Sana Karam, MD, PhD

Professional Titles

• Vice Chair of Translational Research
• Marsico Endowed Chair in Head and Neck Cancer
• Professor

Recognitions

• Educator of The Year Award, ARRO (2020)
  National award for recognition by the Association of Residents in Radiation Oncology as a member of the Program’s Faculty for excellence in teaching.
• Recurrent/Metastatic Head and Neck Cancer Task Force, Co-Chair, NCI (2022)
• Co-Chair, AACR-AHNS Head and Neck Cancer Conference, AACR (2022)
• Vice Chair, ASTRO Biology Track, ASTRO (2022)
• NCI Steering Committee Immunosuppressed HN, R/M subcommittee, Co-chair, NCI (2022)

Research Interests

Publications

• Stokes WA, Karam SD. In Reply to Overgaard et al. Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):805-807. PubMed PMID: 29413295
• Stokes WA, Binder DC, Jones BL, Oweida AJ, Liu AK, Rusthoven CG, Karam SD. Impact of immunotherapy among patients with melanoma brain metastases managed with radiotherapy. J Neuroimmunol. 2017 Dec 15;313:118-122. PubMed PMID: 29153603
• Oweida A, Lennon S, Calame D, Korpela S, Bhatia S, Sharma J, Graham C, Binder D, Serkova N, Raben D, Heasley L, Clambey E, Nemenoff R, Karam SD. Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma. Oncoimmunology. 2017;6(10):e1356153. PubMed PMID: 29123967
• Sumner WA, Amini A, Hankinson TC, Foreman NK, Gaspar LE, Kavanagh BD, Karam SD, Rusthoven CG, Liu AK. Survival benefit of postoperative radiation in papillary meningioma: Analysis of the National Cancer Data Base. Rep Pract Oncol Radiother. 2017 Nov-Dec;22(6):495-501. PubMed PMID: 29123457
• Stokes WA, Sumner WA, Breggren KL, Rathbun JT, Raben D, McDermott JD, Gan G, Karam SD. A comparison of concurrent cisplatin versus cetuximab with radiotherapy in locally-advanced head and neck cancer: A bi-institutional analysis. Rep Pract Oncol Radiother. 2017 Sep-Oct;22(5):389-395. PubMed PMID: 28808428
• Stokes WA, Stumpf PK, Jones BL, Blatchford PJ, Karam SD, Lanning RM, Raben D. Patterns of fractionation for patients with T2N0M0 glottic larynx cancer undergoing definitive radiotherapy in the United States. Oral Oncol. 2017 Sep;72:110-116. PubMed PMID: 28797446
• Sumner WA, Stokes WA, Oweida A, Berggren KL, McDermott JD, Raben D, Abbott D, Jones B, Gan G, Karam SD. Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy. J Transl Med. 2017 Aug 2;15(1):168. PubMed PMID: 28764811
• Stokes WA, Abbott D, Phan A, Raben D, Lanning RM, Karam SD. Patterns of Care for Patients With Early-Stage Glottic Cancer Undergoing Definitive Radiation Therapy: A National Cancer Database Analysis. Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):1014-1021. PubMed PMID: 28721883
• Wie SM, Wellberg E, Karam SD, Reyland ME. Tyrosine Kinase Inhibitors Protect the Salivary Gland from Radiation Damage by Inhibiting Activation of Protein Kinase C-d. Mol Cancer Ther. 2017 Sep;16(9):1989-1998. PubMed PMID: 28637715
• Rusthoven CG, Lanning RM, Jones BL, Amini A, Koshy M, Sher DJ, Bowles DW, McDermott JD, Jimeno A, Karam SD. Metastatic nasopharyngeal carcinoma: Patterns of care and survival for patients receiving chemotherapy with and without local radiotherapy. Radiother Oncol. 2017 Jul;124(1):139-146. PubMed PMID: 28433411
• Robin TP, Jones BL, Gordon OM, Phan A, Abbott D, McDermott JD, Goddard JA, Raben D, Lanning RM, Karam SD. A comprehensive comparative analysis of treatment modalities for sinonasal malignancies. Cancer. 2017 Aug 15;123(16):3040-3049. PubMed PMID: 28369832
• Bhatia S, Hirsch K, Bukkapatnam S, Baig NA, Oweida A, Griego A, Calame D, Sharma J, Donson A, Foreman N, Albanese C, Venkataraman S, Vibhakar R, Karam SD. Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma. Cancer Cell Int. 2017;17:41. PubMed PMID: 28360821
• Wang K, McDermott JD, Schrock AB, Elvin JA, Gay L, Karam SD, Raben D, Somerset H, Ali SM, Ross JS, Bowles DW. Comprehensive genomic profiling of salivary mucoepidermoid carcinomas reveals frequent BAP1, PIK3CA, and other actionable genomic alterations. Ann Oncol. 2017 Apr 1;28(4):748-753. PubMed PMID: 28327999
• Stokes WA, Amini A, Jones BL, McDermott JD, Raben D, Ghosh D, Goddard JA, Bowles DW, Karam SD. Survival impact of induction chemotherapy in advanced head and neck cancer: A National Cancer Database analysis. Head Neck. 2017 Jun;39(6):1113-1121. PubMed PMID: 28301079
• Stokes WA, Amini A, Jones BL, McDermott JD, Raben D, Ghosh D, Goddard JA, Bowles DW, Karam SD. Survival impact of induction chemotherapy in advanced head and neck cancer: A National Cancer Database analysis. Head Neck. 2017 Jun;39(6):1113-1121. PubMed PMID: 28301079
• Oweida A, Bhatia S, Hirsch K, Calame D, Griego A, Keysar S, Pitts T, Sharma J, Eckhardt G, Jimeno A, Wang XJ, Parkash G, Califano J, Karam SD. Ephrin-B2 overexpression predicts for poor prognosis and response to therapy in solid tumors. Mol Carcinog. 2017 Mar;56(3):1189-1196. PubMed PMID: 27649287
• Stokes WA, Jones BL, Bhatia S, Oweida AJ, Bowles DW, Raben D, Goddard JA, McDermott JD, Karam SD. A comparison of overall survival for patients with T4 larynx cancer treated with surgical versus organ-preservation approaches: A National Cancer Data Base analysis. Cancer. 2017 Feb 15;123(4):600-608. PubMed PMID: 27727461
• Hernandez AL, Wang Y, Somerset HL, Keysar SB, Aisner DL, Marshall C, Bowles DW, Karam SD, Raben D, Jimeno A, Varella-Garcia M, Wang XJ. Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas. Mol Carcinog. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30575147
• Ding D, Stokes W, Eguchi M, Hararah M, Sumner W, Amini A, Goddard J, Somerset H, Bradley C, McDermott J, Raben D, Karam SD. Association Between Lymph Node Ratio and Recurrence and Survival Outcomes in Patients With Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg. 2018 Nov 15. [Epub ahead of print] PubMed PMID: 30452499
