Mary Haag, PhD

Professional Titles

• Medical Laboratory Director

Publications

• Alamri, L., Ludwigson, A., Kaizer, L. K., Hamilton, S., Haag, M., Sammel, M. D., & Putra, M. (2025). Clinical factors that influence chorionic villus sampling sample size. Archives of gynecology and obstetrics, 10.1007/s00404-024-07881-9. Advance online publication. https://doi.org/10.1007/s00404-024-07881-9
• Erythroblastic sarcoma from adult and pediatric populations: Different pathways to the same destination. Zenggang Pan, senior author. Mary Haag, author. Submitted to Modern Pathology. MODPAT 100716, Article number 100716.
• Katherine Haines, Deborah M. Hazard, Billie Carstens, Patricia Trevisan, Peter M. Brzeskiewicz, Thomas M. Gilfillan, Hala Nijmeh, Andrea Cortes Fernandez, Chandra Perez-Gill, Mikayla Stoecker, Aaina Kochhar, Mary M. Haag. Uncovering hidden complex structural mechanisms: Conventional karyotype as a complement to chromosomal microarray . Abstract accepted for poster at ACMG annual meeting 2024. Genetics in Medicine, March 2024.
• Jeanine Ruggeri, Billie Carstens, Veronica McDaniel, Christine Henderson, Hala Nijmeh, Patricia Trevisan, Sudabeh Balakhani, Kimberly Harding, Aline Murakami-Walter, Alex Ohene-Mobley, Karen Swisshelm, Stephen Wicks, Laura Schultz-Rogers, Mary M Haag. Donor-Cell Derived Hematological Neoplasm: Case Presentations of a Complex and Rare Event. Abstracted accepted for a poster for the 2024 ACMG annual meeting, Genetics in Medicine, March 2024.
• Justin Watts, Connor Sohalski, Alessia Zoso, Diana Abbott, Maria Amaya, Jonathan A. Gutman, Andrew Kent, Christine McMahon, Marc Schwartz, Mikkael Sekeres, Clayton Smith, Sangeetha Venugopal, Craig Jordan, Mary Berg, Mary Haag, Nicholas Willard, Dara Aisner, Jeffrey Schowinsky, Zenggang Pan, Jinjing Zhang, Jessie Dell-Martin, Daniel A. Pollyea. Venetoclax Plus Azacitidine for Newly Diagnosed Younger Acute Myeloid Leukemia Patients Independent of Fitness for Intensive Chemotherapy. Presented at the 2024 annual ASH meeting. Abstract # 199267. Accepted for oral presentation.
• Guimaraes-Young, A., Davies, K. D., Trevisan, P., Nijmeh, H., Haag, M., Aisner, D. L., & Patil, T. (2024). Clinical and Radiographic Benefit of a Patient With Metastatic Non-Small Cell Lung Cancer Harboring an EGFR::ERBB4 Fusion Through Use of EGFR Tyrosine Kinase Inhibitors. JCO precision oncology, 8, e2400526. https://doi.org/10.1200/PO-24-00526
• Mixing Ploidies and Assays: A Case Report of Perinatal Diagnosis and Outcome for Diploid/Triploid Mixoploidy.Jeanine M Ruggeri, PhD, MLS, MB (ASCP)CM Emily Kudalkar, PhD Deborah M Hazard BS CG(ASCP)CM Thomas Gilfillan, MBA, CG(ASCP)CM Sudabeh Balakhani, CG(ASCP)CM Aline Murakami Walter, MS, CG(ASCP)CM Billie Carstens, CG(ASCP)CM Kimberly Harding, CG(ASCP)CM Dara L Aisner, MD, PhD K. Joseph Hurt, MD, PhD Mary Haag, PhD. Poster presented at ACC bi-annual meeting, June 2024.
