Adam Green, MD

Website

Medical School

MD, New York University School of Medicine (2006)

Undergraduate School

BA, Dartmouth College (NH) (2002)

Internship

University of Colorado (Children's Hospital Colorado) Program (2007)

Residencies

University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2009)
University of Colorado (Children's Hospital Colorado) Program, Chief Resident, Pediatrics (2010)

Fellowships

Dana-Farber Cancer Institute/Boston Children’s Hospital/Harvard Medical School Program, Pediatric Hematology / Oncology (2013)

Languages

English, Spanish

Department

Pediatrics-Heme/Onc and Bone Marrow Transplantation

Professional Titles

Attending Physician

Recognitions

Young Investigator Award, American Society of Pediatric Hematology-Oncology (2017)
Awarded to two pediatric hematology-oncology investigators in the United States each year for early career research accomplishment

Research Interests

My research focuses on a specific type of cancer called high-grade glioma, an aggressive brain tumor affecting both children and adults. We focus especially on two pediatric subtypes called diffuse intrinsic pontine glioma and pediatric glioblastoma. I work in the lab to find new treatments for these tumors; we then study the treatments in laboratory models of the tumors, including mouse models, and then bring the treatments most likely to be successful to clinical trials in children.

Publications

Bryan G, Guolla L, Villanueva GI, Cohen-Gogo S, Casanovas A, Medina R, Revon-Riviere G, Coltin H, Kahalley LS, Withycombe JS, van Ewijk R, Schoot RA, Cash T, Baertschiger RM, McAleer MF, Benedetti DJ, Greengard E, Kitko CL, Green AL, Dhall G, Esbenshade AJ. Impact of the COVID-19 Pandemic Onset on the Early Careers of Pediatric Oncology Health Professionals and Researchers: A Report From the Children's Oncology Group Young Investigators Committee, Young SIOP Network, and Young SIOPE. Pediatr Blood Cancer. 2024 Nov 6;:e31419. [Epub ahead of print] PubMed PMID: 39502016
Martinez PJ, Song JJ, Castillo JI, DeSisto J, Song KH, Green AL, Borden M. Effect of Microbubble Size, Composition, and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood-Brain Barrier Opening. ACS Biomater Sci Eng. 2024 Nov 5. [Epub ahead of print] PubMed PMID: 39497639
DeSisto J, Balakrishnan I, Knox AJ, Link G, Venkataraman S, Vibhakar R, Green AL. PRMT5 maintains tumor stem cells to promote pediatric high-grade glioma tumorigenesis. Mol Cancer Res. 2024 Oct 18. [Epub ahead of print] PubMed PMID: 39422546
Ross JL, Puigdelloses-Vallcorba M, Piñero G, Soni N, Thomason W, DeSisto J, Angione A, Tsankova NM, Castro MG, Schniederjan M, Wadhwani NR, Raju GP, Morgenstern P, Becher OJ, Green AL, Tsankov AM, Hambardzumyan D. Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations. Immunity. 2024 Oct 8. [Epub ahead of print] PubMed PMID: 39395421
Ou JY, Kaddas HK, Alonzo TA, Spector LG, Fallahazad N, Owens E, Collin LJ, Green AL, Kirchhoff AC. Sociodemographic and Socioeconomic Factors Correlate with Late-Stage Pediatric Hodgkin Lymphoma and Rhabdomyosarcoma: A Report from the Children's Oncology Group Registries. Cancer Epidemiol Biomarkers Prev. 2024 Oct 2;33(10):1327-1338. PubMed PMID: 39083086
Martinez PJ, Song JJ, Garay FG, Song KH, Mufford T, Steiner J, DeSisto J, Ellens N, Serkova NJ, Green AL, Borden M. Comprehensive assessment of blood-brain barrier opening and sterile inflammatory response: unraveling the therapeutic window. Sci Rep. 2024 Jul 24;14(1):17036. PubMed PMID: 39043894
Martinez PJ, Song JJ, Castillo J, DeSisto J, Song KH, Green AL, Borden M. Effect of Microbubble Size, Composition and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood-Brain Barrier Opening. bioRxiv. 2024 Apr 30. PubMed PMID: 38746278
Collins A, Molina Kuna E, Anderson-Mellies A, Cost C, Green AL. Investigating the Impact of Tumor Biology and Social Determinants on Time to Diagnosis and Stage at Presentation of Wilms Tumor. J Pediatr Hematol Oncol. 2024 Apr 1;46(3):147-153. PubMed PMID: 38447110
Pool A, Kuna EM, Anderson-Mellies A, Kreis A, Marable M, Fraley C, Pacheco D, Green AL. Medical Record Level-Evaluation of Impact of Demographic and Socioeconomic Factors on Pediatric Neuro-Oncology Outcomes at Children's Hospital Colorado. Res Sq. 2024 Jan 11. PubMed PMID: 38260550
Martinez PJ, Green AL, Borden MA. Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening. J Control Release. 2024 Jan;365:412-421. PubMed PMID: 38000663
DeSisto J, Donson AM, Griesinger AM, Fu R, Riemondy K, Mulcahy Levy J, Siegenthaler JA, Foreman NK, Vibhakar R, Green AL. Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high-grade glioma. Neuro Oncol. 2024 Mar 4;26(3):538-552. PubMed PMID: 37934854
Link G, Garey S, DeSisto J, Antonakakis M, McGrath S, Chow L, Slade M, Dow S, Green AL. “Characterization of spontaneous canine high-grade glioma models as clinically-relevant surrogates of pediatric high-grade glioma.” 21st International Symposium on Pediatric Neuro-Oncology, Philadelphia, PA, July 2024.
Haase RB, Kilburn L, Filbin M, Green A. “Combined preclinical and clinical investigation of which pediatric high-grade glioma subtypes benefit from CCNU/temozolomide.” 21st International Symposium on Pediatric Neuro-Oncology, Philadelphia, PA, July 2024.
Winzent-Oonk S, Vallejos C, Hemenway M, Lindsay HB, Green AL. “Medical aid in dying: experience in the Center for Cancer and Blood Disorders at Children’s Hospital Colorado.” 21st International Symposium on Pediatric Neuro-Oncology, Philadelphia, PA, July 2024.
DeSisto J, Knox A, Slade M, Link G, Zhuang Y, Donson A, Miller K, Barsh E, Arnold M, Armstrong FT, Bhatia S, Karam S, Serkova N, Vibhakar R, Foreman N, Green AL. Pediatric radiation-induced glioma patient samples and novel patient-derived models reveal translationally relevant treatment susceptibilities and potential germline risk factors. 21st International Symposium on Pediatric Neuro-Oncology, Philadelphia, PA, July 2024.
