Sana Karam, MD, PhD
Associate Professor, Radiation Oncology

Professional Titles

• Vice Chair of Translational Research
• Marsico Endowed Chair in Head and Neck Cancer

Recognition & Awards

• Educator of The Year Award, ARRO (2020)
  National award for recognition by the Association of Residents in Radiation Oncology as a member of the Program’s Faculty for excellence in teaching.

Research Interests

Teaching

Publications

• Darragh LB, Karam SD. Amateur antigen-presenting cells in the tumor microenvironment. Mol Carcinog. 2022 Feb;61(2):153-164. PubMed PMID: 34570920
• Karam SD, Anderson CM, Ma D, Chua MLK, Kimple RJ. Immunotherapy in Head and Neck Cancer-Ready for Prime Time or More Research Needed?. Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):647-650. PubMed PMID: 33516431
• Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. J Immunother Cancer. 2021 Mar;9(3). PubMed PMID: 33789881
• Mirian C, Gerds TA, Pedersen MM, de Ridder M, Balm A, Mattavelli D, Piazza C, Jensen LR, Balasubramanian D, Subramaniam N, Dokhe Y, Thankappan K, Iyer S, Karam SD, Wiegand S, Feeley L, Milross C, Gao K, Palme CE, Low TH, Gupta R, Freudlsperger C, Moratin J, Sheahan P, Clark J, Ovesen T. Metrics of pN-staging in oral squamous cell carcinoma: An analysis of 1,905 patients. Eur J Cancer. 2021 Jun;150:33-41. PubMed PMID: 33887515
• Morgan RL, Eguchi MM, McDermott J, Mueller AC, Amini A, Goddard JA, Trivedi PS, Karam SD. Comparative effectiveness of posttreatment imaging modalities for Medicare patients with advanced head and neck cancer. Cancer. 2021 Feb 15;127(4):535-543. PubMed PMID: 33119176
• Veo B, Danis E, Pierce A, Wang D, Fosmire S, Sullivan KD, Joshi M, Khanal S, Dahl N, Karam S, Serkova N, Venkataraman S, Vibhakar R. Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma. Cell Rep. 2021 Apr 27;35(4):109013. PubMed PMID: 33910002
• Knitz MW, Bickett TE, Darragh LB, Oweida AJ, Bhatia S, Van Court B, Bhuvane S, Piper M, Gadwa J, Mueller AC, Nguyen D, Nangia V, Osborne DG, Bai X, Ferrara SE, Boss MK, Goodspeed A, Burchill MA, Tamburini BAJ, Chan ED, Pickering CR, Clambey ET, Karam SD. Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. J Immunother Cancer. 2021 Apr;9(4). PubMed PMID: 33883256
• Oweida AJ, Mueller AC, Piper M, Milner D, Van Court B, Bhatia S, Phan A, Bickett T, Jordan K, Proia T, Schulick R, Messersmith WA, Del Chiaro M, Clambey E, Gough MJ, Williams J, Hansen K, Goodman K, Karam SD. Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide. Cancer Immunol Immunother. 2021 Apr;70(4):989-1000. PubMed PMID: 33097963
• Yu J, Pham TT, Wandrey N, Daly M, Karam SD. Multimodality Management of EBV-Associated Nasopharyngeal Carcinoma. Cancers (Basel). 2021 Dec 2;13(23). PubMed PMID: 34885187
• Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2021 Dec 3. [Epub ahead of print] PubMed PMID: 34862244
• Bickett TE, Knitz MW, Piper M, Oweida AJ, Gadwa J, Darragh LB, Nguyen D, Bhatia S, Bhuvane S, Phan AV, Van Court B, Corbo S, Pham T, Dent AL, Lenz L, Karam SD. Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC. Mol Ther. 2021 Nov 15. [Epub ahead of print] PubMed PMID: 34793974
• Boss MK, Ke Y, Bian L, Harrison LG, Lee BI, Prebble A, Martin T, Trageser E, Hall S, Wang DD, Wang S, Chow L, Holwerda B, Raben D, Regan D, Karam SD, Dow S, Young CD, Wang XJ. Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis. Int J Radiat Oncol Biol Phys. 2021 Oct 3. [Epub ahead of print] PubMed PMID: 34610386
