Stacey Martiniano, MD

Recognitions

• ATS Fellows Track Symposium Award, American Thoracic Society (2012)
  
• Best Doctors in America, Best Doctors in America (2015)
  Top 5% of doctors selected nationwide by peers

Research Interests

As a national clinical expert and lead researcher, Dr. Martiniano serves as national principal investigator of two multicenter studies in NTM: The Prospective Evaluation of NTM Disease in Cystic Fibrosis (PREDICT Study) and The Prospective Algorithm for Treatment of NTM in Cystic Fibrosis (PATIENCE Study). Both are funded by the Cystic Fibrosis Foundation. She is also the co-investigator and director of the Clinical Research Core for the Cystic Fibrosis Foundation Colorado’s CF NTM Research Development Program. Her clinical and translational research has already confirmed the rate of the infection and established the feasibility of new clinical tools such as diagnostic algorithms. Over time, Dr. Martiniano seeks not only to improve outcomes for patients with NTM, but also to help clinicians and the broader cystic fibrosis community care for kids with cystic fibrosis and NTM.

Publications

• Martiniano SL, Sontag MK, Daley CL, Nick JA, Sagel SD. Clinical significance of a first positive nontuberculous mycobacteria culture in cystic fibrosis. Ann Am Thorac Soc. 2014 Jan;11(1):36-44. PubMed PMID: 24251858
• Malcolm KC, Nichols EM, Caceres SM, Kret JE, Martiniano SL, Sagel SD, Chan ED, Caverly L, Solomon GM, Reynolds P, Bratton DL, Taylor-Cousar JL, Nichols DP, Saavedra MT, Nick JA. Mycobacterium abscessus induces a limited pattern of neutrophil activation that promotes pathogen survival. PLoS One. 2013;8(2):e57402. PubMed PMID: 23451220
• Martiniano SL, Sontag MK, Daley CL, Nick JA, Sagel SD. Clinical significance of a first positive nontuberculous mycobacteria culture in cystic fibrosis. Ann Am Thorac Soc. 2014 Jan;11(1):36-44. PubMed PMID: 24251858
• Martiniano SL, Hoppe JE, Sagel SD, Zemanick ET. Advances in the diagnosis and treatment of cystic fibrosis. Adv Pediatr. 2014 Aug;61(1):225-43. PubMed PMID: 25037130
• Federico MJ, Baker CD, Balasubramaniam V, DeBoer EM, Deterding RR, Halbower A, Kupfer O, Martiniano SL, Sagel SD, Stillwell P, Zemanick ET. In: Current Diagnosis and Treatment Pediatrics, Twenty-Second Edition. Ed: WW Hay, MJ Levin, RR Deterding, MJ Abzud. McGraw-Hill, New York, pp 534-586, 2014.
• Martiniano S, Sagel, S, Zemanick, E, DeVoogd, R, Accurso, F, Nick, J, Saavedra, M, Nichols, D, Taylor-Cousar, J, Levin, A, Czaja, C, Huitt, G, Kasperbauer, S, Daley, C. Use of clofazimine in difficult to treat nontuberculous mycobacterial infections. Pediatr Pulmonol Suppl 38: A356, 2014.
• Martiniano SL, Nick JA. Nontuberculous Mycobacterial Infections in Cystic Fibrosis. Clin Chest Med. 2015 Mar;36(1):101-115. PubMed PMID: 25676523
• Martiniano SL, Nick JA. Nontuberculous mycobacterial infections in cystic fibrosis. Clin Chest Med. 2015 Mar;36(1):101-15. PubMed PMID: 25676523
• Federico MJ, Baker CD, DeBoer EM, Deterding RR, Halbower A, Kupfer O, Martiniano SL, Sagel SD, Stillwell P, Zemanick ET. In: Current Diagnosis and Treatment Pediatrics, Twenty-Third Edition. Ed: WW Hay, MJ Levin, RR Deterding, MJ Abzud. McGraw-Hill, New York, (in press).
• Martiniano SL, Nick JA, Daley CL. Nontuberculous mycobacterial infections in cystic fibrosis. Clin Chest Med. (in press)
• Nick JA, Pohl K, Martiniano SL. Nontuberculous mycobacterial infections in cystic fibrosis: to treat or not to treat?. Curr Opin Pulm Med. 2016 Nov;22(6):629-36. PubMed PMID: 27583673