van Thiel Berghuijs KM, Kaddas HK, Warner EL, Fair DB, Fluchel M, Knackstedt ED, Verma A, Kepka D, Green AL, Smitherman AB, Draper L, Johnson RH, Kirchhoff AC. Vaccination practices of pediatric oncologists from eight states. BMC Health Serv Res. 2023 Nov 7;23(1):1215. PubMed PMID: 37932718
Roberts HJ, Ji S, Picca A, Sanson M, Garcia M, Snuderl M, Schüller U, Picart T, Ducray F, Green AL, Nakano Y, Sturm D, Abdullaev Z, Aldape K, Dang D, Kumar-Sinha C, Wu YM, Robinson D, Vo JN, Chinnaiyan AM, Cartaxo R, Upadhyaya SA, Mody R, Chiang J, Baker S, Solomon D, Venneti S, Pratt D, Waszak SM, Koschmann C. Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations. Acta Neuropathol. 2023 Dec;146(6):849-852. PubMed PMID: 37851269
Martinez P, Nault G, Steiner J, Wempe MF, Pierce A, Brunt B, Slade M, Song JJ, Mongin A, Song KH, Ellens N, Serkova N, Green AL, Borden M. MRI-guided focused ultrasound blood-brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model. Neurooncol Adv. 2023 Jan-Dec;5(1):vdad111. PubMed PMID: 37795179
Lind KT, Molina E, Mellies A, Schneider KW, Daley W, Green AL. Early death from childhood cancer: First medical record-level analysis reveals insights on diagnostic timing and cause of death. Cancer Med. 2023 Oct;12(19):20201-20211. PubMed PMID: 37787020
Okonechnikov K, Joshi P, Sepp M, Leiss K, Sarropoulos I, Murat F, Sill M, Beck P, Chan KC, Korshunov A, Sah F, Deng MY, Sturm D, DeSisto J, Donson AM, Foreman NK, Green AL, Robinson G, Orr BA, Gao Q, Darrow E, Hadley JL, Northcott PA, Gojo J, Kawauchi D, Hovestadt V, Filbin MG, von Deimling A, Zuckermann M, Pajtler KW, Kool M, Jones DTW, Jäger N, Kutscher LM, Kaessmann H, Pfister SM. Mapping pediatric brain tumors to their origins in the developing cerebellum. Neuro Oncol. 2023 Oct 3;25(10):1895-1909. PubMed PMID: 37534924
Johann PD, Altendorf L, Efremova EM, Holsten T, Steinbügl M, Nemes K, Eckhardt A, Kresbach C, Bockmayr M, Koch A, Haberler C, Antonelli M, DeSisto J, Schuhmann MU, Hauser P, Siebert R, Bens S, Kool M, Green AL, Hasselblatt M, Frühwald MC, Schüller U. Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics. Acta Neuropathol. 2023 Sep;146(3):527-541. PubMed PMID: 37450044
Knox AJ, Van Court B, Oweida A, Barsh E, DeSisto J, Flannery P, Lemma R, Chatwin H, Vibhakar R, Dorris K, Serkova NJ, Karam SD, Gilani A, Green AL. A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease. Front Oncol. 2023;13:1105395. PubMed PMID: 37124531
Fraley CE, Neiman JS, Feddersen CR, James C, Jones TG, Mikkelsen M, Nuss R, Schlenz AM, Winters AC, Green AL, Compas BE. Identifying patterns of neurocognitive dysfunction through direct comparison of children with leukemia, central nervous system tumors, and sickle cell disease. Pediatr Blood Cancer. 2023 Jun;70(6):e30299. PubMed PMID: 37036272
Berkman AM, Andersen CR, Hildebrandt MAT, Livingston JA, Green AL, Puthenpura V, Peterson SK, Milam J, Miller KA, Freyer DR, Roth ME. Risk of early death in adolescents and young adults with cancer: a population-based study. J Natl Cancer Inst. 2023 Apr 11;115(4):447-455. PubMed PMID: 36682385
Goulding D, Arguinchona L, Anderson-Mellies A, Mikkelsen M, Eguchi M, Marinoff H, Zahedi S, Ribeiro KB, Cockburn M, Rodriguez Galindo C, Green AL. Sociodemographic Disparities in Presentation and Survival of Pediatric Bone Cancers. J Pediatr Hematol Oncol. 2023 Jan 1;45(1):e31-e43. PubMed PMID: 36044295
DeSisto J, Donson AM, Griesinger AM, Fu R, Riemondy K, Mulcahy Levy J, Siegenthaler JA, Foreman NK, Vibhakar R, Green AL. Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high grade glioma. Neuro Oncol. 2023 Nov 2. [Epub ahead of print] PubMed PMID: 37934854
Esbenshade AJ, Kahalley LS, Wistinghausen B, Cash T, Baertschiger RM, Zarnegar-Lumley S, Green A, Dhall G. Children's Oncology Group's 2023 blueprint for research: Young investigators. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30567. PubMed PMID: 37438856
Martinez P, Nault G, Steiner J, Wempte M, Pierce A, Brunt B, Slade M, Mongin A, Song J, Song KH, Serkova N, Green A, Borden M. “MRI-guided focused ultrasound blood-brain barrier disruption increases drug delivery and efficacy in an orthotopic DIPG model.” Society for Neuro-Oncology’s 7th Pediatric Neuro-Oncology Basic and Translational Research Conference, Washington DC, June 2023.
Slade M, Link G, DeSisto J, Feddersen C, Bargas D, Knox A, Green AL. “Testing for synergy among radiation and highly clinically relevant chemotherapeutic agents in patient-derived models of diffuse midline glioma.” Society for Neuro-Oncology’s 7th Pediatric Neuro-Oncology Basic and Translational Research Conference, Washington DC, June 2023.
DeSisto J, Donson A, Griesinger AM, Fu R, Mulcahy Levy J, Foreman NK, Vibhakar R, Green AL. “Single cell RNA-seq analysis of pediatric high-grade glioma patient samples identifies common glial and immune cell types that help to explain heterogeneity and tumorigenesis.” Society for Neuro-Oncology’s 7th Pediatric Neuro-Oncology Basic and Translational Research Conference, Washington DC, June 2023.
Lind K, Mellies A, Green AL. “Death within one month of pediatric cancer diagnosis: a retrospective, patient-level study of clinical, diagnostic, demographic, and socioeconomic factors.” American Society of Pediatric Hematology-Oncology Annual Meeting, Pittsburgh, May 2022.
Hilliard A, Mellies A, Kreis A, Marable M, Fraley C, Pacheco D, Green AL. “Patient-level analysis of pediatric CNS tumor survival based on demographic/socioeconomic variables.” American Society of Pediatric Hematology-Oncology Annual Meeting, Pittsburgh, May 2022.
DeSisto J, Knox A, Balakrishnan I, Charwin H, Coleman P, Venkataraman S, Vibhakar R, Green AL. “PRMT5 promotes the formation and growth of pediatric high-grade glioma by maintaining tumor stem cell populations.” 20th International Symposium on Pediatric Neuro-Oncology, Hamburg, Germany, June 2022.
Pacheco D, Fraley C, Walker D, Green AL. “Creation, use, and effectiveness of a primary provider education tool for timely pediatric CNS tumor diagnosis based on HeadSmart.” 20th International Symposium on Pediatric Neuro-Oncology, Hamburg, Germany, June 2022.
