Peter Dempsey, PhD

Publications

• Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem. 2013 Oct 18;288(42):30742-51. PubMed PMID: 24043629
• Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol. 2013 Mar;14(3):262-70. PubMed PMID: 23377202
• Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 regulates Notch function in intestinal stem cells of mice. Gastroenterology. 2014 Oct;147(4):822-834.e13. PubMed PMID: 25038433
• Feng Y, Tsai YH, Xiao W, Ralls MW, Stoeck A, Wilson CL, Raines EW, Teitelbaum DH, Dempsey PJ. Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Mol Cell Biol. 2015 Nov 1;35(21):3604-21. PubMed PMID: 26283731
• Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 3. [Epub ahead of print] PubMed PMID: 26050928
• Freeman JJ, Feng Y, Demehri FR, Dempsey PJ, Teitelbaum DH. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J. 2015 Jul;29(7):2943-58. PubMed PMID: 25782989
• Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 regulates Notch function in intestinal stem cells of mice. Gastroenterology. 2014 Oct;147(4):822-834.e13. PubMed PMID: 25038433
• Jones JC, Dempsey PJ. Enterocyte progenitors can dedifferentiate to replace lost Lgr5( ) intestinal stem cells revealing that many different progenitor populations can regain stemness. Stem Cell Investig. 2016 Oct 21;3:61. PubMed PMID: 27868043
• Dempsey PJ. Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?. Gastroenterology. 2016 Jul;151(1):27-9. PubMed PMID: 27237596
• Jones JC, Rustagi S, Dempsey PJ. ADAM Proteases and Gastrointestinal Function. Annu Rev Physiol. 2016;78:243-76. PubMed PMID: 26667078
• Feng Y, Demehri FR, Xiao W, Tsai Y-H, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH and DEMPSEY PJ. Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cellular Molecular Gastroenterology Hepatology, in press 2017.
• Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C. Mucus Detachment by Host Metalloprotease Meprin ß Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017 Nov 21;21(8):2090-2103. PubMed PMID: 29166602
• Dempsey PJ. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis. Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2228-2239. PubMed PMID: 28739265
• Feng Y, Demehri FR, Xiao W, Tsai YH, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH, Dempsey PJ. Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cell Mol Gastroenterol Hepatol. 2017 May;3(3):447-468. PubMed PMID: 28462383
• Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23;8(2):e2622. PubMed PMID: 28230865
• Jones JC, Dempsey PJ. Enterocyte progenitors can dedifferentiate to replace lost Lgr5( ) intestinal stem cells revealing that many different progenitor populations can regain stemness. Stem Cell Investig. 2016;3:61. PubMed PMID: 27868043
• Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. J Exp Med. 2018 Apr 2;215(4):1205-1225. PubMed PMID: 29472497
• Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C. Mucus Detachment by Host Metalloprotease Meprin ß Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Rep. 2017 Nov 21;21(8):2090-2103. PubMed PMID: 29166602
• Dempsey PJ. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2228-2239. PubMed PMID: 28739265
• Feng Y, Demehri FR, Xiao W, Tsai YH, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH, Dempsey PJ. Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cell Mol Gastroenterol Hepatol. 2017 May;3(3):447-468. PubMed PMID: 28462383
• Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23;8(2):e2622. PubMed PMID: 28230865
• Jones JC, Rustagi S, Dempsey PJ. ADAM Proteases and Gastrointestinal Function. Annu Rev Physiol. 2016;78:243-76. PubMed PMID: 26667078
• Jones JC, Brindley CD, Elder NH, Myers MG, Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF DEMPSEY PJ. Cellular Plasticity of Defa4Cre-expressing Paneth cells in Response to Notch Activation and Intestinal Injury. (accepted CMGH, Nov. 2018).
• DEMPSEY PJ Bohin N and Samuelson LC. Chapter: “Developmental Signaling Networks: Notch Pathway Regulation of Intestinal Cell Fate” in Physiology of the Gastrointestinal Tract. 6th Edition Editor: Johnson L. 2018.
• Dempsey PJ. Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?. Gastroenterology. 2016 Jul;151(1):27-9. PubMed PMID: 27237596
• Notch Pathway Regulation of Intestinal Cell Fate. Dempsey PJ, Bohin N and Samuelson LC. “Physiology of the Gastrointestinal Tract”, 6th Edition. Editor-in-Chief - Johnson LR. Asscoaie Editors- Ghishan FK, Kaunitz JD, Merchant JL, Said HM and Wood JD. Academic Press 2017 in press.