• McDermott JD, Eguchi M, Stokes WA, Amini A, Hararah M, Ding D, Valentine A, Bradley CJ, Karam SD. Short- and Long-term Opioid Use in Patients with Oral and Oropharynx Cancer. Otolaryngol Head Neck Surg. 2018 Nov 6;:194599818808513. [Epub ahead of print] PubMed PMID: 30396321
• Amini A, Eguchi M, Jones BL, Stokes WA, Gupta A, McDermott JD, Massarelli E, Bradley CJ, Karam SD. Comparing outcomes of concurrent chemotherapy regimens in patients 65 years old or older with locally advanced oropharyngeal carcinoma. Cancer. 2018 Nov 15;124(22):4322-4331. PubMed PMID: 30291789
• Stokes WA, Eguchi M, Amini A, Hararah MK, Ding D, McDermott JD, Bradley CJ, Karam SD. Survival impact and toxicity of metformin in head and neck cancer: An analysis of the SEER-Medicare dataset. Oral Oncol. 2018 Sep;84:12-19. PubMed PMID: 30115470
• Hararah MK, Stokes WA, Jones BL, Oweida A, Ding D, McDermott J, Goddard J, Karam SD. Nomogram for preoperative prediction of nodal extracapsular extension or positive surgical margins in oropharyngeal squamous cell carcinoma. Oral Oncol. 2018 Aug;83:73-80. PubMed PMID: 30098782
• Karam SD, Reddy K, Blatchford PJ, Waxweiler T, DeLouize AM, Oweida A, Somerset H, Marshall C, Young C, Davies KD, Kane M, Tan AC, Wang XJ, Jimeno A, Aisner DL, Bowles DW, Raben D. Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer. Clin Cancer Res. 2018 Oct 15;24(20):4949-4959. PubMed PMID: 30084837
• Oweida A, Hararah MK, Phan A, Binder D, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey E, Nemenoff R, Karam SD. Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration. Clin Cancer Res. 2018 Nov 1;24(21):5368-5380. PubMed PMID: 30042205
• Bhatia S, Griego A, Lennon S, Oweida A, Sharma J, Rohmer C, Uyanga N, Bukkapatnam S, Van Court B, Raben D, Young C, Heasley L, Karam SD. Role of EphB3 Receptor in Mediating Head and Neck Tumor Growth, Cell Migration, and Response to PI3K Inhibitor. Mol Cancer Ther. 2018 Sep;17(9):2049-2059. PubMed PMID: 29970482
• Robin TP, Breeze RE, Smith DE, Rusthoven CG, Lewis KD, Gonzalez R, Brill A, Saiki R, Stuhr K, Gaspar LE, Karam SD, Raben D, Kavanagh BD, Nath SK, Liu AK. Immune checkpoint inhibitors and radiosurgery for newly diagnosed melanoma brain metastases. J Neurooncol. 2018 Oct;140(1):55-62. PubMed PMID: 29909499
• Bhatia S, Sharma J, Bukkapatnam S, Oweida A, Lennon S, Phan A, Milner D, Uyanga N, Jimeno A, Raben D, Somerset H, Heasley L, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers. Clin Cancer Res. 2018 Sep 15;24(18):4539-4550. PubMed PMID: 29848571
• Oweida A, Phan A, Vancourt B, Robin T, Hararah MK, Bhatia S, Milner D, Lennon S, Pike L, Raben D, Haugen B, Pozdeyev N, Schweppe R, Karam SD. Hypofractionated Radiotherapy Is Superior to Conventional Fractionation in an Orthotopic Model of Anaplastic Thyroid Cancer. Thyroid. 2018 Jun;28(6):739-747. PubMed PMID: 29774792
• Stokes WA, Karam SD. In Reply to Overgaard et al. Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):805-807. PubMed PMID: 29413295
• Amini A, Yeh N, Jones BL, Bedrick E, Vinogradskiy Y, Rusthoven CG, Amini A, Purcell WT, Karam SD, Kavanagh BD, Guntupalli SR, Fisher CM. Perioperative Mortality in Nonelderly Adult Patients With Cancer: A Population-based Study Evaluating Health Care Disparities in the United States According to Insurance Status. Am J Clin Oncol. 2018 May;41(5):476-484. PubMed PMID: 27281264
• Karam SD, Anderson CM, Ma D, Chua MLK, Kimple RJ. Immunotherapy in Head and Neck Cancer-Ready for Prime Time or More Research Needed?. Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):647-650. PubMed PMID: 33516431
• Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. J Immunother Cancer. 2021 Mar;9(3). PubMed PMID: 33789881
• Mirian C, Gerds TA, Pedersen MM, de Ridder M, Balm A, Mattavelli D, Piazza C, Jensen LR, Balasubramanian D, Subramaniam N, Dokhe Y, Thankappan K, Iyer S, Karam SD, Wiegand S, Feeley L, Milross C, Gao K, Palme CE, Low TH, Gupta R, Freudlsperger C, Moratin J, Sheahan P, Clark J, Ovesen T. Metrics of pN-staging in oral squamous cell carcinoma: An analysis of 1,905 patients. Eur J Cancer. 2021 Jun;150:33-41. PubMed PMID: 33887515
• Morgan RL, Eguchi MM, McDermott J, Mueller AC, Amini A, Goddard JA, Trivedi PS, Karam SD. Comparative effectiveness of posttreatment imaging modalities for Medicare patients with advanced head and neck cancer. Cancer. 2021 Feb 15;127(4):535-543. PubMed PMID: 33119176
• Veo B, Danis E, Pierce A, Wang D, Fosmire S, Sullivan KD, Joshi M, Khanal S, Dahl N, Karam S, Serkova N, Venkataraman S, Vibhakar R. Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma. Cell Rep. 2021 Apr 27;35(4):109013. PubMed PMID: 33910002
• Knitz MW, Bickett TE, Darragh LB, Oweida AJ, Bhatia S, Van Court B, Bhuvane S, Piper M, Gadwa J, Mueller AC, Nguyen D, Nangia V, Osborne DG, Bai X, Ferrara SE, Boss MK, Goodspeed A, Burchill MA, Tamburini BAJ, Chan ED, Pickering CR, Clambey ET, Karam SD. Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. J Immunother Cancer. 2021 Apr;9(4). PubMed PMID: 33883256
• Oweida AJ, Mueller AC, Piper M, Milner D, Van Court B, Bhatia S, Phan A, Bickett T, Jordan K, Proia T, Schulick R, Messersmith WA, Del Chiaro M, Clambey E, Gough MJ, Williams J, Hansen K, Goodman K, Karam SD. Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide. Cancer Immunol Immunother. 2021 Apr;70(4):989-1000. PubMed PMID: 33097963
• Gadwa J, Karam SD. Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer. Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):46-55. PubMed PMID: 32629082