Feddersen C, Knox AJ, DeSisto J, Nelson-Taylor S, Coleman P, Van Court B, Donson A, Karam SD, Green AL. “Novel in vivo models of post-radiation recurrent pediatric high-grade glioma show increased susceptibility to MAPK inhibition.” 20th International Symposium on Pediatric Neuro-Oncology, Hamburg, Germany, June 2022.
Leary JB, Anderson-Mellies A, Green AL. “Characterizing the epidemiology of radiation-induced gliomas following cranial radiotherapy for pediatric cancers: a population-based study.” 20th International Symposium on Pediatric Neuro-Oncology, Hamburg, Germany, June 2022.
Beltrami A, Hilliard A, Green AL. Demographic and socioeconomic disparities in pediatric cancer in the United States: Current knowledge, deepening understanding, and expanding intervention. Cancer Epidemiol. 2022 Feb;76:102082. PubMed PMID: 34923289
Goulding D, Arguinchona L, Anderson-Mellies A, Mikkelsen M, Eguchi M, Marinoff H, Zahedi S, Ribeiro KB, Cockburn M, Rodriguez Galindo C, Green AL. Sociodemographic Disparities in Presentation and Survival of Pediatric Bone Cancers. J Pediatr Hematol Oncol. 2022 Aug 26. [Epub ahead of print] PubMed PMID: 36044295
Milgrom SA, Koo J, Foreman N, Liu AK, Campbell K, Dorris K, Green AL, Dahl N, Donson AM, Vibhakar R, Levy JMM. Radiation Therapy for Young Children Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant for Primary Brain Tumors. Adv Radiat Oncol. 2022 Jul-Aug;7(4):100945. PubMed PMID: 35814855
Greer HR, Miller K, Samay S, Nellan A, Green AL. Investigation of white blood cell characteristics in cerebrospinal fluid samples at pediatric brain tumor diagnosis. J Neurooncol. 2022 Sep;159(2):301-308. PubMed PMID: 35731362
Hart M, Anderson-Mellies A, Beltrami A, Gilani A, Green AL. Population-based analysis of CNS tumor diagnoses, treatment, and survival in congenital and infant age groups. J Neurooncol. 2022 Apr;157(2):333-344. PubMed PMID: 35175546
Lassman AB, Wen PY, van den Bent MJ, Plotkin SR, Walenkamp AME, Green AL, Li K, Walker CJ, Chang H, Tamir S, Henegar L, Shen Y, Alvarez MJ, Califano A, Landesman Y, Kauffman MG, Shacham S, Mau-Sørensen M. A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma. Clin Cancer Res. 2022 Feb 1;28(3):452-460. PubMed PMID: 34728525
DeSisto J, Lucas JT Jr, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schüller U, Venkataraman S, Hoffman LM, Dorris K, Mulcahy Levy JM, Hankinson TC, Handler M, Liu AK, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL. Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma. Nat Commun. 2021 Sep 20;12(1):5531. PubMed PMID: 34545084
Deng MY, Sturm D, Pfaff E, Sill M, Stichel D, Balasubramanian GP, Tippelt S, Kramm C, Donson AM, Green AL, Jones C, Schittenhelm J, Ebinger M, Schuhmann MU, Jones BC, van Tilburg CM, Wittmann A, Golanov A, Ryzhova M, Ecker J, Milde T, Witt O, Sahm F, Reuss D, Sumerauer D, Zamecnik J, Korshunov A, von Deimling A, Pfister SM, Jones DTW. Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B. Nat Commun. 2021 Sep 20;12(1):5530. PubMed PMID: 34545083
Schreck KC, Morin A, Zhao G, Allen AN, Flannery P, Glantz M, Green AL, Jones C, Jones KL, Kilburn LB, Nazemi KJ, Samuel D, Sanford B, Solomon DA, Wang J, Pratilas CA, Nicolaides T, Mulcahy Levy JM. Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF(V600E)-Mutant Human Glioma. Clin Cancer Res. 2021 Nov 15;27(22):6197-6208. PubMed PMID: 34433654
Darlington WS, Green AL. The role of geographic distance from a cancer center in survival and stage of AYA cancer diagnoses. Cancer. 2021 Oct 1;127(19):3508-3510. PubMed PMID: 34232508
Norris GA, Tsai AC, Schneider KW, Wu YH, Caulfield T, Green AL. A novel, germline, deactivating CBL variant p.L493F alters domain orientation and is associated with multiple childhood cancers. Cancer Genet. 2021 Jun;254-255:18-24. PubMed PMID: 33550024
Chatwin HV, Cruz Cruz J, Green AL. Pediatric high-grade glioma: moving toward subtype-specific multimodal therapy. FEBS J. 2021 Nov;288(21):6127-6141. PubMed PMID: 33523591
Greer HR, Orbach DB, Yock TI, Rodriguez-Galindo C, Green AL. Intra-arterial chemotherapy for rhabdomyosarcoma. Pediatr Hematol Oncol. 2021 May;38(4):391-396. PubMed PMID: 33439069
Galinski B, Alexander TB, Mitchell DA, Chatwin HV, Awah C, Green AL, Weiser DA. Therapeutic Targeting of Exportin-1 in Childhood Cancer. Cancers (Basel). 2021 Dec 7;13(24). PubMed PMID: 34944778
Lind KT, Chatwin HV, DeSisto J, Coleman P, Sanford B, Donson AM, Davies KD, Willard N, Ewing CA, Knox AJ, Mulcahy Levy JM, Gilani A, Green AL. Novel RAF Fusions in Pediatric Low-Grade Gliomas Demonstrate MAPK Pathway Activation. J Neuropathol Exp Neurol. 2021 Dec 29;80(12):1099-1107. PubMed PMID: 34850053
DeSisto J, Lucas JT Jr, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schüller U, Venkataraman S, Hoffman LM, Dorris K, Mulcahy Levy JM, Hankinson TC, Handler M, Liu AK, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL. Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma. Nat Commun. 2021 Sep 20;12(1):5531. PubMed PMID: 34545084
Deng MY, Sturm D, Pfaff E, Sill M, Stichel D, Balasubramanian GP, Tippelt S, Kramm C, Donson AM, Green AL, Jones C, Schittenhelm J, Ebinger M, Schuhmann MU, Jones BC, van Tilburg CM, Wittmann A, Golanov A, Ryzhova M, Ecker J, Milde T, Witt O, Sahm F, Reuss D, Sumerauer D, Zamecnik J, Korshunov A, von Deimling A, Pfister SM, Jones DTW. Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B. Nat Commun. 2021 Sep 20;12(1):5530. PubMed PMID: 34545083
Schreck KC, Morin A, Zhao G, Allen AN, Flannery P, Glantz M, Green AL, Jones C, Jones KL, Kilburn LB, Nazemi KJ, Samuel D, Sanford B, Solomon DA, Wang J, Pratilas CA, Nicolaides T, Mulcahy Levy JM. Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAF(V600E)-Mutant Human Glioma. Clin Cancer Res. 2021 Aug 25. [Epub ahead of print] PubMed PMID: 34433654
Darlington WS, Green AL. The role of geographic distance from a cancer center in survival and stage of AYA cancer diagnoses. Cancer. 2021 Oct 1;127(19):3508-3510. PubMed PMID: 34232508