• Jurica JM, Carsten B, Balakhani S, Haag MM, Aisner DL, Camidge DR. CSF Cytology Identifies Mechanisms of Tyrosine Kinase Inhibitor Resistance in Patient With EGFR-Mutated NSCLC With CNS Progression. Clin Lung Cancer. 2024 Jan;25(1):77-79. PubMed PMID: 37932178
• A multi-center analysis of 46,XX mosaic Klinefelter syndrome Tiffany Guess, Ferrin Wheeler, Ashwini Yenemandra, Hannah S. Anderson, Kathleen Bone, Billie Carstens, Laura Conlin, Matthew Dulik, Barbra Dupont, Juli-Anne Gardner, Mary Haag, Ben Hilton, Jill Johson, Jillene Kogen, Jacyln Murry, Katarzyna Polonis, Denise Quigley, Elena Repnikova, Ross Rowsey, Samantha Schilit, Nancy Spinner, Mikayla Stoeker, Jennie Thurston, Margaret Wiley, Lei Zhang
• Katherine Haines, Deborah M. Hazard, Billie Carstens, Patricia Trevisan, Peter M. Brzeskiewicz, Thomas M. Gilfillan, Hala Nijmeh, Andrea Cortes Fernandez, Chandra Perez-Gill, Mikayla Stoecker, Aaina Kochhar, Mary M. Haag Uncovering hidden complex structural mechanisms: Conventional karyotype as a complement to chromosomal microarray 2024 ACMG annual meeting, Genetics in Medicine Abstract Number: 344850 Poster Number:P743. Topic Focus: Laboratory Genetics and Genomics Presenting Author: Katherine Haines, PhD
• Jeanine Ruggeri, Billie Carstens, Veronica McDaniel, Christine Henderson, Hala Nijmeh, Patricia Trevisan, Sudabeh Balakhani, Kimberly Harding, Aline Murakami-Walter, Alex Ohene-Mobley, Karen Swisshelm, Stephen Wicks, Laura Schultz-Rogers, Mary M Haag Donor-Cell Derived Hematological Neoplasm: Case Presentations of a Complex and Rare Event. 2024 ACMG annual meeting, Genetics in Medicine. Abstract Number: 364721, Poster Number: P123. Topic Focus: Cancer Genetics and Therapeutics Presenting Author: Jeanine M. Ruggeri, PhD
• Xiayuan Liang, Mary Haag, Billie Carstens, and Bradford Siegele Clinicopathogenetic Heterogeneity of Lineage Switch in Pediatric Acute Leukemia Society of Pediatric Pathology Spring 2024 meeting, March 22-23, 2024, Baltimore MD.
• Melanie Bourgeau, Michael R Clay, Carrie Marshall, Jeffrey T. Schowinsky, Billie J Carstens, Mary M Haag Impact of Routine Cytogenetic Analysis in Fresh Bone and Soft Tissue Specimens. Abstract ID: 298 USCAP 113th Annual Meeting, March 23-28, 2024, Baltimore MD
• Jacob Fang, Nakul Shankar, Liming Bao, Mary Haag, Billie J Carstens, Changlee Pang, Clinicopathological Analysis of Near-Tetraploidy/Tetraploidy Acute Myeloid Leukemia in Patients Treated with 7+3 Chemotherapy Versus Venetoclax, Abstract ID: 410 USCAP 113th Annual Meeting, March 23-28, 2024, Baltimore MD
• Fang J, Shankar N, Bao L, Haag M, Carstens B, Pang CS. Near-tetraploidy/tetraploidy acute myeloid leukemia with clinical, pathologic and molecular characteristics. Leuk Lymphoma. 2024 Dec;65(12):1820-1829. PubMed PMID: 39052840
• Howell S, Davis SM, Carstens B, Haag M, Ross JL, Tartaglia NR. Discordant Prenatal Cell-Free DNA Screening vs. Diagnostic Results of Sex Chromosome Aneuploidies: Implications for Newborn Screening and Genetic Counseling. Int J Neonatal Screen. 2024 Jul 10;10(3). PubMed PMID: 39051404
