Christine Vohwinkel, MD, PhD

Professional Titles

• Attending physician

Research Interests

Publications

• Roy RM, Allawzi A, Burns N, Sul C, Rubio V, Graham J, Stenmark K, Nozik ES, Tuder RM, Vohwinkel CU. Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury. FASEB J. 2023 Dec;37(12):e23316. PubMed PMID: 37983890
• Vaughn AE, Lehmann T, Sul C, Wallbank AM, Lyttle BD, Bardill J, Burns N, Apte A, Nozik ES, Smith B, Vohwinkel CU, Zgheib C, Liechty KW. CNP-miR146a Decreases Inflammation in Murine Acute Infectious Lung Injury. Pharmaceutics. 2023 Aug 26;15(9). PubMed PMID: 37765178
• Sul C, Lewis C, Dee N, Burns N, Oshima K, Schmidt E, Vohwinkel C, Nozik E. Release of extracellular superoxide dismutase into alveolar fluid protects against acute lung injury and inflammation in Staphylococcus aureus pneumonia. Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1;324(4):L445-L455. PubMed PMID: 36749572
• Roy RM, Allawzi A, Burns N, Sul C, Rubio V, Graham J, Stenmark K, Nozik ES, Tuder RM, Vohwinkel CU. Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury. FASEB J. 2023 Dec;37(12):e23316. PubMed PMID: 37983890
• Vaughn AE, Lehmann T, Sul C, Wallbank AM, Lyttle BD, Bardill J, Burns N, Apte A, Nozik ES, Smith B, Vohwinkel CU, Zgheib C, Liechty KW. CNP-miR146a Decreases Inflammation in Murine Acute Infectious Lung Injury. Pharmaceutics. 2023 Aug 26;15(9). PubMed PMID: 37765178
• Sul C, Lewis C, Dee N, Burns N, Oshima K, Schmidt E, Vohwinkel C, Nozik E. Release of extracellular superoxide dismutase into alveolar fluid protects against acute lung injury and inflammation in Staphylococcus aureus pneumonia. Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1;324(4):L445-L455. PubMed PMID: 36749572
• Vohwinkel CU, Burns N, Coit E, Yuan X, Vladar EK, Sul C, Schmidt EP, Carmeliet P, Stenmark K, Nozik ES, Tuder RM, Eltzschig HK. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight. 2022 Nov 3. [Epub ahead of print] PubMed PMID: 36326834
• Ohlstrom DJ, Sul C, Vohwinkel CU, Hernandez-Lagunas L, Karimpour-Fard A, Mourani PM, Carpenter TC, Nozik ES, Sucharov CC. Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study. Sci Rep. 2022 Aug 26;12(1):14560. PubMed PMID: 36028738
• Oyama Y, Shuff SR, Burns N, Vohwinkel CU, Eckle T. Intense light-elicited alveolar type 2-specific circadian PER2 protects from bacterial lung injury via BPIFB1. Am J Physiol Lung Cell Mol Physiol. 2022 May 1;322(5):L647-L661. PubMed PMID: 35272486
• Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB. Endothelial cell PHD2-HIF1a-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L675-L685. PubMed PMID: 34346780
• Vohwinkel CU, Tuder RM. Bronchopulmonary Dysplasia: Endothelial Cells in the Driver's Seat. Am J Respir Cell Mol Biol. 2021 Jul;65(1):6-7. PubMed PMID: 33856963
• Vohwinkel CU, Coit EJ, Burns N, Elajaili H, Hernandez-Saavedra D, Yuan X, Eckle T, Nozik E, Tuder RM, Eltzschig HK. Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury. FASEB J. 2021 Apr;35(4):e21468. PubMed PMID: 33687752
• Fredericks RM, Wang GS, Vohwinkel CU, Graham JK. An Unusual Case of Severe Anion Gap Metabolic Acidosis in a 3-year-old Girl. Pediatr Rev. 2021 Jan;42(Suppl 1):S46-S51. PubMed PMID: 33386361
• Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB. Endothelial cell PHD2-HIF1a-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L675-L685. PubMed PMID: 34346780
• Vohwinkel CU, Tuder RM. Bronchopulmonary Dysplasia: Endothelial Cells in the Driver's Seat. Am J Respir Cell Mol Biol. 2021 Jul;65(1):6-7. PubMed PMID: 33856963
• Vohwinkel CU, Coit EJ, Burns N, Elajaili H, Hernandez-Saavedra D, Yuan X, Eckle T, Nozik E, Tuder RM, Eltzschig HK. Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury. FASEB J. 2021 Apr;35(4):e21468. PubMed PMID: 33687752
• Fredericks RM, Wang GS, Vohwinkel CU, Graham JK. An Unusual Case of Severe Anion Gap Metabolic Acidosis in a 3-year-old Girl. Pediatr Rev. 2021 Jan;42(Suppl 1):S46-S51. PubMed PMID: 33386361
• Good RJ, Hernandez-Lagunas L, Allawzi A, Maltzahn JK, Vohwinkel CU, Upadhyay AK, Kompella UB, Birukov KG, Carpenter TC, Sucharov CC, Nozik-Grayck E. MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L584-L594. PubMed PMID: 30024304
• Hoegl S, Burns N, Angulo M, Francis D, Osborne CM, Mills TW, Blackburn MR, Eltzschig HK, Vohwinkel CU. Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury. Physiol Rep. 2018 Mar;6(6):e13648. PubMed PMID: 29595879
• Mazzocchi LC, Vohwinkel CU, Mayer K, Herold S, Morty RE, Seeger W, Vadász I. TGF-ß inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L807-L824. PubMed PMID: 28705909
