D'Alessandro A, Earley EJ, Nemkov T, Stephenson D, Dzieciatkowska M, Hansen KC, Minetti G, Champigneulle B, Stauffer E, Pichon A, Furian M, Verges S, Kleinman S, Norris PJ, Busch MP, Page GP, Kaestner L. Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2315930120. PubMed PMID: 38147558
Nemkov T, Stephenson D, Erickson C, Dzieciatkowska M, Key A, Moore A, Earley EJ, Page GP, Lacroix IS, Stone M, Deng X, Raife TJ, Kleinman SH, Zimring JC, Roubinian NH, Hansen KC, Busch MP, Norris PJ, D'Alessandro A. Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo. Blood. 2023 Nov 17. [Epub ahead of print] PubMed PMID: 37976448
Heidarian Y, Tourigny JP, Fasteen TD, Mahmoudzadeh NH, Hurlburt AJ, Nemkov T, Reisz JA, D'Alessandro A, Tennessen JM. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. G3 (Bethesda). 2023 Dec 29;14(1). PubMed PMID: 37792629
Diaz AV, Stephenson D, Nemkov T, D'Alessandro A, Reis T. Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells. Genetics. 2023 Nov 1;225(3). PubMed PMID: 37738330
Craighead DH, Freeberg KA, Heinbockel TC, Rossman MJ, Jackman RA, McCarty NP, Jankowski LR, Nemkov T, Reisz JA, D'Alessandro A, Chonchol M, Bailey EF, Seals DR. Time-Efficient, High-Resistance Inspiratory Muscle Strength Training Increases Exercise Tolerance in Midlife and Older Adults. Med Sci Sports Exerc. 2023 Sep 13. [Epub ahead of print] PubMed PMID: 37707508
Fleck SA, Biswas P, DeWitt ED, Knuteson RL, Eisman RC, Nemkov T, D'Alessandro A, Tennessen JM, Rideout EJ, Weaver LN. Auxin Exposure Disrupts Feeding Behavior and Fatty Acid Metabolism in Adult Drosophila. bioRxiv. 2023 Dec 4. PubMed PMID: 37645868
D'Alessandro A, Anastasiadi AT, Tzounakas VL, Nemkov T, Reisz JA, Kriebardis AG, Zimring JC, Spitalnik SL, Busch MP. Red Blood Cell Metabolism In Vivo and In Vitro. Metabolites. 2023 Jun 27;13(7). PubMed PMID: 37512500
Bolf EL, Beadnell TC, Rose MM, D'Alessandro A, Nemkov T, Hansen KC, Schweppe RE. Dasatinib and Trametinib Promote Anti-Tumor Metabolic Activity. Cells. 2023 May 12;12(10). PubMed PMID: 37408209
Heidarian Y, Tourigny JP, Fasteen TD, Mahmoudzadeh NH, Hurlburt AJ, Nemkov T, Reisz JA, D'Alessandro A, Tennessen JM. Metabolomic analysis of Drosophila melanogaster larvae lacking Pyruvate kinase. bioRxiv. 2023 Jun 19. PubMed PMID: 37333180
Skinner SC, Nemkov T, Diaw M, Mbaye MN, Diedhiou D, Sow D, Gueye F, Lopez P, Connes P, D'Alessandro A. Metabolic Profile of Individuals with and without Type 2 Diabetes from Sub-Saharan Africa. J Proteome Res. 2023 Jul 7;22(7):2319-2326. PubMed PMID: 37264938
Esparza O, Hernandez G, Rojas-Sanchez G, Calzada-Martinez J, Nemkov T, Kelher M, Kelly K, Silliman CC, DomBourian M, Dumont LJ, D'Alessandro A, Davizon-Castillo P. Platelets from blood diversion pouches (DPs) are a suitable alternative for functional, bioenergetic, and metabolomic analyses. Blood Transfus. 2023 Mar 31;21(6):488-93. [Epub ahead of print] PubMed PMID: 37235734
