-1 DNA Initiates De Novo Integration. Retrovirology, in press.
• Poeschla EM. Hemingway's Last Letter. Southwest Review, 100th Anniversary Edition
• Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb;185(2):496-512. PubMed PMID: 25499974
• Painter MM, Morrison JH, Zoecklein LJ, Rinkoski TA, Watzlawik JO, Papke LM, Warrington AE, Bieber AJ, Matchett WE, Turkowski KL, Poeschla EM*, Rodriguez M. Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity. PLoS Pathog. 2015 Dec;11(12):e1005311. PubMed PMID: 26633895. *Sole corresponding author. Wrote paper.
• Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL. LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev. 2015 Nov 1;29(21):2287-97. PubMed PMID: 26545813
• Thierry S, Munir S, Thierry E, Subra F, Leh H, Zamborlini A, Saenz D, Levy DN, Lesbats P, Saïb A, Parissi V, Poeschla E, Deprez E, Delelis O. Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration. Retrovirology. 2015 Mar 12;12:24. PubMed PMID: 25808736
• Pattabiraman PP, Rinkoski T, Poeschla E, Proia A, Challa P, Rao PV. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Am J Pathol. 2015 Feb;185(2):496-512. PubMed PMID: 25499974
• Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of N ¿ -protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25;11(1):100. [Epub ahead of print] PubMed PMID: 25421939
• Abidi MZ, Sohail MR, Cummins N, Wilhelm M, Wengenack N, Brumble L, Shah H, Jane Hata D, McCullough A, Wendel A, Vikram HR, Kusne S, Litzow M, Letendre L, Lahr BD, Poeschla E, Walker RC. Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: a comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies. Mycoses. 2014 Nov;57(11):687-98. PubMed PMID: 25040241
• Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014 Sep 1;88(17):9704-17. PubMed PMID: 24942577
• Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014 May;10(5):e1004171. PubMed PMID: 24874515
• Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014 Feb;10(2):e1003969. PubMed PMID: 24586169
• Morrison JH, Guevara RB, Marcano AC, Saenz DT, Fadel HJ, Rogstad DK, Poeschla EM. Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation. J Virol. 2014 Mar;88(6):3255-72. PubMed PMID: 24390322
• Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Mol Carcinog. 2014 Apr;53(4):300-13. PubMed PMID: 23138933
• Poeschla E. The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis. Virology. 2013 Jun 20;441(1):1-11. PubMed PMID: 23561461
• Boisgerault N, Kottke T, Pulido J, Thompson J, Diaz RM, Rommelfanger-Konkol D, Embry A, Saenz D, Poeschla E, Pandha H, Harrington K, Melcher A, Selby P, Vile R. Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse. Mol Ther. 2013 Aug;21(8):1507-16. PubMed PMID: 23752316
• Bancos I, Bida JP, Tian D, Bundrick M, John K, Holte MN, Her YF, Evans D, Saenz DT, Poeschla EM, Hook D, Georg G, Maher LJ 3rd. High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma. PLoS One. 2013;8(2):e56827. PubMed PMID: 23451094
• Elinav H, Wu Y, Coskun A, Hryckiewicz K, Kemler I, Hu Y, Rogers H, Hao B, Ben Mamoun C, Poeschla E, Sutton R. Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. J Virol. 2012 Nov;86(22):12053-68. PubMed PMID: 22933280
• Fadel HJ, Saenz DT, Poeschla EM. Construction and testing of orfA +/- FIV reporter viruses. Viruses. 2012 Jan;4(1):184-99. PubMed PMID: 22355458
• Fadel HJ, Saenz DT, Guevara R, von Messling V, Peretz M, Poeschla EM. Productive replication and evolution of HIV-1 in ferret cells. J Virol. 2012 Feb;86(4):2312-22. PubMed PMID: 22171279
• Kemler I, Saenz D, Poeschla E. Feline immunodeficiency virus Gag is a nuclear shuttling protein. J Virol. 2012 Aug;86(16):8402-11. PubMed PMID: 22623802
