Laura Pyle, PhD
Associate Professor, Pediatrics-Endocrinology

Publications

• Shah VN, Akturk HK, Vigers T, Pyle L, Oliver N, Klonoff DC. Relationship Between Daytime Versus Nighttime Continuous Glucose Monitoring Metrics with A1C in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2023 Jan;25(1):62-68. PubMed PMID: 36306519
• Schaub JA, AlAkwaa FM, McCown PJ, Naik AS, Nair V, Eddy S, Menon R, Otto EA, Demeke D, Hartman J, Fermin D, O'Connor C, Subramanian L, Bitzer M, Harned R, Ladd P, Pyle L, Pennathur S, Inoki K, Hodgin JB, Brosius FC, Nelson RG, Kretzler M, Bjornstad P. SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth onset type 2 diabetes. J Clin Invest. 2023 Jan 13. [Epub ahead of print] PubMed PMID: 36637914
• Navanandan N, Thompson T, Pyle L, Florin TA. Defining Treatment Response for Clinical Trials of Pediatric Acute Asthma. J Allergy Clin Immunol Pract. 2023 Jan 5. [Epub ahead of print] PubMed PMID: 36621607
• Vigers T, Vinovskis C, Li LP, Prasad P, Heerspink H, D'Alessandro A, Reisz JA, Piani F, Cherney DZ, van Raalte DH, Nadeau KJ, Pavkov ME, Nelson RG, Pyle L, Bjornstad P. Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes. Pediatr Nephrol. 2023 Jan;38(1):193-202. PubMed PMID: 35507146
• Nguyen-Tran H, Thompson C, Butler M, Miller KR, Pyle L, Jung S, Rogers S, Ng TFF, Routh J, Dominguez SR, Messacar K. Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA. Emerg Infect Dis. 2023 Nov;29(11):2315-2324. PubMed PMID: 37877582
• Wang CS, Sadun RE, Zhou W, Miller KR, Pyle L, Ardoin SP, Bacha C, Hause E, Hui-Yuen J, Ling N, Pereira M, Riebschleger M, Rouster-Stevens K, Sarkissian A, Shalen J, Soulsby W, Twilt M, Wu EY, Lewandowski LB, Wenderfer SE, Cooper JC. Renal Response Outcomes of the EuroLupus and NIH Cyclophosphamide Dosing Regimens in Childhood-Onset Proliferative Lupus Nephritis. Arthritis Rheumatol. 2023 Oct 6. [Epub ahead of print] PubMed PMID: 37800549
• Akturk HK, Sakamoto C, Vigers T, Shah VN, Pyle L. Minimum Sampling Duration for Continuous Glucose Monitoring Metrics to Achieve Representative Glycemic Outcomes in Suboptimal Continuous Glucose Monitor Use. J Diabetes Sci Technol. 2023 Sep 25;:19322968231200901. [Epub ahead of print] PubMed PMID: 37747124
• Conway RB, Gerard Gonzalez A, Shah VN, Geno Rasmussen C, Akturk HK, Pyle L, Forlenza G, Alonso GT, Snell-Bergeon J. Racial Disparities in Diabetes Technology Adoption and Their Association with HbA1c and Diabetic Ketoacidosis. Diabetes Metab Syndr Obes. 2023;16:2295-2310. PubMed PMID: 37551339
• Sen T, Ju W, Nair V, Ladd P, Menon R, Otto EA, Pyle L, Vigers T, Nelson RG, Arnott C, Neal B, Hansen MK, Kretzler M, Bjornstad P, Heerspink HJL. Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes. Kidney Int. 2023 Oct;104(4):828-839. PubMed PMID: 37543256
• Huang SD, Bamba V, Bothwell S, Fechner PY, Furniss A, Ikomi C, Nahata L, Nokoff NJ, Pyle L, Seyoum H, Davis SM. Development and Validation of a Computable Phenotype for Turner Syndrome Utilizing Electronic Health Records from a National Pediatric Network. medRxiv. 2023 Jul 23. PubMed PMID: 37502850
• Frost HM, Geno Rasmussen C, Shorrosh H, Pyle L, Bautista K, Frohnert BI, Stahl M, Simmons K, Steck AK, Jia X, Yu L, Rewers M. Prevalence of SARS-CoV-2 Antibodies Among Healthy Children From Colorado From 2020 to 2021: A Brief Report. J Prim Care Community Health. 2023 Jan-Dec;14:21501319231189147. PubMed PMID: 37501515
• Messer LH, Vigers T, Akturk HK, Forlenza GP, Huss KB, Karami AJ, Malecha E, Oser SM, Polsky S, Pyle L, Shah VN, Wadwa RP, Oser TK. Increasing Use of Diabetes Devices: What Do Health Care Professionals Need?. Clin Diabetes. 2023 Summer;41(3):386-398. PubMed PMID: 37456091
• Finn E, Severn C, Pyle L, Garrish J, Vigers T, Behn CGD, Zeitler PS, Sagel SD, Nadeau KJ, Chan CL. Hypoglycemia in children and young adults with cystic fibrosis during oral glucose tolerance testing vs. continuous glucose monitoring. Pediatr Pulmonol. 2023 Sep;58(9):2495-2504. PubMed PMID: 37350354
• O'Donnell HK, Trojanowski PJ, Alonso GT, Majidi S, Snell-Bergeon J, Wadwa RP, Vigers T, Pyle L, Gurka MJ, Shaffer E, Driscoll KA. A randomized controlled clinical trial to improve health outcomes in youth with type 1 diabetes: Study design and baseline characteristics. Contemp Clin Trials. 2023 Aug;131:107270. PubMed PMID: 37348599
• Corrado MM, Jia X, Geno Rasmussen C, Pyle L, Yu L, Liu E, Stahl M, Rewers MJ. Previous SARS-CoV-2 Infection Is Not Associated With Increased Celiac Disease Autoimmunity in Children and Adolescents. Am J Gastroenterol. 2023 Sep 1;118(9):1698-1700. PubMed PMID: 37159249
• Alonso GT, Triolo TM, Akturk HK, Pauley ME, Sobczak M, Forlenza GP, Sakamoto C, Pyle L, Frohnert BI. Increased Technology Use Associated With Lower A1C in a Large Pediatric Clinical Population. Diabetes Care. 2023 Jun 1;46(6):1218-1222. PubMed PMID: 37023293
• Jia X, Dong F, Pyle L, Michels AW, Yu L, Rewers M. Similar Time Course of Humoral Response to SARS-CoV-2 mRNA Vaccines in People With and Without Type 1 Diabetes. Diabetes Technol Ther. 2023 Jul;25(7):492-496. PubMed PMID: 36989496
• Gutierrez-Colina AM, Bristol M, Clark ELM, Sanchez N, Gulley LD, Ruzicka E, Handing EP, Kinsella E, Kutchman E, Witten M, Clementi MA, Thompson T, Pyle L, Aichele S, Goldschmidt AB, Belcher B, Nadeau KJ, Kelsey MM, Shomaker LB. Cognitive-behavioral therapy and exercise training in adolescent females with elevated depression symptoms and at-risk for type 2 diabetes: Protocol for a randomized controlled trial. Contemp Clin Trials. 2023 May;128:107150. PubMed PMID: 36918091
• Shah VN, Vigers T, Pyle L, Calhoun P, Bergenstal RM. Discordance Between Glucose Management Indicator and Glycated Hemoglobin in People Without Diabetes. Diabetes Technol Ther. 2023 May;25(5):324-328. PubMed PMID: 36790875
• Schaub JA, AlAkwaa FM, McCown PJ, Naik AS, Nair V, Eddy S, Menon R, Otto EA, Demeke D, Hartman J, Fermin D, O'Connor CL, Subramanian L, Bitzer M, Harned R, Ladd P, Pyle L, Pennathur S, Inoki K, Hodgin JB, Brosius FC 3rd, Nelson RG, Kretzler M, Bjornstad P. SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes. J Clin Invest. 2023 Mar 1;133(5). PubMed PMID: 36637914
• Pauley ME, Vinovskis C, MacDonald A, Baca M, Pyle L, Wadwa RP, Fornoni A, Nadeau KJ, Pavkov M, Nelson RG, Gordin D, de Boer IH, Tommerdahl KL, Bjornstad P. Triglyceride content of lipoprotein subclasses and kidney hemodynamic function and injury in adolescents with type 1 diabetes. J Diabetes Complications. 2023 Feb;37(2):108384. PubMed PMID: 36623423
• Navanandan N, Thompson T, Pyle L, Florin TA. Defining Treatment Response for Clinical Trials of Pediatric Acute Asthma. J Allergy Clin Immunol Pract. 2023 May;11(5):1450-1458.e1. PubMed PMID: 36621607
• Cho S, Vigers T, Pyle L, Franklin A, Sopfe J, Jeney F, Forlenza G. Composite Metric of Glycemic Control Q-Score Is Elevated in Pediatric and Adolescent/Young Adult Hematopoietic Stem Cell Transplant Recipients. Diabetes Technol Ther. 2023 Feb;25(2):116-121. PubMed PMID: 36511871
• Breslow E, Taylor A, Chan CL, Severn C, Pyle L, Torchen L, Sisk R, Legro R, Turcu AF, Auchus RJ, Dunaif A, Kelsey MM, Cree-Green M. 11-Oxygenated Androgen Metabolite Concentrations Are Affected by Pubertal Progression and Obesity. Horm Res Paediatr. 2023;96(4):412-422. PubMed PMID: 36446347
• Shah VN, Sakamoto C, Pyle L. Optimal Sampling Duration for Continuous Glucose Monitoring for the Estimation of Glycemia Risk Index. Diabetes Technol Ther. 2023 Feb;25(2):140-142. PubMed PMID: 36399111
• Shah VN, Akturk HK, Vigers T, Pyle L, Oliver N, Klonoff DC. Relationship Between Daytime Versus Nighttime Continuous Glucose Monitoring Metrics with A1C in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2023 Jan;25(1):62-68. PubMed PMID: 36306519
• Tinsley JP, Carpenter RD, Pyle LL, Snell-Bergeon JK, Sherk VD, Shah VN. Femoral neck structural properties are altered in adults with type 1 diabetes. J Diabetes Complications. 2022 Nov;36(11):108308. PubMed PMID: 36257238
• Kravets V, Dwulet JM, Schleicher WE, Hodson DJ, Davis AM, Pyle L, Piscopio RA, Sticco-Ivins M, Benninger RKP. Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response. PLoS Biol. 2022 Sep;20(9):e3001761. PubMed PMID: 36099294