Nemkov T, Cendali F, Stefanoni D, Martinez JL, Hansen KC, San-Millán I, D'Alessandro A. Metabolic Signatures of Performance in Elite World Tour Professional Male Cyclists. Sports Med. 2023 Aug;53(8):1651-1665. PubMed PMID: 37148487
Cendali FI, Nemkov T, Lisk C, Lacroix IS, Nouraie SM, Zhang Y, Gordeuk VR, Buehler PW, Irwin D, D'Alessandro A. Metabolic correlates to critical speed in murine models of sickle cell disease. Front Physiol. 2023;14:1151268. PubMed PMID: 37007990
Kumar S, Vassallo JD, Nattamai KJ, Hassan A, Karns R, Vollmer A, Soller K, Sakk V, Sacma M, Nemkov T, D'Alessandro A, Geiger H. pH regulates hematopoietic stem cell potential via polyamines. EMBO Rep. 2023 May 4;24(5):e55373. PubMed PMID: 36943011
Mian SA, Philippe C, Maniati E, Protopapa P, Bergot T, Piganeau M, Nemkov T, Di Bella D, Morales V, Finch AJ, D'Alessandro A, Bianchi K, Wang J, Gallipoli P, Kordasti S, Kubasch AS, Cross M, Platzbecker U, Wiseman DH, Bonnet D, Bernard DG, Gribben JG, Rouault-Pierre K. Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia. Sci Transl Med. 2023 Mar;15(685):eabn5135. PubMed PMID: 36857430
Diaz AV, Matheny T, Stephenson D, Nemkov T, D'Alessandro A, Reis T. Spenito-dependent metabolic sexual dimorphism intrinsic to fat storage cells. bioRxiv. 2023 Feb 18. PubMed PMID: 36824729
Pacheco A, Issaian A, Davis J, Anderson N, Nemkov T, Paukovich N, Henen MA, Vögeli B, Sikela JM, Hansen K. Proteolytic activation of human-specific Olduvai domains by the furin protease. Int J Biol Macromol. 2023 Apr 15;234:123041. PubMed PMID: 36581038
Hay A, Nemkov T, Gamboni F, Dzieciatkowska M, Key A, Galbraith M, Bartsch K, Sun K, Xia Y, Stone M, Busch MP, Norris PJ, Zimring JC, D'Alessandro A. Sphingosine 1-phosphate has a negative effect on RBC storage quality. Blood Adv. 2023 Apr 25;7(8):1379-1393. PubMed PMID: 36469038
Miglio A, Maslanka M, Di Tommaso M, Rocconi F, Nemkov T, Buehler PW, Antognoni MT, Spitalnik SL, D'Alessandro A. ZOOMICS : comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days. Blood Transfus. 2023 Jul;21(4):314-326. PubMed PMID: 35969134
Pacheco A, Issaian A, Davis J, Anderson N, Nemkov T, Paukovich N, Henen MA, Vögeli B, Sikela JM, Hansen K. Proteolytic activation of human-specific Olduvai domains by the furin protease. Int J Biol Macromol. 2022 Dec 26. [Epub ahead of print] PubMed PMID: 36581038
Setua S, Thangaraju K, Dzieciatkowska M, Wilkerson RB, Nemkov T, Lamb DR, Tagaya Y, Boyer T, Rowden T, Doctor A, D'Alessandro A, Buehler PW. Coagulation potential and the integrated omics of extracellular vesicles from COVID-19 positive patient plasma. Sci Rep. 2022 Dec 23;12(1):22191. PubMed PMID: 36564503
Hay AM, Nemkov T, Gamboni F, Dzieciatkowska M, Key A, Galbraith M, Bartsch K, Sun K, Xia Y, Stone M, Busch MP, Norris PJ, Zimring JC, D'Alessandro A. S1P has a negative effect on RBC storage quality. Blood Adv. 2022 Dec 5. [Epub ahead of print] PubMed PMID: 36469038
LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Nemkov T, Schaid TR Jr, Debot M, Jones K, Silliman CC, Hansen KC, D'Alessandro A. Omics Markers of Red Blood Cell Transfusion in Trauma. Int J Mol Sci. 2022 Nov 10;23(22). PubMed PMID: 36430297
Guntur VP, Nemkov T, de Boer E, Mohning MP, Baraghoshi D, Cendali FI, San-Millán I, Petrache I, D'Alessandro A. Signatures of Mitochondrial Dysfunction and Impaired Fatty Acid Metabolism in Plasma of Patients with Post-Acute Sequelae of COVID-19 (PASC). Metabolites. 2022 Oct 26;12(11). PubMed PMID: 36355108
Nikulina M, Nemkov T, D'Alessandro A, Gaccione P, Yoshida T. A deep 96-well plate RBC storage platform for high-throughput screening of novel storage solutions. Front Physiol. 2022;13:1004936. PubMed PMID: 36277188
Miglio A, Maslanka M, Di Tommaso M, Rocconi F, Nemkov T, Buehler PW, Antognoni MT, Spitalnik SL, D'Alessandro A. ZOOMICS: comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days. Blood Transfus. 2022 Jul 25. [Epub ahead of print] PubMed PMID: 35969134
Nemkov T, Skinner S, Diaw M, Diop S, Samb A, Connes P, D'Alessandro A. Plasma Levels of Acyl-Carnitines and Carboxylic Acids Correlate With Cardiovascular and Kidney Function in Subjects With Sickle Cell Trait. Front Physiol. 2022;13:916197. PubMed PMID: 35910560
Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14;27(14). PubMed PMID: 35889366
Robert M, Laperrousaz B, Piedrahita D, Gautier EF, Nemkov T, Dupuy F, Nader E, Salnot V, Mayeux P, D'Alessandro A, Lavazec C, Joly P, Scheer A, Connes P, Cibiel A. Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process. Acta Pharm Sin B. 2022 Apr;12(4):2089-2102. PubMed PMID: 35847505
Patel SB, Nemkov T, D'Alessandro A, Welner RS. Deciphering Metabolic Adaptability of Leukemic Stem Cells. Front Oncol. 2022;12:846149. PubMed PMID: 35756656
Guard SE, Chapnick DA, Poss ZC, Ebmeier CC, Jacobsen J, Nemkov T, Ball KA, Webb KJ, Simpson HL, Coleman S, Bunker E, Ramirez A, Reisz JA, Sievers R, Stowell MHB, D'Alessandro A, Liu X, Old WM. Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines. Mol Cell Proteomics. 2022 Oct;21(10):100262. PubMed PMID: 35753663
Crist SB, Nemkov T, Dumpit RF, Dai J, Tapscott SJ, True LD, Swarbrick A, Sullivan LB, Nelson PS, Hansen KC, Ghajar CM. Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells. Nat Cell Biol. 2022 Apr;24(4):538-553. PubMed PMID: 35411081
Nemkov T, Yoshida T, Nikulina M, D'Alessandro A. High-Throughput Metabolomics Platform for the Rapid Data-Driven Development of Novel Additive Solutions for Blood Storage. Front Physiol. 2022;13:833242. PubMed PMID: 35360223
Stephenson D, Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A. Inductively-Coupled Plasma Mass Spectrometry-Novel Insights From an Old Technology Into Stressed Red Blood Cell Physiology. Front Physiol. 2022;13:828087. PubMed PMID: 35197866
Bissinger R, Bohnert BN, Nemkov T, Artunc F. The authors reply. Kidney Int. 2022 Mar;101(3):649-650. PubMed PMID: 35190041