• Knitz MW, Darragh LB, Bickett TE, Bhatia S, Bukkapatnam S, Gadwa J, Piper M, Corbo S, Nguyen D, Van Court B, Oweida A, Karam SD. Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma. Cancer Immunol Immunother. 2021 Sep 24. [Epub ahead of print] PubMed PMID: 34559306
• Márquez-Ortiz RA, Contreras-Zárate MJ, Tesic V, Alvarez-Eraso KLF, Kwak G, Littrell Z, Costello JC, Sreekanth V, Ormond DR, Karam SD, Kabos P, Cittelly DM. IL13Ra2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases. Clin Cancer Res. 2021 Nov 15;27(22):6209-6221. PubMed PMID: 34544797
• Bickett TE, Knitz M, Darragh LB, Bhatia S, Van Court B, Gadwa J, Bhuvane S, Piper M, Nguyen D, Tu H, Lenz L, Clambey ET, Barry K, Karam SD. FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC. Clin Cancer Res. 2021 Nov 15;27(22):6235-6249. PubMed PMID: 34518311
• Strait AA, Woolaver RA, Hall SC, Young CD, Karam SD, Jimeno A, Lan Y, Raben D, Wang JH, Wang XJ. Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFß/PD-L1 blockade-treated squamous cell carcinoma. Commun Biol. 2021 Aug 25;4(1):1005. PubMed PMID: 34433873
• Amini A, Morgan R, Meyer E, Fakhoury K, Ladbury C, Bickett T, McDermott JD, Stokes W, Karam SD. Outcomes between intensity-modulated radiation therapy versus 3D-conformal in early stage glottic cancer. Head Neck. 2021 Nov;43(11):3393-3403. PubMed PMID: 34382714
• DeLouize AM, Eick G, Karam SD, Snodgrass JJ. Current and future applications of biomarkers in samples collected through minimally invasive methods for cancer medicine and population-based research. Am J Hum Biol. 2021 Aug 9;:e23665. [Epub ahead of print] PubMed PMID: 34374148
• Stokes WA, Molina E, McDermott JD, Morgan RL, Bickett T, Fakhoury KR, Amini A, Karam SD. Survival impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in head and neck cancer. Head Neck. 2021 Nov;43(11):3255-3275. PubMed PMID: 34289190
• Knitz MW, Bickett TE, Darragh LB, Oweida AJ, Bhatia S, Van Court B, Bhuvane S, Piper M, Gadwa J, Mueller AC, Nguyen D, Nangia V, Osborne DG, Bai X, Ferrara SE, Boss MK, Goodspeed A, Burchill MA, Tamburini BAJ, Chan ED, Pickering CR, Clambey ET, Karam SD. Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. J Immunother Cancer. 2021 Apr;9(4). PubMed PMID: 33883256
• Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. J Immunother Cancer. 2021 Mar;9(3). PubMed PMID: 33789881
• Mueller AC, Piper M, Goodspeed A, Bhuvane S, Williams JS, Bhatia S, Phan AV, Van Court B, Zolman KL, Peña B, Oweida AJ, Zakem S, Meguid C, Knitz MW, Darragh L, Bickett TE, Gadwa J, Mestroni L, Taylor MRG, Jordan KR, Dempsey P, Lucia MS, McCarter MD, Chiaro MD, Messersmith WA, Schulick RD, Goodman KA, Gough MJ, Greene CS, Costello JC, Neto AG, Lagares D, Hansen KC, Van Bokhoven A, Karam SD. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021 Jun 15;81(12):3255-3269. PubMed PMID: 33526513
• Karam SD, Anderson CM, Ma D, Chua MLK, Kimple RJ. Immunotherapy in Head and Neck Cancer-Ready for Prime Time or More Research Needed?. Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):647-650. PubMed PMID: 33516431
• Oweida AJ, Mueller AC, Piper M, Milner D, Van Court B, Bhatia S, Phan A, Bickett T, Jordan K, Proia T, Schulick R, Messersmith WA, Del Chiaro M, Clambey E, Gough MJ, Williams J, Hansen K, Goodman K, Karam SD. Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide. Cancer Immunol Immunother. 2021 Apr;70(4):989-1000. PubMed PMID: 33097963
• Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. J Transl Med. 2021 Jan 23;19(1):43. PubMed PMID: 33485341