Norris GA, Tsai AC, Schneider KW, Wu YH, Caulfield T, Green AL. A novel, germline, deactivating CBL variant p.L493F alters domain orientation and is associated with multiple childhood cancers. Cancer Genet. 2021 Jun;254-255:18-24. PubMed PMID: 33550024
Chatwin HV, Cruz Cruz J, Green AL. Pediatric high-grade glioma: moving toward subtype-specific multimodal therapy. FEBS J. 2021 Nov;288(21):6127-6141. PubMed PMID: 33523591
Greer HR, Orbach DB, Yock TI, Rodriguez-Galindo C, Green AL. Intra-arterial chemotherapy for rhabdomyosarcoma. Pediatr Hematol Oncol. 2021 May;38(4):391-396. PubMed PMID: 33439069
Green AL, Minard CG, Liu X, Reid JM, Pinkney K, Voss S, Nelson MD, Fox E, Weigel BJ, Glade Bender J. "Phase 1 trial of selinexor in children and adolescents with recurrent/refractory solid and CNS tumors (ADVL1414): A Children’s Oncology Group Phase 1 Consortium trial." AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics 2021.
3 senior author abstracts presented at the 2021 Pediatric Research Meeting of the Society for Neuro-Oncology: HGG-26. SINGLE-CELL RNA-SEQ OF PEDIATRIC HIGH-GRADE GLIOMAS IDENTIFIES COMMON ONCOGENIC PROCESSES AMONG DISTINCT TUMOR HISTOLOGIES J DeSisto, A Donson, R Fu, B Sanford, K Riemondy, A Green Neuro-Oncology 23 (Suppl 1), i22 HGG-25. PRMT5 PROMOTES TUMOR GROWTH BY MAINTAINING STEMNESS OF PEDIATRIC HIGH-GRADE GLIOMA CELLS J DeSisto, A Knox, H Chatwin, I Balakrishnan, S Venkataraman, ... Neuro-Oncology 23 (Supplement_1), i22-i22 LGG-13. PILOCYTIC ASTROCYTOMAS WITH NOVEL BRAF FUSIONS DEMONSTRATE MAPK PATHWAY ACTIVATION H Chatwin, K Lind, J DeSisto, B Sanford, A Gilani, A Green Neuro-Oncology 23 (Supplement_1), i34-i34
Balakrishnan I, Danis E, Pierce A, Madhavan K, Wang D, Dahl N, Sanford B, Birks DK, Davidson N, Metselaar DS, Meel MH, Lemma R, Donson A, Vijmasi T, Katagi H, Sola I, Fosmire S, Alimova I, Steiner J, Gilani A, Hulleman E, Serkova NJ, Hashizume R, Hawkins C, Carcaboso AM, Gupta N, Monje M, Jabado N, Jones K, Foreman N, Green A, Vibhakar R, Venkataraman S. Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. Cell Rep. 2020 Oct 20;33(3):108286. PubMed PMID: 33086074
Grob ST, Nobre L, Campbell KR, Davies KD, Ryall S, Aisner DL, Hoffman L, Zahedi S, Morin A, Crespo M, Nellan A, Green AL, Foreman N, Vibhakar R, Hankinson TC, Handler MH, Hawkins C, Tabori U, Kleinschmidt-DeMasters BK, Mulcahy Levy JM. Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa103. PubMed PMID: 33063010
Green AL, Flannery P, Hankinson TC, O'Neill B, Amani V, DeSisto J, Knox A, Chatwin H, Lemma R, Hoffman LM, Mulcahy Levy J, Raybin J, Hemenway M, Gilani A, Koschmann C, Dahl N, Handler M, Pierce A, Venkataraman S, Foreman N, Vibhakar R, Wempe MF, Dorris K. Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa021. PubMed PMID: 32642682
Bhatia S, Bukkapatnam S, Van Court B, Phan A, Oweida A, Gadwa J, Mueller AC, Piper M, Darragh L, Nguyen D, Gilani A, Knitz M, Bickett T, Green A, Venkataraman S, Vibhakar R, Cittelly D, Karam SD. The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. Mol Carcinog. 2020 Sep;59(9):1064-1075. PubMed PMID: 32567728
Faulk KE, Anderson-Mellies A, Cockburn M, Green AL. Assessment of enrollment characteristics for Children's Oncology Group (COG) upfront therapeutic clinical trials 2004-2015. PLoS One. 2020;15(4):e0230824. PubMed PMID: 32324751
Dahl NA, Danis E, Balakrishnan I, Wang D, Pierce A, Walker FM, Gilani A, Serkova NJ, Madhavan K, Fosmire S, Green AL, Foreman NK, Venkataraman S, Vibhakar R. Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma. Cell Rep. 2020 Apr 7;31(1):107485. PubMed PMID: 32268092
Moreira DC, Venkataraman S, Subramanian A, Desisto J, Balakrishnan I, Prince E, Pierce A, Griesinger A, Green A, Eberhardt CG, Foreman NK, Vibhakar R. Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine. J Neurooncol. 2020 May;147(3):531-545. PubMed PMID: 32180106
Fineberg R, Zahedi S, Eguchi M, Hart M, Cockburn M, Green AL. Population-Based Analysis of Demographic and Socioeconomic Disparities in Pediatric CNS Cancer Survival in the United States. Sci Rep. 2020 Mar 12;10(1):4588. PubMed PMID: 32165703
Whiteway SL, Betts AM, O'Neil ER, Green AL, Gilani A, Orr BA, Mathis DA. Oncogenic GOPC-ROS1 Fusion Identified in a Congenital Glioblastoma Case. J Pediatr Hematol Oncol. 2020 Nov;42(8):e813-e818. PubMed PMID: 31929384
Gilani A, Donson A, Davies KD, Whiteway SL, Lake J, DeSisto J, Hoffman L, Foreman NK, Kleinschmidt-DeMasters BK, Green AL. Targetable molecular alterations in congenital glioblastoma. J Neurooncol. 2020 Jan;146(2):247-252. PubMed PMID: 31875306
Green AL, DeSisto J, Flannery P, Lemma R, Knox A, Lemieux M, Sanford B, O'Rourke R, Ramkissoon S, Jones K, Perry J, Hui X, Moroze E, Balakrishnan I, O'Neill AF, Dunn K, DeRyckere D, Danis E, Safadi A, Gilani A, Hubbell-Engler B, Nuss Z, Levy JMM, Serkova N, Venkataraman S, Graham DK, Foreman N, Ligon K, Jones K, Kung AL, Vibhakar R. BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway. Oncogene. 2020 Mar;39(11):2305-2327. PubMed PMID: 31844250
Lake JA, Donson AM, Prince E, Davies KD, Nellan A, Green AL, Mulcahy Levy J, Dorris K, Vibhakar R, Hankinson TC, Foreman NK, Ewalt MD, Kleinschmidt-DeMasters BK, Hoffman LM, Gilani A. Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. Pediatr Blood Cancer. 2020 Jan;67(1):e28028. PubMed PMID: 31595628
DeSisto JA, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, Bales NJ, Kashyap T, Moroze E, Venkataraman S, Kung AL, Carter BD, Landesman Y, Vibhakar R, Green AL. Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-?B Pathway in Preclinical Models of Pediatric High-Grade Glioma. Mol Cancer Ther. 2020 Feb;19(2):540-551. PubMed PMID: 31594826
Hart M, Mellies A, Beltrami A. Gilani A, Green A. "A population-based analysis of CNS tumor diagnoses, treatment, and survival in congenital and infant age groups." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
Greer H, Campbell K, Samay S, Green A. "Investigation of white blood cell characteristics in CSF samples at pediatric brain tumor diagnosis." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
