Tina Roark, PhD

Associate Professor, Medicine-Allergy/Clinical Immunology

FacultyPhoto
Graduate School
  • PhD, University of Colorado Health Sciences Center (1995)
Undergraduate School
  • BA, Colorado College (CO) (1990)
Languages
English
Department
Medicine-Allergy/Clinical Immunology

Professional Titles

  • Assistant Professor

Recognitions

  • Summit Award, University of Colorado Department of Pathology (2022)
    Excellence in teaching and the education of pathologists

Publications

  • Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, and Freed BM. Multiple HLA epitopes contribute to type I diabetes susceptibility. Poster presented at: 14th Annual Colorado Immunology Conference; 2013 Sept 11-13; Vail CO.
  • Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, and Freed BM. Identification of class I and class II HLA epitopes in type 1 diabetes. Oral presentation at: ASHI 39th Annual Meeting; 2013 Nov 17-21; Chicago, IL.
  • Wedermyer GM, Roark CL, Freed BM. Validation of virtual crossmatch using donor specific antibodies. Poster presented at: ASHI 39th Annual Meeting; 2013 Nov 17-21; Chicago, IL.
  • Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, Freed BM. Multiple HLA epitopes contribute to type 1 diabetes susceptibility. Diabetes. 2014 Jan;63(1):323-31. PubMed PMID: 24357703
  • Roark CL, Anderson KM, Aubrey MT, Rosloniec EF, Freed BM. Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis. J Autoimmun. 2016 Aug;72:25-32. PubMed PMID: 27143337
  • Anderson KM, Roark CL, Portas M, Aubrey MT, Rosloniec EF, Freed BM. A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles. Arthritis Rheumatol. 2016 Jul;68(7):1627-36. PubMed PMID: 26866513
  • Anderson K, Carey B, Martin A, Roark C, Chalk C, Nowell-Bostic M, Freed B, Aubrey M, Trapnell B, Fontenot A. Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association. PLoS One. 2019;14(3):e0213179. PubMed PMID: 30845238
  • Scott R. Solomon, Michael T Aubrey, Xu Zhang, Katelin C Jackson, Christina L Roark, Brian M Freed, Lawrence E Morris, H. Kent Holland, Asad Bashey, Melhem Solh; Recipient HLA-B Leader Genotype, and Its Relationship to Total KIR Missing Ligand, Informs Relapse and Survival Following Haploidentical Transplantation Using Post-Transplant Cyclophosphamide. Blood 2021; 138 (Supplement 1): 418. doi: https://doi.org/10.1182/blood-2021-151496
  • Scott R. Solomon, Michael T Aubrey, Xu Zhang, Melhem Solh, Lawrence E Morris, H. Kent Holland, Katelin C Jackson, Brian M Freed, Christina L Roark, Asad Bashey; Optimizing Donor Selection for Haploidentical Transplantation Utilizing the Four-Group T Cell Epitope (TCE-4) Algorithm for Prediction of HLA-DPB1 Non-Permissive Mismatches. Blood 2021; 138 (Supplement 1): 420. doi: https://doi.org/10.1182/blood-2021-149289
  • C.L. Roark, E.R. Sunderhaus, V. Jha, M. Aubrey, J. Matsuda, B.M. Freed. Editing of the HLA Gene: A Novel Therapy for Autoimmunity. Human Immunology 2021. 82 (Supplement): 44-45. doi: https://doi.org/10.1016/j.humimm.2021.08.002
  • V. Jha, M. Coulombe, E.F. Rosloniec, J. Matsuda, B.M. Freed, C.L. Roark. Gene Editing of DRB1*04:01 at Position 71 Blocks Collagen Sensitization and Avoids Allorecognition. Human Immunology 2021. 82 (Supplement): 39-40. doi: https://doi.org/10.1016/j.humimm.2021.08.002
  • M. Nevski, M. McAuliffe, G. Wedermyer, C.L. Roark, B.M. Freed. De Novo HLA Antibody Production Following Clinical Trial CMV Vaccine. Human Immunology 2021. 82 (Supplement): 66. doi: https://doi.org/10.1016/j.humimm.2021.08.003
  • Roark CL, Ho BE, Aubrey MT, Anobile C, Israeli S, Phang TL, Braxton D, Ho AP, Freed BM. HLA homozygosity is associated with Non-Hodgkin lymphoma. Hum Immunol. 2022 Oct;83(10):730-735. PubMed PMID: 35953408