• Jones JC, Brindley CD, Elder NH, Myers MG Jr, Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF, Dempsey PJ. Cellular Plasticity of Defa4(Cre)-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cell Mol Gastroenterol Hepatol. 2019;7(3):533-554. PubMed PMID: 30827941
• Yavitt FM, Brown TE, Hushka EA, Brown ME, Gjorevski N, Dempsey PJ, Lutolf MP, Anseth KS. The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging. Adv Mater. 2020 Jul;32(30):e1905366. PubMed PMID: 32548863
• Bohin N, Keeley TM, Carulli AJ, Walker EM, Carlson EA, Gao J, Aifantis I, Siebel CW, Rajala MW, Myers MG Jr, Jones JC, Brindley CD, Dempsey PJ, Samuelson LC. Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition. Stem Cell Reports. 2020 Jul 14;15(1):156-170. PubMed PMID: 32531190
• Hushka EA, Yavitt FM, Brown TE, Dempsey PJ, Anseth KS. Relaxation of Extracellular Matrix Forces Directs Crypt Formation and Architecture in Intestinal Organoids. Adv Healthc Mater. 2020 Apr;9(8):e1901214. PubMed PMID: 31957249
• Cartwright IM, Curtis VF, Lanis JM, Alexeev EE, Welch N, Goldberg MS, Schaefer REM, Gao RY, Chun C, Fennimore B, Onyiah JC, Gerich ME, Dempsey PJ, Colgan SP. Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3. Mucosal Immunol. 2020 Mar;13(2):230-244. PubMed PMID: 31792360
• Mueller AC, Piper M, Goodspeed A, Bhuvane S, Williams JS, Bhatia S, Phan AV, Van Court B, Zolman KL, Peña B, Oweida AJ, Zakem S, Meguid C, Knitz MW, Darragh L, Bickett TE, Gadwa J, Mestroni L, Taylor MRG, Jordan KR, Dempsey P, Lucia MS, McCarter MD, Chiaro MD, Messersmith WA, Schulick RD, Goodman KA, Gough MJ, Greene CS, Costello JC, Neto AG, Lagares D, Hansen KC, Van Bokhoven A, Karam SD. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021 Jun 15;81(12):3255-3269. PubMed PMID: 33526513
• Blatchley MR, Günay KA, Yavitt FM, Hawat EM, Dempsey PJ, Anseth KS. In Situ Super-Resolution Imaging of Organoids and Extracellular Matrix Interactions via Phototransfer by Allyl Sulfide Exchange-Expansion Microscopy (PhASE-ExM). Adv Mater. 2022 Apr;34(16):e2109252. PubMed PMID: 35182403
• Meyer AR, Brown ME, McGrath PS, Dempsey PJ. Injury-Induced Cellular Plasticity Drives Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2022;13(3):843-856. PubMed PMID: 34915204
• Xiao W, Pinilla-Baquero A, Faulkner J, Song X, Prabhakar P, Qiu H, Moremen KW, Ludwig A, Dempsey PJ, Azadi P, Wang L. Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep. 2022 Mar 14;12(1):4352. PubMed PMID: 35288626
• In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis. Yavitt FM, Michael R. Blatchley MR, Speckl KF, Mohagheghian E, Kirkpatrick BE, Wang N, Peter J. Dempsey PJ, Kristi S. Anseth KS. Science Advances in press Dec 2022.
• Yavitt FM, Kirkpatrick BE, Blatchley MR, Speckl KF, Mohagheghian E, Moldovan R, Wang N, Dempsey PJ, Anseth KS. In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis. Sci Adv. 2023 Jan 20;9(3):eadd5668. PubMed PMID: 36662859
• Blatchley MR, Günay KA, Yavitt FM, Hawat EM, Dempsey PJ, Anseth KS. In Situ Super-Resolution Imaging of Organoids and Extracellular Matrix Interactions via Phototransfer by Allyl Sulfide Exchange-Expansion Microscopy (PhASE-ExM). Adv Mater. 2022 Apr;34(16):e2109252. PubMed PMID: 35182403
• Shechtman LA, Scott JK, Larson ED, Isner TJ, Johnson BJ, Gaillard D, Dempsey PJ, Barlow LA. High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro. Development. 2023 Feb 15;150(4). PubMed PMID: 36794954
• Hushka EA, Blatchley MR, Macdougall LJ, Yavitt FM, Kirkpatrick BE, Bera K, Dempsey PJ, Anseth KS. Fully synthetic hydrogels promote robust crypt formation in intestinal organoids. bioRxiv. 2024 Jul 10. PubMed PMID: 39026840
• Hawkins HJ, Yacob BW, Brown ME, Goldstein BR, Arcaroli JJ, Bagby SM, Hartman SJ, Macbeth M, Goodspeed A, Danhorn T, Lentz RW, Lieu CH, Leal AD, Messersmith WA, Dempsey PJ, Pitts TM. Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL). PLoS One. 2024;19(4):e0298808. PubMed PMID: 38598488