Chatwin H, Lema R, DeSisto J, Knox A, Mestnik S, Reid A, Vibhakar R, Venkataraman S, Green A. "H3K27M induces epigenetic and oncogenic changes that are partially reversed by small molecule Aurora kinase B/C inhibition." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
Knox AJ, Gilani A, van Court B, Oweida A, Flannery P, DeSisto J, Lemma R, Chatwin H, Gamboni F, Brown B, SerkovaN, Vibhakar R, Dorris K, Reisz JA, Karam SD, Green AL. "Toward multimodality therapy for DIPG/DMG: Development and investigation of craniospinal irradiation and convection-enhanced delivery PDX models." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
Knox AJ, Flannery P, Zukosky A, DeSisto J, Sanford B, van Court B, Donson A, Lemma R, Chatwin H, Karam SD, Vibhakar R, Jones K, Green AL. "Radiation-derived treatment-resistant PDX and cell culture models recapitulate the characteristics of matched primary/recurrent pediatric high-grade glioma." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
Lind K, Mellies A, Green A. "Retrospective patient-level study of early death from childhood cancer in Colorado." American Society of Pediatric Hematology-Oncology Annual Meeting, 2020.
Lucas J, DeSisto J, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schuller U, Hoffman LM, Dorris K, Mulcahy Levy J, Hankinson TC, Handler M, Liu A, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL. "Pediatric treatment induced high-grade gliomas have molecular alterations and a mutational signature which distinguish it from de novo pediatric high-grade gliomas." 19th International Symposium on Pediatric Neuro-Oncology, Karuizawa, Japan, December 2020.
Lake JA, Donson AM, Prince E, Davies KD, Nellan A, Green AL, Mulcahy Levy J, Dorris K, Vibhakar R, Hankinson TC, Foreman NK, Ewalt MD, Kleinschmidt-DeMasters BK, Hoffman LM, Gilani A. Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. Pediatr Blood Cancer. 2019 Oct 8;:e28028. [Epub ahead of print] PubMed PMID: 31595628
DeSisto JA, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, Bales NJ, Kashyap T, Moroze E, Venkataraman S, Kung AL, Carter BD, Landesman Y, Vibhakar R, Green AL. Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma. Mol Cancer Ther. 2019 Oct 8. [Epub ahead of print] PubMed PMID: 31594826
Zahedi S, Fitzwalter BE, Morin A, Grob S, Desmarais M, Nellan A, Green AL, Vibhakar R, Hankinson TC, Foreman NK, Mulcahy Levy JM. Effect of early-stage autophagy inhibition in BRAF(V600E) autophagy-dependent brain tumor cells. Cell Death Dis. 2019 Sep 12;10(9):679. PubMed PMID: 31515514
Norris GA, Garcia J, Hankinson TC, Handler M, Foreman N, Mirsky D, Stence N, Dorris K, Green AL. Diagnostic accuracy of neuroimaging in pediatric optic chiasm/sellar/suprasellar tumors. Pediatr Blood Cancer. 2019 Jun;66(6):e27680. PubMed PMID: 30848081
Steiner J, Pierce A, Griesinger AM, Veo BL, Knox A, Dahl N, Green A, Foreman NK, Vibhakar R, Serkova NJ. “Multiparametric Advanced Fast Imaging (MAFI) to Characterize Tumor Habitat in Orthotopic Mouse Models of Pediatric Brain Tumors.” International Society of Magnetic Resonance in Medicine, Montreal, May 2019.
Lassman AB, Wen PY, van den Bent M, Plotkin SR, Walenkamp A, Green A, Huang X, Rodriguez-Lopez K, Kauffman MG, Shacham S, Mau-Soerensen M. “Efficacy and safety of selinexor (KPT-330) in recurrent glioblastoma (KING).” American Society of Clinical Oncology Annual Meeting, Chicago, June 2019.
Steiner J, Pierce A, Griesinger A, Veo B, Knox A, Dahl N, Green A, Foreman N, Vibhakar R, Serkova N. “Advanced ultra-high field MRI on tumor habitat in orthotopic mouse models for pediatric brain tumors.” Society for Neuro-Oncology’s 5th Pediatric Neuro-Oncology Basic and Translational Research Conference, San Francisco, May 2019.
Gilani A, Donson A, Whiteway S, DeSisto J, Hoffman L, Foreman N, Kleinschmidt-DeMasters BK, Green A. “Targetable molecular alterations in congenital glioblastoma.” Society for Neuro-Oncology’s 5th Pediatric Neuro-Oncology Basic and Translational Research Conference, San Francisco, May 2019.
Faulk K, Anderson-Mellies A, Cockburn M, Green A. “Assessment of enrollment characteristics for Children’s Oncology Group (COG) upfront therapeutic clinical trials 2004-2015.” American Society of Clinical Oncology Annual Meeting, Chicago, June 2019.
Colton MD, Goulding D, Beltrami A, Cost C, Franklin A, Cockburn MG, Green AL. A U.S. population-based study of insurance disparities in cancer survival among adolescents and young adults. Cancer Med. 2019 Aug;8(10):4867-4874. PubMed PMID: 31240865
Flannery PC, DeSisto JA, Amani V, Venkataraman S, Lemma RT, Prince EW, Donson A, Moroze EE, Hoffman L, Levy JMM, Foreman N, Vibhakar R, Green AL. Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma. Oncol Rep. 2018 Feb;39(2):455-464. PubMed PMID: 29207163
Colton MD, Hawkins M, Goulding D, Cockburn M, Green AL. Socioeconomics, Race, and Ethnicity in Childhood Cancer Survival: Accessing and Addressing Root Causes of Disparities. Cancer. 2018 Aug 20. [Epub ahead of print] PubMed PMID: 30125347
Zahedi S, Fiineberg R, Eguchi M, Cockburn M, Green A. “Population-based analysis of demographic and socioeconomic disparities in pediatric CNS tumor survival in the United States.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018 (oral presentation; abstract published in Neuro-Oncology, Volume 20, Supplement 2, June 2018)
DeSisto J, Lucas J, Donson A, Sanford B, Wu G, Armstrong G, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Hoffman L, Dorris K, Liu A, Foreman N, Vibhakar R, Jones K, Allen S, Baker S, Merchant T, Orr B, Green A. “Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: germline DNA repair defects as a potential etiology.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. (oral presentation; abstract published in Neuro-Oncology, Volume 20, Supplement 2, June 2018)
Flannery P, DeSisto J, Donson A, Lemma R, vibhakar R, Jones K, Green A. “Transcriptional analysis of ATRT samples from long-term survivors and matched primary/recurrent pairs.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. (poster presentation; abstract published in Neuro-Oncology, Volume 20, Supplement 2, June 2018)