• Mitchell AM, Baschal EE, McDaniel KA, Simmons KM, Pyle L, Waugh K, Steck AK, Yu L, Gottlieb PA, Rewers MJ, Nakayama M, Michels AW. Temporal development of T cell receptor repertoires during childhood in health and disease. JCI Insight. 2022 Sep 22;7(18). PubMed PMID: 35998036
• Magge SN, Wolf RM, Pyle L, Brown EA, Benavides VC, Bianco ME, Chao LC, Cymbaluk A, Balikcioglu PG, Halpin K, Hsia DS, Huerta-Saenz L, Kim JJ, Kumar S, Levitt Katz LE, Marks BE, Neyman A, O'Sullivan KL, Pillai SS, Shah AS, Shoemaker AH, Siddiqui JAW, Srinivasan S, Thomas IH, Tryggestad JB, Yousif MF, Kelsey MM. The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes. J Pediatr. 2022 Dec;251:51-59.e2. PubMed PMID: 35985535
• Valentine A, Davis S, Furniss A, Dowshen N, Kazak AE, Lewis C, Loeb DF, Nahata L, Pyle L, Schilling LM, Sequeira GM, Nokoff N. Multicenter Analysis of Cardiometabolic-related Diagnoses in Transgender and Gender-Diverse Youth: A PEDSnet Study. J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4004-e4014. PubMed PMID: 35945152
• Pauley ME, Vinovskis C, MacDonald A, Baca M, Pyle L, Wadwa RP, Fornoni A, Nadeau KJ, Pavkov M, Nelson RG, Gordin D, de Boer IH, Tommerdahl KL, Bjornstad P. Triglyceride content of lipoprotein subclasses and kidney hemodynamic function and injury in adolescents with type 1 diabetes. J Diabetes Complications. 2022 Dec 13;37(2):108384. [Epub ahead of print] PubMed PMID: 36623423
• Thompson T, Davis S, Janusz J, Frith E, Pyle L, Howell S, Boada R, Wilson R, Tartaglia N. Supporting students with sex chromosome aneuploidies in educational settings: Results of a nationwide survey. J Sch Psychol. 2022 Aug;93:28-40. PubMed PMID: 35934449
• Rewers M, Bonifacio E, Ewald D, Geno Rasmussen C, Jia X, Pyle L, Ziegler AG. SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents From Colorado, USA, and Bavaria, Germany. JAMA. 2022 Sep 27;328(12):1252-1255. PubMed PMID: 35930271
• Tayachew B, Vanden Brink H, Garcia-Reyes Y, Rahat H, D'Alessandro A, Frank DN, Robertson CE, Silveira L, Kelsey M, Pyle L, Cree-Green M. Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome but Affects Amino Acid Metabolism in Sera of Obese Girls With Polycystic Ovary Syndrome. Front Physiol. 2022;13:887077. PubMed PMID: 35800349
• Singh I, Noel G, Barker JM, Chatfield KC, Furniss A, Khanna AD, Nokoff NJ, Patel S, Pyle L, Nahata L, Cole FS, Ikomi C, Bamba V, Fechner PY, Davis SM. Hepatic abnormalities in youth with Turner syndrome. Liver Int. 2022 Oct;42(10):2237-2246. PubMed PMID: 35785515
• Akturk HK, Couts KL, Baschal EE, Karakus KE, Van Gulick RJ, Turner JA, Pyle L, Robinson WA, Michels AW. Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma. JAMA Netw Open. 2022 Dec 1;5(12):e2246400. PubMed PMID: 36512357
• Messer LH, Vigers T, Pyle L, Fivekiller E, Wadwa RP, Hernandez TL, Cook PF. Novel predictors of daily fluctuations in glycemia and self-management in adolescents and young adults with type 1 diabetes. Diabet Med. 2022 Sep;39(9):e14910. PubMed PMID: 35776655
• Cho S, Vigers T, Pyle L, Franklin A, Sopfe J, Jeney F, Forlenza G. Composite Metric of Glycemic Control Q-Score Is Elevated in Pediatric and Adolescent/Young Adult Hematopoietic Stem Cell Transplant Recipients. Diabetes Technol Ther. 2022 Dec 29. [Epub ahead of print] PubMed PMID: 36511871
• Breslow E, Taylor A, Chan CL, Severn C, Pyle L, Torchen L, Sisk R, Legro R, Turcu AF, Auchus RJ, Duanaif A, Kelsey MM, Cree-Green M. 11-Oxygenated Androgen Metabolite Concentrations are Affected by Pubertal Progression and Obesity. Horm Res Paediatr. 2022 Nov 29. [Epub ahead of print] PubMed PMID: 36446347
• Shah VN, Sakamoto C, Pyle L. Optimal Sampling Duration for Continuous Glucose Monitoring for the Estimation of Glycemia Risk Index. Diabetes Technol Ther. 2022 Dec 2. [Epub ahead of print] PubMed PMID: 36399111
• Wigglesworth KRS, Vigers T, Pyle L, Youngkin EM, Fay-Itzkowitz E, Tilden J, Raymond JK, Snell-Bergeon J, Sass A, Majidi S. Follow-Up Mental Health Care in Youth and Young Adults With Type 1 Diabetes After Positive Depression Screen and/or Suicidal Ideation. Clin Diabetes. 2022 Fall;40(4):449-457. PubMed PMID: 36385972
• Taylor AE, Ware MA, Breslow E, Pyle L, Severn C, Nadeau KJ, Chan CL, Kelsey MM, Cree-Green M. 11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome. J Endocr Soc. 2022 Jul 1;6(7):bvac037. PubMed PMID: 35611324
• Kim YK, Walters JA, Moss ND, Wells KL, Sheridan R, Miranda JG, Benninger RKP, Pyle LL, O'Brien RM, Sussel L, Davidson HW. Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration. Mol Metab. 2022 Dec;66:101632. PubMed PMID: 36347424
• O'Donnell HK, Vigers T, Johnson SB, Pyle L, Gonder-Fredrick L, Hendrieckx C, Driscoll KA. Bring Blood Glucose Down! An intervention to reduce fear of hypoglycemia in caregivers of adolescents with type 1 diabetes: Study design and participant characteristics. Contemp Clin Trials. 2022 Jul;118:106792. PubMed PMID: 35589025
• Melena I, Piani F, Tommerdahl KL, Severn C, Chung LT, MacDonald A, Vinovskis C, Cherney D, Pyle L, Roncal-Jimenez CA, Lanaspa MA, Rewers A, van Raalte DH, Cara-Fuentes G, Parikh CR, Nelson RG, Pavkov ME, Nadeau KJ, Johnson RJ, Bjornstad P. Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study. J Diabetes Complications. 2022 Jun;36(6):108203. PubMed PMID: 35523653
• Vo M, Miller K, Bennett TD, Mourani PM, LaVelle J, Carpenter TC, Scott Watson R, Pyle LL, Maddux AB. Postdischarge health resource use in pediatric survivors of prolonged mechanical ventilation for acute respiratory illness. Pediatr Pulmonol. 2022 Jul;57(7):1651-1659. PubMed PMID: 35438830
• Shao B, Snell-Bergeon JK, Pyle LL, Thomas KE, de Boer IH, Kothari V, Segrest J, Davidson WS, Bornfeldt KE, Heinecke JW. Pulmonary surfactant protein B carried by HDL predicts incident CVD in patients with type 1 diabetes. J Lipid Res. 2022 Apr;63(4):100196. PubMed PMID: 35300983
• Johnson MJ, Tommerdahl KL, Vinovskis C, Waikar S, Reinicke T, Parikh CR, Obeid W, Nelson RG, van Raalte DH, Pyle L, Nadeau KJ, Bjornstad P. Relationship between biomarkers of tubular injury and intrarenal hemodynamic dysfunction in youth with type 1 diabetes. Pediatr Nephrol. 2022 Dec;37(12):3085-3092. PubMed PMID: 35286453
• Maddux AB, Mourani PM, Miller K, Carpenter TC, LaVelle J, Pyle LL, Watson RS, Bennett TD. Identifying Long-Term Morbidities and Health Trajectories After Prolonged Mechanical Ventilation in Children Using State All Payer Claims Data. Pediatr Crit Care Med. 2022 Apr 1;23(4):e189-e198. PubMed PMID: 35250002
• Rydin AA, Severn C, Pyle L, Dorris K, Chambers C, Stiller D, Hankinson TC, Inge T, Haemer MA, Mirsky DM, Moore J, Kelsey MM. Novel clinical algorithm for hypothalamic obesity in youth with brain tumours and factors associated with excess weight gain. Pediatr Obes. 2022 Jul;17(7):e12903. PubMed PMID: 35224874
• Davis SM, Nokoff NJ, Furniss A, Pyle L, Valentine A, Fechner P, Ikomi C, Magnusen B, Nahata L, Vogiatzi MG, Dempsey A. Population-based Assessment of Cardiometabolic-related Diagnoses in Youth With Klinefelter Syndrome: A PEDSnet Study. J Clin Endocrinol Metab. 2022 Apr 19;107(5):e1850-e1859. PubMed PMID: 35106546
• Looker HC, Pyle L, Vigers T, Severn C, Saulnier PJ, Najafian B, Mauer M, Nelson RG, Bjornstad P. Structural Lesions on Kidney Biopsy in Youth-Onset and Adult-Onset Type 2 Diabetes. Diabetes Care. 2022 Feb 1;45(2):436-443. PubMed PMID: 35006272
• Sklar J, Pyle L, Snell-Bergeon JK, Garcetti R, Joshee P, Demmitt JK, Polsky S. Glycemic variability and indices of glycemic control among pregnant women with type 1 diabetes (T1D) based on the use of continuous glucose monitoring share technology. J Matern Fetal Neonatal Med. 2022 Dec;35(25):8968-8974. PubMed PMID: 34875947
• Triolo TM, Pyle L, Broncucia H, Armstrong T, Yu L, Gottlieb PA, Steck AK. Association of High-Affinity Autoantibodies With Type 1 Diabetes High-Risk HLA Haplotypes. J Clin Endocrinol Metab. 2022 Mar 24;107(4):e1510-e1517. PubMed PMID: 34850014