• Morgan RL, Eguchi MM, McDermott J, Mueller AC, Amini A, Goddard JA, Trivedi PS, Karam SD. Comparative effectiveness of posttreatment imaging modalities for Medicare patients with advanced head and neck cancer. Cancer. 2021 Feb 15;127(4):535-543. PubMed PMID: 33119176
• Shinde A, Jones B, Luu M, Li R, Glaser S, Massarelli E, Freeman M, Gernon T, Maghami E, Kang R, Zumsteg Z, Karam SD, Amini A. Factors predictive of 90-day mortality after surgical resection for oral cavity cancer: Development of a recursive partitioning analysis for risk stratification. Head Neck. 2021 Sep;43(9):2731-2739. PubMed PMID: 34013577
• Gadwa J, Karam SD. Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer. Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):46-55. PubMed PMID: 32629082
• Bhatia S, Bukkapatnam S, Van Court B, Phan A, Oweida A, Gadwa J, Mueller AC, Piper M, Darragh L, Nguyen D, Gilani A, Knitz M, Bickett T, Green A, Venkataraman S, Vibhakar R, Cittelly D, Karam SD. The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. Mol Carcinog. 2020 Sep;59(9):1064-1075. PubMed PMID: 32567728
• Hernandez AL, Young CD, Bian L, Weigel K, Nolan K, Frederick B, Han G, He G, Devon Trahan G, Rudolph MC, Jones KL, Oweida AJ, Karam SD, Raben D, Wang XJ. PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models. Clin Cancer Res. 2020 Jun 15;26(12):3058-3070. PubMed PMID: 32139402
• Chua MLK, Ma DJ, Anderson CM, Karam SD, Margalit DN, Kimple RJ. Follow-Up and Management of Patients With Head and Neck Cancer During the 2019 Novel Coronavirus (SARS-CoV-2) Disease Pandemic. Adv Radiat Oncol. 2020 Jul-Aug;5(4):631-636. PubMed PMID: 32426556
• Piper M, Mueller AC, Karam SD. The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy. Mol Carcinog. 2020 Jul;59(7):754-765. PubMed PMID: 32363633
• Amini A, Verma V, Li R, Vora N, Kang R, Gernon TJ, Chang S, Karam S, Massarelli E, Maghami EG, Glaser S. Factors predicting for patient refusal of head and neck cancer therapy. Head Neck. 2020 Jan;42(1):33-42. PubMed PMID: 31584746
• Hararah MK, Stokes WA, Oweida A, Patil T, Amini A, Goddard J, Bowles DW, Karam SD. Epidemiology and treatment trends for primary tracheal squamous cell carcinoma. Laryngoscope. 2020 Feb;130(2):405-412. PubMed PMID: 30977524
• Morgan RL, Karam SD, Bradley CJ. Ethnic Disparities in Imaging Utilization at Diagnosis of Non-Small Cell Lung Cancer. J Natl Cancer Inst. 2020 Dec 14;112(12):1204-1212. PubMed PMID: 32134453
• Margalit DN, Karam SD, Chua MLK, Anderson C, Kimple RJ. Four Influential Clinical Trials in Human Papilloma Virus-Associated Oropharynx Cancer. Int J Radiat Oncol Biol Phys. 2020 Apr 1;106(5):893-899. PubMed PMID: 32171456
• Mueller AC, Karam SD. SBRT for Early Stage Larynx: A Go or No Go? It's All in the Delivery. Int J Radiat Oncol Biol Phys. 2019 Sep 1;105(1):119-120. PubMed PMID: 31422804
• Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res. 2019 May 15;79(10):2722-2735. PubMed PMID: 30894369
• Gupta A, Stokes W, Eguchi M, Hararah M, Amini A, Mueller A, Morgan R, Bradley C, Raben D, McDermott J, Karam SD. Statin use associated with improved overall and cancer specific survival in patients with head and neck cancer. Oral Oncol. 2019 Mar;90:54-66. PubMed PMID: 30846177
• Lennon S, Oweida A, Milner D, Phan AV, Bhatia S, Van Court B, Darragh L, Mueller AC, Raben D, Martínez-Torrecuadrada JL, Pitts TM, Somerset H, Jordan KR, Hansen KC, Williams J, Messersmith WA, Schulick RD, Owens P, Goodman KA, Karam SD. Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination. Clin Cancer Res. 2019 Jun 1;25(11):3352-3365. PubMed PMID: 30944125