Norris G, Garcia J, Hankinson T, Handler M, Foreman N, Mirsky D, Stence N, Dorris K, Green A. “Diagnostic accuracy of neuroimaging in pediatric optic pathway/sellar/suprasellar tumors.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. (poster presentation; abstract published in Neuro-Oncology, Volume 20, Supplement 2, June 2018)
Green A, Flannery P, Hankinson T, O’Neill B, DeSisto J, Lemma R, Hoffman L, Mulcahy Levy J, Raybin J, Hemenway M, Koschmann C, Handler M, Foreman N, Vibhakar R, Wempe M, Dorris K. “Intratumoral pharmacokinetics of chemotherapy in DIPG: xenograft and initial phase 0 clinical trial results.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. (poster presentation; abstract published in Neuro-Oncology, Volume 20, Supplement 2, June 2018)
Lemma R, DeSisto J, Flannery P, Sanford B, Balakrishnan I, Madhavan K, Veo B, Mulcahy Levy J, Foreman N, Vibhakar R, Jones K, Venkataraman S, Green A. “The H3K27M mutation causes wide-ranging changes mediating DIPG tumorigenesis.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. (poster presentation; abstract published in Neuro-Oncology, Volume 20, Supplement 2, June 2018)
Two additional oral presentations/abstracts published in Neuro-Oncology, Volume 20, Supplement 2, June 2018: Stence N, Mulcahy Levy J, Hoffman L, Green A, Mirsky D, Neuberger I, Fenton L, Maloney J, Kleinschmidt-DeMasters B, Vibhakar R, Foreman N, Dorris K. “Imaging characteristics of BRAF V600E mutated pediatric brain tumors.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. Mulcahy Levy J, Sanford B, Morin A, Green A, Flannery P, Jones K, Banerjee A, Nazemi K, Samuel D, Kilburn L, Solomon D, Nicolaides T. “Analysis of paired BRAFV600E mutant glioma patient samples identifies novel resistance mechanisms to targeted BRAF inhibition.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018.
Four additional poster presentations; abstracts published in Neuro-Oncology, Volume 20, Supplement 2, June 2018: McEvoy M, Hemenway M, Raybin J, Green A, Nellan A, Mulcahy Levy J, Vibhakar R, Foreman N, McCourt E, Dorris K. “Improvement in visual acuity of pediatric patients with brain tumors with bevacizumab.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. Balakrishnan I, Madhavan K, Pierce A, Dahl N, Lemma R, Fosmire S, Wang D, Prince E, Alimova I, Hashizume R, Huellman E, Hawkins C, Montero Carcaboso A, Gupta N, Monje M, Jones K, Green A, Foreman N, Vibhakar R, Venkataraman S. “Targeting senescent cells with ABT-263 enhances cell death induced by BMI1 inhibition and ionizing radiation in DIPG.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. Griesinger A, Pierce A, Witt D, Flannery P, Donson A, Gowan K, Hankinson T, Handler M, Jones K, Green A, Vibhakar R, Foreman N. “Patient-derived PFA ependymoma xenograft model.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018. Morin A, Soane C, Pierce A, Alimoa I, Desmarais M, Zahedi S, Vibhakar R, Griesinger A, Green A, Hoffman L, Mulcahy Levy J. “Validation of proteasome inhibition as a therapeutic target in atypical teratoid/rhabdoid tumors.” International Symposium on Pediatric Neuro-Oncology, Denver, July 2018.
Green A, DeSisto J, Flannery P, Lemma R, Kashyap T, Kung A, Landeman Y, Vibhakar R. “Mechanism of action and combination therapy studies of the XPO1 inhibitor selinexor in pediatric high-grade glioma and diffuse intrinsic pontine glioma.” NINDS K Award Symposium, Atlanta, October 2018.
Marini BL, Benitez LL, Zureick AH, Salloum R, Gauthier AC, Brown J, Wu YM, Robinson DR, Kumar C, Lonigro R, Vats P, Cao X, Kasaian K, Anderson B, Mullan B, Chandler B, Linzey JR, Camelo-Piragua SI, Venneti S, McKeever PE, McFadden KA, Lieberman AP, Brown N, Shao L, Leonard MAS, Junck L, McKean E, Maher CO, Garton HJL, Muraszko KM, Hervey-Jumper S, Mulcahy-Levy JM, Green A, Hoffman LM, Dorris K, Vitanza NA, Wang J, Schwartz J, Lulla R, Smiley NP, Bornhorst M, Haas-Kogan DA, Robertson PL, Chinnaiyan AM, Mody R, Koschmann C. Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors. Transl Res. 2017 Oct;188:27.e1-27.e14. PubMed PMID: 28860053
McEvoy M, Robison N, Manley P, Yock T, Konopka K, Brown RE, Wolff J, Green AL. Successful Treatment of Recurrent Li-Fraumeni Syndrome-related Choroid Plexus Carcinoma. J Pediatr Hematol Oncol. 2017 Aug 30. [Epub ahead of print] PubMed PMID: 28859040
Green AL, Mulcahy Levy JM, Vibhakar R, Hemenway M, Madden J, Foreman N, Dorris K. Tumor treating fields in pediatric high-grade glioma. Childs Nerv Syst. 2017 Jul;33(7):1043-1045. PubMed PMID: 28470383
Green AL, Furutani E, Ribeiro KB, Rodriguez Galindo C. Death Within 1 Month of Diagnosis in Childhood Cancer: An Analysis of Risk Factors and Scope of the Problem. J Clin Oncol. 2017 Apr 20;35(12):1320-1327. PubMed PMID: 28414926
Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Elife. 2017 Jan 17;6. PubMed PMID: 28094001
DeSisto J, Donson A, Flannery P, Lemma R, Sanford B, Foreman N, Vibhakar R, Jones K, Green A. “Pediatric radiation-induced glioblastoma: transcriptomic and drug screening analysis of primary patient samples.” Pediatric Neuro-Oncology Basic and Translational Research Conference, New York, NY, June 2017 [platform presentation].
Mulcahy Levy J, Sanford B, Morin A, Green A, Flannery P, Jones K, Banerjee A, Solomon D, Nicolaides T. “Analysis of paired BRAFV600E mutant glioma patient samples identifies novel resistance mechanisms to targeted BRAF inhibition.” Annual Meeting of the Society of Neuro-Oncology, San Francisco, CA, November 2017 [platform presentation].
DeSisto J, Donson A, Flannery P, Lemma R, Sanford B, Foreman N, Vibhakar R, Jones K, Green A. “Pediatric radiation-induced glioblastoma: transcriptomic and drug screening analysis of primary patient samples.” Annual Meeting of the Society of Neuro-Oncology, San Francisco, CA, November 2017 [platform presentation].