• Guess T, Wheeler FC, Yenamandra A, Schilit SLP, Anderson HS, Bone KM, Carstens B, Conlin L, Dulik MC, Dupont BR, Fanning E, Gardner JA, Haag M, Hilton BA, Johnson J, Kogan J, Murry J, Polonis K, Quigley DI, Repnikova EA, Rowsey RA, Spinner N, Stoeker M, Thurston V, Wiley M, Zhang L. A multicenter analysis of individuals with a 47,XXY/46,XX karyotype. Genet Med. 2024 Oct;26(10):101212. PubMed PMID: 39011769
• Jurica JM, Carsten B, Balakhani S, Haag MM, Aisner DL, Camidge DR. CSF Cytology Identifies Mechanisms of Tyrosine Kinase Inhibitor Resistance in Patient With EGFR-Mutated NSCLC With CNS Progression. Clin Lung Cancer. 2024 Jan;25(1):77-79. PubMed PMID: 37932178
• Daniel A. Pollyea; Brett M. Stevens; Diana Abbott; Maria Amaya; Jonathan A. Gutman; Andrew Kent; Christine McMahon; Marc Schwartz; Clayton Smith; Jessie Dell-Martin; Connor Sohalski; Alexandra Ellis; Mary Haag; Jeffrey Schowinsky; Zenggang Pan; Sweta B. Patel; Monica Ransom; Austin Gillen; Craig T. Jordan; Eric M. Pietras. Omacetaxine and Azacitidine or Untreated Patients with Myelodysplastic Syndromes and Excess Blasts. The Lancet Haematology. https://doi.org/10.1182/blood-2024-199336
• Melanie Bourgeau, Michael R Clay, Carrie Marshall, Jeffrey T. Schowinsky, Billie J Carstens, Mary M Haag. Impact of Routine Cytogenetic Analysis in Fresh Bone and Soft Tissue Specimens. Abstract accepted for the United States and Canadian Academy of Pathology’s 113th Annual Meeting, March 23-28, 2024.
• Patil T, Staley A, Nie Y, Sakamoto M, Stalker M, Jurica JM, Koehler K, Cass A, Kuykendall H, Schmitt E, Filar E, Reventaite E, Davies KD, Nijmeh H, Haag M, Yoder BA, Bunn PA, Schenk EL, Aisner DL, Iams WT, Marmarelis ME, Camidge DR. The Efficacy and Safety of Treating Acquired MET Resistance Through Combinations of Parent and MET Tyrosine Kinase Inhibitors in Patients With Metastatic Oncogene-Driven NSCLC. JTO Clin Res Rep. 2024 Jan 18;5(2):100637. doi: 10.1016/j.jtocrr.2024.100637. PMID: 38361741; PMCID: PMC10867444.
• Bradford Siegele, MD, JD, Stephen Wicks, PhD, Sudabeh Balakhani, Mary Haag, PhD, Csaba Galambos , MD, PhD. EWSR1::NFATC2 rearranged vascular anomaly arising in early childhood with morphologic atypia. Society of Pediatric Pathology Spring 2023 meeting, New Orleans, LA. Mar 10-11, 2023 Poster 35 Pediatric and Developmental Pathology Volume 26, Issue 2 March/April 2023 Pages 97-
• Norris GA, Willard N, Donson AM, Gaskell A, Milgrom SA, O'Neill BR, Nijmeh H, Haag M, Gilani A, Foreman NK, Dahl NA. PDGFB:APOBEC3C fusion in congenital diffuse high-grade glioma of the brainstem. J Neuropathol Exp Neurol. 2023 Jan 20;82(2):183-186. PubMed PMID: 36440550
• Emily M. Kudalkar, Changlee Pang, Mary M. Haag, Daniel A. Pollyea, Manali Kamdar, Gang Xu, Meng Su, Billie Carstens, Karen Swisshelm and Liming Bao.. Cytogenomic profiling and clinical correlation of 21q22 amplification in acute myeloid leukemia reveal distinct cytogenomic features and poor outcomes. Submitted for publication to Annals of Hematology on November 11, 2021.