• Bhatia S, Bukkapatnam S, Van Court B, Phan A, Oweida A, Gadwa J, Mueller AC, Piper M, Darragh L, Nguyen D, Gilani A, Knitz M, Bickett T, Green A, Venkataraman S, Vibhakar R, Cittelly D, Karam SD. The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. Mol Carcinog. 2020 Sep;59(9):1064-1075. PubMed PMID: 32567728
• Hernandez AL, Young CD, Bian L, Weigel K, Nolan K, Frederick B, Han G, He G, Devon Trahan G, Rudolph MC, Jones KL, Oweida AJ, Karam SD, Raben D, Wang XJ. PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models. Clin Cancer Res. 2020 Jun 15;26(12):3058-3070. PubMed PMID: 32139402
• Chua MLK, Ma DJ, Anderson CM, Karam SD, Margalit DN, Kimple RJ. Follow-Up and Management of Patients With Head and Neck Cancer During the 2019 Novel Coronavirus (SARS-CoV-2) Disease Pandemic. Adv Radiat Oncol. 2020 Jul-Aug;5(4):631-636. PubMed PMID: 32426556
• Piper M, Mueller AC, Karam SD. The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy. Mol Carcinog. 2020 Jul;59(7):754-765. PubMed PMID: 32363633
• Amini A, Verma V, Li R, Vora N, Kang R, Gernon TJ, Chang S, Karam S, Massarelli E, Maghami EG, Glaser S. Factors predicting for patient refusal of head and neck cancer therapy. Head Neck. 2020 Jan;42(1):33-42. PubMed PMID: 31584746
• Hararah MK, Stokes WA, Oweida A, Patil T, Amini A, Goddard J, Bowles DW, Karam SD. Epidemiology and treatment trends for primary tracheal squamous cell carcinoma. Laryngoscope. 2020 Feb;130(2):405-412. PubMed PMID: 30977524
• Morgan RL, Karam SD, Bradley CJ. Ethnic Disparities in Imaging Utilization at Diagnosis of Non-Small Cell Lung Cancer. J Natl Cancer Inst. 2020 Dec 14;112(12):1204-1212. PubMed PMID: 32134453
• Margalit DN, Karam SD, Chua MLK, Anderson C, Kimple RJ. Four Influential Clinical Trials in Human Papilloma Virus-Associated Oropharynx Cancer. Int J Radiat Oncol Biol Phys. 2020 Apr 1;106(5):893-899. PubMed PMID: 32171456
• Mueller AC, Karam SD. SBRT for Early Stage Larynx: A Go or No Go? It's All in the Delivery. Int J Radiat Oncol Biol Phys. 2019 Sep 1;105(1):119-120. PubMed PMID: 31422804
• Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res. 2019 May 15;79(10):2722-2735. PubMed PMID: 30894369
• Gupta A, Stokes W, Eguchi M, Hararah M, Amini A, Mueller A, Morgan R, Bradley C, Raben D, McDermott J, Karam SD. Statin use associated with improved overall and cancer specific survival in patients with head and neck cancer. Oral Oncol. 2019 Mar;90:54-66. PubMed PMID: 30846177
• Lennon S, Oweida A, Milner D, Phan AV, Bhatia S, Van Court B, Darragh L, Mueller AC, Raben D, Martínez-Torrecuadrada JL, Pitts TM, Somerset H, Jordan KR, Hansen KC, Williams J, Messersmith WA, Schulick RD, Owens P, Goodman KA, Karam SD. Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination. Clin Cancer Res. 2019 Jun 1;25(11):3352-3365. PubMed PMID: 30944125
• Anderson CM, Kimple RJ, Lin A, Karam SD, Margalit DN, Chua MLK. De-Escalation Strategies in HPV-Associated Oropharynx Cancer-Are we Putting the Cart Before the Horse?. Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):705-709. PubMed PMID: 31204653
• Amini A, Stokes WA, Jones BL, Sampath S, Kang RS, Gernon TJ, Maghami EG, Massarelli E, Bradley CJ, Karam SD. Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma. Head Neck. 2019 Jul;41(7):2299-2308. PubMed PMID: 30737961
• Amini A, Karam SD. Concurrent chemotherapy in oropharyngeal cancer: Cisplatin wins. Oncotarget. 2019 Jan 18;10(6):624-625. PubMed PMID: 30774757
• Pierce AM, Witt DA, Donson AM, Gilani A, Sanford B, Sill M, Van Court B, Oweida A, Prince EW, Steiner J, Danis E, Dorris K, Hankinson T, Handler MH, Jones KL, Karam SD, Serkova NJ, Vibhakar R, Foreman NK, Griesinger AM. Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma. Neuro Oncol. 2019 Dec 17;21(12):1540-1551. PubMed PMID: 31276586
• Oweida AJ, Darragh L, Phan A, Binder D, Bhatia S, Mueller A, Court BV, Milner D, Raben D, Woessner R, Heasley L, Nemenoff R, Clambey E, Karam SD. STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. J Natl Cancer Inst. 2019 Dec 1;111(12):1339-1349. PubMed PMID: 30863843
• Morgan RL, Eguchi MM, Mueller AC, Daugherty SL, Amini A, Karam SD. Imaging at diagnosis impacts cancer-specific survival among patients with cancer of the oropharynx. Cancer. 2019 Aug 15;125(16):2794-2802. PubMed PMID: 31042320
• Yu J, Pham TT, Wandrey N, Daly M, Karam SD. Multimodality Management of EBV-Associated Nasopharyngeal Carcinoma. Cancers (Basel). 2021 Dec 2;13(23). PubMed PMID: 34885187
• Li R, Shinde A, Glaser S, Chao J, Kim J, Karam SD, Goodman K, Chen YJ, Amini A. Analyzing the impact of neoadjuvant radiation dose on pathologic response and survival outcomes in esophageal and gastroesophageal cancers. J Gastrointest Oncol. 2019 Aug;10(4):712-722. PubMed PMID: 31392052
• Karam SD, Raben D. Radioimmunotherapy for the treatment of head and neck cancer. Lancet Oncol. 2019 Aug;20(8):e404-e416. PubMed PMID: 31364593
• Pacheco JM, Gao D, Smith D, Purcell T, Hancock M, Bunn P, Robin T, Liu A, Karam S, Gaspar L, Kavanagh B, Rusthoven C, Aisner D, Doebele R, Camidge DR. Natural History and Factors Associated with Overall Survival in Stage IV ALK-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2019 Apr;14(4):691-700. PubMed PMID: 30599201
• Darragh LB, Oweida AJ, Karam SD. Overcoming Resistance to Combination Radiation-Immunotherapy: A Focus on Contributing Pathways Within the Tumor Microenvironment. Front Immunol. 2018;9:3154. PubMed PMID: 30766539
• Amini A, Waxweiler TV, Brower JV, Jones BL, McDermott JD, Raben D, Ghosh D, Bowles DW, Karam SD. Association of Adjuvant Chemoradiotherapy vs Radiotherapy Alone With Survival in Patients With Resected Major Salivary Gland Carcinoma: Data From the National Cancer Data Base. JAMA Otolaryngol Head Neck Surg. 2016 Nov 1;142(11):1100-1110. PubMed PMID: 27541166