• Anderson CM, Kimple RJ, Lin A, Karam SD, Margalit DN, Chua MLK. De-Escalation Strategies in HPV-Associated Oropharynx Cancer-Are we Putting the Cart Before the Horse?. Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):705-709. PubMed PMID: 31204653
• Amini A, Stokes WA, Jones BL, Sampath S, Kang RS, Gernon TJ, Maghami EG, Massarelli E, Bradley CJ, Karam SD. Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma. Head Neck. 2019 Jul;41(7):2299-2308. PubMed PMID: 30737961
• Amini A, Karam SD. Concurrent chemotherapy in oropharyngeal cancer: Cisplatin wins. Oncotarget. 2019 Jan 18;10(6):624-625. PubMed PMID: 30774757
• Pierce AM, Witt DA, Donson AM, Gilani A, Sanford B, Sill M, Van Court B, Oweida A, Prince EW, Steiner J, Danis E, Dorris K, Hankinson T, Handler MH, Jones KL, Karam SD, Serkova NJ, Vibhakar R, Foreman NK, Griesinger AM. Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma. Neuro Oncol. 2019 Dec 17;21(12):1540-1551. PubMed PMID: 31276586
• Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Court BV, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. J Natl Cancer Inst. 2019 Dec 1;111(12):1339-1349. PubMed PMID: 30863843
• Morgan RL, Eguchi MM, Mueller AC, Daugherty SL, Amini A, Karam SD. Imaging at diagnosis impacts cancer-specific survival among patients with cancer of the oropharynx. Cancer. 2019 Aug 15;125(16):2794-2802. PubMed PMID: 31042320
• Li R, Shinde A, Glaser S, Chao J, Kim J, Karam SD, Goodman K, Chen YJ, Amini A. Analyzing the impact of neoadjuvant radiation dose on pathologic response and survival outcomes in esophageal and gastroesophageal cancers. J Gastrointest Oncol. 2019 Aug;10(4):712-722. PubMed PMID: 31392052
• Karam SD, Raben D. Radioimmunotherapy for the treatment of head and neck cancer. Lancet Oncol. 2019 Aug;20(8):e404-e416. PubMed PMID: 31364593
• Pacheco JM, Gao D, Smith D, Purcell T, Hancock M, Bunn P, Robin T, Liu A, Karam S, Gaspar L, Kavanagh B, Rusthoven C, Aisner D, Doebele R, Camidge DR. Natural History and Factors Associated with Overall Survival in Stage IV ALK-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2019 Apr;14(4):691-700. PubMed PMID: 30599201
• Stokes WA, Karam SD. In Reply to Overgaard et al. Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):805-807. PubMed PMID: 29413295
• Hernandez AL, Wang Y, Somerset HL, Keysar SB, Aisner DL, Marshall C, Bowles DW, Karam SD, Raben D, Jimeno A, Varella-Garcia M, Wang XJ. Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas. Mol Carcinog. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30575147
• Ding D, Stokes W, Eguchi M, Hararah M, Sumner W, Amini A, Goddard J, Somerset H, Bradley C, McDermott J, Raben D, Karam SD. Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg. 2018 Nov 15. [Epub ahead of print] PubMed PMID: 30452499
• McDermott JD, Eguchi M, Stokes WA, Amini A, Hararah M, Ding D, Valentine A, Bradley CJ, Karam SD. Short- and Long-term Opioid Use in Patients with Oral and Oropharynx Cancer. Otolaryngol Head Neck Surg. 2018 Nov 6;:194599818808513. [Epub ahead of print] PubMed PMID: 30396321
• Amini A, Eguchi M, Jones BL, Stokes WA, Gupta A, McDermott JD, Massarelli E, Bradley CJ, Karam SD. Comparing outcomes of concurrent chemotherapy regimens in patients 65 years old or older with locally advanced oropharyngeal carcinoma. Cancer. 2018 Nov 15;124(22):4322-4331. PubMed PMID: 30291789
• Stokes WA, Eguchi M, Amini A, Hararah MK, Ding D, McDermott JD, Bradley CJ, Karam SD. Survival impact and toxicity of metformin in head and neck cancer: An analysis of the SEER-Medicare dataset. Oral Oncol. 2018 Sep;84:12-19. PubMed PMID: 30115470