  • M. McAuliffe, M. Nevski, G. Wedermyer, C.L. Roark, B.M. Freed. Analysis of HLA Antibodies After COVID-19 mRNA Vaccination in Post-Transplant Kidney Recipients and Healthy Volunteers. Human Immunology 2021. 82 (Supplement): 128. https://doi.org/10.1016/j.humimm.2021.08.003
  • Solomon SR, Aubrey MT, Zhang X, Jackson KC, Roark CL, Freed BM, Morris LE, Holland HK, Solh MM, Bashey A. Lineage-Specific Relapse Prediction After Haploidentical Transplantation With Post-Transplant Cyclophosphamide Based on Recipient HLA-B-Leader Genotype and HLA-C-Group KIR Ligand. Transplant Cell Ther. 2022 Sep;28(9):601.e1-601.e8. PubMed PMID: 35788088
  • P91: AUTOIMMUNE DEMYELINATING DISEASES AND THE PEPTIDE-BINDING PROFILES OF HLA CLASS II ALLELES E.R. Sunderhaus, E.B. Prage, C.L. Roark, B. Freed https://doi.org/10.1016/j.humimm.2022.08.008
  • P63: PREDICTING EPLET MISMATCHES USING DONOR LOW RESOLUTION TYPING AND HAPLOSTATS J. Lee, J. Li, M. Aubrey, C.L. Roark, B. Freed https://doi.org/10.1016/j.humimm.2022.08.008
  • Scott R. Solomon, Michael T Aubrey, Lizamarie Bachier-Rodriguez, Melhem M. Solh, Katelin C Jackson, Xu Zhang, Christina Roark, H. Kent Holland, Lawrence Morris, Asad Bashey; Impact of an HLA-DPB1 Non-Permissive Mismatch By the Revised T Cell Epitope (TCE)-Core Algorithm on Survival Following Haploidentical Donor Transplantation (HIDT) with Post-Transplant Cyclophosphamide (PTCy). Blood 2023; 142 (Supplement 1): 2240. doi: https://doi.org/10.1182/blood-2023-182499
  • Scott R. Solomon, Michael T Aubrey, Xu Zhang, Lizamarie Bachier-Rodriguez, Lawrence Morris, H. Kent Holland, Christina Roark, Katelin C Jackson, Asad Bashey, Melhem M. Solh; Impact of HLA-DQ Heterodimer Group (G1/G2) Mismatch on Relapse and Survival Following Haploidentical Donor Transplantation. Blood 2023; 142 (Supplement 1): 4984. doi: https://doi.org/10.1182/blood-2023-182503
  • L. Helander, C.L. Roark, B. Freed, M. Adams, M. Wachs, M. Bock, P214 Donor-specific antibodies (DSA) in liver transplantation: Should DSA be considered?, Human Immunology, Volume 84, Supplement, 2023, Page 97, ISSN 0198-8859, https://doi.org/10.1016/j.humimm.2023.08.043. (https://www.sciencedirect.com/science/article/pii/S0198885923002112)
  • C.L. Roark, V. Jha, E.R. Sunderhaus, J.E. Lee, E.B. Prage, A.S. McKee, B. Freed, J.L. Matsuda, E.F. Rosloniec, M.G. Coulombe, O6 Substitution of glutamic acid at position 71 of DR?1*04:01 eliminates collagen sensitivity without inducing alloreactivity, Human Immunology, Volume 84, Supplement, 2023, Page 19, ISSN 0198-8859, https://doi.org/10.1016/j.humimm.2023.07.015. (https://www.sciencedirect.com/science/article/pii/S0198885923001349)
  • L. Helander, C.L. Roark, B.M. Freed, M.D. Everitt. Donor Specific Antibody After Heart Transplant: Is C1Q Antibody Generated From Memory B-Cells? Human Immunology 2021. 82 (Supplement): 68. https://doi.org/10.1016/j.humimm.2021.08.003
  • Elizabeth Sunderhaus, Anita C. Hohenstein, Rocky L. Baker, Christina L. Roark, Brian M. Freed. Dissecting the Restriction of a Diabetogenic T Cell Clone from an Entire Genotype Using Cloned HLA Molecules. Human Immunology 2021. 82 (Supplement): 135-136. https://doi.org/10.1016/j.humimm.2021.08.003

Professional Memberships

  • American Society for Histocompatibility and Immunogenetics, member

Specialty Information

Specialties
  • Allergy and Immunology
  • American College of Histocompatibility and Immunogenetics, Board Certification (2017)
  • Fellow of American College of Histocompatibility and Immunogenetics, Specialized Training (2021)

School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

School
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