• Amini A, Jones BL, McDermott JD, Serracino HS, Jimeno A, Raben D, Ghosh D, Bowles DW, Karam SD. Survival outcomes with concurrent chemoradiation for elderly patients with locally advanced head and neck cancer according to the National Cancer Data Base. Cancer. 2016 May 15;122(10):1533-43. PubMed PMID: 26969811
• Amini A, Jasem J, Jones BL, Robin TP, McDermott JD, Bhatia S, Raben D, Jimeno A, Bowles DW, Karam SD. Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer using the National Cancer Data Base. Oral Oncol. 2016 May;56:1-7. PubMed PMID: 27086480
• Rusthoven CG, Koshy M, Sher DJ, Ney DE, Gaspar LE, Jones BL, Karam SD, Amini A, Ormond DR, Youssef AS, Kavanagh BD. Combined-Modality Therapy With Radiation and Chemotherapy for Elderly Patients With Glioblastoma in the Temozolomide Era: A National Cancer Database Analysis. JAMA Neurol. 2016 Jul 1;73(7):821-8. PubMed PMID: 27214765
• Amini A, Rusthoven CG, Waxweiler TV, Jones BL, Fisher CM, Karam SD, Raben D. Association of health insurance with outcomes in adults ages 18 to 64 years with melanoma in the United States. J Am Acad Dermatol. 2016 Feb;74(2):309-16. PubMed PMID: 26670715
• Rashid A, Karam SD, Rashid B, Kim JH, Pang D, Jean W, Grimm J, Collins SP. Multisession Radiosurgery for Hearing Preservation. Semin Radiat Oncol. 2016 Apr;26(2):105-11. PubMed PMID: 27000506
• O'Sullivan B, Huang SH, Su J, Garden AS, Sturgis EM, Dahlstrom K, Lee N, Riaz N, Pei X, Koyfman SA, Adelstein D, Burkey BB, Friborg J, Kristensen CA, Gothelf AB, Hoebers F, Kremer B, Speel EJ, Bowles DW, Raben D, Karam SD, Yu E, Xu W. Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study. Lancet Oncol. 2016 Apr;17(4):440-451. PubMed PMID: 26936027
• Robin TP, Gan GN, Tam M, Westerly D, Riaz N, Karam SD, Lee N, Raben D. Safety of contralateral submandibular gland sparing in locally advanced oropharyngeal cancers: A multicenter review. Head Neck. 2016 Apr;38(4):506-11. PubMed PMID: 25482748
• Waye S, Naeem A, Choudhry MU, Parasido E, Tricoli L, Sivakumar A, Mikhaiel JP, Yenugonda V, Rodriguez OC, Karam SD, Rood BR, Avantaggiati ML, Albanese C. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging (Albany NY). 2015 Oct;7(10):854-68. PubMed PMID: 26540407
• Amini A, Altoos B, Bourlon MT, Bedrick E, Bhatia S, Kessler ER, Flaig TW, Fisher CM, Kavanagh BD, Lam ET, Karam SD. Local control rates of metastatic renal cell carcinoma (RCC) to the bone using stereotactic body radiation therapy: Is RCC truly radioresistant?. Pract Radiat Oncol. 2015 Nov-Dec;5(6):e589-e596. PubMed PMID: 26142027
• Karam SD, Bhatia S. The radiobiological targets of SBRT: tumor cells or endothelial cells?. Ann Transl Med. 2015 Nov;3(19):290. PubMed PMID: 26697450
• Rusthoven CG, Kavanagh BD, Karam SD. Improved survival with stereotactic ablative radiotherapy (SABR) over lobectomy for early stage non-small cell lung cancer (NSCLC): addressing the fallout of disruptive randomized data. Ann Transl Med. 2015 Jul;3(11):149. PubMed PMID: 26244136
• Bhatia S, Baig NA, Timofeeva O, Pasquale EB, Hirsch K, MacDonald TJ, Dritschilo A, Lee YC, Henkemeyer M, Rood B, Jung M, Wang XJ, Kool M, Rodriguez O, Albanese C, Karam SD. Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization. Oncotarget. 2015 Apr 20;6(11):8929-46. PubMed PMID: 25879388
• Karam SD, Rashid A, Snider JW, Wooster M, Bhatia S, Jay AK, Newkirk K, Davidson B, Harter WK. IMRT with Stereotactic Body Radiotherapy Boost for High Risk Malignant Salivary Gland Malignancies: A Case Series. Front Oncol. 2014;4:268. PubMed PMID: 25374840
• Amini A, McDermott JD, Gan G, Bhatia S, Sumner W, Fisher CM, Jimeno A, Bowles DW, Raben D, Karam SD. Stereotactic body radiotherapy as primary therapy for head and neck cancer in the elderly or patients with poor performance. Front Oncol. 2014;4:274. PubMed PMID: 25340041
• Karam SD, Horne ZD, Hong RL, McRae D, Duhamel D, Nasr NM. Hypofractionated stereotactic body radiation therapy for elderly patients with stage IIB-IV nonsmall cell lung cancer who are ineligible for or refuse other treatment modalities. Lung Cancer (Auckl). 2014;5:59-66. PubMed PMID: 28210143
• Karam SD, Tai A, Wooster M, Rashid A, Chen R, Baig N, Jay A, Harter KW, Randolph-Jackson P, Omogbehin A, Aulisi EF, Jacobson J. Trigeminal neuralgia treatment outcomes following Gamma Knife radiosurgery with a minimum 3-year follow-up. J Radiat Oncol. 2014;3:125-130. PubMed PMID: 24955219
• Karam SD, Jay AK, Anyanwu C, Steehler MK, Davidson B, Debrito P, Harter KW. Pathologic collision of inverted papilloma with esthesioneuroblastoma. Front Oncol. 2014;4:44. PubMed PMID: 24672769
• Karam SD, Horne ZD, Hong RL, Baig N, Gagnon GJ, McRae D, Duhamel D, Nasr NM. Robotic stereotactic body radiation therapy for elderly medically inoperable early-stage non-small cell lung cancer. Lung Cancer (Auckl). 2013;4:35-42. PubMed PMID: 28210133
• Karam SD, Tai A, Strohl A, Steehler MK, Rashid A, Gagnon G, Harter KW, Jay AK, Collins SP, Kim JH, Jean W. Frameless fractionated stereotactic radiosurgery for vestibular schwannomas: a single-institution experience. Front Oncol. 2013;3:121. PubMed PMID: 23730624
• Horne ZD, Karam SD, Rashid A, Snider JW, Lax A, Ozdemirli M, Harter KW. The use of stereotactic body radiation therapy for local control of glomangiomatosis: a case report. Front Oncol. 2013;3:26. PubMed PMID: 23467385
• Sirajuddin P, Das S, Ringer L, Rodriguez OC, Sivakumar A, Lee YC, Üren A, Fricke ST, Rood B, Ozcan A, Wang SS, Karam S, Yenugonda V, Salinas P, Petricoin E 3rd, Pishvaian M, Lisanti MP, Wang Y, Schlegel R, Moasser B, Albanese C. Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. Cell Cycle. 2012 Oct 15;11(20):3801-9. PubMed PMID: 22983062
• Karam SD, Snider JW, Wang H, Wooster M, Lominska C, Deeken J, Newkirk K, Davidson B, Harter KW. Reirradiation of recurrent salivary gland malignancies with fractionated stereotactic body radiation therapy. J Radiat Oncol. 2012 Jun;1(2):147-153. PubMed PMID: 23440688