• Hararah MK, Stokes WA, Jones BL, Oweida A, Ding D, McDermott J, Goddard J, Karam SD. Nomogram for preoperative prediction of nodal extracapsular extension or positive surgical margins in oropharyngeal squamous cell carcinoma. Oral Oncol. 2018 Aug;83:73-80. PubMed PMID: 30098782
• Karam SD, Reddy K, Blatchford PJ, Waxweiler T, DeLouize AM, Oweida A, Somerset H, Marshall C, Young C, Davies KD, Kane M, Tan AC, Wang XJ, Jimeno A, Aisner DL, Bowles DW, Raben D. Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer. Clin Cancer Res. 2018 Oct 15;24(20):4949-4959. PubMed PMID: 30084837
• Oweida A, Hararah MK, Phan A, Binder D, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey E, Nemenoff R, Karam SD. Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration. Clin Cancer Res. 2018 Nov 1;24(21):5368-5380. PubMed PMID: 30042205
• Bhatia S, Griego A, Lennon S, Oweida A, Sharma J, Rohmer C, Uyanga N, Bukkapatnam S, Van Court B, Raben D, Young C, Heasley L, Karam SD. Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor. Mol Cancer Ther. 2018 Sep;17(9):2049-2059. PubMed PMID: 29970482
• Robin TP, Breeze RE, Smith DE, Rusthoven CG, Lewis KD, Gonzalez R, Brill A, Saiki R, Stuhr K, Gaspar LE, Karam SD, Raben D, Kavanagh BD, Nath SK, Liu AK. Immune checkpoint inhibitors and radiosurgery for newly diagnosed melanoma brain metastases. J Neurooncol. 2018 Oct;140(1):55-62. PubMed PMID: 29909499
• Bhatia S, Sharma J, Bukkapatnam S, Oweida A, Lennon S, Phan A, Milner D, Uyanga N, Jimeno A, Raben D, Somerset H, Heasley L, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers. Clin Cancer Res. 2018 Sep 15;24(18):4539-4550. PubMed PMID: 29848571
• Oweida A, Phan A, Vancourt B, Robin T, Hararah MK, Bhatia S, Milner D, Lennon S, Pike L, Raben D, Haugen B, Pozdeyev N, Schweppe R, Karam SD. Hypofractionated Radiotherapy Is Superior to Conventional Fractionation in an Orthotopic Model of Anaplastic Thyroid Cancer. Thyroid. 2018 Jun;28(6):739-747. PubMed PMID: 29774792
• Stokes WA, Karam SD. In Reply to Overgaard et al. Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):805-807. PubMed PMID: 29413295
• Amini A, Yeh N, Jones BL, Bedrick E, Vinogradskiy Y, Rusthoven CG, Amini A, Purcell WT, Karam SD, Kavanagh BD, Guntupalli SR, Fisher CM. Perioperative Mortality in Nonelderly Adult Patients With Cancer: A Population-based Study Evaluating Health Care Disparities in the United States According to Insurance Status. Am J Clin Oncol. 2018 May;41(5):476-484. PubMed PMID: 27281264
• Darragh LB, Oweida AJ, Karam SD. Overcoming Resistance to Combination Radiation-Immunotherapy: A Focus on Contributing Pathways Within the Tumor Microenvironment. Front Immunol. 2018;9:3154. PubMed PMID: 30766539
• Stokes WA, Binder DC, Jones BL, Oweida AJ, Liu AK, Rusthoven CG, Karam SD. Impact of immunotherapy among patients with melanoma brain metastases managed with radiotherapy. J Neuroimmunol. 2017 Dec 15;313:118-122. PubMed PMID: 29153603
• Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967
• Sumner WA, Amini A, Hankinson TC, Foreman NK, Gaspar LE, Kavanagh BD, Karam SD, Rusthoven CG, Liu AK. Survival benefit of postoperative radiation in papillary meningioma: Analysis of the National Cancer Data Base. Rep Pract Oncol Radiother. 2017 Nov-Dec;22(6):495-501. PubMed PMID: 29123457
• Stokes WA, Sumner WA, Breggren KL, Rathbun JT, Raben D, McDermott JD, Gan G, Karam SD. A comparison of concurrent cisplatin versus cetuximab with radiotherapy in locally-advanced head and neck cancer: A bi-institutional analysis. Rep Pract Oncol Radiother. 2017 Sep-Oct;22(5):389-395. PubMed PMID: 28808428