Kalani Roy M, La Carpia F, Cendali F, Fernando S, Moriconi C, Wojczyk BS, Wang L, Nemkov T, Hod EA, D'Alessandro A. Irradiation Causes Alterations of Polyamine, Purine, and Sulfur Metabolism in Red Blood Cells and Multiple Organs. J Proteome Res. 2022 Feb 4;21(2):519-534. PubMed PMID: 35043621
Ferrero E, Villa A, Stefanoni D, Nemkov T, D'Alessandro A, Tengesdal I, Belloni D, Molteni R, Vergani B, De Luca G, Grassini G, Cangi MG, Dagna L, Doglioni C, Cavalli G, Ferrarini M. Immunometabolic activation of macrophages leads to cytokine production in the pathogenesis of KRAS-mutated histiocytosis. Rheumatology (Oxford). 2022 Apr 11;61(4):e93-e96. PubMed PMID: 34919661
Ferrero E, Villa A, Stefanoni D, Nemkov T, D'Alessandro A, Tengesdal I, Belloni D, Molteni R, Vergani B, De Luca G, Grassini G, Cangi MG, Dagna L, Doglioni C, Cavalli G, Ferrarini M. Immunometabolic activation of macrophages leads to cytokine production in the pathogenesis of KRAS-mutated histiocytosis. Rheumatology (Oxford). 2021 Nov 23. [Epub ahead of print] PubMed PMID: 34919661
D'Alessandro A, Thomas T, Akpan IJ, Reisz JA, Cendali FI, Gamboni F, Nemkov T, Thangaraju K, Katneni U, Tanaka K, Kahn S, Wei AZ, Valk JE, Hudson KE, Roh D, Moriconi C, Zimring JC, Hod EA, Spitalnik SL, Buehler PW, Francis RO. Biological and Clinical Factors Contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19. Cells. 2021 Sep 2;10(9). PubMed PMID: 34571942
Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D'Alessandro A, Nemkov T, Nelson MT, Freeman K. Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels. Function (Oxf). 2021;2(3). PubMed PMID: 34568829
Bissinger R, Nemkov T, D'Alessandro A, Grau M, Dietz T, Bohnert BN, Essigke D, Wörn M, Schaefer L, Xiao M, Beirne JM, Kalo MZ, Schork A, Bakchoul T, Omage K, Kong L, Gonzalez-Menendez I, Quintanilla-Martinez L, Fehrenbacher B, Schaller M, Dhariwal A, Birkenfeld AL, Grahammer F, Qadri SM, Artunc F. Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, deformability and metabolism. Kidney Int. 2021 Dec;100(6):1227-1239. PubMed PMID: 34537228
Qiang Q, Manalo JM, Sun H, Zhang Y, Song A, Wen AQ, Wen YE, Chen C, Liu H, Cui Y, Nemkov T, Reisz JA, Edwards Iii G, Perreira FA, Kellems RE, Soto C, D'Alessandro A, Xia Y. Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming. PLoS Biol. 2021 Jun;19(6):e3001239. PubMed PMID: 34138843
Patel SB, Nemkov T, Stefanoni D, Benavides GA, Bassal MA, Crown BL, Matkins VR, Camacho V, Kuznetsova V, Hoang AT, Tenen DE, Wolock SL, Park J, Ying L, Yue Z, Chen JY, Yang H, Tenen DG, Ferrell PB, Lu R, Darley-Usmar V, D'Alessandro A, Bhatia R, Welner RS. Metabolic alterations mediated by STAT3 promotes drug persistence in CML. Leukemia. 2021 Dec;35(12):3371-3382. PubMed PMID: 34120146
Molteni R, Biavasco R, Stefanoni D, Nemkov T, Domínguez-Andrés J, Arts RJ, Merelli I, Mazza D, Zambrano S, Panigada M, Cantoni E, Tengesdal IW, Maksud P, Piras F, Cesana D, Cassina L, Distefano G, Loffreda A, Gnani D, De Luca G, Tomelleri A, Campochiaro C, Joosten LAB, Dinarello CA, Kajaste-Rudnitski A, Haroche J, Cardaci S, Cenci S, Dagna L, Doglioni C, Ferrarini M, Ferrero E, Boletta A, D'Alessandro A, Montini E, Netea MG, Cavalli G. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood. 2021 Oct 28;138(17):1554-1569. PubMed PMID: 34077954