• Forlenza GP, Vigers T, Berget C, Messer LH, Lal RA, Basina M, Maahs DM, Hood K, Buckingham B, Wilson DM, Wadwa RP, Driscoll KA, Pyle L. Predicting Success with a First-Generation Hybrid Closed-Loop Artificial Pancreas System Among Children, Adolescents, and Young Adults with Type 1 Diabetes: A Model Development and Validation Study. Diabetes Technol Ther. 2022 Mar;24(3):157-166. PubMed PMID: 34780306
• Nunes-Moreno M, Buchanan C, Cole FS, Davis S, Dempsey A, Dowshen N, Furniss A, Kazak AE, Kerlek AJ, Margolis P, Pyle L, Razzaghi H, Reirden DH, Schwartz B, Sequeira GM, Nokoff NJ. Behavioral Health Diagnoses in Youth with Gender Dysphoria Compared with Controls: A PEDSnet Study. J Pediatr. 2022 Feb;241:147-153.e1. PubMed PMID: 34571022
• Chan CL, Pyle L, Vigers T, Zeitler PS, Nadeau KJ. The Relationship Between Continuous Glucose Monitoring and OGTT in Youth and Young Adults With Cystic Fibrosis. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e548-e560. PubMed PMID: 34537845
• Cobry EC, Reznick-Lipina T, Pyle L, Slover R, Thomas JF, Alonso GT, Wadwa RP. Diabetes Technology Use in Remote Pediatric Patients with Type 1 Diabetes Using Clinic-to-Clinic Telemedicine. Diabetes Technol Ther. 2022 Jan;24(1):67-74. PubMed PMID: 34524007
• Akturk HK, Vigers T, Forlenza G, Champakanath A, Pyle L. Comparison of Cgmanalysis, a Free Open-Source Continuous Glucose Monitoring Data Management and Analysis Software, with Commercially Available CGM Platforms: Data Standardization for Diabetes Technology Research. Diabetes Technol Ther. 2022 Jan;24(1):54-60. PubMed PMID: 34524001
• Mullin BC, Holzman JBW, Pyle L, Perks EL, Chintaluru Y, Gulley LD, Haraden DA, Hankin BL. Relationships between attention to emotion and anxiety among a community sample of adolescents. Psychol Med. 2022 Jun;52(8):1548-1559. PubMed PMID: 33641686
• Cung S, Pyle L, Nadeau K, Dabelea D, Cree-Green M, Davis SM. In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome. J Investig Med. 2022 Jan;70(1):104-107. PubMed PMID: 34493629
• Akturk HK, Couts KL, Baschal EE, Karakus KE, Van Gulick RJ, Turner JA, Pyle L, Robinson WA, Michels AW. Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma. JAMA Netw Open. 2022 Dec 1;5(12):e2246400. PubMed PMID: 36512357
• Wigglesworth KRS, Vigers T, Pyle L, Youngkin EM, Fay-Itzkowitz E, Tilden J, Raymond JK, Snell-Bergeon J, Sass A, Majidi S. Follow-Up Mental Health Care in Youth and Young Adults With Type 1 Diabetes After Positive Depression Screen and/or Suicidal Ideation. Clin Diabetes. 2022 Fall;40(4):449-457. PubMed PMID: 36385972
• Kim YK, Walters JA, Moss ND, Wells KL, Sheridan R, Miranda JG, Benninger RKP, Pyle LL, O'Brien RM, Sussel L, Davidson HW. Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration. Mol Metab. 2022 Dec;66:101632. PubMed PMID: 36347424
• Anderson AM, Landry LG, Alkanani AA, Pyle L, Powers AC, Atkinson MA, Mathews CE, Roep BO, Michels AW, Nakayama M. Human islet T cells are highly reactive to preproinsulin in type 1 diabetes. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41). PubMed PMID: 34611019
• Nunes-Moreno M, Buchanan C, Cole FS, Davis S, Dempsey A, Dowshen N, Furniss A, Kazak AE, Kerlek AJ, Margolis P, Pyle L, Razzaghi H, Reirden DH, Schwartz B, Sequeira GM, Nokoff NJ. Behavioral Health Diagnoses in Youth with Gender Dysphoria Compared with Controls: A PEDSnet Study. J Pediatr. 2021 Sep 24. [Epub ahead of print] PubMed PMID: 34571022
• Hwang SS, Tong S, Pyle L, Battaglia C, McManus B, Niermeyer S, Sauaia A. Impact of State Prioritization of Safe Infant Sleep Programs on Supine Sleep Positioning for Non-Hispanic White and Non-Hispanic Black Infants. Am J Perinatol. 2021 Sep 20. [Epub ahead of print] PubMed PMID: 34544194
• Chan CL, Pyle L, Vigers T, Zeitler PS, Nadeau KJ. Full The Relationship between Continuous Glucose Monitoring and OGTT in Youth and Young Adults with Cystic Fibrosis. J Clin Endocrinol Metab. 2021 Sep 19. [Epub ahead of print] PubMed PMID: 34537845
• Shah VN, Snell-Bergeon JK, Demmitt JK, Joshee P, Garcetti R, Pyle L, Polsky S. Relationship Between Time-in-Range, HbA1c, and the Glucose Management Indicator in Pregnancies Complicated by Type 1 Diabetes. Diabetes Technol Ther. 2021 Nov 3. [Epub ahead of print] PubMed PMID: 34524020
• Cobry E, Reznick-Lipina T, Pyle L, Slover RJ, Thomas JF, Alonso GT, Wadwa RP. Diabetes Technology Use in Remote Pediatric Patients with Type 1 Diabetes Using Clinic-to-Clinic Telemedicine. Diabetes Technol Ther. 2021 Sep 15. [Epub ahead of print] PubMed PMID: 34524007
• Akturk HK, Vigers T, Forlenza GP, Champakanath A, Pyle L. Comparison of cgmanalysis, a free, open-source continuous glucose monitoring (CGM) data management and analysis software to commercially available CGM platforms: Data standardization for diabetes technology research. Diabetes Technol Ther. 2021 Sep 15. [Epub ahead of print] PubMed PMID: 34524001
• Cung S, Pyle L, Nadeau K, Dabelea D, Cree-Green M, Davis SM. In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome. J Investig Med. 2021 Sep 7. [Epub ahead of print] PubMed PMID: 34493629
• Akturk HK, Snell-Bergeon J, Pyle L, Fivekiller E, Garg S, Cobry E. Accuracy of a breath ketone analyzer to detect ketosis in adults and children with type 1 diabetes. J Diabetes Complications. 2021 Nov;35(11):108030. PubMed PMID: 34481712
• Sewell R, Buchanan CL, Davis S, Christakis DA, Dempsey A, Furniss A, Kazak AE, Kerlek AJ, Magnusen B, Pajor NM, Pyle L, Pyle LC, Razzaghi H, Schwartz BI, Vogiatzi MG, Nokoff NJ. Behavioral Health Diagnoses in Youth with Differences of Sex Development or Congenital Adrenal Hyperplasia Compared with Controls: A PEDSnet Study. J Pediatr. 2021 Aug 27. [Epub ahead of print] PubMed PMID: 34461062
• Vigers T, Vanderlinden LA, Johnson RK, Carry PM, Yang I, DeFelice BC, Kaizer AM, Pyle L, Rewers M, Fiehn O, Norris JM, Kechris K. A Mediation Approach to Discovering Causal Relationships between the Metabolome and DNA Methylation in Type 1 Diabetes. Metabolites. 2021 Aug 14;11(8). PubMed PMID: 34436483
• Piani F, Melena I, Severn C, Chung LT, Vinovskis C, Cherney D, Pyle L, Roncal-Jimenez CA, Lanaspa MA, Rewers A, van Raalte DH, Obeid W, Parikh C, Nelson RG, Pavkov ME, Nadeau KJ, Johnson RJ, Bjornstad P. Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study. Pediatr Diabetes. 2021 Nov;22(7):1031-1039. PubMed PMID: 34435718
• Gourgari E, Nadeau KJ, Pyle L, Playford MP, Ma J, Mehta NN, Remaley AT, Gordon SM. Effect of metformin on the high-density lipoprotein proteome in youth with type 1 diabetes. Endocrinol Diabetes Metab. 2021 Jul;4(3):e00261. PubMed PMID: 34277985
• Buschur EO, Campbell K, Pyle L, Garcetti R, Joshee P, Demmitt JK, Snell-Bergeon JK, Polsky S. Exploratory Analysis of Glycemic Control and Variability Over Gestation Among Pregnant Women with Type 1 Diabetes. Diabetes Technol Ther. 2021 Nov;23(11):768-772. PubMed PMID: 34115946
• Messer LH, Berget C, Pyle L, Vigers T, Cobry E, Driscoll KA, Forlenza GP. Real-World Use of a New Hybrid Closed Loop Improves Glycemic Control in Youth with Type 1 Diabetes. Diabetes Technol Ther. 2021 Jun 21. [Epub ahead of print] PubMed PMID: 34096789
• Pyle L, Kelsey MM. Youth-onset type 2 diabetes: translating epidemiology into clinical trials. Diabetologia. 2021 Aug;64(8):1709-1716. PubMed PMID: 34075436
• Berget C, Akturk HK, Messer LH, Vigers T, Pyle L, Snell-Bergeon J, Driscoll KA, Forlenza GP. Real-world performance of hybrid closed loop in youth, young adults, adults and older adults with type 1 diabetes: Identifying a clinical target for hybrid closed-loop use. Diabetes Obes Metab. 2021 Sep;23(9):2048-2057. PubMed PMID: 34010499
• Hudnut-Beumler J, Kaar JL, Taylor A, Kelsey MM, Nadeau KJ, Zeitler P, Snell-Bergeon J, Pyle L, Cree-Green M. Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity. Pediatr Diabetes. 2021 Aug;22(5):699-706. PubMed PMID: 33870630
• Levin P, Hoogwerf BJ, Snell-Bergeon J, Vigers T, Pyle L, Bromberger L. Ultra Rapid-Acting Inhaled Insulin Improves Glucose Control in Patients With Type 2 Diabetes Mellitus. Endocr Pract. 2021 May;27(5):449-454. PubMed PMID: 33853718
