Julie Siegenthaler, PhD

Publications

• Choe Y, Siegenthaler JA, Pleasure SJ. A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron. 2012 Feb 23;73(4):698-712. PubMed PMID: 22365545
• Zarbalis K, Choe Y, Siegenthaler JA, Orosco LA, Pleasure SJ. Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Dev. 2012 Jan 17;7:2. PubMed PMID: 22248045
• Siegenthaler JA, Sohet F, Daneman R. 'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis. Curr Opin Neurobiol. 2013 Dec;23(6):1057-64. PubMed PMID: 23867075
• Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ. Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15;2(7):647-59. PubMed PMID: 23862012
• Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ. CoupTFI interacts with retinoic acid signaling during cortical development. PLoS One. 2013;8(3):e58219. PubMed PMID: 23472160
• Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aVß8-TGFß signaling in the brain. Development. 2014 Dec;141(23):4489-99. PubMed PMID: 25406396
• Keeney JG, Davis JM, Siegenthaler J, Post MD, Nielsen BS, Hopkins WD, Sikela JM. DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primates. Brain Struct Funct. 2015 Sep;220(5):3053-60. PubMed PMID: 24957859
• Mishra S, Choe Y, Pleasure SJ, Siegenthaler JA. Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges. Dev Biol. 2016 Dec 1;420(1):148-165. PubMed PMID: 27671872
• Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 Jul 20;36(29):7786-801. PubMed PMID: 27445154
• Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA. Col1a1 perivascular cells in the brain are a source of retinoic acid following stroke. BMC Neurosci. 2016 Jul 15;17(1):49. PubMed PMID: 27422020
• Wang L, Siegenthaler JA, Dowell RD, Yi R. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science. 2016 Feb 5;351(6273):613-7. PubMed PMID: 26912704
• Cheng L, Ge M, Lan Z, Ma Z, Chi W, Kuang W, Sun K, Zhao X, Liu Y, Feng Y, Huang Y, Luo M, Li L, Zhang B, Hu X, Xu L, Liu X, Huo Y, Deng H, Yang J, Xi Q, Zhang Y, Siegenthaler JA, Chen L. Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2017 Sep 4. [Epub ahead of print] PubMed PMID: 28871336
• Bonney S, Siegenthaler JA. Differential Effects of Retinoic Acid Concentrations in Regulating Blood-Brain Barrier Properties. eNeuro. 2017 May-Jun;4(3). PubMed PMID: 28560318
• Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, Chen J, Huo Y, Xu L, Liu X, Deng H, Siegenthaler JA, Chen L. Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity. Sci Rep. 2017 Apr 11;7:46344. PubMed PMID: 28397817
• Wilde JJ, Siegenthaler JA, Dent SY, Niswander LA. Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. J Neurosci. 2017 Mar 8;37(10):2565-2579. PubMed PMID: 28154153
• Mishra S, Kelly KK, Rumian NL, Siegenthaler JA. Retinoic Acid Is Required for Neural Stem and Progenitor Cell Proliferation in the Adult Hippocampus. Stem Cell Reports. 2018 Jun 5;10(6):1705-1720. PubMed PMID: 29805108
• Bonney, S, Mishra, S, Pleasure, SJ, and Siegenthaler JA “Meninges and Brain Vasculature” (2019) in Comprehensive Developmental Neuroscience, 2nd Edition (Eds. Pasko Rakic, John L.R. Rubenstein, Bin Chen and Kenneth Kwan).
• Bonney S, Dennison, BJC, Wendlandt, M, Siegenthaler, JS (2018) "Retinoic acid regulates endothelial ß-catenin expression and pericyte numbers in the developing brain vasculature." Frontiers in Cellular Neuroscience https://doi.org/10.3389/fncel.2018.00476
• Pawlikowski B, Wragge J, Siegenthaler JA. Retinoic acid signaling in vascular development. Genesis. 2019 Jul;57(7-8):e23287. PubMed PMID: 30801891
• Adane B, Ye H, Khan N, Pei S, Minhajuddin M, Stevens BM, Jones CL, D'Alessandro A, Reisz JA, Zaberezhnyy V, Gasparetto M, Ho TC, Kelly KK, Myers JR, Ashton JM, Siegenthaler J, Kume T, Campbell EL, Pollyea DA, Becker MW, Jordan CT. The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells. Cell Rep. 2019 Apr 2;27(1):238-254.e6. PubMed PMID: 30943405
• Bonney S, Seitz S, Ryan CA, Jones KL, Clarke P, Tyler KL, Siegenthaler JA. Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. MBio. 2019 Aug 6;10(4). PubMed PMID: 31387911
• DeSisto, J, O'Rourke, R, Bonney, S, Jones, HE, Guimiot, F, Jones, KL, Siegenthaler, JA "A cellular atlas of the developing meninges reveals meningeal fibroblast diversity and function." BioRxiv 2019 doi: https://doi.org/10.1101/648642