• Stokes WA, Stumpf PK, Jones BL, Blatchford PJ, Karam SD, Lanning RM, Raben D. Patterns of fractionation for patients with T2N0M0 glottic larynx cancer undergoing definitive radiotherapy in the United States. Oral Oncol. 2017 Sep;72:110-116. PubMed PMID: 28797446
• Sumner WA, Stokes WA, Oweida A, Berggren KL, McDermott JD, Raben D, Abbott D, Jones B, Gan G, Karam SD. Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy. J Transl Med. 2017 Aug 2;15(1):168. PubMed PMID: 28764811
• Stokes WA, Abbott D, Phan A, Raben D, Lanning RM, Karam SD. Patterns of Care for Patients With Early-Stage Glottic Cancer Undergoing Definitive Radiation Therapy: A National Cancer Database Analysis. Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1014-1021. PubMed PMID: 28721883
• Wie SM, Wellberg E, Karam SD, Reyland ME. Tyrosine Kinase Inhibitors Protect the Salivary Gland from Radiation Damage by Inhibiting Activation of Protein Kinase C-d. Mol Cancer Ther. 2017 Sep;16(9):1989-1998. PubMed PMID: 28637715
• Rusthoven CG, Lanning RM, Jones BL, Amini A, Koshy M, Sher DJ, Bowles DW, McDermott JD, Jimeno A, Karam SD. Metastatic nasopharyngeal carcinoma: Patterns of care and survival for patients receiving chemotherapy with and without local radiotherapy. Radiother Oncol. 2017 Jul;124(1):139-146. PubMed PMID: 28433411
• Robin TP, Jones BL, Gordon OM, Phan A, Abbott D, McDermott JD, Goddard JA, Raben D, Lanning RM, Karam SD. A comprehensive comparative analysis of treatment modalities for sinonasal malignancies. Cancer. 2017 Aug 15;123(16):3040-3049. PubMed PMID: 28369832
• Bhatia S, Hirsch K, Bukkapatnam S, Baig NA, Oweida A, Griego A, Calame D, Sharma J, Donson A, Foreman N, Albanese C, Venkataraman S, Vibhakar R, Karam SD. Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma. Cancer Cell Int. 2017;17:41. PubMed PMID: 28360821
• Wang K, McDermott JD, Schrock AB, Elvin JA, Gay L, Karam SD, Raben D, Somerset H, Ali SM, Ross JS, Bowles DW. Comprehensive genomic profiling of salivary mucoepidermoid carcinomas reveals frequent BAP1, PIK3CA, and other actionable genomic alterations. Ann Oncol. 2017 Apr 1;28(4):748-753. PubMed PMID: 28327999
• Stokes WA, Amini A, Jones BL, McDermott JD, Raben D, Ghosh D, Goddard JA, Bowles DW, Karam SD. Survival impact of induction chemotherapy in advanced head and neck cancer: A National Cancer Database analysis. Head Neck. 2017 Jun;39(6):1113-1121. PubMed PMID: 28301079
• Stokes WA, Amini A, Jones BL, McDermott JD, Raben D, Ghosh D, Goddard JA, Bowles DW, Karam SD. Survival impact of induction chemotherapy in advanced head and neck cancer: A National Cancer Database analysis. Head Neck. 2017 Jun;39(6):1113-1121. PubMed PMID: 28301079
• Oweida A, Bhatia S, Hirsch K, Calame D, Griego A, Keysar S, Pitts T, Sharma J, Eckhardt G, Jimeno A, Wang XJ, Parkash G, Califano J, Karam SD. Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors. Mol Carcinog. 2017 Mar;56(3):1189-1196. PubMed PMID: 27649287
• Stokes WA, Jones BL, Bhatia S, Oweida AJ, Bowles DW, Raben D, Goddard JA, McDermott JD, Karam SD. A comparison of overall survival for patients with T4 larynx cancer treated with surgical versus organ-preservation approaches: A National Cancer Data Base analysis. Cancer. 2017 Feb 15;123(4):600-608. PubMed PMID: 27727461
• Amini A, Waxweiler TV, Brower JV, Jones BL, McDermott JD, Raben D, Ghosh D, Bowles DW, Karam SD. Association of Adjuvant Chemoradiotherapy vs Radiotherapy Alone With Survival in Patients With Resected Major Salivary Gland Carcinoma: Data From the National Cancer Data Base. JAMA Otolaryngol Head Neck Surg. 2016 Nov 1;142(11):1100-1110. PubMed PMID: 27541166