• Alonso GT, Murphy C, Pyle L, Thomas S, Ohman-Hanson R, Rewers A. Increased Prevalence of Diabetic Ketoacidosis Among Colorado Children at Diagnosis of Type 1 Diabetes During the COVID-19 Pandemic Lockdown Resolves After Reopening. Diabetes Technol Ther. 2021 Sep;23(9):663-664. PubMed PMID: 33835859
• Triolo TM, Pyle L, Seligova S, Yu L, Simmons K, Gottlieb P, Evans-Molina C, Steck AK. Proinsulin:C-peptide ratio trajectories over time in relatives at increased risk of progression to type 1 diabetes. J Transl Autoimmun. 2021;4:100089. PubMed PMID: 33748733
• Kelsey MM, Hilkin A, Pyle L, Severn C, Utzschneider K, Van Pelt RE, Zeitler PS, Nadeau KJ. Two-Year Treatment With Metformin During Puberty Does Not Preserve ß-Cell Function in Youth With Obesity. J Clin Endocrinol Metab. 2021 Jun 16;106(7):e2622-e2632. PubMed PMID: 33728428
• Hwang SS, Tong S, Smith RA, Barfield WD, Pyle L, Battaglia C, McManus B, Niermeyer S, Sauaia A. Persistent Racial/Ethnic Disparities in Supine Sleep Positioning among US Preterm Infants, 2000-2015. J Pediatr. 2021 Jun;233:51-57.e3. PubMed PMID: 33676934
• Pyle L, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Nadeau KJ, Cree-Green M. Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity. Metabol Open. 2021 Mar;9:100085. PubMed PMID: 33665598
• Andrisse S, Garcia-Reyes Y, Pyle L, Kelsey MM, Nadeau KJ, Cree-Green M. Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome. J Endocr Soc. 2021 Apr 1;5(4):bvab008. PubMed PMID: 33644620
• Mullin BC, Holzman JBW, Pyle L, Perks EL, Chintaluru Y, Gulley LD, Haraden DA, Hankin BL. Relationships between attention to emotion and anxiety among a community sample of adolescents. Psychol Med. 2021 Mar 1;:1-12. [Epub ahead of print] PubMed PMID: 33641686
• Mitchell AM, Alkanani AA, McDaniel KA, Pyle L, Waugh K, Steck AK, Nakayama M, Yu L, Gottlieb PA, Rewers MJ, Michels AW. T-cell responses to hybrid insulin peptides prior to type 1 diabetes development. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6). PubMed PMID: 33542101
• Bartlette K, Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Pyle L, Nadeau KJ, Cree-Green M, Diniz Behn C. Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration. Metabol Open. 2021 Mar;9:100078. PubMed PMID: 33511337
• Jobira B, Frank DN, Silveira LJ, Pyle L, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome. PLoS One. 2021;16(1):e0245219. PubMed PMID: 33465100
• O'Donnell HK, Vigers T, Johnson SB, Pyle L, Wright N, Deeb LC, Driscoll KA. Pump It Up! A randomized clinical trial to optimize insulin pump self-management behaviors in adolescents with type 1 diabetes. Contemp Clin Trials. 2021 Mar;102:106279. PubMed PMID: 33440262
• Tommerdahl KL, Baumgartner K, Schäfer M, Bjornstad P, Melena I, Hegemann S, Baumgartner AD, Pyle L, Cree-Green M, Truong U, Browne L, Regensteiner JG, Reusch JEB, Nadeau KJ. Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes. Diabetes Care. 2021 Mar;44(3):795-803. PubMed PMID: 33402367
• Kelsey MM, Severn C, Hilkin AM, Pyle L, Nadeau KJ, Zeitler PS. Puberty Is Associated with a Rising Hemoglobin A1c, Even in Youth with Normal Weight. J Pediatr. 2021 Mar;230:244-247. PubMed PMID: 33300876
• Tommerdahl KL, Bjornstad P, Kendrick J, Cree-Green M, Baumgartner AD, Pyle L, Reusch JEB, Nadeau KJ. Results from the Effects of MEtformin on cardiovasculaR function in AdoLescents with type 1 Diabetes (EMERALD) study: A brief report of kidney and inflammatory outcomes. Diabetes Obes Metab. 2021 Mar;23(3):844-849. PubMed PMID: 33236509
• Shah VN, Pyle L, Snell-Bergeon JK. Response to Authors' concern. Bone. 2021 Feb;143:115750. PubMed PMID: 33188957
• Champakanath A, Keshawarz A, Pyle L, Snell-Bergeon JK, Shah VN. Fracture risk assessment (FRAX) without BMD and risk of major osteoporotic fractures in adults with type 1 diabetes. Bone. 2021 Feb;143:115614. PubMed PMID: 32853853
• Shah V, Pyle L. Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1. New England Journal of Medicine 2021, 385(e69). DOI: 10.1056/NEJMc2107661.
• Breslow E, Taylor A, Severn C, Chan C, Pyle L, Kelsey MM, Cree-Green M. 11-oxyandrogen Concentrations in Adolescents With Polycystic Ovary Syndrome (PCOS). Poster presentation, ENDO 2021 (accepted).
• Valentine A, Davis S, Dempsey A, Furniss A, Juarez-Colunga E, Pyle L, Reirden DH, Nokoff NJ. Multicenter analysis of cardiometabolic-related diagnoses in transgender adolescents. Poster presentation, ENDO 2021 (accepted).
• Taylor A, Ware M, Breslow E, Pyle L, Severn C, Chan CL, Kelsey MM, Cree-Green M. 11-oxo-androgens in youth with polycystic ovary syndrome. Poster presentation, ENDO 2021 (accepted).
• Kelsey MM, Pyle L, Hilkin S, Severn C, Nadeau KJ, Zeitler PS. Adipokines and liver fat predict rising HbA1c during puberty. Poster presentation, Pediatric Endocrine Society 2021.
• Stuppy J, Severn C, Parks EJ, Wolfe RR, Carreau AM, Garcia-Reyes Y, Rahat H, Wagner DA, Nadeau KJ, Pyle L, Cree-Green M. Short-term GLP-1 receptor agonist therapy does not influence hepatic de novo lipogenesis in polcystic ovary syndrome. Poster presentation, Experimental Biology 2021 (accepted).
• Pyle L, Vigers T, Schauer I, Bergman B, Snell-Bergeon JK. Differential associations between plasma lipids and insulin resistance in women with and without type 1 diabetes. Poster presentation, American Diabetes Association 2021 (accepted).
• O’Donnell HK, Vigers T, Alonso GT, Gomer T, Majidi S, Pyle L, Snell-Bergeon J, Sileo D, Wadwa P, Driscoll KA. Support for using objective data from diabetes devices to assess self-management behaviors in adolescents with T1D. Poster presentation, American Diabetes Association 2021 (accepted).
• Looker HC, Severn C, Vigers TB, Pyle L, Saulnier P, Najafian B, Mauer M, Nelson RG, Bjornstad P. Youth-onset type 2 diabetes is associated with more severe structural lesions on kidney biopsy than adult-onset type 2 diabetes. Oral presentation, American Diabetes Association.
• Mitchell AM, Alkanani A, McDaniel K, Pyle L, Waugh K, Steck A, Nakayama M, Yu L, Gottlieb P, Rewers M, Michels AW. T-cell responses to hybrid insulin peptides precede type 1 diabetes development. Oral presentation, American Diabetes Association 2021.
• Cobry E, Karami A, Jost E, Pyle L, Meltzer L, Wadwa RP. Initial impact of the transition to Tandem Control-IQ on sleep in youth with type 1 diabetes and their parents. Poster presentation, ATTD 2021 (accepted).
• Maddux AB, Campbell K, Sierra Y, Van KA, Mansour R, Bennett TD, Kerby G, Liptzin DR, Pyle LL, Watson RS, Mourani PM. Pulmonary morbidities are common after pediatric acute respiratory distress syndrome. Poster presentation, American Thoracic Society 2021 (accepted).
• Nicklas JM, Leiferman J, Pyle L, Soares A, Bull S, Tong S, Barbour LA. Feasibility of an mHealth Postpartum lifestyle intervention for women with cardiometabolic risk pre- and mid-COVID: the Fit After Baby pilot randomized controlled trial. Oral presentation, Society for General Internal Medicine 2021.
• Cobry E, Vigers T, Pyle L, Meltzer LJ. Family exposure and impact of COVID-19 on a pediatric T1D population. Poster presentation, American Diabetes Association 2021.
• Karami AJ, Pyle L, Jost E, Wadwa PR, Meltzer LJ, Cobry E. Association of glycemic ranges and sleep measures in youth with type 1 diabetes and their parents. Poster presentation, American Diabetes Association 2021.
• Rubio VY, Pyle L, Vigers T, Johnson R, Snell-Bergeon J, Zhang Q. Chemical isotope labeling-based metabolomics to discover cardiovascular disease biomarkers from the Epidemiology of Diabetes Interventions and Complications Study. Poster presentation, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics (accepted).
• Tang Y, Pyle L, Vigers T, Johnson R, Snell-Bergeon J, Zhang Q. High-throughput plasma glycated proteome profiling to discover cardiovascular disease biomarkers from the Epidemiology of Diabetes Interventions and Complications Study. Poster presentation, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics (accepted).
• Tinsely JP, Carpenter RD, Prakriti J, Pyle LL, Snell-Bergeon S, Shah VN. Femoral neck structure properties are altered in individuals with type 1 diabetes. Poster presentation, American Society for Bone Mineral Research (accepted).