DeSisto JA, Flannery PM, Kafhyap T, Lemma R, Mestnik S, Kung AL, Vibhakar R, Landesman Y, Green AL. “Synergistic effects fo the XPO1 inhibitor selinexor with proteasome inhibitors in pediatric high-grade glioma and diffuse intrinsic pontine glioma.” American Association of Clinical Research Annual Meeting, Washington, DC, April 2017 [poster presentation].
Flannery P, DeSisto J, Lemma R, Donson A, Foreman N, Vibhakar R, Jones K, Green A. “A comparison of primary and recurrent pediatric high-grade gliomas via RNA sequencing and drug screening.” Pediatric Neuro-Oncology Basic and Translational Research Conference, New York, NY, June 2017 [poster presentation].
Green A, DeSisto J, Flannery P, Lemma R, Kashyap T, Kung A, Landesman Y, Vibhakar R. “Mechanism of action and combination therapy studies on the XPO1 inhibitor selinexor in pediatric high-grade glioma and diffuse intrinsic pontine glioma.” American Society of Pediatric Hematology-Oncology Annual Meeting, Montreal, April 2017 [platform presentation].
Green AL, Chintagumpala M, Krailo M, Langholz B, Albert D, Eagle R, Cockburn M, Chevez-Barrios P, Rodriguez-Galindo C. Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort: A Children's Oncology Group Study. Ophthalmology. 2016 Aug;123(8):1817-23. doi: 10.1016/j.ophtha.2016.04.043. PubMed PMID: 27262763.
Green AL, Yi J, Bezler N, Pikman Y, Tubman VN, Obeng EA, O'Neil T, Mersereau R, Morrissey L, Billett AL. A Prospective Cohort Quality Improvement Study to Reduce the Time to Antibiotics for New Fever in Neutropenic Pediatric Oncology Inpatients. Pediatr Blood Cancer. 2016 Jan;63(1):112-7. doi: 10.1002/pbc.25712. PubMed PMID: 26292080.
Green AL, Flannery P, DeSisto J, Lemieux M, Ramkissoon S, Jones K, Perry J, DeRyckere D, Venkataraman S, Foreman N, Orkin S, Ligon K, Jones K, Graham D, Kung AL, Vibhakar R. “An epigenomic screen reveals the chromatin remodeling protein BPTF as a driver of high-grade glioma in vitro and in vivo.” International Symposium on Pediatric Neuro-Oncology, Liverpool, June 2016.
Green AL, Flannery P, DeSisto J, Lemieux M, Ramkissoon S, Jones K, Perry J, DeRyckere D, Venkataraman S, Pomerantz W, Foreman N, Orkin S, Ligon K, Jones K, Graham D, Kung AL, Vibhakar R. “An epigenomic screen reveals the chromatin remodeling protein BPTF as a driver of high-grade glioma in vitro and in vivo.” Child Health Research K-12 Meeting, Bethesda, MD, September 2016.
Colton M, Green A. “A population-based study of racial/ethnic disparities in cancer survival among adolescents and young adults.” American Society of Clinical Oncology Annual Meeting, Chicago, June 2016.
DeSisto J, Flannery P, Kashyap T, Venkataraman S, Kung A, Vibhakar R, Landesman Y, Green A. “Effects of the XPO1 inhibitor selinexor on the NGFR/NF-kB pathway in pediatric high-grade glioma and diffuse intrinsic pontine glioma.” International Symposium on Pediatric Neuro-Oncology, Liverpool, June 2016.
Flannery P, DeSisto J, Amani V, Venkataraman S, Vibhakar R, Green A. “The effects of MTOR Complex 1/2 inhibition in diffuse intrinsic pontine glioma cells.” International Symposium on Pediatric Neuro-Oncology, Liverpool, June 2016.
Green A, Foreman N, Mulcahy Levy J, Madden J, Hemenway M, Vibhakar R, Dorris K. “Case series of three pediatric brain tumor patients treated with tumor-treating fields.” International Symposium on Pediatric Neuro-Oncology, Liverpool, June 2016.
Hankinson TC, Patibandla MR, Green A, Hemenway M, Foreman N, Handler M, Liu AK. Hypofractionated Radiotherapy for Children With Diffuse Intrinsic Pontine Gliomas. Pediatr Blood Cancer. 2016 Apr;63(4):716-8. PubMed PMID: 26544789
Truong B, Green AL, Friedrich P, Ribeiro KB, Rodriguez-Galindo C. Ethnic, Racial, and Socioeconomic Disparities in Retinoblastoma. JAMA Pediatr. 2015 Oct 5;:1-9. [Epub ahead of print] PubMed PMID: 26436436
Green AL, Kieran MW. Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors. Curr Oncol Rep. 2015 Mar;17(3):436. PubMed PMID: 25702179
Green AL, Ramkissoon SH, McCauley D, Jones K, Perry JA, Hsu JH, Ramkissoon LA, Maire CL, Hubbell-Engler B, Knoff DS, Shacham S, Ligon KL, Kung AL. Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. Neuro Oncol. 2015 May;17(5):697-707. PubMed PMID: 25366336
Hankinson TC, Patibandla MR, Green A, Hemenway M, Foreman N, Handler M, Liu AK. Hypofractionated Radiotherapy for Children With Diffuse Intrinsic Pontine Gliomas. Pediatr Blood Cancer. 2015 Nov 6. [Epub ahead of print] PubMed PMID: 26544789
Green AL, Srivatsa A, Rodriguez-Galindo C. Delayed diagnosis and false relapse due to paternal testosterone use in adrenocortical carcinoma. Pediatrics. 2014 Jun;133(6):e1772-6. PubMed PMID: 24799542
Ross SG, Northman L, Morris M, Green AL, Ullrich NJ. Cerebellar mutism after posterior fossa tumor resection: case discussion and recommendations for psychoeducational intervention. J Pediatr Oncol Nurs. 2014 Mar-Apr;31(2):78-83. PubMed PMID: 24608700
Gardner SL, Asgharzadeh S, Green A, Horn B, McCowage G, Finlay J. Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors. Pediatr Blood Cancer. 2008 Aug;51(2):235-40. PubMed PMID: 18381756
Taylor NC, Li A, Green A, Kinney HC, Nattie EE. Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2. J Appl Physiol (1985). 2004 Nov;97(5):1763-73. PubMed PMID: 15273241
Lind KT, Chatwin HV, DeSisto, J, Coleman P, Sanford B, Donson AM, Davies KD, Willard N, Ewing C, Knox A, Mulcahy Levy JM, Gilani A, Green AL. "Novel RAF fusions in pediatric low-grade gliomas demonstrate MAPK pathway activation." J Neuropathol Exp Neurol [in press].
Lassman AB, Wen PY, van den Bent M, Plotkin SR, Walenkamp A, Green AL, Li K, Walker CJ, Chang H, Tamir S, Henegar L, Shen Y, Alvarez MJ, Califano A, Landesman Y, Kauffman MG, Shacham S, Mau-Soerensen M. "A phase 2 study of the efficacy and safety of oral selinexor in recurrent glioblastoma." Clin Cancer Res [in press].
Berkman AM, Andersen CR, Hildebrandt MAT, Livingston JA, Green AL, Puthenpura V, Peterson SK, Milam J, Miller KA, Freyer DR, Roth ME. “Risk of early death in adolescents and young adults diagnosed with cancer: a population-based study.” J Nat Cancer Inst [in press].