• Martiniano SL, Sagel SD, Zemanick ET. Cystic fibrosis: a model system for precision medicine. Curr Opin Pediatr. 2016 Jun;28(3):312-7. PubMed PMID: 27031658
• Martiniano SL, Nick JA, Daley CL. Nontuberculous Mycobacterial Infections in Cystic Fibrosis. Clin Chest Med. 2016 Mar;37(1):83-96. PubMed PMID: 26857770
• Knight-Perry J, Branchford BR, Thornhill D, Martiniano SL, Sagel SD, Wang M. Venous thromboembolism in children with cystic fibrosis: Retrospective incidence and intrapopulation risk factors. Thromb Res. 2017 Oct;158:161-166. PubMed PMID: 28934665
• Martiniano SL, Davidson RM, Nick JA. Nontuberculous mycobacteria in cystic fibrosis: Updates and the path forward. Pediatr Pulmonol. 2017 Nov;52(S48):S29-S36. PubMed PMID: 28881094
• Martiniano SL, Wagner BD, Levin A, Nick JA, Sagel SD, Daley CL. Safety and Effectiveness of Clofazimine for Primary and Refractory Nontuberculous Mycobacterial Infection. Chest. 2017 Oct;152(4):800-809. PubMed PMID: 28483608
• LeGrys VA, Moon TC, Laux J, Accurso F, Martiniano SL. A multicenter evaluation of sweat chloride concentration and variation in infants with cystic fibrosis. J Cyst Fibros. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30583934
• Martiniano SL, Nick JA, Daley CL. Nontuberculous Mycobacterial Infections in Cystic Fibrosis. Thorac Surg Clin. 2019 Feb;29(1):95-108. PubMed PMID: 30454926
• Martiniano SL, Toprak D, Ong T, Zemanick ET, Daines CL, Muhlebach MS, Esther CR Jr, Dellon EP. Highlights from the 2017 North American Cystic Fibrosis Conference. Pediatr Pulmonol. 2018 Jul;53(7):979-986. PubMed PMID: 29660839
• Martiniano SL, Esther CR, Haworth CS, Kasperbauer SH, Zemanick ET, Caverly LJ. Challenging scenarios in nontuberculous mycobacterial infection in cystic fibrosis. Pediatr Pulmonol. 2019 Dec 10. [Epub ahead of print] PubMed PMID: 31821718
• Gross JE, Martiniano SL, Nick JA. Prevention of transmission of Mycobacterium abscessus among patients with cystic fibrosis. Curr Opin Pulm Med. 2019 Nov;25(6):646-653. PubMed PMID: 31436542
• Martiniano SL, Daines CL, Dellon EP, Esther CR Jr, Muhlebach MS, Ong T, Rabinowitz EC, Toprak D, Zemanick ET. Highlights from the 2018 North American cystic fibrosis conference. Pediatr Pulmonol. 2019 Jul;54(7):941-948. PubMed PMID: 31091021
• LeGrys VA, Moon TC, Laux J, Accurso F, Martiniano SA. A multicenter evaluation of sweat chloride concentration and variation in infants with cystic fibrosis. J Cyst Fibros. 2019 Mar;18(2):190-193. PubMed PMID: 30583934
• Martiniano SL, Nick JA, Daley CL. Nontuberculous Mycobacterial Infections in Cystic Fibrosis. Thorac Surg Clin. 2019 Feb;29(1):95-108. PubMed PMID: 30454926
• Somayaji R, Parkins MD, Shah A, Martiniano SL, Tunney MM, Kahle JS, Waters VJ, Elborn JS, Bell SC, Flume PA, VanDevanter DR. Antimicrobial susceptibility testing (AST) and associated clinical outcomes in individuals with cystic fibrosis: A systematic review. J Cyst Fibros. 2019 Mar;18(2):236-243. PubMed PMID: 30709744
• Hasan NA, Davidson RM, Epperson LE, Kammlade SM, Rodger RR, Levin AR, Sherwood A, Sagel SD, Martiniano SL, Daley CL, Salfinger M, Nick JA, Strong M. Population genomics of nontuberculous mycobacteria recovered from United States cystic fibrosis patients. bioRxiv. 2019 June
• Martiniano SL, Nick JA, Daley CL. Nontuberculous mycobacterial infections in cystic fibrosis. Thorac Surg Clin. 2019 Feb;29(1):95-108.
• Lenhart-Pendergrass PM, Caverly LJ, Wagner BD, Sagel SD, Nick JA, LiPuma JJ, Martiniano SL. Clinical characteristics and outcomes associated with Inquilinus infection in cystic fibrosis. J Cyst Fibros. 2020 Jul 31. [Epub ahead of print] PubMed PMID: 32747193