• DeSisto J, O'Rourke R, Jones HE, Pawlikowski B, Malek AD, Bonney S, Guimiot F, Jones KL, Siegenthaler JA. Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function. Dev Cell. 2020 Jul 6;54(1):43-59.e4. PubMed PMID: 32634398
• Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aVß8-TGFß signaling in the brain. Development. 2014 Dec;141(23):4489-99. PubMed PMID: 25406396
• Keeney JG, Davis JM, Siegenthaler J, Post MD, Nielsen BS, Hopkins WD, Sikela JM. DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primates. Brain Struct Funct. 2014 Jun 25. [Epub ahead of print] PubMed PMID: 24957859
• Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. Nature. 2022 Mar;603(7903):885-892. PubMed PMID: 35165441
• Jones HE, Abrams KA, Siegenthaler JA. Techniques for visualizing fibroblast-vessel interactions in the developing and adult CNS. Neurophotonics. 2022 Apr;9(2):021911. PubMed PMID: 35402637
• Derk, J, Como, CN, Jones, HE, Joyce, LR, Bonney, S, O'Rourke, R, Pawlikowski, B, Doran, KS, Siegenthaler JA (2022) 'Formation and function of the meninges arachnoid barrier around the developing brain' BioRxiv doi: https://doi.org/10.1101/2022.06.10.495709
• Como, CN, Cervantes, C, Pawlikowski, B, Siegenthaler, JA (2022) 'Retinoic acid signaling in mouse retina endothelial cells is required for early angiogenic growth' BioRxiv doi: https://doi.org/10.1101/2022.05.09.491241
• Dorrier CE, Jones HE, Pintaric L, Siegenthaler JA, Daneman R. Emerging roles for CNS fibroblasts in health, injury and disease. Nat Rev Neurosci. 2021 Oct 20. [Epub ahead of print] PubMed PMID: 34671105
• DeSisto J, Donson AM, Griesinger AM, Fu R, Riemondy K, Mulcahy Levy J, Siegenthaler JA, Foreman NK, Vibhakar R, Green AL. Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high grade glioma. Neuro Oncol. 2023 Nov 2. [Epub ahead of print] PubMed PMID: 37934854
• Jones HE, Coelho-Santos V, Bonney SK, Abrams KA, Shih AY, Siegenthaler JA. Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature. Development. 2023 Oct 1;150(19). PubMed PMID: 37756588
• Derk J, Como CN, Jones HE, Joyce LR, Kim S, Spencer BL, Bonney S, O'Rourke R, Pawlikowski B, Doran KS, Siegenthaler JA. Formation and function of the meningeal arachnoid barrier around the developing mouse brain. Dev Cell. 2023 Apr 24;58(8):635-644.e4. PubMed PMID: 36996816
• Jones HE, Coelho-Santos V, Bonney SK, Abrams KA, Shih AY, Siegenthaler JA. Meningeal origins and dynamics of perivascular fibroblast development on the mouse cerebral vasculature. bioRxiv. 2023 Mar 23. PubMed PMID: 36993587
• Como CN, Kim S, Siegenthaler J. Stuck on you: Meninges cellular crosstalk in development. Curr Opin Neurobiol. 2023 Apr;79:102676. PubMed PMID: 36773497
• Como CN, Cervantes C, Pawlikowski B, Siegenthaler J. Retinoic acid signaling in mouse retina endothelial cells is required for early angiogenic growth. Differentiation. 2023 Mar-Apr;130:16-27. PubMed PMID: 36528974
• Betsholtz C, Engelhardt B, Koh GY, McDonald DM, Proulx ST, Siegenthaler J. Advances and controversies in meningeal biology. Nat Neurosci. 2024 Sep 27. [Epub ahead of print] PubMed PMID: 39333784
• Siegenthaler J, Betsholtz C. Commentary on "Structural characterization of SLYM - a 4th meningeal membrane". Fluids Barriers CNS. 2024 Sep 9;21(1):69. PubMed PMID: 39252039
• Joyce LR, Kim S, Spencer BL, Christensen PM, Palmer KL, Guan Z, Siegenthaler JA, Doran KS. Streptococcus agalactiae glycolipids promote virulence by thwarting immune cell clearance. Sci Adv. 2024 May 31;10(22):eadn7848. PubMed PMID: 38809989
• Como, C, O’Rourke, R, Winkler, C, Mitchell, D, Tran, L, Lorberbaum, D, Sussel, L, Franco, S and Siegenthaler, J (2024) “Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2” bioRxiv doi: https://doi.org/10.1101/2024.04.05.588348.
• Como CN, Jones HE, Siegenthaler JA. Not just a 'drain': venules sprout brain capillaries. Trends Neurosci. 2021 Nov;44(11):849-851. PubMed PMID: 34452754
• Derk J, Jones HE, Como C, Pawlikowski B, Siegenthaler JA. Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease. Front Cell Neurosci. 2021;15:703944. PubMed PMID: 34276313