Kathrin Bernt, MD

Publications

• Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Chen L, Deshpande AJ, Banka D, Bernt KM, Dias S, Buske C, Olhava EJ, Daigle SR, Richon VM, Pollock RM, Armstrong SA. Leukemia. 2012 Nov 9. doi: 10.1038/leu.2012.327. [Epub ahead of print] PMID:23138183
• Chromatin-modifying enzymes as modulators of reprogramming. Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Nature. 2012 Mar 4;483(7391):598-602. doi: 10.1038/nature10953. PMID: 22388813
• Bernt KM. HDAC expression patterns in pediatric ALL. Leuk Res. 2013 Oct;37(10):1191-2. PubMed PMID: 23962567
• Ho LL, Sinha A, Verzi M, Bernt KM, Armstrong SA, Shivdasani RA. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol. 2013 May;33(9):1735-45. PubMed PMID: 23428873
• Deshpande AJ, Chen L, Fazio M, Sinha AU, Bernt KM, Banka D, Dias S, Chang J, Olhava EJ, Daigle SR, Richon VM, Pollock RM, Armstrong SA. Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. Blood. 2013 Mar 28;121(13):2533-41. PubMed PMID: 23361907
• Chen L, Deshpande AJ, Banka D, Bernt KM, Dias S, Buske C, Olhava EJ, Daigle SR, Richon VM, Pollock RM, Armstrong SA. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22. PubMed PMID: 23138183
• Epigenetics and Chemoresistance in Childhood Acute Lymphoblastic Leukemia. Timothy P Newton, Christopher T Cummings, Douglas K Graham, Kathrin M Bernt International Journal of Hematologic Oncology In press
• Kathrin M Bernt & Stephen P. Hunger: Current Concepts in Pediatric Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Review Article (peer reviewed) Frontiers in Oncology Full citation TBD
• Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. PubMed PMID: 25464900
• Bernt KM, Hunger SP. Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia. Front Oncol. 2014;4:54. PubMed PMID: 24724051
• Epigenetic modifiers in normal and malignant hematopoiesis Jessica Haladyna, Taylor Yamauchi, Tobias Neff and Kathrin M. Bernt Scheduled to appear in the spring issue of "epigenomics"
• MDR1 Mediated Drug Resistance to a Histone Methyltansferase Inhibitor (KMT) Blood 2014 124:3622; published ahead of print December 5, 2014 Jessica Haladyna, Taylor Yamauchi, Tobias Neff, Kathrin M Bernt
• Histone Profiling in Leukemia Using LC-MS/MS Blood 2014 124:2202; published ahead of print December 5, 2014 Gina South, Jessica Haladyna, Kirk Hansen, Kathrin M Bernt
• Context Dependent Role of Polycomb Repressive Complex 2 in Acute Leukemia Blood 2014 124:610; published ahead of print December 5, 2014 Etienne Danis, Taylor Yamauchi, Kristen Echanique, Jessica Haladyna, Huafeng Xie, Nan Zhu, Simone Riedel, Kathrin M Bernt, Stuart H. Orkin, Scott A. Armstrong, Tobias Neff
• Targeting Meningeoma-1 Driven AML through Epigenetic Modulation of the Cell of Origin Blood 2014 124:838; published ahead of print December 5, 2014 Simone Riedel, Jessica Haladyna, Matthew Bezzant, Brett Stevens, Daniel A. Pollyea, Amit U. Sinha, Scott A. Armstrong, Qi Wei, Craig T. Jordan, Tobias Neff, Kathrin M Bernt
• Riedel SS, Neff T, Bernt KM. Histone profiles in cancer. Pharmacol Ther. 2015 Oct;154:87-109. PubMed PMID: 26210403
• Danis E, Yamauchi T, Echanique K, Haladyna J, Kalkur R, Riedel S, Zhu N, Xie H, Bernt KM, Orkin SH, Armstrong SA, Neff T. Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model. Exp Hematol. 2015 Nov;43(11):930-935.e6. PubMed PMID: 26118502
• Haladyna JN, Yamauchi T, Neff T, Bernt KM. Epigenetic modifiers in normal and malignant hematopoiesis. Epigenomics. 2015;7(2):301-20. PubMed PMID: 25942537
• Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat Med. 2015 Apr;21(4):335-43. PubMed PMID: 25822366
• Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer Cell. 2014 Dec 8;26(6):896-908. PubMed PMID: 25464900
• Bernt KM, Hunger SP. Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia. Front Oncol. 2014;4:54. PubMed PMID: 24724051

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Specialty Information

Specialties

• Pediatric Hematology / Oncology, Board Certification