• Karam SD, Snider JW, Wang H, Wooster M, Lominska C, Deeken J, Newkirk K, Davidson B, Harter KW. Survival outcomes of patients treated with hypofractionated stereotactic body radiation therapy for parotid gland tumors: a retrospective analysis. Front Oncol. 2012;2:55. PubMed PMID: 22666661
• Cramer KS, Karam SD, Bothwell M, Cerretti DP, Pasquale EB, Rubel EW. Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. J Comp Neurol. 2002 Oct 7;452(1):51-64. PubMed PMID: 12205709
• Karam SD, Dottori M, Ogawa K, Henderson JT, Boyd AW, Pasquale EB, Bothwell M. EphA4 is not required for Purkinje cell compartmentation. Brain Res Dev Brain Res. 2002 Apr 30;135(1-2):29-38. PubMed PMID: 11978390
• Karam SD, Kim YS, Bothwell M. Granule cells migrate within raphes in the developing cerebellum: an evolutionarily conserved morphogenic event. J Comp Neurol. 2001 Nov 12;440(2):127-35. PubMed PMID: 11745612
• Karam SD, Burrows RC, Logan C, Koblar S, Pasquale EB, Bothwell M. Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. J Neurosci. 2000 Sep 1;20(17):6488-500. PubMed PMID: 10964955
• Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Umaña P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Simultaneous targeting of PD-1 and IL-2Rß? with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023 May 8;41(5):950-969.e6. PubMed PMID: 37116489
• El Karam SA, Ferrand M, Astruc T, Germond A. Evaluation and prediction of salt effects on pig muscle by deep UV and machine learning. Meat Sci. 2023 May;199:109136. PubMed PMID: 36774742
• Karam S, Haidous M, Dalle IA, Dendooven A, Moukalled N, Van Craenenbroeck A, Bazarbachi A, Sprangers B. Monoclonal gammopathy of renal significance: Multidisciplinary approach to diagnosis and treatment. Crit Rev Oncol Hematol. 2023 Mar;183:103926. PubMed PMID: 36736510
• McDermott JD, Amini A, Molina E, Stokes WA, Karam SD. Treatment outcomes and cost comparisons for older adults with T4 laryngeal squamous cell cancer. Head Neck. 2023 Mar;45(3):664-674. PubMed PMID: 36563300
• Karam S, Haidous M, Royal V, Leung N. Renal AA amyloidosis: presentation, diagnosis, and current therapeutic options: a review. Kidney Int. 2023 Mar;103(3):473-484. PubMed PMID: 36502873
• Piper M, Ross RB, Hu J, Watanabe S, Knitz M, Mehrotra S, Shulick R, Chiaro MD, Karam SD. Vasculitis, CA19-9, and Perineural Invasion Differentially Predict Response and Surgical Outcome in Pancreatic Ductal Adenocarcinoma. Int J Radiat Oncol Biol Phys. 2023 Jul 1;116(3):627-639. PubMed PMID: 36599398
• Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2023 Jan;4(1):148. PubMed PMID: 36577897
• Sterbis E, Liang R, Trivedi P, Kwak J, Major EC, Karam SD, Morgan RL. Lack of Adherence to Guideline-Based Imaging Before Subsequent Radiation in Patients with Non-Small Cell Lung Cancer: Impact on Patient Outcomes. J Nucl Med. 2023 Jan;64(1):75-81. PubMed PMID: 35680415
• Aleman JD, Young CD, Karam SD, Wang XJ. Revisiting laminin and extracellular matrix remodeling in metastatic squamous cell carcinoma: What have we learned after more than four decades of research?. Mol Carcinog. 2023 Jan;62(1):5-23. PubMed PMID: 35596706
• Al-Hajj S, Farran SH, Zgheib H, Tfaily MA, Halaoui A, Wehbe S, Karam S, Fadlallah Y, Fahd F, Toufaili L, Arjinian S, Al-Zaghrini E, Al Hariri M, El Hussein M, Souaiby N, Mowafi H, Mufarrij AJ. The Beirut ammonium nitrate blast: A multicenter study to assess injury characteristics and outcomes. J Trauma Acute Care Surg. 2023 Feb 1;94(2):328-335. PubMed PMID: 35999664
• Abdel-Ghaffar A, Elhossary GG, Mahmoud AM, Elshazly AHM, Hassanin OA, Saleh A, Mansour SM, Metwally FG, Hanafy LK, Karam SH, Darweesh N, Ata AM. Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation. Arch Physiol Biochem. 2023 Dec;129(4):964-974. PubMed PMID: 33653182
• Karam SA, Costa FDS, Peres KG, Peres MA, Barros FC, Bertoldi AD, Santos IS, Tovo L, Matijasevich A, B Menezes AM, Gonçalves H, Correa MB, Demarco FF. Two decades of socioeconomic inequalities in the prevalence of untreated dental caries in early childhood: Results from three birth cohorts in southern Brazil. Community Dent Oral Epidemiol. 2023 Apr;51(2):355-363. PubMed PMID: 35362631
• Cuker A, Tseng EK, Schünemann HJ, Angchaisuksiri P, Blair C, Dane K, DeSancho MT, Diuguid D, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo KM, Siegal DM, Skara M, Terrell DR, Touri K, Akl EA, Al Jabiri R, Al Jabiri Y, Boulos M, Brignardello-Petersen R, Charide R, Colunga-Lozano LE, Dearness K, Darzi AJ, Karam SG, Morgano GP, Morsi RZ, Philip BA, Benitez YR, Stevens A, Solo K, Wiercioch W, Mustafa RA, Nieuwlaat R. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis for patients with COVID-19: March 2022 update on the use of anticoagulation in critically ill patients. Blood Adv. 2022 Sep 13;6(17):4975-4982. PubMed PMID: 35748885
• Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, DeSancho MT, Diuguid D, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo KM, Siegal DM, Skara M, Terrell DR, Touri K, Akl EA, Al Jabiri R, Al Jabiri Y, Barbara AM, Bognanni A, Boulos M, Brignardello-Petersen R, Charide R, Colunga-Lozano LE, Dearness K, Darzi AJ, Hussein H, Karam SG, Mansour R, Morgano GP, Morsi RZ, Muti-Schünemann G, Nadim MK, Philip BA, Qiu Y, Benitez YR, Stevens A, Solo K, Wiercioch W, Mustafa RA, Schünemann HJ. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients. Blood Adv. 2022 Sep 13;6(17):4915-4923. PubMed PMID: 35503027
• Ekrikpo U, Obiagwu P, Chika-Onu U, Yadla M, Karam S, Tannor EK, Bello AK, Okpechi IG. Epidemiology and Outcomes of Glomerular Diseases in Low- and Middle-Income Countries. Semin Nephrol. 2022 Sep;42(5):151316. PubMed PMID: 36773418