• Escobar E, Towers L, Berget C, Vigers T, Pyle L, Messer L, Cobry E, Slover R, Wadwa RP, Driscoll KA, Forlenza GP. Psychosocial impacts of the t:slim X2 pump with Control-IQ technology in a clinical population of youth with type 1 diabetes after 6 months of use. ePoster presentation, International Society for Pediatric and Adolescent Diabetes 2021.
• Cobry E, Pyle L, Vigers T, Meltzer L. COVID exposure, impact, and pediatric diabetes quality of life in a population of youth with type 1 diabetes. Poster presentation, International Society for Pediatric and Adolescent Diabetes 2021.
• Chan CL, Severn C, Sagel S, Pyle L, Nadeau K. Mechanisms of hypoglycemia during oral glucose tolerance testing in youth with cystic fibrosis. Oral presentation, International Society for Pediatric and Adolescent Diabetes 2021.
• Forlenza GP, Vigers T, Berget C, Messer LH, Lal RA, Basina M, Maahs DM, Hood K, Buckingham B, Wilson DM, Wadwa RP, Driscoll KA, Pyle L. Predicting success with a first-generation hybrid closed loop artificial pancreas system among children, adolescents, and young adults with type 1 diabetes: a model development and validation study. ePoster presentation, International Society for Pediatric and Adolescent Diabetes 2021.
• Pauley M, Vigers T, Pyle L, Majidi S, Frohnert BI, Simmons KM. Determination of insulin doses in youth with new onset type 1 diabetes. ePoster presentation, International Society for Pediatric and Adolescent Diabetes 2021.
• Morelli N, Fordham T, Garcia-Reyes Y, Ware MA, Rahat H, Sundararajan D, Severn C, Pyle L, Parks EJ, Wolfe RR, Cree-Green M. Essential amino acid supplement decreases liver fat in adolescents with PCOS and obesity. Oral presentation, Obesity Week 2021.
• Lo JS, Nokoff NJ, Alexander K, D’Alessandro A, Morelli N, Garcia-Reyes Y, Ware M, Rahat H, Severn C, Pyle L, Wolfe RR, Cree-Green M. Effect of essential amino acid supplementation on metabolome and liver fat in adolescents with PCOS. Poster presentation, Obesity Week 2021.
• Sundararajan D, Morelli N, Garcia-Reyes Y, Ware M, Rahat H, Sundaram S, Severn C, Pyle L, Cree-Green M. Measuring hepatic steatosis with transient elastography or PCOS-HS score in adolescents with PCOS and obesity. Poster presentation, Obesity Week 2021.
• Sherk VD, Vigers T, Pyle L, Snell-Bergeon JK, Nadeau KJ, Rickels MR, Miller KM, Greenbaum CJ, Shah VN. Acute Hyperinsulinemia Alters Bone Turnover in Women and Men With Type 1 Diabetes. JBMR Plus. 2020 Sep;4(9):e10389. PubMed PMID: 32995692
• Buyers E, Sass AE, Severn CD, Pyle L, Cree-Green M. 12-month Continuation of the Etonogestrel Implant in Adolescents with Polycystic Ovary Syndrome. J Pediatr Adolesc Gynecol. 2020 Sep 9. [Epub ahead of print] PubMed PMID: 32919086
• Champakanath A, Keshawarz A, Pyle L, Snell-Bergeon JK, Shah VN. Fracture risk assessment (FRAX) without BMD and risk of major osteoporotic fractures in adults with type 1 diabetes. Bone. 2020 Aug 24;:115614. [Epub ahead of print] PubMed PMID: 32853853
• Benson J, Severn C, Hudnut-Beumler J, Simon SL, Abramson N, Shomaker LB, Gulley LD, Taylor A, Kelsey MM, Nadeau KJ, Zeitler PS, Pyle L, Cree-Green M. Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes. Can J Diabetes. 2020 Aug;44(6):507-513. PubMed PMID: 32792104
• Messer LH, Campbell K, Pyle L, Forlenza GP. Basal-IQ technology in the real world: satisfaction and reduction of diabetes burden in individuals with type 1 diabetes. Diabet Med. 2020 Aug 7;:e14381. [Epub ahead of print] PubMed PMID: 32767401
• Vinovskis C, Li LP, Prasad P, Tommerdahl K, Pyle L, Nelson RG, Pavkov ME, van Raalte D, Rewers M, Pragnell M, Mahmud FH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes. Diabetes. 2020 Jul 31. [Epub ahead of print] PubMed PMID: 32737116
• Carreau AM, Xie D, Garcia-Reyes Y, Rahat H, Bartlette K, Behn CD, Pyle L, Nadeau KJ, Cree-Green M. Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents. Pediatr Diabetes. 2020 Jun 26. [Epub ahead of print] PubMed PMID: 32592269
• Triolo TM, Pyle L, Seligova S, Yu L, Gottlieb PA, Steck AK. Risk of Islet and Celiac Autoimmunity in Cotwins of Probands With Type 1 Diabetes. J Endocr Soc. 2020 Jun 1;4(6):bvaa053. PubMed PMID: 32537543
• Thompson T, Howell S, Davis S, Wilson R, Janusz J, Boada R, Pyle L, Tartaglia N. Current survey of early childhood intervention services in infants and young children with sex chromosome aneuploidies. Am J Med Genet C Semin Med Genet. 2020 Jun;184(2):414-427. PubMed PMID: 32449585
• Simmons KM, Mitchell AM, Alkanani AA, McDaniel KA, Baschal EE, Armstrong T, Pyle L, Yu L, Michels AW. Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02 . Diabetes. 2020 Aug;69(8):1763-1769. PubMed PMID: 32439825
• Polsky S, Garcetti R, Pyle L, Joshee P, Demmitt JK, Snell-Bergeon JK. Continuous glucose monitor use with and without remote monitoring in pregnant women with type 1 diabetes: A pilot study. PLoS One. 2020;15(4):e0230476. PubMed PMID: 32298269
• Ravi SJ, Coakley A, Vigers T, Pyle L, Forlenza GP, Alonso T. Pediatric Medicaid Patients With Type 1 Diabetes Benefit From Continuous Glucose Monitor Technology. J Diabetes Sci Technol. 2020 Mar 14;:1932296820906214. [Epub ahead of print] PubMed PMID: 32172603
• Sopfe J, Vigers T, Pyle L, Giller RH, Forlenza GP. Safety and Accuracy of Factory-Calibrated Continuous Glucose Monitoring in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation. Diabetes Technol Ther. 2020 Oct;22(10):727-733. PubMed PMID: 32105513
• Kelsey MM, Pyle L, Hilkin A, Severn CD, Utzschneider K, Van Pelt RE, Nadeau KJ, Zeitler PS. The Impact of Obesity On Insulin Sensitivity and Secretion During Pubertal Progression: A Longitudinal Study. J Clin Endocrinol Metab. 2020 May 1;105(5). PubMed PMID: 31996919
• Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M. Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota. J Clin Endocrinol Metab. 2020 Jun 1;105(6). PubMed PMID: 31970418
• Duca LM, Pyle L, Khanna AD, Ong T, Kahn MG, DiGuiseppi C, Scott K, Daley MF, Costa E 3rd, Davidson AJ, Crume TL. Estimating the prevalence of congenital heart disease among adolescents and adults in Colorado adjusted for incomplete case ascertainment. Am Heart J. 2020 Mar;221:95-105. PubMed PMID: 31955128
• Chan CL, Steck AK, Severn C, Pyle L, Rewers M, Zeitler PS. Lessons From Continuous Glucose Monitoring in Youth With Pre-Type 1 Diabetes, Obesity, and Cystic Fibrosis. Diabetes Care. 2020 Mar;43(3):e35-e37. PubMed PMID: 31937609
• Simon S, Rahat H, Carreau AM, Garcia-Reyes Y, Halbower A, Pyle L, Nadeau KJ, Cree-Green M. Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity. J Clin Endocrinol Metab. 2020 Apr 1;105(4). PubMed PMID: 31901092
• Messer LH, Berget C, Vigers T, Pyle L, Geno C, Wadwa RP, Driscoll KA, Forlenza GP. Real world hybrid closed-loop discontinuation: Predictors and perceptions of youth discontinuing the 670G system in the first 6 months. Pediatr Diabetes. 2020 Mar;21(2):319-327. PubMed PMID: 31885123
• Berget C, Messer LH, Vigers T, Frohnert BI, Pyle L, Wadwa RP, Driscoll KA, Forlenza GP. Six months of hybrid closed loop in the real-world: An evaluation of children and young adults using the 670G system. Pediatr Diabetes. 2020 Mar;21(2):310-318. PubMed PMID: 31837064
• Lytvyn Y, Bjornstad P, Katz A, Singh SK, Godoy LC, Chung LT, Vinovskis CL, Pyle L, Roussel R, Perkins BA, Cherney D. SGLT2 inhibition increases serum copeptin in young adults with type 1 diabetes. Diabetes Metab. 2020 Jun;46(3):203-209. PubMed PMID: 31816431
• Polsky S, Garcetti R, Pyle L, Joshee P, Demmitt JK, Snell-Bergeon JK. Continuous Glucose Monitor Use With Remote Monitoring Reduces Fear of Hypoglycemia in Pregnant Women With Type 1 Diabetes: A Pilot Study. J Diabetes Sci Technol. 2020 Jan;14(1):191-192. PubMed PMID: 31779476
• Alonso GT, Coakley A, Pyle L, Manseau K, Thomas S, Rewers A. Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Colorado Children, 2010-2017. Diabetes Care. 2020 Jan;43(1):117-121. PubMed PMID: 31601639
• Cobry E, Berget C, Messer L, Wadwa P, Driscoll K, Pyle P, Forlenza G. Psychosocial outcomes after one year of real-world hybrid closed loop therapy in youth with type 1 diabetes. E-poster presentation, ATTD 2020.
• Buyers E, Sass A, Severn CD, Pyle L, Cree-Green M. Continuation of the etonogestrel implant in adolescents with polycystic ovary syndrome. Oral presentation North American Society for Pediatric and Adolescent Gynecology 2020.
• Andrisse S, Torres M, Garcia-Reyes Y, Pyle L, Nadeau KJ, Kelsey MM, Cree-Green M. Racial and ethnic differences in metabolic disease in obese adolescents with polycystic ovary syndrome. Poster presentation, ENDO 2020.