• Amini A, Jones BL, McDermott JD, Serracino HS, Jimeno A, Raben D, Ghosh D, Bowles DW, Karam SD. Survival outcomes with concurrent chemoradiation for elderly patients with locally advanced head and neck cancer according to the National Cancer Data Base. Cancer. 2016 May 15;122(10):1533-43. PubMed PMID: 26969811
• Amini A, Jasem J, Jones BL, Robin TP, McDermott JD, Bhatia S, Raben D, Jimeno A, Bowles DW, Karam SD. Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer using the National Cancer Data Base. Oral Oncol. 2016 May;56:1-7. PubMed PMID: 27086480
• Rusthoven CG, Koshy M, Sher DJ, Ney DE, Gaspar LE, Jones BL, Karam SD, Amini A, Ormond DR, Youssef AS, Kavanagh BD. Combined-Modality Therapy With Radiation and Chemotherapy for Elderly Patients With Glioblastoma in the Temozolomide Era: A National Cancer Database Analysis. JAMA Neurol. 2016 Jul 1;73(7):821-8. PubMed PMID: 27214765
• Amini A, Rusthoven CG, Waxweiler TV, Jones BL, Fisher CM, Karam SD, Raben D. Association of health insurance with outcomes in adults ages 18 to 64 years with melanoma in the United States. J Am Acad Dermatol. 2016 Feb;74(2):309-16. PubMed PMID: 26670715
• Rashid A, Karam SD, Rashid B, Kim JH, Pang D, Jean W, Grimm J, Collins SP. Multisession Radiosurgery for Hearing Preservation. Semin Radiat Oncol. 2016 Apr;26(2):105-11. PubMed PMID: 27000506
• O'Sullivan B, Huang SH, Su J, Garden AS, Sturgis EM, Dahlstrom K, Lee N, Riaz N, Pei X, Koyfman SA, Adelstein D, Burkey BB, Friborg J, Kristensen CA, Gothelf AB, Hoebers F, Kremer B, Speel EJ, Bowles DW, Raben D, Karam SD, Yu E, Xu W. Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study. Lancet Oncol. 2016 Apr;17(4):440-451. PubMed PMID: 26936027
• Robin TP, Gan GN, Tam M, Westerly D, Riaz N, Karam SD, Lee N, Raben D. Safety of contralateral submandibular gland sparing in locally advanced oropharyngeal cancers: A multicenter review. Head Neck. 2016 Apr;38(4):506-11. PubMed PMID: 25482748
• Waye S, Naeem A, Choudhry MU, Parasido E, Tricoli L, Sivakumar A, Mikhaiel JP, Yenugonda V, Rodriguez OC, Karam SD, Rood BR, Avantaggiati ML, Albanese C. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging (Albany NY). 2015 Oct;7(10):854-68. PubMed PMID: 26540407
• Amini A, Altoos B, Bourlon MT, Bedrick E, Bhatia S, Kessler ER, Flaig TW, Fisher CM, Kavanagh BD, Lam ET, Karam SD. Local control rates of metastatic renal cell carcinoma (RCC) to the bone using stereotactic body radiation therapy: Is RCC truly radioresistant?. Pract Radiat Oncol. 2015 Nov-Dec;5(6):e589-e596. PubMed PMID: 26142027
• Karam SD, Bhatia S. The radiobiological targets of SBRT: tumor cells or endothelial cells?. Ann Transl Med. 2015 Nov;3(19):290. PubMed PMID: 26697450
• Rusthoven CG, Kavanagh BD, Karam SD. Improved survival with stereotactic ablative radiotherapy (SABR) over lobectomy for early stage non-small cell lung cancer (NSCLC): addressing the fallout of disruptive randomized data. Ann Transl Med. 2015 Jul;3(11):149. PubMed PMID: 26244136
• Bhatia S, Baig NA, Timofeeva O, Pasquale EB, Hirsch K, MacDonald TJ, Dritschilo A, Lee YC, Henkemeyer M, Rood B, Jung M, Wang XJ, Kool M, Rodriguez O, Albanese C, Karam SD. Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization. Oncotarget. 2015 Apr 20;6(11):8929-46. PubMed PMID: 25879388
• Karam SD, Rashid A, Snider JW, Wooster M, Bhatia S, Jay AK, Newkirk K, Davidson B, Harter WK. IMRT with Stereotactic Body Radiotherapy Boost for High Risk Malignant Salivary Gland Malignancies: A Case Series. Front Oncol. 2014;4:268. PubMed PMID: 25374840