• Vohwinkel CU, Buchäckert Y, Al-Tamari HM, Mazzocchi LC, Eltzschig HK, Mayer K, Morty RE, Herold S, Seeger W, Pullamsetti SS, Vadász I. Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 Nov;57(5):589-602. PubMed PMID: 28678521
• Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU. Correction: Detrimental ELAVL-1/HuR-dependent GSK3ß mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One. 2017;12(4):e0176134. PubMed PMID: 28407018
• Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU. Detrimental ELAVL-1/HuR-dependent GSK3ß mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One. 2017;12(2):e0172116. PubMed PMID: 28196122
• Mazzocchi LC, Vohwinkel CU, Mayer K, Herold S, Morty RE, Seeger W, Vadász I. TGF-ß inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis and transcriptional downregulation of megalin. Am J Physiol Lung Cell Mol Physiol. 2017 Jul 13;:ajplung.00569.2016. [Epub ahead of print] PubMed PMID: 28705909
• Vohwinkel CU, Buchäckert Y, Al-Tamari HM, Mazzocchi LC, Eltzschig HK, Mayer K, Morty RE, Herold S, Seeger W, Pullamsetti SS, Vadász I. Restoration of Megalin-mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 Jul 5. [Epub ahead of print] PubMed PMID: 28678521
• Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU. Detrimental ELAVL-1/HuR-dependent GSK3ß mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One. 2017;12(2):e0172116. PubMed PMID: 28196122
• Hoffman O, Burns N, Vadász I, Eltzschig HK, Edwards MG, Vohwinkel CU. Correction: Detrimental ELAVL-1/HuR-dependent GSK3ß mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS One. 2017;12(4):e0176134. PubMed PMID: 28407018
• McNamee EN, Vohwinkel C, Eltzschig HK. Hydroxylation-independent HIF-1a stabilization through PKA: A new paradigm for hypoxia signaling. Sci Signal. 2016 May 31;9(430):fs11. PubMed PMID: 27245611
• Hoegl S, Zwissler B, Eltzschig HK, Vohwinkel C. Acute respiratory distress syndrome following cardiovascular surgery: current concepts and novel therapeutic approaches. Curr Opin Anaesthesiol. 2016 Feb;29(1):94-100. PubMed PMID: 26598954
• Cao D, Maddux AB, Mashburn D, Vohwinkel C, Wang GS. Pediatric occult methanol intoxication with hyperammonemia. Am J Emerg Med. 2016 Feb;34(2):343.e5-6. PubMed PMID: 26162618
• Good R, Hernandez-Lagunas L, Swain K, Vohwinkel C, Sucharov C, Kompella U, Carpenter T, Grayck E. 969: DYSREGULATED MICRORNAS IN ACUTE LUNG INJURY: MIR-26A REGULATES LUNG ENDOTHELIAL CELL PERMEABILITY. Crit Care Med. 2016 Dec;44(12 Suppl 1):318. PubMed PMID: 27850607
• McNamee EN, Vohwinkel C, Eltzschig HK. Hydroxylation-independent HIF-1a stabilization through PKA: A new paradigm for hypoxia signaling. Sci Signal. 2016 May 31;9(430):fs11. PubMed PMID: 27245611
• Hoegl S, Zwissler B, Eltzschig HK, Vohwinkel C. Acute respiratory distress syndrome following cardiovascular surgery: current concepts and novel therapeutic approaches. Curr Opin Anaesthesiol. 2016 Feb;29(1):94-100. PubMed PMID: 26598954
• Cao D, Maddux AB, Mashburn D, Vohwinkel C, Wang GS. Pediatric occult methanol intoxication with hyperammonemia. Am J Emerg Med. 2016 Feb;34(2):343.e5-6. PubMed PMID: 26162618
• Vohwinkel CU, Hoegl S, Eltzschig HK. Hypoxia signaling during acute lung injury. J Appl Physiol (1985). 2015 Nov 15;119(10):1157-63. PubMed PMID: 25977449
• Grzesik BA, Vohwinkel CU, Morty RE, Mayer K, Herold S, Seeger W, Vadász I. Efficient gene delivery to primary alveolar epithelial cells by nucleofection. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(11):L786-94. PubMed PMID: 24077946
• Gates KL, Howell HA, Nair A, Vohwinkel CU, Welch LC, Beitel GJ, Hauser AR, Sznajder JI, Sporn PH. Hypercapnia impairs lung neutrophil function and increases mortality in murine pseudomonas pneumonia. Am J Respir Cell Mol Biol. 2013 Nov;49(5):821-8. PubMed PMID: 23777386
• Vohwinkel CU, Vadász I. Influenza A matrix protein M2 downregulates CFTR: inhibition of chloride transport by a proton channel of the viral envelope. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L813-6. PubMed PMID: 23605001
• Roger's Textbook of Pediatric Critical Care 6th Edition Chapter 44: The Molecular Biology of Acute Lung Injury

Professional Memberships

• American Thoracic Society (ATS), Member
• Society of Critical Care Medicine, Member

Practice Locations

• Children's Hospital Colorado

• Colorado Clinical & Translational Sciences Institute (CCTSI)

Specialty Information

• Pediatrics, Board Certification (2007)
• Pediatric Critical Care Medicine, Board Certification (2010)

• Critical Care