• Norris GA, Willard N, Donson AM, Gaskell A, Milgrom SA, O'Neill BR, Nijmeh H, Haag M, Gilani A, Foreman NK, Dahl NA. PDGFB:APOBEC3C fusion in congenital diffuse high-grade glioma of the brainstem [published online ahead of print, 2022 Nov 28]. J Neuropathol Exp Neurol. 2022;nlac112. doi:10.1093/jnen/nlac112
• Dowlut-McElroy T, Davis S, Howell S, Gutmark-Little I, Bamba V, Prakash S, Patel S, Fadoju D, Vijayakanthi N, Haag M, Hennerich D, Dugoff L, Shankar RK. Cell-free DNA screening positive for monosomy X: clinical evaluation and management of suspected maternal or fetal Turner syndrome. Am J Obstet Gynecol. 2022;227(6):862-870. doi:10.1016/j.ajog.2022.07.004
• Kudalkar EM, Pang C, Haag MM, Pollyea DA, Kamdar M, Xu G, Su M, Carstens B, Swisshelm K, Bao L. 21q22 amplification detection in three patients with acute myeloid leukemia: cytogenomic profiling and literature review. Mol Cytogenet. 2022 Jul 7;15(1):30. doi: 10.1186/s13039-022-00606-0. PMID: 35799207; PMCID: PMC9264596.
• Su M, Page S, Haag M, Swisshelm K, Hennerich D, Graw S, LeRoux J, Brzeskiewicz P, Svihovec S, Bao L. Clinical utility and cost-effectiveness analysis of chromosome testing concomitant with chromosomal microarray of patients with constitutional disorders in a U.S. academic medical center. J Genet Couns. 2022 Apr;31(2):364-374. doi: 10.1002/jgc4.1496. Epub 2021 Aug 16. PMID: 34397147.
• Chromosomal microarray characterization of a prenatal case of 46,XX SRY-positive Disorder of Sex Development (DSD) Jamie LeRoux , Deborrah Hennerich, Sudabeh Balakhani, Kimberly Harding , Catherine Burson, Meghan Donnelly, Mary M. Haag Cancer Genetics doi: 10.1016/j.cancergen.2021.01.045
• Masked hypodiploid B-Cell Lymphoblastic Leukemia (B-ALL) characterized by SNP microarray in a Li Fraumeni syndrome patient with post therapy karyotype changes Mary M. Haag, Billie Carstens, Veronica McDaniel, Alex Ohene-Mobley, Jamie LeRoux, Peter Brzeskiewicz, Kimberly Harding, Sudabeh Balakhani, Rui Zheng, Michael Verneris, Karen Swisshelm, Liming Bao Cancer Genetics doi: 10.1016/j.cancergen.2021.01.033
• Meng Su, PhD, Stephanie Page, MS, Mary Haag, PhD, Karen Swisshelm, PhD, Deborrah Hennerich, MS, CGC, Sharon Graw, PhD, CGC, Jamie Leroux, BS, Peter Brzeskiewicz, BS, Shayna Svihovec, MS, CGC3, and Liming Bao, MD, PhD; Clinical Utility and Cost Benefit of Chromosome Analysis Concomitant with Chromosomal Microarray Testing of Patients with Multiple Congenital Anomalies, Autism Spectrum Disorder, Developmental Delay, and Intellectual Disability. Journal of Genetic Counseling, 2021, August, pp1-11. doi.org/10.1002/jgc4.149.
• CMA and concurrent karyotyping for MCA, ASD, and/or DD/ID patients: Cost effectiveness based on our 7-year experience.Meng Su, Stephanie Page, Mary Haag, Karen Swisshelm, Deborrah Hennerich, Sharon Graw, Jamie Leroux, Peter Brzeskiewicz, Shayna Svihovec, and Liming Bao
• Porreco R, Burson C, Bao L, Haag M, Monozygosity by cell-free DNA screening in a dichorionic twin pregnancy with discordant fetal sex: informed antenatal and postnatal care. Prenatal Diagnosis. 2020,;4( 6) https://doi.org/10.1002/pd.5761.