• Karam SG, Darzi AJ, Bognanni A, Morsi RZ, Tannous EE, Charide R, Choe SI, Stalteri R, Lee Y, Piggott T, Jewell L, Schünemann F, Langendam M, Parmelli E, Saz-Parkinson Z, Roi A, Vilahur N, Vali Y, Waffenschmidt S, Owens DK, Leontiadis GI, Moayyedi P, Brozek JL, Schünemann HJ. Analytical frameworks in colorectal cancer guidelines: development of methods for systematic reviews, their application and practical guidance for their use. J Clin Epidemiol. 2022 Sep;149:206-216. PubMed PMID: 35724863
• Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2022 Nov;3(11):1300-1317. PubMed PMID: 36434392
• Arafat K, Sulaiman S, Al-Azawi AM, Yasin J, Sugathan S, Nemmar A, Karam S, Attoub S. Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo. Biomed Pharmacother. 2022 Nov;155:113762. PubMed PMID: 36182733
• Francis A, Abdul Hafidz MI, Ekrikpo UE, Chen T, Wijewickrama E, Tannor EK, Nakhoul G, Wong MMY, Pereira-Kamath N, Chanchlani R, Kalyesubula R, Karam S, Kumar V, Calice-Silva V, Jha V. Barriers to accessing essential medicines for kidney disease in low- and lower middle-income countries|. Kidney Int. 2022 Nov;102(5):969-973. PubMed PMID: 36044940
• Abboud M, Karam S. Hypertension in the Middle East: current state, human factors, and barriers to control. J Hum Hypertens. 2022 May;36(5):428-436. PubMed PMID: 34075186
• Guillo L, Delanaye P, Flamant M, Figueres L, Karam S, Lemoine S, Benezech A, Pelletier AL, Amiot A, Caron B, Stefanescu C, Boschetti G, Bouguen G, Rahier JF, Gornet JM, Hugot JP, Bonnet J, Vuitton L, Nachury M, Vidon M, Uzzan M, Serrero M, Dib N, Seksik P, Hebuterne X, Bertocchio JP, Mariat C, Peyrin-Biroulet L. Kidney function monitoring in inflammatory bowel disease: The MONITORED consensus. Dig Liver Dis. 2022 Mar;54(3):309-315. PubMed PMID: 34866011
• Sánchez-Luquez KY, Carpena MX, Karam SM, Tovo-Rodrigues L. The contribution of whole-exome sequencing to intellectual disability diagnosis and knowledge of underlying molecular mechanisms: A systematic review and meta-analysis. Mutat Res Rev Mutat Res. 2022 Jul-Dec;790:108428. PubMed PMID: 35905832
• Shiao JC, Holt D, Ladbury C, Gao D, Jones B, Karam SD, Amini A. The role of concomitant chemoradiotherapy versus radiation alone in T1-3N0 HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma. Oral Oncol. 2022 Jul;130:105907. PubMed PMID: 35605559
• Cuker A, Tseng EK, Nieuwlaat R, Angchaisuksiri P, Blair C, Dane K, Davila J, DeSancho MT, Diuguid D, Griffin DO, Kahn SR, Klok FA, Lee AI, Neumann I, Pai A, Righini M, Sanfilippo KM, Siegal D, Skara M, Terrell DR, Touri K, Akl EA, Al Jabiri RN, Al Jabiri YN, Barbara AM, Bognanni A, Bou Akl I, Boulos M, Brignardello-Petersen R, Charide R, Chan M, Colunga-Lozano LE, Dearness K, Darzi AJ, Hussein H, Karam SG, Kolb P, Mansour R, Morgano GP, Morsi RZ, Muti-Schünemann G, Nadim MK, Noori A, Philip BA, Piggott T, Qiu Y, Benitez YR, Schünemann F, Stevens A, Solo K, Wiercioch W, Mustafa RA, Schünemann HJ. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on postdischarge thromboprophylaxis. Blood Adv. 2022 Jan 25;6(2):664-671. PubMed PMID: 34727173
• Lawson R, Leymarie S, Nikitopoulos C, Humeau A, Bouchenaki H, Duroux JL, Fourcade L, Karam S, Picard N, Demiot C. Alternative to animal experimentation in pharmacology teaching: Development and validation of an equivalent digital learning tool. Pharmacol Res Perspect. 2022 Feb;10(1):e00908. PubMed PMID: 35147294
• Claure-Del Granado R, Anandh U, Lerma E, Conjeevaram A, Arce-Amaré F, Dos Santos ACS Jr, Basu G, Bek S, Dhakal AK, Gawad MA, AkL A, Turgut D, Karam S, Bajpai D, Pecoits-Filho R, Parikh N. Challenges and Opportunities of a Virtual Nephrology Meeting: The ISN World Congress of Nephrology 2021. Kidney Int Rep. 2022 Feb;7(2):133-137. PubMed PMID: 35036661
• Schlafstein AJ, Goyal S, Amini A, Karam SD, Saba NF, Kaka AS, Aiken AH, Beitler JJ, Stokes WA. The impact of operability status on outcomes in patients with T4 larynx cancer undergoing larynx preservation. Head Neck. 2022 Dec;44(12):2854-2864. PubMed PMID: 36196859
• Oba A, Wu YHA, Colborn KL, Karam SD, Meguid C, Al-Musawi MH, Bao QR, Gleisner AL, Ahrendt S, Schulick RD, Del Chiaro M. Comparing neoadjuvant chemotherapy with or without radiation therapy for pancreatic ductal adenocarcinoma: National Cancer Database cohort analysis. Br J Surg. 2022 Apr 19;109(5):450-454. PubMed PMID: 35136963
• Abi-Said M, Bou Shroush J, Karam S, Shaib H. Intestinal parasites of Apodemus mystacinus along altitudinal stratification of Ibrahim River, Mount Lebanon. Ann Parasitol. 2022;68(2):227-239. PubMed PMID: 35809400
• Karam S, Seidou O, Nagabhatla N, Perera D, Tshimanga RM. Assessing the impacts of climate change on climatic extremes in the Congo River Basin. Clim Change. 2022;170(3-4):40. PubMed PMID: 35250125
• Charlton NP, Swain JM, Brozek JL, Ludwikowska M, Singletary E, Zideman D, Epstein J, Darzi A, Bak A, Karam S, Les Z, Carlson JN, Lang E, Nieuwlaat R. Control of Severe, Life-Threatening External Bleeding in the Out-of-Hospital Setting: A Systematic Review. Prehosp Emerg Care. 2021 Mar-Apr;25(2):235-267. PubMed PMID: 32208060
• Blumenberg C, Wehrmeister FC, Barros FC, Flesch BD, Guimarães F, Valério I, Ferreira LZ, Echeverria M, Karam SA, Gonçalves H, Menezes AMB. Association of the length of time using computers and mobile devices with low back, neck and mid-back pains: findings from a birth cohort. Public Health. 2021 Jun;195:1-6. PubMed PMID: 34022663
• Karam SA, Costa FDS, Schwendicke F, Correa MB, Demarco FF. Oral health and academic performance or absenteeism: Findings from a University in Southern Brazil. Community Dent Oral Epidemiol. 2021 Jun;49(3):267-274. PubMed PMID: 33210324