• Amini A, McDermott JD, Gan G, Bhatia S, Sumner W, Fisher CM, Jimeno A, Bowles DW, Raben D, Karam SD. Stereotactic body radiotherapy as primary therapy for head and neck cancer in the elderly or patients with poor performance. Front Oncol. 2014;4:274. PubMed PMID: 25340041
• Karam SD, Horne ZD, Hong RL, McRae D, Duhamel D, Nasr NM. Hypofractionated stereotactic body radiation therapy for elderly patients with stage IIB-IV nonsmall cell lung cancer who are ineligible for or refuse other treatment modalities. Lung Cancer (Auckl). 2014;5:59-66. PubMed PMID: 28210143
• Karam SD, Tai A, Wooster M, Rashid A, Chen R, Baig N, Jay A, Harter KW, Randolph-Jackson P, Omogbehin A, Aulisi EF, Jacobson J. Trigeminal neuralgia treatment outcomes following Gamma Knife radiosurgery with a minimum 3-year follow-up. J Radiat Oncol. 2014;3:125-130. PubMed PMID: 24955219
• Karam SD, Jay AK, Anyanwu C, Steehler MK, Davidson B, Debrito P, Harter KW. Pathologic collision of inverted papilloma with esthesioneuroblastoma. Front Oncol. 2014;4:44. PubMed PMID: 24672769
• Karam SD, Horne ZD, Hong RL, Baig N, Gagnon GJ, McRae D, Duhamel D, Nasr NM. Robotic stereotactic body radiation therapy for elderly medically inoperable early-stage non-small cell lung cancer. Lung Cancer (Auckl). 2013;4:35-42. PubMed PMID: 28210133
• Karam SD, Tai A, Strohl A, Steehler MK, Rashid A, Gagnon G, Harter KW, Jay AK, Collins SP, Kim JH, Jean W. Frameless fractionated stereotactic radiosurgery for vestibular schwannomas: a single-institution experience. Front Oncol. 2013;3:121. PubMed PMID: 23730624
• Horne ZD, Karam SD, Rashid A, Snider JW, Lax A, Ozdemirli M, Harter KW. The use of stereotactic body radiation therapy for local control of glomangiomatosis: a case report. Front Oncol. 2013;3:26. PubMed PMID: 23467385
• Sirajuddin P, Das S, Ringer L, Rodriguez OC, Sivakumar A, Lee YC, Üren A, Fricke ST, Rood B, Ozcan A, Wang SS, Karam S, Yenugonda V, Salinas P, Petricoin E 3rd, Pishvaian M, Lisanti MP, Wang Y, Schlegel R, Moasser B, Albanese C. Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. Cell Cycle. 2012 Oct 15;11(20):3801-9. PubMed PMID: 22983062
• Karam SD, Snider JW, Wang H, Wooster M, Lominska C, Deeken J, Newkirk K, Davidson B, Harter KW. Reirradiation of recurrent salivary gland malignancies with fractionated stereotactic body radiation therapy. J Radiat Oncol. 2012 Jun;1(2):147-153. PubMed PMID: 23440688
• Karam SD, Snider JW, Wang H, Wooster M, Lominska C, Deeken J, Newkirk K, Davidson B, Harter KW. Survival outcomes of patients treated with hypofractionated stereotactic body radiation therapy for parotid gland tumors: a retrospective analysis. Front Oncol. 2012;2:55. PubMed PMID: 22666661
• Cramer KS, Karam SD, Bothwell M, Cerretti DP, Pasquale EB, Rubel EW. Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. J Comp Neurol. 2002 Oct 7;452(1):51-64. PubMed PMID: 12205709
• Karam SD, Dottori M, Ogawa K, Henderson JT, Boyd AW, Pasquale EB, Bothwell M. EphA4 is not required for Purkinje cell compartmentation. Brain Res Dev Brain Res. 2002 Apr 30;135(1-2):29-38. PubMed PMID: 11978390
• Karam SD, Kim YS, Bothwell M. Granule cells migrate within raphes in the developing cerebellum: an evolutionarily conserved morphogenic event. J Comp Neurol. 2001 Nov 12;440(2):127-35. PubMed PMID: 11745612
• Karam SD, Burrows RC, Logan C, Koblar S, Pasquale EB, Bothwell M. Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. J Neurosci. 2000 Sep 1;20(17):6488-500. PubMed PMID: 10964955