• Su, M, Page S, Haag M, Swisshelm K, Hennerich D, Graw S, Leroux J, Brzeskiewicz P, Svihovec S, Bao, L. Clinical utility and cost benefit of chromosome analysis concomitant with chromosomal microarray testing of patients with multiple congenital anomalies, autism spectrum disorder, developmental delay, and intellectual disability. Submitted. November 2020.
• Deborrah Hennerich, Jamie LeRoux, Kieu Ha, Stephen Wicks, Mary Haag, Liming Bao, Katie Angione, Matthew Hiller, Timothy Bernard, Kestutis Micke, Michael Zaretsky, Hoanh Nguyen, Margarita Saenz, and Meng Su. Novel Case of Distal 5p and Proximal 13q Partial Trisomies in a Female with Congenital Anomalies of Kidney and Urinary Tract.
• MM Haag, B Carstens, V McDaniel, A Ohene-Mobley, J LeRoux, P Brzeskiewicz, K Harding, S Balakhani, RM Zheng, M Verneris, K Swisshelm, L Bao. Masked hypodiploid B-Cell Lymphoblastic Leukemia (B-ALL) characterized by SNP microarray in a Li Fraumeni syndrome patient with post therapy karyotype changes.
• J LeRoux, D Hennerich, C Burson, M Donnally, MM Haag. Chromosomal Microarray Characterization of a Prenatal Case of 46,XX SRY-Positive Disorder of Sex Development (DSD).
• Jaramillo C, Gilani, A, Haag, M, Donaldson, N, Mack, C. Synovial cell sarcoma in an adolescent liver transplant recipient. ACG Case Reports Journal: May 2019 - Vol 6 ( 5) p e00091 doi: 10.14309/crj.0000000000000091
• Brzeskiewicz P, Haag M, Swisshelm K, Liang X, McDaniel V, Carstens B, LeRoux J, Wicks S, Narayanan D, Bao L. Cytogenomic profiling of 26 cases with iAMP21 acute lymphoblastic leukemia. Cancer Gen. 2019 233-234 (S1) 16.
• Knez V, Liu X, Schowinsky J, Pan Z, Wang D, Lorsbach R, Lu C, Luedke C, Haag M, Carstens B, Swisshelm K, Yang LH, Jug R, Wang E, Liang X. Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study. Leuk Lymphoma. 2018 Sep 6:1-8. doi: 10.1080/10428194.2018.1508667
• Rachel A. Rowe, Billie J. Carstens, Mary M. Haag, Deborrah D. Hennerich, Jamie LeRoux, Divya Narayanan, Peter Brzeskiewicz, Kimberly E. Harding, Elizabeth Dubob, Kaitlin M. Angione, Karen Swisshelm. NEOCENTRIC supernumerary ring chromosome 8 balanced with homolog deletion along with presence of a 7.4 Mb deletion of 2q24.3q31.1 in a child with seizures. Abstract for CGC meeting. Published in Cancer Genetics, Volume 214-215, August 2017. Pp: 49-50.
• Divya Narayanana, Deborrah D. Hennericha, Mary M. Haaga, Anne Chun-Hui Tsai, Katherine Small, Peter M. Brzeskiewicza, Heather M. Jacquesa, Anna Skoniecznya, Billie J. Carstensa, and Karen Swisshelma . INTERSTITIAL duplication in chromosome 14q: a rare constitutional case. Abstract and poster presented at CGC meeting 2017. Cancer Genetics, Vol 214-215, August 2017, pg: 48.
• Bethany Tucker; Nicholas Behrendt; Deborrah Hennerich; Jeanne Zenge; Lorna Browne; Karrie Villavicencio1; Mary Haag; Karon R. Montgomery; Michael B. Schneider; Kenneth Liechty. Prenatal Diagnosis of Kabuki Syndrome due to a Deletion Involving Exons 5 and 6 of the KDM6A Gene. National Genetic Counseling Meeting poster presentation, 2017.