• AbdullGaffar B, Karam S, Odeh B. Extramedullary hematopoiesis occurring as a gastric polyp in a woman with a myeloproliferative disorder. Hematol Oncol Stem Cell Ther. 2021 Jun;14(2):156-159. PubMed PMID: 31201781
• Simpson SA, Karam S, Roosevelt G. Consultee satisfaction with integrated behavioral health in a pediatric emergency department. Gen Hosp Psychiatry. 2021 Jan-Feb;68:104-105. PubMed PMID: 33339606
• Patel AS, Yoo S, Kong R, Sato T, Sinha A, Karam S, Bao L, Fridrikh M, Emoto K, Nudelman G, Powell CA, Beasley MB, Zhu J, Watanabe H. Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer. Sci Adv. 2021 Jan;7(5). PubMed PMID: 33514539
• Oba A, Wu YHA, Lieu CH, Meguid C, Colborn KL, Beaty L, Al-Musawi MH, Davis SL, Leal AD, Purcell T, King G, Wooten ES, Fujiwara Y, Goodman KA, Schefter T, Karam SD, Gleisner AL, Ahrendt S, Leong S, Messersmith WA, Schulick RD, Del Chiaro M. Outcome of neoadjuvant treatment for pancreatic cancer in elderly patients: comparative, observational cohort study. Br J Surg. 2021 Aug 19;108(8):976-982. PubMed PMID: 34155509
• Fakhoury KR, Hu J, Kim E, Hansen KA, Koval TR, Wolff K, Foote-Pearce MC, Karam SD, Stavas MJ. An Integrative Medicine Educational Program for Radiation Oncology Patients: Patient-Reported Outcomes. Adv Radiat Oncol. 2024 Feb;9(2):101350. PubMed PMID: 38405305
• Ross RB, Gadwa J, Yu J, Darragh LB, Knitz MW, Nguyen D, Olimpo NA, Abdelazeem KNM, Nguyen A, Corbo S, Van Court B, Beynor J, Neupert B, Saviola AJ, D'Alessandro A, Karam SD. PPARa Agonism Enhances Immune Response to Radiotherapy while Dietary Oleic Acid Results in Counteraction. Clin Cancer Res. 2024 Feb 16. [Epub ahead of print] PubMed PMID: 38363297
• Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Publisher Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2024 Jan;5(1):210. PubMed PMID: 38200246
• Del Chiaro M, Sugawara T, Karam SD, Messersmith WA. Advances in the management of pancreatic cancer. BMJ. 2023 Dec 13;383:e073995. PubMed PMID: 38164628
• Borrayo EA, Juarez-Colunga E, Kilbourn K, Waxmonsky J, Jacobson M, Okuyama S, Swaney R, Wamboldt FS, Karam S, Lopez Alvarez S, Jin X, Nguyen J. Stepped-care to improve mental health outcomes among underserved patients with lung and head and neck cancer. Psychooncology. 2023 Nov;32(11):1718-1726. PubMed PMID: 37772984
• Amo-Aparicio J, Dominguez A, Atif SM, Dinarello A, Azam T, Alula KM, Piper M, Lieu CH, Lentz RW, Leal AD, Bagby SM, Messersmith WA, Karam SD, Dinarello CA, Pitts TM, Marchetti C. Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment. Cancer Res Commun. 2023 Sep 20;3(9):1899-1911. PubMed PMID: 37772994
• Gadwa J, Amann M, Bickett TE, Knitz MW, Darragh LB, Piper M, Van Court B, Bukkapatnam S, Pham TT, Wang XJ, Saviola AJ, Deak LC, Umaña P, Klein C, D'Alessandro A, Karam SD. Selective targeting of IL2Rß? combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC. Cell Rep Med. 2023 Aug 15;4(8):101150. PubMed PMID: 37586327
• Van Court B, Neupert B, Nguyen D, Ross R, Knitz MW, Karam SD. Measurement of mouse head and neck tumors by automated analysis of CBCT images. Sci Rep. 2023 Jul 25;13(1):12033. PubMed PMID: 37491456
• Knox AJ, Van Court B, Oweida A, Barsh E, DeSisto J, Flannery P, Lemma R, Chatwin H, Vibhakar R, Dorris K, Serkova NJ, Karam SD, Gilani A, Green AL. A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease. Front Oncol. 2023;13:1105395. PubMed PMID: 37124531
• Piper M, Hoen M, Darragh LB, Knitz MW, Nguyen D, Gadwa J, Durini G, Karakoc I, Grier A, Neupert B, Van Court B, Abdelazeem KNM, Yu J, Olimpo NA, Corbo S, Ross RB, Pham TT, Joshi M, Kedl RM, Saviola AJ, Amann M, Umaña P, Codarri Deak L, Klein C, D'Alessandro A, Karam SD. Simultaneous targeting of PD-1 and IL-2Rß? with radiation therapy inhibits pancreatic cancer growth and metastasis. Cancer Cell. 2023 May 8;41(5):950-969.e6. PubMed PMID: 37116489
• Contreras-Zárate MJ, Alvarez-Eraso KLF, Jaramillo-Gómez JA, Littrell Z, Tsuji N, Ormond DR, Karam SD, Kabos P, Cittelly DM. Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis. Neuro Oncol. 2023 Oct 3;25(10):1802-1814. PubMed PMID: 37053041
• Reyngold M, Karam SD, Hajj C, Wu AJ, Cuaron J, Lobaugh S, Yorke ED, Dickinson S, Jones B, Vinogradskiy Y, Shukla-Dave A, Do RKG, Sigel C, Zhang Z, Crane CH, Goodman KA. Phase 1 Dose Escalation Study of SBRT Using 3 Fractions for Locally Advanced Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):53-63. PubMed PMID: 36918130
• Contreras-Zárate MJ, Alvarez-Eraso KL, Jaramillo-Gómez JA, Littrell Z, Tsuji N, Ormond DR, Karam SD, Kabos P, Cittelly DM. Short-term Topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis. bioRxiv. 2023 Feb 15. PubMed PMID: 36824740
• Walker FM, Sobral LM, Danis E, Sanford B, Balakrishnan I, Wang D, Pierce A, Karam SD, Serkova NJ, Foreman NK, Venkataraman S, Dowell R, Vibhakar R, Dahl NA. Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy. bioRxiv. 2023 Jan 25. PubMed PMID: 36747867
• Boss MK, Harrison LG, Gold A, Karam SD, Regan DP. Canine oral squamous cell carcinoma as a spontaneous, translational model for radiation and immunology research. Front Oncol. 2022;12:1033704. PubMed PMID: 36698398
• Piper M, Ross RB, Hu J, Watanabe S, Knitz M, Mehrotra S, Shulick R, Chiaro MD, Karam SD. Vasculitis, CA19-9, and Perineural Invasion Differentially Predict Response and Surgical Outcome in Pancreatic Ductal Adenocarcinoma. Int J Radiat Oncol Biol Phys. 2023 Jul 1;116(3):627-639. PubMed PMID: 36599398
• Darragh LB, Knitz MM, Hu J, Clambey ET, Backus J, Dumit A, Samedi V, Bubak A, Greene C, Waxweiler T, Mehrotra S, Bhatia S, Gadwa J, Bickett T, Piper M, Fakhoury K, Liu A, Petit J, Bowles D, Thaker A, Atiyeh K, Goddard J, Hoyer R, Van Bokhoven A, Jordan K, Jimeno A, D'Alessandro A, Raben D, McDermott JD, Karam SD. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC. Nat Cancer. 2023 Jan;4(1):148. PubMed PMID: 36577897