• Poeschla EM. Primate and feline lentiviruses in current intrinsic immunity research: the cat is back. Vet Immunol Immunopathol. 2011 Oct 15;143(3-4):215-20. PubMed PMID: 21715025
• Fadel HJ, Poeschla EM. Retroviral restriction and dependency factors in primates and carnivores. Vet Immunol Immunopathol. 2011 Oct 15;143(3-4):179-89. PubMed PMID: 21715018
• Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD. The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak. J Virol. 2011 Aug;85(16):7965-75. PubMed PMID: 21653671
• Meehan AM, Saenz DT, Morrison J, Hu C, Peretz M, Poeschla EM. LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity. J Virol. 2011 Apr;85(7):3570-83. PubMed PMID: 21270171
• Hu C, Saenz DT, Fadel HJ, Walker W, Peretz M, Poeschla EM. The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F. J Virol. 2010 Nov;84(22):11981-93. PubMed PMID: 20844042
• Barraza RA, McLaren JW, Poeschla EM. Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure. Mol Ther. 2010 Mar;18(3):491-501. PubMed PMID: 19953083
• Stern MA, Hu C, Saenz DT, Fadel HJ, Sims O, Peretz M, Poeschla EM. Productive replication of Vif-chimeric HIV-1 in feline cells. J Virol. 2010 Jul;84(14):7378-95. PubMed PMID: 20463079
• Meehan AM, Poeschla EM. Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses. Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):182-91. PubMed PMID: 19836475
• Kemler I, Meehan A, Poeschla EM. Live-cell coimaging of the genomic RNAs and Gag proteins of two lentiviruses. J Virol. 2010 Jul;84(13):6352-66. PubMed PMID: 20392841
• Lachance DH, Lennon VA, Pittock SJ, Tracy JA, Krecke KN, Amrami KK, Poeschla EM, Orenstein R, Scheithauer BW, Sejvar JJ, Holzbauer S, Devries AS, Dyck PJ. An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study. Lancet Neurol. 2010 Jan;9(1):55-66. PubMed PMID: 19945916
• Barraza RA, Rasmussen CA, Loewen N, Cameron JD, Gabelt BT, Teo WL, Kaufman PL, Poeschla EM. Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates. Hum Gene Ther. 2009 Mar;20(3):191-200. PubMed PMID: 19301472
• Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM. LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors. PLoS Pathog. 2009 Jul;5(7):e1000522. PubMed PMID: 19609362
• Miest T, Saenz D, Meehan A, Llano M, Poeschla EM. Intensive RNAi with lentiviral vectors in mammalian cells. Methods. 2009 Apr;47(4):298-303. PubMed PMID: 19041944
• Llano M, Morrison J, Poeschla EM. Virological and cellular roles of the transcriptional coactivator LEDGF/p75. Curr Top Microbiol Immunol. 2009;339:125-46. PubMed PMID: 20012527
• Llano M, Gaznick N, Poeschla EM. Rapid, controlled and intensive lentiviral vector-based RNAi. Methods Mol Biol. 2009;485:257-70. PubMed PMID: 19020831
• Ezzat MK, Howell KG, Bahler CK, Beito TG, Loewen N, Poeschla EM, Fautsch MP. Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin. Exp Eye Res. 2008 Oct;87(4):376-84. PubMed PMID: 18674535
• Barraza RA, Poeschla EM. Human gene therapy vectors derived from feline lentiviruses. Vet Immunol Immunopathol. 2008 May 15;123(1-2):23-31. PubMed PMID: 18289699
• Poeschla EM. Integrase, LEDGF/p75 and HIV replication. Cell Mol Life Sci. 2008 May;65(9):1403-24. PubMed PMID: 18264802
• Khare PD, Loewen N, Teo W, Barraza RA, Saenz DT, Johnson DH, Poeschla EM. Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork. Mol Ther. 2008 Jan;16(1):97-106. PubMed PMID: 17912236
• Diaz-Griffero F, Kar A, Lee M, Stremlau M, Poeschla E, Sodroski J. Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCyp. Virology. 2007 Dec 20;369(2):400-10. PubMed PMID: 17920096
• Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM. An essential role for LEDGF/p75 in HIV integration. Science. 2006 Oct 20;314(5798):461-4. PubMed PMID: 16959972
• Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM. Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75. J Mol Biol. 2006 Jul 21;360(4):760-73. PubMed PMID: 16793062
• Fautsch MP, Bahler CK, Vrabel AM, Howell KG, Loewen N, Teo WL, Poeschla EM, Johnson DH. Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor. Invest Ophthalmol Vis Sci. 2006 Jan;47(1):213-21. PubMed PMID: 16384965
• Temesgen Z, Cainelli F, Poeschla EM, Vlahakis SA, Vento S. Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults. Lancet Infect Dis. 2006 Aug;6(8):496-507. PubMed PMID: 16870528
• Merten CA, Stitz J, Braun G, Poeschla EM, Cichutek K, Buchholz CJ. Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles. J Virol. 2005 Jan;79(2):834-40. PubMed PMID: 15613311
• Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, Ecker JR, Bushman F. A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med. 2005 Dec;11(12):1287-9. PubMed PMID: 16311605
• Saenz DT, Teo W, Olsen JC, Poeschla EM. Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. J Virol. 2005 Dec;79(24):15175-88. PubMed PMID: 16306589
• Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J Cell Sci. 2005 Apr 15;118(Pt 8):1733-43. PubMed PMID: 15797927
• Loewen N, Poeschla EM. Lentiviral vectors. Adv Biochem Eng Biotechnol. 2005;99:169-91. PubMed PMID: 16568892
• Kemler I, Azmi I, Poeschla EM. The critical role of proximal gag sequences in feline immunodeficiency virus genome encapsidation. Virology. 2004 Sep 15;327(1):111-20. PubMed PMID: 15327902
• Loewen N, Fautsch MP, Teo WL, Bahler CK, Johnson DH, Poeschla EM. Long-term, targeted genetic modification of the aqueous humor outflow tract coupled with noninvasive imaging of gene expression in vivo. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3091-8. PubMed PMID: 15326125
• Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol. 2004 Sep;78(17):9524-37. PubMed PMID: 15308744
• Saenz DT, Loewen N, Peretz M, Whitwam T, Barraza R, Howell KG, Holmes JM, Good M, Poeschla EM. Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J Virol. 2004 Mar;78(6):2906-20. PubMed PMID: 14990709
• Nguyen KL, llano M, Akari H, Miyagi E, Poeschla EM, Strebel K, Bour S. Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression. Virology. 2004 Feb 20;319(2):163-75. PubMed PMID: 15015498
• Saenz DT, Poeschla EM. FIV: from lentivirus to lentivector. J Gene Med. 2004 Feb;6 Suppl 1:S95-104. PubMed PMID: 14978754
• Llano M, Delgado S, Vanegas M, Poeschla EM. Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase. J Biol Chem. 2004 Dec 31;279(53):55570-7. PubMed PMID: 15475359
• Poeschla EM. Non-primate lentiviral vectors. Curr Opin Mol Ther. 2003 Oct;5(5):529-40. PubMed PMID: 14601523
• Loewen N, Barraza R, Whitwam T, Saenz DT, Kemler I, Poeschla EM. FIV Vectors. Methods Mol Biol. 2003;229:251-71. PubMed PMID: 12824636
• Loewen N, Leske DA, Chen Y, Teo WL, Saenz DT, Peretz M, Holmes JM, Poeschla EM. Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium. J Gene Med. 2003 Dec;5(12):1009-17. PubMed PMID: 14661176
• Cheng L, Chaidhawangul S, Wong-Staal F, Gilbert J, Poeschla E, Toyoguchi M, El-Bradey M, Bergeron-Lynn G, Soules KA, Freeman WR. Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res. 2002 Mar;24(3):196-201. PubMed PMID: 12221527
• Meehan AM, Virk A, Swanson K, Poeschla EM. Severe pleuropulmonary paragonimiasis 8 years after emigration from a region of endemicity. Clin Infect Dis. 2002 Jul 1;35(1):87-90. PubMed PMID: 12060881
• Thompson DL, Sabbagh Y, Tenenhouse HS, Roche PC, Drezner MK, Salisbury JL, Grande JP, Poeschla EM, Kumar R. Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts. J Bone Miner Res. 2002 Feb;17(2):311-20. PubMed PMID: 11811562