• Maddux AB, Campbell K, Pyle LL, LaVelle J, Watson RS, Mourani PM, Bennett TD. Functional outcome phenotypes derived from insurance claim data in children who survived prolonged mechanical ventilation. Poster presentation, American Thoracic Society 2020.
• Maddux AB, Campbell K, Pyle LL, Sierra Y, Spear M, Van KA, Grosskreuz R, Bennett TD, Buchowski M, Watson RS, Mourani PM. Accelerometry: an objective evaluation of physical functional recovery in children who survive prolonged mechanical ventilation. Poster presentation, American Thoracic Society 2020.
• Levin P, Snell-Bergeon J, Vigers T, Pyle L, Bromberger L. Effective treatment of patients with uncontrolled type 2 diabetes on multiple diabetes medications by adding mealtime ultra-rapid technosphere insulin. Poster presentation, ATTD 2020.
• Rydin A, Severn C, Pyle L, Reyes YG, Nadeau K, Cree-Gree M. Development of a new predictive equation for basal energy expenditure and the accuracy of current equations for overweight and obese females. Poster presentation, Pediatric Endocrine Society Annual Meeting 2020.
• Kelsey MM, Benjamin H, Pyle L, Severn C, Zeitler PS, Nadeau KJ. Rise in liver fat during puberty is predicted by leptin and glycemia, but not by insulin sensitivity. Poster presentation, Pediatric Endocrine Society Annual Meeting 2020.
• Jensen R, Campbell K, Pyle L, Gerard Gonzalez A. Novel culturally sensitive shared medical appointment model for high risk Latino youth with type 1 diabetes: one year follow up post pilot intervention. Poster presentation, American Diabetes Association 2020.
• Cobry E, Reznick-Lepina T, Pyle L, Slover R, Thomas JF, Wadwa RP. Lower use of technology in youth with type 1 diabetes in locations distant from subspecialty care. Poster presentation, American Diabetes Association 2020.
• Simmons KM, Mitchell AM, Alkanani AA, McDaniel KA, Baschal EE, Armstrong T, Pyle L, Yu L, Michels AW. Failed Genetic Protection: Type 1 Diabetes in the presence of HLA-DQB1*06:02. Oral presentation, American Diabetes Association 2020.
• Snell-Bergeon JK, Schauer IE, Bergman BC, Nadeau KJ, Cree-Green M, Keshawarz A, Pyle L. Metabolites associated with insulin resistance in women with and without type 1 diabetes. Moderated poster presentation, American Diabetes Association 2020.
• Jimenez V, Gulley L, Hilkin AM, Conte I, Verros M, Clark E, Casamassima M, Miller R, Bernstein R, Pyle L, Nadeau KJ, Kelsey MM, Shomaker LB. Trauma and loss-of-Control eating relate to elevated type 2 diabetes risk in adolescents. Poster presentation, American Diabetes Association 2020.
• Pyle L, Carreau A, Rahat H, Garcia-Reyes Y, Nadeau KJ, Cree-Green M. Challenges in handling missing data in untargeted LC-MS metabolomics experiments. Poster presentation, International Biometric Conference 2020.
• Palmer C, Driver C, Brown LD, Hobbins J, Pyle L. The use of multivariate latent class mixed effect models to predict pathological fetal growth restriction. Poster presentation, International Biometric Conference 2020.
• Kelsey M, Hilkin AM, Severn C, Pyle L, Nadeau KJ, Zeitler P. Puberty is associated with a rising HbA1c, even in healthy normal weight youth. Poster presentation, American Diabetes Association 2020.
• Cobry E, Berget C, Messer L, Wadwa RP, Vigers T, Pyle L, Slover R, Forlenza G. Nocturnal alarms: a potential barrier to diabetes technology use. Poster presentation, American Diabetes Association 2020.
• Triolo T, Pyle L, Yu L, Gottlieb P, Steck AK and the Type 1 Diabetes TrialNet Study Group. Association of high-affinity antibodies with high-risk HLA haplotypes. Poster presentation, American Diabetes Association 2020.
• Kelsey MM, Hilkin AM, Severn C, Pyle L, Nadeau KJ, Zeitler P. Puberty is associated with a rising HbA1c, even in healthy normal weight youth. Poster presentation, American Diabetes Association 2020.
• Vinoskis CL, Nadeau KJ, Tommerdahl KL, Prasad PV, Li L, Pyle L, Rewers M, Pragnell M, Mahmud FH, Van raalte DHV, Cherney D, Nelson R, Bjornstad P. A metabolic mismatch between renal oxygenation and glomerular filtration rate in type 1 diabetes. Oral presentation, American Diabetes Association 2020 (ADA Presidents’ Select Abstract Presentation).
• Sopfe J, Campbell K, Keating AK, Pyle L, Liu AK, Verneris MR, Giller RH, Forlenza GP. Glycemic variability is associated with poor outcomes in pediatric hematopoietic stem cell transplant patients. Pediatr Blood Cancer. 2020 Nov;67(11):e28626. PubMed PMID: 33480469
• Bryant A, Kalra A, Truesdale A, Pyle L, Martinez-Camacho A. Favorable Sustained Virologic Response Rates Using Direct-Acting Antiviral Therapies at a Large Safety-Net Hospital. J Health Care Poor Underserved. 2020;31(3):1213-1227. PubMed PMID: 33416690
• Keshawarz A, Pyle L, Alman A, Sassano C, Westfeldt E, Sippl R, Snell-Bergeon J. Type 1 Diabetes Accelerates Progression of Coronary Artery Calcium Over the Menopausal Transition: The CACTI Study. Diabetes Care. 2019 Dec;42(12):2315-2321. PubMed PMID: 31558547
• Srinivasan Sridhar V, Ambinathan JPN, Kretzler M, Pyle LL, Bjornstad P, Eddy S, Cherney DZ, Reich HN. Renal SGLT mRNA expression in human health and disease: a study in two cohorts. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1224-F1230. PubMed PMID: 31545924
• Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA, Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP. Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes. Pediatr Diabetes. 2019 Dec;20(8):1110-1117. PubMed PMID: 31433534
• Simmons KM, Fouts A, Pyle L, Clark P, Dong F, Yu L, Usmani-Brown S, Gottlieb P, Herold KC, Steck AK. Unmethylated Insulin as an Adjunctive Marker of Beta Cell Death and Progression to Type 1 Diabetes in Participants at Risk for Diabetes. Int J Mol Sci. 2019 Aug 8;20(16). PubMed PMID: 31398795
• Kaur H, Schneider N, Pyle L, Campbell K, Akturk HK, Shah VN. Efficacy of Hybrid Closed-Loop System in Adults with Type 1 Diabetes and Gastroparesis. Diabetes Technol Ther. 2019 Aug 16. [Epub ahead of print] PubMed PMID: 31347928
• Carreau AM, Pyle L, Garcia-Reyes Y, Rahat H, Vigers T, Jensen T, Scherzinger A, Nadeau KJ, Cree-Green M. Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index). Clin Endocrinol (Oxf). 2019 Oct;91(4):544-552. PubMed PMID: 31301251
• Wiromrat P, Bjornstad P, Roncal C, Pyle L, Johnson RJ, Cherney DZ, Lipina T, Bishop F, Maahs DM, Wadwa RP. Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes. J Diabetes Complications. 2019 Sep;33(9):648-650. PubMed PMID: 31253490
• Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
• Pascual AB, Pyle L, Nieto J, Klingensmith GJ, Gonzalez AG. Novel, culturally sensitive, shared medical appointment model for Hispanic pediatric type 1 diabetes patients. Pediatr Diabetes. 2019 Jun;20(4):468-473. PubMed PMID: 30938029
• Shah VN, Joshee P, Sippl R, Pyle L, Vigers T, Carpenter RD, Kohrt W, Snell-Bergeon JK. Type 1 diabetes onset at young age is associated with compromised bone quality. Bone. 2019 Jun;123:260-264. PubMed PMID: 30936041
• Stanek KR, Youngkin EM, Pyle LL, Raymond JK, Driscoll KA, Majidi S. Prevalence, characteristics, and diabetes management in children with comorbid autism spectrum disorder and type 1 diabetes. Pediatr Diabetes. 2019 Aug;20(5):645-651. PubMed PMID: 30912248
• Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ß-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 May;42(3):424-437. PubMed PMID: 30873612
• Sopfe J, Pyle L, Keating AK, Campbell K, Liu AK, Wadwa RP, Verneris MR, Giller RH, Forlenza GP. Malglycemia is associated with poor outcomes in pediatric and adolescent hematopoietic stem cell transplant patients. Blood Adv. 2019 Feb 12;3(3):350-359. PubMed PMID: 30718242
• Li A, Vigers T, Pyle L, Zemanick E, Nadeau K, Sagel SD, Chan CL. Continuous glucose monitoring in youth with cystic fibrosis treated with lumacaftor-ivacaftor. J Cyst Fibros. 2019 Jan;18(1):144-149. PubMed PMID: 30104123
• Triolo TM, Fouts A, Pyle L, Yu L, Gottlieb PA, Steck AK. Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes. Diabetes Care. 2019 Feb;42(2):192-199. PubMed PMID: 30061316
• Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ. Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism. Obesity (Silver Spring). 2019 Dec;27(12):2046-2054. PubMed PMID: 31659873
• Vigers T, Chan CL, Snell-Bergeon J, Bjornstad P, Zeitler PS, Forlenza G, Pyle L. cgmanalysis: An R package for descriptive analysis of continuous glucose monitor data. PLoS One. 2019;14(10):e0216851. PubMed PMID: 31603912