D'Alessandro A, Akpan I, Thomas T, Reisz J, Cendali F, Gamboni F, Nemkov T, Thangaraju K, Katneni U, Tanaka K, Kahn S, Wei A, Valk J, Hudson K, Roh D, Moriconi C, Zimring J, Hod E, Spitalnik S, Buehler P, Francis R. Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19. Res Sq. 2021 May 10. PubMed PMID: 34013258
Thomas T, Cendali F, Fu X, Gamboni F, Morrison EJ, Beirne J, Nemkov T, Antonelou MH, Kriebardis A, Welsby I, Hay A, Dziewulska KH, Busch MP, Kleinman S, Buehler PW, Spitalnik SL, Zimring JC, D'Alessandro A. Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. Transfusion. 2021 Jun;61(6):1867-1883. PubMed PMID: 33904180
Li M, Riddle S, Kumar S, Poczobutt J, McKeon BA, Frid MG, Ostaff M, Reisz JA, Nemkov T, Fini MA, Laux A, Hu CJ, El Kasmi KC, D'Alessandro A, Brown RD, Zhang H, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol. 2021;12:640718. PubMed PMID: 33868271
Cavalli G, Tengesdal IW, Gresnigt M, Nemkov T, Arts RJW, Domínguez-Andrés J, Molteni R, Stefanoni D, Cantoni E, Cassina L, Giugliano S, Schraa K, Mills TS, Pietras EM, Eisenmensser EZ, Dagna L, Boletta A, D'Alessandro A, Joosten LAB, Netea MG, Dinarello CA. The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. Cell Rep. 2021 Apr 6;35(1):108955. PubMed PMID: 33826894
Esquer H, Zhou Q, Nemkov T, Abraham AD, Rinaldetti S, Chen YC, Zhang X, Orman MV, D'Alessandro A, Ferrer M, Messersmith WA, LaBarbera DV. Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer. Oncogene. 2021 Apr;40(16):2884-2897. PubMed PMID: 33742123
Broussard JL, Perreault L, Macias E, Newsom SA, Harrison K, Bui HH, Milligan P, Roth KD, Nemkov T, D'Alessandro A, Brozinick JT, Bergman BC. Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution. Obesity (Silver Spring). 2021 Mar;29(3):550-561. PubMed PMID: 33624435
Nemkov T, Skinner SC, Nader E, Stefanoni D, Robert M, Cendali F, Stauffer E, Cibiel A, Boisson C, Connes P, D'Alessandro A. Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling. Int J Mol Sci. 2021 Jan 18;22(2). PubMed PMID: 33477427
Nemkov T, Stefanoni D, Bordbar A, Issaian A, Palsson BO, Dumont LJ, Hay A, Song A, Xia Y, Redzic JS, Eisenmesser EZ, Zimring JC, Kleinman S, Hansen KC, Busch MP, D'Alessandro A. Blood donor exposome and impact of common drugs on red blood cell metabolism. JCI Insight. 2021 Feb 8;6(3). PubMed PMID: 33351786
Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. Nat Mater. 2021 Apr;20(4):548-559. PubMed PMID: 33257795
Thangaraju K, Katneni U, Akpan IJ, Tanaka K, Thomas T, Setua S, Reisz JA, Cendali F, Gamboni F, Nemkov T, Kahn S, Wei AZ, Valk JE, Hudson KE, Roh DJ, Moriconi C, Zimring JC, D'Alessandro A, Spitalnik SL, Francis RO, Buehler PW. The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients. Front Med (Lausanne). 2021;8:817305. PubMed PMID: 35087853