Niklaus Mueller, PhD
Sr. Research Instructor, Neurology

Graduate School :
  • PhD, Georgetown University (2006)
Undergraduate Schools:
  • BS, University of Minnesota–Twin Cities (MN)
  • BS, University of Missouri (MO)
Department: Neurology


  • Como CN, Bubak AN, Blackmon AM, Jones D, Mueller NH, Davidson R, Nagel MA. Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):704-711. PubMed PMID: 30786281
  • Droho S, Keener ME, Mueller NH. Heparan sulfate mediates cell uptake of aB-crystallin fused to the glycoprotein C cell penetration peptide. Biochim Biophys Acta Mol Cell Res. 2018 Apr;1865(4):598-604. PubMed PMID: 29408057
  • Droho S, Keener ME, Mueller NH. Changes in function but not oligomeric size are associated with aB-crystallin lysine substitution. Biochem Biophys Rep. 2018 Jul;14:1-6. PubMed PMID: 29872727
  • Fan B, Wang T, Bian L, Jian Z, Wang DD, Li F, Wu F, Bai T, Zhang G, Muller N, Holwerda B, Han G, Wang XJ. Topical Application of Tat-Rac1 Promotes Cutaneous Wound Healing in Normal and Diabetic Mice. Int J Biol Sci. 2018;14(10):1163-1174. PubMed PMID: 30123066
  • Nagaraj RH, Nahomi RB, Mueller NH, Raghavan CT, Ammar DA, Petrash JM. Therapeutic potential of a-crystallin. Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):252-7. PubMed PMID: 25840354
  • Mueller NH, Fogueri U, Pedler MG, Montana K, Petrash JM, Ammar DA. Impact of Subunit Composition on the Uptake of a-Crystallin by Lens and Retina. PLoS One. 2015;10(9):e0137659. PubMed PMID: 26355842
  • Christopher KL, Pedler MG, Shieh B, Ammar DA, Petrash JM, Mueller NH. Alpha-crystallin-mediated protection of lens cells against heat and oxidative stress-induced cell death. Biochim Biophys Acta. 2014 Feb;1843(2):309-15. PubMed PMID: 24275510
  • Mueller NH, Gilden D, Cohrs RJ. Varicella-zoster virus open reading frame 48 encodes an active nuclease. J Virol. 2013 Nov;87(21):11936-8. PubMed PMID: 23966396
  • Mueller NH, Ammar DA, Petrash JM. Cell penetration peptides for enhanced entry of aB-crystallin into lens cells. Invest Ophthalmol Vis Sci. 2013 Jan 2;54(1):2-8. PubMed PMID: 23150610
  • Mueller NH, Bos NL, Seitz S, Wellish M, Mahalingam R, Gilden D, Cohrs RJ. Recombinant monoclonal antibody recognizes a unique epitope on varicella-zoster virus immediate-early 63 protein. J Virol. 2012 Jun;86(11):6345-9. PubMed PMID: 22438547
  • Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov DA, Padmanabhan R. Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Res. 2012 Apr;94(1):18-24. PubMed PMID: 22343093
  • Brazeau E, Wellish M, Kaufer BB, Tischer BK, Gray W, Zhou F, Osterrieder N, Hanlon T, Golive A, Hall T, Nair S, Owens GP, Mueller NH, Cohrs RJ, Pugazhenthi S, Gilden D, Mahalingam R. Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture. J Neurovirol. 2011 Jun;17(3):274-80. PubMed PMID: 21479719
  • Validandi V, Reddy VS, Srinivas PN, Mueller NH, Bhagyalaxmi SG, Padma T, Petrash JM, Reddy GB. Temperature-dependent structural and functional properties of a mutant (F71L) aA-crystallin: molecular basis for early onset of age-related cataract. FEBS Lett. 2011 Dec 15;585(24):3884-9. PubMed PMID: 22085609
  • Mueller NH, Walters MS, Marcus RA, Graf LL, Prenni J, Gilden D, Silverstein SJ, Cohrs RJ. Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63. J Gen Virol. 2010 May;91(Pt 5):1133-7. PubMed PMID: 20089801
  • Ezgimen MD, Mueller NH, Teramoto T, Padmanabhan R. Effects of detergents on the West Nile virus protease activity. Bioorg Med Chem. 2009 May 1;17(9):3278-82. PubMed PMID: 19369080
  • Gilden D, Nagel MA, Mahalingam R, Mueller NH, Brazeau EA, Pugazhenthi S, Cohrs RJ. Clinical and molecular aspects of varicella zoster virus infection. Future Neurol. 2009 Jan 1;4(1):103-117. PubMed PMID: 19946620
  • Mueller NH, Graf LL, Orlicky D, Gilden D, Cohrs RJ. Phosphorylation of the nuclear form of varicella-zoster virus immediate-early protein 63 by casein kinase II at serine 186. J Virol. 2009 Dec;83(23):12094-100. PubMed PMID: 19759161
  • Mueller NH, Pattabiraman N, Ansarah-Sobrinho C, Viswanathan P, Pierson TC, Padmanabhan R. Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen. Antimicrob Agents Chemother. 2008 Sep;52(9):3385-93. PubMed PMID: 18606844
  • Mueller NH, Graf LL, Shearer AJ, Owens GP, Gilden DH, Cohrs RJ. Construction of recombinant mouse IgG1 antibody directed against varicella zoster virus immediate early protein 63. Hybridoma (Larchmt). 2008 Feb;27(1):1-10. PubMed PMID: 18294070
  • Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA. Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency. Neurol Clin. 2008 Aug;26(3):675-97, viii. PubMed PMID: 18657721
  • Mueller NH, Yon C, Ganesh VK, Padmanabhan R. Characterization of the West Nile virus protease substrate specificity and inhibitors. Int J Biochem Cell Biol. 2007;39(3):606-14. PubMed PMID: 17188926
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General Information

Graduate Schools:
  • PhD, Georgetown University (2006)
Undergraduate Schools:
  • BS, University of Minnesota–Twin Cities (MN) (0001)
  • BS, University of Missouri (MO) (0001)
Department: Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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