View All (132 Total)

Professional Memberships

Children's Oncology Group, Member, CNS Committee
University of Colorado Cancer Center, Mentored Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

Children's Hospital Colorado

Center Affiliations

University of Colorado Cancer Center

Specialty Information

Specialties

Pediatrics, Board Certification (2010)
Pediatric Hematology / Oncology, Board Certification (2015)

Conditions & Treatments

Brain and Nervous System - Brain Tumors
Cancers - Pediatric Cancer
Brain and Nervous System
Cancers
Cancers - Brain Cancer
Child and Teen Health

Clinical Interests
I help lead national clinical trials and give second opinions for other institutions for pediatric high-grade glioma, diffuse intrinsic pontine glioma (DIPG), and diffuse midline glioma. I also specialize in the diagnosis and management of other childhood tumors of the brain and spinal cord. In addition, I have expertise in other childhood cancers, benign blood disorders, and cell transplant.

Care Philosophy
I am committed to providing exceptional child- and family-centered care to my patients. I strive to communicate information truthfully to families at all times, and in an age-appropriate way to patients throughout childhood. As part of a team that includes physicians, nurse practitioners, nurses, social workers, and others, I aim to provide the highest quality, most innovative care to all patients from Colorado and beyond, to maximize cure rates and minimize adverse effects of treatment.

Personal Interests
Spending time with my wife and three children, playing piano, singing, road cycling, running, tennis, and triathlon.

Volunteer Activities
I enjoy educating the community on childhood cancer research and advocating for our patients. I am also a volunteer youth soccer and baseball coach.

Public Speaking
Yes

Associate Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation