Tina Roark, PhD

Graduate School

PhD, University of Colorado Health Sciences Center (1995)

Undergraduate School

BA, Colorado College (CO) (1990)

Languages

English

Department

Medicine-Allergy/Clinical Immunology

Professional Titles

Assistant Professor

Recognitions

Summit Award, University of Colorado Department of Pathology (2022)
Excellence in teaching and the education of pathologists

Publications

Jha V, Freed BM, Sunderhaus ER, Lee JE, Prage EB, Miglani M, Rosloniec EF, Matsuda JL, Coulombe MG, McKee AS, Roark CL. Substitution of Glutamic Acid at Position 71 of DRß1*04:01 Induces Collagen-Specific Tolerance Without Inducing Alloreactivity. Arthritis Rheumatol. 2024 Nov 28. [Epub ahead of print] PubMed PMID: 39609038
Solh M, Aubrey MT, Zhang X, Bashey A, Freed BM, Roark CL, Bachier-Rdriguez L, Morris LE, Kent Holland H, Solomon SR. HLA evolutionary divergence (HED) informs the effect of HLA-B mismatch on outcomes after haploidentical transplantation. Bone Marrow Transplant. 2024 Oct;59(10):1433-1439. PubMed PMID: 39085372
Solomon SR, Aubrey MT, Bachier-Rodriguez L, Solh MM, Jackson KC, Zhang X, Roark CL, Holland HK, Morris LE, Bashey A. Revised HLA-DP TCE-Core Permissiveness Model Better Defines Relapse Risk and Survival following Haploidentical Transplant. Transplant Cell Ther. 2024 Jun;30(6):608.e1-608.e10. PubMed PMID: 38561140
Melhem M. Solh, Asad Bashey, Michael T Aubrey, Brian Freed, Christina Roark, Lawrence E Morris, H Kent Holland, Lizamarie Bachier-Rodriguez, Xu Zhang, Scott R. Solomon, The Degree of HLA-DPB1 Mismatch Predicted By Evolutionary Divergence Scoring Informs the Risk of Chronic Graft-Versus-Host Disease after Haploidentical Transplantation with Post-Transplant Cyclophosphamide, Blood, Volume 144, Supplement 1, 2024, Page 4913, ISSN 0006-4971, https://doi.org/10.1182/blood-2024-210329.
Scott R. Solomon, Michael T Aubrey, Lizamarie Bachier-Rodriguez, Melhem M. Solh, Katelin C Jackson, Xu Zhang, Christina Roark, H. Kent Holland, Lawrence Morris, Asad Bashey; Impact of an HLA-DPB1 Non-Permissive Mismatch By the Revised T Cell Epitope (TCE)-Core Algorithm on Survival Following Haploidentical Donor Transplantation (HIDT) with Post-Transplant Cyclophosphamide (PTCy). Blood 2023; 142 (Supplement 1): 2240. doi: https://doi.org/10.1182/blood-2023-182499
Scott R. Solomon, Michael T Aubrey, Xu Zhang, Lizamarie Bachier-Rodriguez, Lawrence Morris, H. Kent Holland, Christina Roark, Katelin C Jackson, Asad Bashey, Melhem M. Solh; Impact of HLA-DQ Heterodimer Group (G1/G2) Mismatch on Relapse and Survival Following Haploidentical Donor Transplantation. Blood 2023; 142 (Supplement 1): 4984. doi: https://doi.org/10.1182/blood-2023-182503
L. Helander, C.L. Roark, B. Freed, M. Adams, M. Wachs, M. Bock, P214 Donor-specific antibodies (DSA) in liver transplantation: Should DSA be considered?, Human Immunology, Volume 84, Supplement, 2023, Page 97, ISSN 0198-8859, https://doi.org/10.1016/j.humimm.2023.08.043. (https://www.sciencedirect.com/science/article/pii/S0198885923002112)
C.L. Roark, V. Jha, E.R. Sunderhaus, J.E. Lee, E.B. Prage, A.S. McKee, B. Freed, J.L. Matsuda, E.F. Rosloniec, M.G. Coulombe, O6 Substitution of glutamic acid at position 71 of DR?1*04:01 eliminates collagen sensitivity without inducing alloreactivity, Human Immunology, Volume 84, Supplement, 2023, Page 19, ISSN 0198-8859, https://doi.org/10.1016/j.humimm.2023.07.015. (https://www.sciencedirect.com/science/article/pii/S0198885923001349)
Roark CL, Ho BE, Aubrey MT, Anobile C, Israeli S, Phang TL, Braxton D, Ho AP, Freed BM. HLA homozygosity is associated with Non-Hodgkin lymphoma. Hum Immunol. 2022 Oct;83(10):730-735. PubMed PMID: 35953408
Solomon SR, Aubrey MT, Zhang X, Jackson KC, Roark CL, Freed BM, Morris LE, Holland HK, Solh MM, Bashey A. Lineage-Specific Relapse Prediction After Haploidentical Transplantation With Post-Transplant Cyclophosphamide Based on Recipient HLA-B-Leader Genotype and HLA-C-Group KIR Ligand. Transplant Cell Ther. 2022 Sep;28(9):601.e1-601.e8. PubMed PMID: 35788088
P91: AUTOIMMUNE DEMYELINATING DISEASES AND THE PEPTIDE-BINDING PROFILES OF HLA CLASS II ALLELES E.R. Sunderhaus, E.B. Prage, C.L. Roark, B. Freed https://doi.org/10.1016/j.humimm.2022.08.008
P63: PREDICTING EPLET MISMATCHES USING DONOR LOW RESOLUTION TYPING AND HAPLOSTATS J. Lee, J. Li, M. Aubrey, C.L. Roark, B. Freed https://doi.org/10.1016/j.humimm.2022.08.008
Scott R. Solomon, Michael T Aubrey, Xu Zhang, Katelin C Jackson, Christina L Roark, Brian M Freed, Lawrence E Morris, H. Kent Holland, Asad Bashey, Melhem Solh; Recipient HLA-B Leader Genotype, and Its Relationship to Total KIR Missing Ligand, Informs Relapse and Survival Following Haploidentical Transplantation Using Post-Transplant Cyclophosphamide. Blood 2021; 138 (Supplement 1): 418. doi: https://doi.org/10.1182/blood-2021-151496
Scott R. Solomon, Michael T Aubrey, Xu Zhang, Melhem Solh, Lawrence E Morris, H. Kent Holland, Katelin C Jackson, Brian M Freed, Christina L Roark, Asad Bashey; Optimizing Donor Selection for Haploidentical Transplantation Utilizing the Four-Group T Cell Epitope (TCE-4) Algorithm for Prediction of HLA-DPB1 Non-Permissive Mismatches. Blood 2021; 138 (Supplement 1): 420. doi: https://doi.org/10.1182/blood-2021-149289
C.L. Roark, E.R. Sunderhaus, V. Jha, M. Aubrey, J. Matsuda, B.M. Freed. Editing of the HLA Gene: A Novel Therapy for Autoimmunity. Human Immunology 2021. 82 (Supplement): 44-45. doi: https://doi.org/10.1016/j.humimm.2021.08.002
V. Jha, M. Coulombe, E.F. Rosloniec, J. Matsuda, B.M. Freed, C.L. Roark. Gene Editing of DRB1*04:01 at Position 71 Blocks Collagen Sensitization and Avoids Allorecognition. Human Immunology 2021. 82 (Supplement): 39-40. doi: https://doi.org/10.1016/j.humimm.2021.08.002
M. Nevski, M. McAuliffe, G. Wedermyer, C.L. Roark, B.M. Freed. De Novo HLA Antibody Production Following Clinical Trial CMV Vaccine. Human Immunology 2021. 82 (Supplement): 66. doi: https://doi.org/10.1016/j.humimm.2021.08.003
M. McAuliffe, M. Nevski, G. Wedermyer, C.L. Roark, B.M. Freed. Analysis of HLA Antibodies After COVID-19 mRNA Vaccination in Post-Transplant Kidney Recipients and Healthy Volunteers. Human Immunology 2021. 82 (Supplement): 128. https://doi.org/10.1016/j.humimm.2021.08.003
L. Helander, C.L. Roark, B.M. Freed, M.D. Everitt. Donor Specific Antibody After Heart Transplant: Is C1Q Antibody Generated From Memory B-Cells? Human Immunology 2021. 82 (Supplement): 68. https://doi.org/10.1016/j.humimm.2021.08.003
Elizabeth Sunderhaus, Anita C. Hohenstein, Rocky L. Baker, Christina L. Roark, Brian M. Freed. Dissecting the Restriction of a Diabetogenic T Cell Clone from an Entire Genotype Using Cloned HLA Molecules. Human Immunology 2021. 82 (Supplement): 135-136. https://doi.org/10.1016/j.humimm.2021.08.003
Anderson K, Carey B, Martin A, Roark C, Chalk C, Nowell-Bostic M, Freed B, Aubrey M, Trapnell B, Fontenot A. Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association. PLoS One. 2019;14(3):e0213179. PubMed PMID: 30845238
Roark CL, Anderson KM, Aubrey MT, Rosloniec EF, Freed BM. Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis. J Autoimmun. 2016 Aug;72:25-32. PubMed PMID: 27143337
Anderson KM, Roark CL, Portas M, Aubrey MT, Rosloniec EF, Freed BM. A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles. Arthritis Rheumatol. 2016 Jul;68(7):1627-36. PubMed PMID: 26866513
Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, Freed BM. Multiple HLA epitopes contribute to type 1 diabetes susceptibility. Diabetes. 2014 Jan;63(1):323-31. PubMed PMID: 24357703
Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, and Freed BM. Multiple HLA epitopes contribute to type I diabetes susceptibility. Poster presented at: 14th Annual Colorado Immunology Conference; 2013 Sept 11-13; Vail CO.
Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, and Freed BM. Identification of class I and class II HLA epitopes in type 1 diabetes. Oral presentation at: ASHI 39th Annual Meeting; 2013 Nov 17-21; Chicago, IL.
Wedermyer GM, Roark CL, Freed BM. Validation of virtual crossmatch using donor specific antibodies. Poster presented at: ASHI 39th Annual Meeting; 2013 Nov 17-21; Chicago, IL.

View All (27 Total)

Professional Memberships

American Society for Histocompatibility and Immunogenetics, member

Specialty Information

Specialties

Allergy and Immunology
American College of Histocompatibility and Immunogenetics, Board Certification (2017)
Fellow of American College of Histocompatibility and Immunogenetics, Specialized Training (2021)

Associate Professor, Medicine-Allergy/Clinical Immunology

Graduate School

Undergraduate School

Languages

Department

Professional Titles

Recognitions

Publications

Professional Memberships

Specialty Information

School of Medicine

CU Anschutz

Fitzsimons Building