• Cree-Green M, Ravi S, Carreau AM, Sewell R, Baumgartner A, Coe G, Bergman BC, Scherzinger A, Jensen T, Pyle L, Nadeau KJ. Nonalcoholic fatty liver disease in obese adolescent females is associated with multi-tissue insulin resistance and visceral adiposity markers. Metabol Open. 2019 Jun;2:100011. PubMed PMID: 32812939
• McClain MR, Klingensmith GJ, Anderson B, Berget C, Cain C, Shea J, Campbell K, Pyle L, Raymond JK. Team Clinic: Group Approach to Care of Early Adolescents With Type 1 Diabetes. Diabetes Spectr. 2018 Aug;31(3):273-278. PubMed PMID: 30140144
• Li A, Vigers T, Pyle L, Zemanick E, Nadeau K, Sagel SD, Chan CL. Continuous glucose monitoring in youth with cystic fibrosis treated with lumacaftor-ivacaftor. J Cyst Fibros. 2018 Aug 10. [Epub ahead of print] PubMed PMID: 30104123
• Triolo TM, Fouts A, Pyle L, Yu L, Gottlieb PA, Steck AK. Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes. Diabetes Care. 2018 Jul 30. [Epub ahead of print] PubMed PMID: 30061316
• Kaur H, Joshee P, Franquemont S, Baumgartner A, Thurston J, Pyle L, Nadeau KJ, Shah VN. Bone mineral content and bone density is lower in adolescents with type 1 diabetes: A brief report from the RESISTANT and EMERALD studies. J Diabetes Complications. 2018 Oct;32(10):931-933. PubMed PMID: 29980432
• Bjornstad P, Maahs DM, Roncal CA, Snell-Bergeon JK, Shah VN, Milagres T, Ellis SL, Hatch M, Chung LT, Rewers MJ, Garg S, Cherney DZ, Pyle L, Nadeau KJ, Johnson RJ. Role of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetes. Diabetes Obes Metab. 2018 Jul;20(7):1776-1780. PubMed PMID: 29498467
• Millstein RJ, Pyle LL, Bergman BC, Eckel RH, Maahs DM, Rewers MJ, Schauer IE, Snell-Bergeon JK. Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort. J Diabetes Complications. 2018 Apr;32(4):418-423. PubMed PMID: 29449137
• Ostrov DA, Alkanani A, McDaniel KA, Case S, Baschal EE, Pyle L, Ellis S, Pöllinger B, Seidl KJ, Shah VN, Garg SK, Atkinson MA, Gottlieb PA, Michels AW. Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. J Clin Invest. 2018 May 1;128(5):1888-1902. PubMed PMID: 29438107
• Nomura Y, Garcia M, Child J, Hurst AL, Hyman D, Poppy A, Palmer C, Ranade D, Pyle L, Parker SK. Effect of provider-selected order indications on appropriateness of antimicrobial orders in a pediatric hospital. Am J Health Syst Pharm. 2018 Feb 15;75(4):213-221. PubMed PMID: 29436467
• Majidi S, Fouts A, Pyle L, Chambers C, Armstrong T, Wang Z, Batish SD, Klingensmith G, Steck AK. Can Biomarkers Help Target Maturity-Onset Diabetes of the Young Genetic Testing in Antibody-Negative Diabetes?. Diabetes Technol Ther. 2018 Feb;20(2):106-112. PubMed PMID: 29355436
• Shah VN, Sippl R, Joshee P, Pyle L, Kohrt WM, Schauer IE, Snell-Bergeon JK. Trabecular bone quality is lower in adults with type 1 diabetes and is negatively associated with insulin resistance. Osteoporos Int. 2018 Mar;29(3):733-739. PubMed PMID: 29290026
• Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2018 May;19(3):436-442. PubMed PMID: 29082640
• Bjornstad P, Pyle L, Cherney DZI, Johnson RJ, Sippl R, Wong R, Rewers M, Snell-Bergeon JK. Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant. 2018 Jul 1;33(7):1189-1196. PubMed PMID: 28992280
• Bjornstad P, Schäfer M, Truong U, Cree-Green M, Pyle L, Baumgartner A, Garcia Reyes Y, Maniatis A, Nayak S, Wadwa RP, Browne LP, Reusch JEB, Nadeau KJ. Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus. Circulation. 2018 Dec 18;138(25):2895-2907. PubMed PMID: 30566007
• McClain MR, Klingensmith GJ, Anderson B, Berget C, Cain C, Shea J, Campbell K, Pyle L, Raymond JK. Team Clinic: Group Approach to Care of Early Adolescents With Type 1 Diabetes. Diabetes Spectr. 2018 Aug;31(3):273-278. PubMed PMID: 30140144
• Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2017 Oct 30. [Epub ahead of print] PubMed PMID: 29082640
• Bjornstad P, Pyle L, Cherney DZI, Johnson RJ, Sippl R, Wong R, Rewers M, Snell-Bergeon JK. Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant. 2017 Aug 21. [Epub ahead of print] PubMed PMID: 28992280
• Maddux AB, Hiller TD, Overdier KH, Pyle LL, Douglas IS. Innate Immune Function and Organ Failure Recovery in Adults With Sepsis. J Intensive Care Med. 2017 Jan 1;:885066617701903. [Epub ahead of print] PubMed PMID: 28372498
• Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schafer M, Pyle L, Regensteiner JG, Reusch JEB, Nadeau KJ. Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study. J Diabetes Complications. 2017 May;31(5):850-853. PubMed PMID: 28336216
• Messacar K, Campbell K, Pearce K, Pyle L, Hurst AL, Child J, Parker SK. A Handshake From Antimicrobial Stewardship Opens Doors for Infectious Disease Consultations. Clin Infect Dis. 2017 May 15;64(10):1449-1452. PubMed PMID: 28186533
• Young BE, Patinkin ZW, Pyle L, de la Houssaye B, Davidson BS, Geraghty S, Morrow AL, Krebs N. Markers of Oxidative Stress in Human Milk do not Differ by Maternal BMI But are Related to Infant Growth Trajectories. Matern Child Health J. 2017 Jun;21(6):1367-1376. PubMed PMID: 28138825
• Stewart CL, Acker SN, Pyle L, Smith DS, Bensard DD, Moulton SL. Mapping pediatric injuries to target prevention, education, and outreach. J Pediatr Surg. 2017 Aug;52(8):1287-1291. PubMed PMID: 28073490
• Bjornstad P, Johnson RJ, Snell-Bergeon JK, Pyle L, Davis A, Foster N, Cherney DZ, Maahs DM. Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank. J Diabetes Complications. 2017 Feb;31(2):387-389. PubMed PMID: 27979439
• Forlenza GP, Pyle LL, Maahs DM, Dunn TC. Ambulatory glucose profile analysis of the juvenile diabetes research foundation continuous glucose monitoring dataset-Applications to the pediatric diabetes population. Pediatr Diabetes. 2017 Nov;18(7):622-628. PubMed PMID: 27878929
• Milan M, Jhajj S, Stewart C, Pyle L, Moulton S. Helmet use and injury severity among pediatric skiers and snowboarders in Colorado. J Pediatr Surg. 2017 Feb;52(2):349-353. PubMed PMID: 27876383
• Mullin BC, Pyle L, Haraden D, Riederer J, Brim N, Kaplan D, Novins D. A Preliminary Multimethod Comparison of Sleep Among Adolescents With and Without Generalized Anxiety Disorder. J Clin Child Adolesc Psychol. 2017 Mar-Apr;46(2):198-210. PubMed PMID: 27736237
• Baldelli L, Flitter B, Pyle L, Maahs DM, Klingensmith G, Slover R, Alonso GT. A survey of youth with new onset type 1 diabetes: Opportunities to reduce diabetic ketoacidosis. Pediatr Diabetes. 2017 Nov;18(7):547-552. PubMed PMID: 27726268
• Bjornstad P, Pyle L, Kinney GL, Rewers M, Johnson RJ, Maahs DM, Snell-Bergeon JK. Adiponectin is associated with early diabetic kidney disease in adults with type 1 diabetes: A Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. J Diabetes Complications. 2017 Feb;31(2):369-374. PubMed PMID: 27368123
• Hurst AL, Olson D, Somme S, Child J, Pyle L, Ranade D, Stamatoiu A, Crombleholme T, Parker SK. Once-Daily Ceftriaxone Plus Metronidazole Versus Ertapenem and/or Cefoxitin for Pediatric Appendicitis. J Pediatric Infect Dis Soc. 2017 Mar 1;6(1):57-64. PubMed PMID: 26703242
• Ohman-Hanson R, Cree-Green M, Kelsey MM, Bessesen DH, Sharp TA, Pyle L, Pereira RI, Nadeau KJ. Ethnic and sex differences in adiponectin: from childhood to adulthood. J Clin Endocrinol Metab. 2016 Sep 7;:jc20161137. [Epub ahead of print] PubMed PMID: 27603898
• Bacha F, Gidding SS, Pyle L, Levitt Katz L, Kriska A, Nadeau KJ, Lima JA. Relationship of Cardiac Structure and Function to Cardiorespiratory Fitness and Lean Body Mass in Adolescents and Young Adults with Type 2 Diabetes. J Pediatr. 2016 Oct;177:159-166.e1. PubMed PMID: 27499218
• Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK. Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects?. Diabetes Care. 2016 Oct;39(10):1738-44. PubMed PMID: 27456836
• Bjornstad P, Pyle L, Kinney GL, Rewers M, Johnson RJ, Maahs DM, Snell-Bergeon JK. Adiponectin is associated with early diabetic kidney disease in adults with type 1 diabetes: A Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. J Diabetes Complications. 2016 Jun 14. [Epub ahead of print] PubMed PMID: 27368123
• Karlin AW, Ly TT, Pyle L, Forlenza GP, Messer L, Wadwa RP, DeSalvo DJ, Payne SL, Hanes S, Clinton P, Maahs DM, Buckingham B. Duration of Infusion Set Survival in Lipohypertrophy Versus Nonlipohypertrophied Tissue in Patients with Type 1 Diabetes. Diabetes Technol Ther. 2016 Jul;18(7):429-35. PubMed PMID: 27227290
• Murphy JL, Fenn N, Pyle L, Heizer H, Hughes S, Nomura Y, Child J, Parker SK. Adverse Events in Pediatric Patients Receiving Long-term Oral and Intravenous Antibiotics. Hosp Pediatr. 2016 Jun;6(6):330-8. PubMed PMID: 27220835
• Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 Aug;30(6):1103-10. PubMed PMID: 27133451
• Ljunggren P, Maahs DM, Johansson P, Ludvigsson J, Pyle L, Sippl R, Wadwa RP, Snell-Bergeon J. Reduced brachial artery distensibility in patients with type 1 diabetes. J Diabetes Complications. 2016 Jul;30(5):893-7. PubMed PMID: 27056753
• Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18;5(3):e002804. PubMed PMID: 26994128
• Bjornstad P, Maahs DM, Duca LM, Pyle L, Rewers M, Johnson RJ, Snell-Bergeon JK. Estimated insulin sensitivity predicts incident micro- and macrovascular complications in adults with type 1 diabetes over 6 years: the coronary artery calcification in type 1 diabetes study. J Diabetes Complications. 2016 May-Jun;30(4):586-90. PubMed PMID: 26936306
• Triolo TM, Maahs DM, Pyle L, Slover R, Buckingham B, Cheng P, DiMeglio LA, Bremer AA, Weinzimer SA, Chase HP. Effects of Frequency of Sensor-Augmented Pump Use on HbA1c and C-Peptide Levels in the First Year of Type 1 Diabetes. Diabetes Care. 2016 Apr;39(4):e61-2. PubMed PMID: 26895885
• Pyle L, Bergman BC, Nadeau KJ, Cree-Green M. Modeling changes in glucose and glycerol rates of appearance when true basal rates of appearance cannot be readily determined. Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E323-31. PubMed PMID: 26714848
• Bjornstad P, Roncal C, Milagres T, Pyle L, Lanaspa MA, Bishop FK, Snell-Bergeon JK, Johnson RJ, Wadwa RP, Maahs DM. Hyperfiltration and uricosuria in adolescents with type 1 diabetes. Pediatr Nephrol. 2016 May;31(5):787-93. PubMed PMID: 26701836
• Stewart CL, Acker SN, Pyle LL, Kulungowski A, Cadnapaphornchai M, Bruny JL, Karrer F. Factors associated with peritoneal dialysis catheter complications in children. J Pediatr Surg. 2016 Jan;51(1):159-62. PubMed PMID: 26572851
• Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan;38(1):126-31. PubMed PMID: 25414156
• Stewart CL, Mulligan J, Grudic GZ, Pyle L, Moulton SL. A noninvasive computational method for fluid resuscitation monitoring in pediatric burns: a preliminary report. J Burn Care Res. 2015 Jan-Feb;36(1):145-50. PubMed PMID: 25383980
• Stewart CL, Acker SN, Pyle LL, Kulungowski A, Cadnapaphornchai M, Bruny JL, Karrer F. Factors associated with peritoneal dialysis catheter complications in children. J Pediatr Surg. 2015 Oct 21. [Epub ahead of print] PubMed PMID: 26572851
• Bjornstad P, Eckel RH, Pyle L, Rewers M, Maahs DM, Snell-Bergeon JK. Relation of Combined Non-High-Density Lipoprotein Cholesterol and Apolipoprotein B With Atherosclerosis in Adults With Type 1 Diabetes Mellitus. Am J Cardiol. 2015 Oct 1;116(7):1057-62. PubMed PMID: 26251001
• Bjornstad P, Cherney DZ, Snell-Bergeon JK, Pyle L, Rewers M, Johnson RJ, Maahs DM. Rapid GFR decline is associated with renal hyperfiltration and impaired GFR in adults with Type 1 diabetes. Nephrol Dial Transplant. 2015 Oct;30(10):1706-11. PubMed PMID: 26050268
• Chan CL, Pyle L, Kelsey M, Newnes L, Zeitler PS, Nadeau KJ. Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin. Pediatr Diabetes. 2015 Feb 5. [Epub ahead of print] PubMed PMID: 25652226
• Stewart CL, Metzger RR, Pyle L, Darmofal J, Scaife E, Moulton SL. Helicopter versus ground emergency medical services for the transportation of traumatically injured children. J Pediatr Surg. 2015 Feb;50(2):347-52. PubMed PMID: 25638635
• Bjornstad P, Pyle L, Nguyen N, Snell-Bergeon JK, Bishop FK, Wadwa RP, Maahs DM. Achieving International Society for Pediatric and Adolescent Diabetes and American Diabetes Association clinical guidelines offers cardiorenal protection for youth with type 1 diabetes. Pediatr Diabetes. 2015 Feb;16(1):22-30. PubMed PMID: 25604668
• Bjornstad P, Nguyen N, Reinick C, Maahs DM, Bishop FK, Clements SA, Snell-Bergeon JK, Lieberman R, Pyle L, Daniels SR, Paul Wadwa R. Association of apolipoprotein B, LDL-C and vascular stiffness in adolescents with type 1 diabetes. Acta Diabetol. 2015 Jun;52(3):611-9. PubMed PMID: 25539881
• Chan CL, Pyle L, Newnes L, Nadeau KJ, Zeitler PS, Kelsey MM. Continuous glucose monitoring and its relationship to hemoglobin A1c and oral glucose tolerance testing in obese and prediabetic youth. J Clin Endocrinol Metab. 2015 Mar;100(3):902-10. PubMed PMID: 25532041
• Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan;38(1):126-31. PubMed PMID: 25414156
• Stewart CL, Mulligan J, Grudic GZ, Pyle L, Moulton SL. A noninvasive computational method for fluid resuscitation monitoring in pediatric burns: a preliminary report. J Burn Care Res. 2015 Jan-Feb;36(1):145-50. PubMed PMID: 25383980
• Levitt Katz L, Gidding SS, Bacha F, Hirst K, McKay S, Pyle L, Lima JA. Alterations in left ventricular, left atrial, and right ventricular structure and function to cardiovascular risk factors in adolescents with type 2 diabetes participating in the TODAY clinical trial. Pediatr Diabetes. 2015 Feb;16(1):39-47. PubMed PMID: 24450390
• Hurst AL, Olson D, Somme S, Child J, Pyle L, Ranade D, Stamatoiu A, Crombleholme T, Parker SK. Once-Daily Ceftriaxone Plus Metronidazole Versus Ertapenem and/or Cefoxitin for Pediatric Appendicitis. J Pediatric Infect Dis Soc. 2015 Dec 24. [Epub ahead of print] PubMed PMID: 26703242
• Lindquist KA, Chow K, West A, Pyle L, Isbell TS, Cree-Green M, Nadeau KJ. The StatStrip Glucose Monitor Is Suitable for Use During Hyperinsulinemic Euglycemic Clamps in a Pediatric Population. Diabetes Technol Ther. 2014 Jan 28. [Epub ahead of print] PubMed PMID: 24471560
• Maahs DM, Chase HP, Westfall E, Slover R, Huang S, Shin JJ, Kaufman FR, Pyle L, Snell-Bergeon JK. The Effects of Lowering Nighttime and Breakfast Glucose Levels with Sensor-Augmented Pump Therapy on Hemoglobin A1c Levels in Type 1 Diabetes. Diabetes Technol Ther. 2014 Jan 22. [Epub ahead of print] PubMed PMID: 24450776
• Bjornstad P, Nguyen N, Reinick C, Maahs DM, Bishop FK, Clements SA, Snell-Bergeon JK, Lieberman R, Pyle L, Daniels SR, Paul Wadwa R. Association of apolipoprotein B, LDL-C and vascular stiffness in adolescents with type 1 diabetes. Acta Diabetol. 2014 Dec 25. [Epub ahead of print] PubMed PMID: 25539881
• Chan CL, Pyle L, Newnes L, Nadeau KJ, Zeitler PS, Kelsey MM. Continuous Glucose Monitoring and its Relationship to Hemoglobin A1c and Oral Glucose Tolerance Testing in Obese and Prediabetic Youth. J Clin Endocrinol Metab. 2014 Dec 22;:jc20143612. [Epub ahead of print] PubMed PMID: 25532041
• Bjornstad P, Maahs DM, Wadwa RP, Pyle L, Rewers M, Eckel RH, Snell-Bergeon JK. Plasma triglycerides predict incident albuminuria and progression of coronary artery calcification in adults with type 1 diabetes: The Coronary Artery Calcification in Type 1 Diabetes Study. J Clin Lipidol. 2014 Nov-Dec;8(6):576-83. PubMed PMID: 25499940
• Bjornstad P, Maahs DM, Cherney DZ, Cree-Green M, West A, Pyle L, Nadeau KJ. Insulin sensitivity is an important determinant of renal health in adolescents with type 2 diabetes. Diabetes Care. 2014 Nov;37(11):3033-9. PubMed PMID: 25071077
• Bjornstad P, Maahs DM, Rivard CJ, Pyle L, Rewers M, Johnson RJ, Snell-Bergeon JK. Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study. Acta Diabetol. 2014 Oct;51(5):783-91. PubMed PMID: 24929955
• Bjornstad P, McQueen RB, Snell-Bergeon JK, Cherney D, Pyle L, Perkins B, Rewers M, Maahs DM. Fasting blood glucose--a missing variable for GFR-estimation in type 1 diabetes?. PLoS One. 2014;9(4):e96264. PubMed PMID: 24781861
• Lindquist KA, Chow K, West A, Pyle L, Isbell TS, Cree-Green M, Nadeau KJ. The StatStrip glucose monitor is suitable for use during hyperinsulinemic euglycemic clamps in a pediatric population. Diabetes Technol Ther. 2014 May;16(5):298-302. PubMed PMID: 24471560
• Forlenza GP, Vigers T, Berget C, Messer LH, Lal RA, Basina M, Maahs DM, Hood K, Buckingham B, Wilson DM, Wadwa RP, Driscoll KA, Pyle L. Predicting success with a first-generation hybrid closed loop artificial pancreas system among children, adolescents, and young adults with type 1 diabetes: a model development and validation study. Diabetes Technology and Therapeutics (in press).
• Nevarez J, Thompson T, Pyle L, Ross J, Tartaglia N. Low sensitivity of the Ages & Stages questionnaire in infants with sex chromosome trisomy at 6 and 12 months of age. Oral presentation, Western Medical Research Conference 2022.
• Davis S, Nokoff N, Furniss A, Valentine A, Pyle L, Dempsey A. Population-based assessment of cardiometabolic-related diagnoses in youth with Klinefelter syndrome: a PEDSNet study. Oral presentation, Western Medical Research Conference 2022.