• McDermott JD, Amini A, Molina E, Stokes WA, Karam SD. Treatment outcomes and cost comparisons for older adults with T4 laryngeal squamous cell cancer. Head Neck. 2023 Mar;45(3):664-674. PubMed PMID: 36563300
• Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2021 Dec 3. [Epub ahead of print] PubMed PMID: 34862244
• Bickett TE, Knitz MW, Piper M, Oweida AJ, Gadwa J, Darragh LB, Nguyen D, Bhatia S, Bhuvane S, Phan AV, Van Court B, Corbo S, Pham T, Dent AL, Lenz L, Karam SD. Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC. Mol Ther. 2021 Nov 15. [Epub ahead of print] PubMed PMID: 34793974
• Darragh LB, Karam SD. Amateur antigen-presenting cells in the tumor microenvironment. Mol Carcinog. 2022 Feb;61(2):153-164. PubMed PMID: 34570920
• Boss MK, Ke Y, Bian L, Harrison LG, Lee BI, Prebble A, Martin T, Trageser E, Hall S, Wang DD, Wang S, Chow L, Holwerda B, Raben D, Regan D, Karam SD, Dow S, Young CD, Wang XJ. Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis. Int J Radiat Oncol Biol Phys. 2021 Oct 3. [Epub ahead of print] PubMed PMID: 34610386
• Knitz MW, Darragh LB, Bickett TE, Bhatia S, Bukkapatnam S, Gadwa J, Piper M, Corbo S, Nguyen D, Van Court B, Oweida A, Karam SD. Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma. Cancer Immunol Immunother. 2021 Sep 24. [Epub ahead of print] PubMed PMID: 34559306
• Márquez-Ortiz RA, Contreras-Zárate MJ, Tesic V, Alvarez-Eraso KLF, Kwak G, Littrell Z, Costello JC, Sreekanth V, Ormond DR, Karam SD, Kabos P, Cittelly DM. IL13Ra2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases. Clin Cancer Res. 2021 Nov 15;27(22):6209-6221. PubMed PMID: 34544797
• Bickett TE, Knitz M, Darragh LB, Bhatia S, Van Court B, Gadwa J, Bhuvane S, Piper M, Nguyen D, Tu H, Lenz L, Clambey ET, Barry K, Karam SD. FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC. Clin Cancer Res. 2021 Nov 15;27(22):6235-6249. PubMed PMID: 34518311
• Strait AA, Woolaver RA, Hall SC, Young CD, Karam SD, Jimeno A, Lan Y, Raben D, Wang JH, Wang XJ. Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFß/PD-L1 blockade-treated squamous cell carcinoma. Commun Biol. 2021 Aug 25;4(1):1005. PubMed PMID: 34433873
• Amini A, Morgan R, Meyer E, Fakhoury K, Ladbury C, Bickett T, McDermott JD, Stokes W, Karam SD. Outcomes between intensity-modulated radiation therapy versus 3D-conformal in early stage glottic cancer. Head Neck. 2021 Nov;43(11):3393-3403. PubMed PMID: 34382714
• DeLouize AM, Eick G, Karam SD, Snodgrass JJ. Current and future applications of biomarkers in samples collected through minimally invasive methods for cancer medicine and population-based research. Am J Hum Biol. 2021 Aug 9;:e23665. [Epub ahead of print] PubMed PMID: 34374148
• Stokes WA, Molina E, McDermott JD, Morgan RL, Bickett T, Fakhoury KR, Amini A, Karam SD. Survival impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in head and neck cancer. Head Neck. 2021 Nov;43(11):3255-3275. PubMed PMID: 34289190
• Knitz MW, Bickett TE, Darragh LB, Oweida AJ, Bhatia S, Van Court B, Bhuvane S, Piper M, Gadwa J, Mueller AC, Nguyen D, Nangia V, Osborne DG, Bai X, Ferrara SE, Boss MK, Goodspeed A, Burchill MA, Tamburini BAJ, Chan ED, Pickering CR, Clambey ET, Karam SD. Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis. J Immunother Cancer. 2021 Apr;9(4). PubMed PMID: 33883256
• Gadwa J, Bickett TE, Darragh LB, Knitz MW, Bhatia S, Piper M, Van Court B, Bhuvane S, Nguyen D, Nangia V, Kleczko EK, Nemenoff RA, Karam SD. Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer. J Immunother Cancer. 2021 Mar;9(3). PubMed PMID: 33789881
• Mueller AC, Piper M, Goodspeed A, Bhuvane S, Williams JS, Bhatia S, Phan AV, Van Court B, Zolman KL, Peña B, Oweida AJ, Zakem S, Meguid C, Knitz MW, Darragh L, Bickett TE, Gadwa J, Mestroni L, Taylor MRG, Jordan KR, Dempsey P, Lucia MS, McCarter MD, Chiaro MD, Messersmith WA, Schulick RD, Goodman KA, Gough MJ, Greene CS, Costello JC, Neto AG, Lagares D, Hansen KC, Van Bokhoven A, Karam SD. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021 Jun 15;81(12):3255-3269. PubMed PMID: 33526513
• Karam SD, Anderson CM, Ma D, Chua MLK, Kimple RJ. Immunotherapy in Head and Neck Cancer-Ready for Prime Time or More Research Needed?. Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):647-650. PubMed PMID: 33516431
• Oweida AJ, Mueller AC, Piper M, Milner D, Van Court B, Bhatia S, Phan A, Bickett T, Jordan K, Proia T, Schulick R, Messersmith WA, Del Chiaro M, Clambey E, Gough MJ, Williams J, Hansen K, Goodman K, Karam SD. Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide. Cancer Immunol Immunother. 2021 Apr;70(4):989-1000. PubMed PMID: 33097963
• Korpela SP, Hinz TK, Oweida A, Kim J, Calhoun J, Ferris R, Nemenoff RA, Karam SD, Clambey ET, Heasley LE. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. J Transl Med. 2021 Jan 23;19(1):43. PubMed PMID: 33485341
• Morgan RL, Eguchi MM, McDermott J, Mueller AC, Amini A, Goddard JA, Trivedi PS, Karam SD. Comparative effectiveness of posttreatment imaging modalities for Medicare patients with advanced head and neck cancer. Cancer. 2021 Feb 15;127(4):535-543. PubMed PMID: 33119176
• Shinde A, Jones B, Luu M, Li R, Glaser S, Massarelli E, Freeman M, Gernon T, Maghami E, Kang R, Zumsteg Z, Karam SD, Amini A. Factors predictive of 90-day mortality after surgical resection for oral cavity cancer: Development of a recursive partitioning analysis for risk stratification. Head Neck. 2021 Sep;43(9):2731-2739. PubMed PMID: 34013577

Practice Locations

• University of Colorado Hospital

Specialty Information

• Radiation Oncology, Board Certification

• Cancers - Head and Neck Cancer
• Cancers
• Cancers - Pancreatic Cancer