• Jamie LeRoux , Mary M. Haag, et al: Challenges of cell free fetal DNA follow-up testing for rare chromosome abnormalities: Lessons from two recent cases. Abstract submitted for CGC meeting, 2016. Abstract submitted for CGC meeting, 2016.
• Billie J Carstens, Mary M Haag, et al. A rare variant pediatric Ph+ acute lymphoblastic leukemia with five copies of the BCR-ABL1 fusion characterized by FISH, cytogenetics, and SNP microarray. Abstract submitted for CGC meeting August 2016.
• Lian Zhang MD. PhD, Billie Carstens CG , Mary M. Haag PhD, Karen Swisshelm PhD. Prenatal Testing and Cytogenetic Results Due to Confined Placental Mosaicism of Trisomy 9: A Case Report and Literature Review. Poster presented for the University of Colorado Dept of Pathology Annual Poster Session 2016.
• Mary M. Haag, Brenda D. Lunt, Deborah D. Hennerich, Kieu Ha, Lamie Le Roux, Karen Swisshelm. Terminal gain of 12p13.33 and terminal loss of 9p24.3, detected in a child with developmental delay and growth issues and due to a maternal unbalanced rearrangement between 12p and 9p. Abstract for poster presentation. Cancer Genetics, 208 (6), p.364, 2015.
• Bethany Tucker, MS, CGC; Deborrah Hennerich, RN, MS, CGC; Susan Toomey, MS; Karon R. Montgomery, MS, CGC; Mary Haag, PhD; Diane Minka, PhD; Peter Hulac, MD; Kenneth Liechty, MD; Michael B. Schneider, MD; Michael V. Zaretsky, MD; and David Manchester, MD. Mosaic Tetrasomy 18p: Discordant Results between Noninvasive Prenatal Screening and Fetal Karyotyping. NSGC Annual meeting, 2015 poser presentation.
• J.P. Johnsona, M. Haag, et al. Deletion rescue by mitotic 11q uniparental disomy in a family with recurrence of 11q deletion Jacobsen syndrome, Clin Genet 2014: 85: 376–380.
• K. Swisshelm, M.Haag, D.Hennerich, P.Brzeskiewicz, B.Lunt, J.LeRoux, G.Bellus, T.Schreiner. A Novel Familial Gain of 3q25.31 involving OMIM genes SLC33A1, GMPS,and MME. Abstract 3205 for the American Society of Human Genetics Meeting, poster presentation, October 2014.
• B Tucker, MS, CGC, D Hennerich MS, RN, CGC, S Toomey, MS, R Reynolds, MD, S Reeves, MD, K Swisshelm, PhD, FACMG, M Haag, PhD, FACMG, D Minka, PhD, FACMG, DK Manchester, MD Clinical description of a newborn male with a prenatal diagnosis of 46,XY,del(16)(q12.1q21)dn, NSGC Annual meeting, 2014
• James KN, Hazard DM, Graw S, Smith AY, Brzeskiewicz P,Jacques H,Rowe R,Duis J,Bao L, Haag M. Mosaic 2q37 Deletion Detected in a Neonate with IUGR and Brain Malformations. Submitted for 2022 ACMG annual meeting, November 2021.
• Emily M. Kudalkar, Changlee Pang, Mary M. Haag, Daniel A. Pollyea Manali Kamdar, Gang Xu, Meng Su, Billie Carstens, Karen Swisshelm and Liming Bao. Cytogenomic profiling and clinical correlation of 21q22 amplification in acute myeloid leukemia reveal distinct cytogenomic features and poor outcomes. Submitted for 2022 ACMG annual meeting, November 2021.
• Porreco RP, Burson C, Bao L, Haag M. Monozygosity by cell-free DNA screening in a dichorionic twin pregnancy with discordant fetal sex: informed antenatal and postnatal care. Prenat Diagn. Forthcoming 2020

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties

• Clinical Cytogenetics and Genomics, Board Certification
• Medical Genetics and Genomics-Clinical Molecular Genetics, Board Certification (1996)