• Loewen N, Bahler C, Teo WL, Whitwam T, Peretz M, Xu R, Fautsch MP, Johnson DH, Poeschla EM. Preservation of aqueous outflow facility after second-generation FIV vector-mediated expression of marker genes in anterior segments of human eyes. Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3686-90. PubMed PMID: 12454037
• Kemler I, Barraza R, Poeschla EM. Mapping the encapsidation determinants of feline immunodeficiency virus. J Virol. 2002 Dec;76(23):11889-903. PubMed PMID: 12414931
• Llano M, Kelly T, Vanegas M, Peretz M, Peterson TE, Simari RD, Poeschla EM. Blockade of human immunodeficiency virus type 1 expression by caveolin-1. J Virol. 2002 Sep;76(18):9152-64. PubMed PMID: 12186899
• Whitwam T, Peretz M, Poeschla E. Identification of a central DNA flap in feline immunodeficiency virus. J Virol. 2001 Oct;75(19):9407-14. PubMed PMID: 11533203
• Loewen N, Fautsch MP, Peretz M, Bahler CK, Cameron JD, Johnson DH, Poeschla EM. Genetic modification of human trabecular meshwork with lentiviral vectors. Hum Gene Ther. 2001 Nov 20;12(17):2109-19. PubMed PMID: 11747600
• Wong-Staal F, Poeschla EM, Looney DJ. A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther. 1998 Nov 1;9(16):2407-25. PubMed PMID: 9829540
• Poeschla EM, Wong-Staal F, Looney DJ. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nat Med. 1998 Mar;4(3):354-7. PubMed PMID: 9500613
• Poeschla EM, Looney DJ. CXCR4 is required by a nonprimate lentivirus: heterologous expression of feline immunodeficiency virus in human, rodent, and feline cells. J Virol. 1998 Aug;72(8):6858-66. PubMed PMID: 9658135
• Poeschla E, Gilbert J, Li X, Huang S, Ho A, Wong-Staal F. Identification of a human immunodeficiency virus type 2 (HIV-2) encapsidation determinant and transduction of nondividing human cells by HIV-2-based lentivirus vectors. J Virol. 1998 Aug;72(8):6527-36. PubMed PMID: 9658096
• Poeschla E, Corbeau P, Wong-Staal F. Development of HIV vectors for anti-HIV gene therapy. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11395-9. PubMed PMID: 8876146
• Yu M, Poeschla E, Yamada O, Degrandis P, Leavitt MC, Heusch M, Yees JK, Wong-Staal F, Hampel A. In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology. 1995 Jan 10;206(1):381-6. PubMed PMID: 7831794
• Leavitt MC, Yu M, Yamada O, Kraus G, Looney D, Poeschla E, Wong-Staal F. Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes. Hum Gene Ther. 1994 Sep;5(9):1115-20. PubMed PMID: 7833371
• Poeschla E, Wong-Staal F. Antiviral and anticancer ribozymes. Curr Opin Oncol. 1994 Nov;6(6):601-6. PubMed PMID: 7827172
• Yu M, Poeschla E, Wong-Staal F. Progress towards gene therapy for HIV infection. Gene Ther. 1994 Jan;1(1):13-26. PubMed PMID: 7584055
• Poeschla E, Wong-Staal F. Molecular biology of HIV: challenges for the second decade. AIDS Res Hum Retroviruses. 1994 Feb;10(2):111-2. PubMed PMID: 8198866
• Kumar S, Morrison J, Dingli D, Poeschla E. HIV-1 activation of innate immunity depends strongly on the intracellular level of TREX1 and sensing of incomplete reverse transcription products. Journal of Virology, 2018
• Vasudevan A, Jill M. Perreira3, Sowd G, Puray-Chavez M, Paulucci-Holthauzen A, Wu X, Fadel H, Poeschla EM, Multani A, Hughes S, Sarafianos SG, Brass A, Engelman A. Pan-Nuclear Distribution of HIV-1 Preintegration Complexes for Viral DNA Integration . In Press, Cell Host and Microbe, 2018
• Liu G, Morisson J, Poeschla E.

Professional Memberships

• Association of American Physicians (AAP), Elected 2016
• Editorial Boards, Journal of Virology, Viruses, Member
• American Society of Virology (ASV), Member
• Association of American Immunologists (AAI), Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Infectious Disease, Board Certification
• Internal Medicine, Board Certification
• ABIM, Board Certification (0001)