• De P, Amin AG, Graham B, Martiniano SL, Caceres SM, Poch KR, Jones MC, Saavedra MT, Malcolm KC, Nick JA, Chatterjee D. Urine lipoarabinomannan as a marker for low-risk of NTM infection in the CF airway. J Cyst Fibros. 2020 Sep;19(5):801-807. PubMed PMID: 32624408
• Hoppe JE, Guimbellot J, Martiniano SL, Toprak D, Davis C, Daines CL, Muhlebach MS, Esther CR Jr, Dellon EP. Highlights from the 2019 North American Cystic Fibrosis Conference. Pediatr Pulmonol. 2020 Sep;55(9):2225-2232. PubMed PMID: 32573948
• Martiniano SL, Esther CR, Haworth CS, Kasperbauer SH, Zemanick ET, Caverly LJ. Challenging scenarios in nontuberculous mycobacterial infection in cystic fibrosis. Pediatr Pulmonol. 2020 Feb;55(2):521-525. PubMed PMID: 31821718
• Poore TS, Meier M, Towler E, Martiniano SL, Brinton JT, DeBoer EM, Sagel SD, Wagner BD, Zemanick ET. Clinical characteristics of people with cystic fibrosis and frequent fungal infection. Pediatr Pulmonol. 2021 Oct 23. [Epub ahead of print] PubMed PMID: 34687280
• Hasan NA, Davidson RM, Epperson LE, Kammlade SM, Beagle S, Levin AR, de Moura VC, Hunkins JJ, Weakly N, Sagel SD, Martiniano SL, Salfinger M, Daley CL, Nick JA, Strong M. Population Genomics and Inference of Mycobacterium avium Complex Clusters in Cystic Fibrosis Care Centers, United States. Emerg Infect Dis. 2021 Nov;27(11):2836-2846. PubMed PMID: 34670648
• Gross JE, McCown MY, Okorie CUA, Bishay LC, Dy FJ, Astudillo CL, Muhlebach MS, Abu-Nassar S, Chen DY, Hossain N, Wang R, Klouda T, Martiniano SL, Lenhart-Pendergrass P, Kirkby S, Ortenberg R, McSparron JI, Wang T, Hayes MM, Çoruh B. ATS Core Curriculum 2021. Pediatric Pulmonary Medicine: Pulmonary Infections. ATS Sch. 2021 Sep;2(3):452-467. PubMed PMID: 34667993
• Martiniano SL, Croak K, Bonn G, Sontag MK, Sagel SD. Improving outcomes for Colorado's IRT-IRT-DNA cystic fibrosis newborn screening algorithm by implementing floating cutoffs. Mol Genet Metab. 2021 Sep-Oct;134(1-2):65-67. PubMed PMID: 34489170
• Martiniano SL, Elbert AA, Farrell PM, Ren CL, Sontag MK, Wu R, McColley SA. Outcomes of infants born during the first 9 years of CF newborn screening in the United States: A retrospective Cystic Fibrosis Foundation Patient Registry cohort study. Pediatr Pulmonol. 2021 Dec;56(12):3758-3767. PubMed PMID: 34469079
• Holsteen P, Meier M, Brennan L, VanHorn T, Kuldanek SA, Wang M, Martiniano SL. Safety and effectiveness of a risk-stratified venous thromboembolism prophylaxis algorithm in young people with cystic fibrosis. Thromb Res. 2021 Oct;206:36-41. PubMed PMID: 34399123
• Martiniano SL, Wagner BD, Brennan L, Wempe MF, Anderson PL, Daley CL, Anthony M, Nick JA, Sagel SD. Pharmacokinetics of oral antimycobacterials and dosing guidance for Mycobacterium avium complex treatment in cystic fibrosis. J Cyst Fibros. 2021 Sep;20(5):772-778. PubMed PMID: 34030986
• Sontag MK, Farrell PM, Kellar-Guenther Y, Martiniano SL, Miller JI, Ren CL, McColley SA. Comment on Munck et al., Feb, 2021. J Cyst Fibros. 2021 Jul;20(4):717-718. PubMed PMID: 34020895
• Davidson RM, Hasan NA, Epperson LE, Benoit JB, Kammlade SM, Levin AR, Calado de Moura V, Hunkins J, Weakly N, Beagle S, Sagel SD, Martiniano SL, Salfinger M, Daley CL, Nick JA, Strong M. Population Genomics of Mycobacterium abscessus from U.S. Cystic Fibrosis Care Centers. Ann Am Thorac Soc. 2021 Dec;18(12):1960-1969. PubMed PMID: 33856965
• Lenhart-Pendergrass PM, Anthony M, Sariyska S, Andrews A, Scavezze H, Towler E, Martiniano SL, Hoppe JE, Zemanick ET. Detection of bacterial pathogens using home oropharyngeal swab collection in children with cystic fibrosis. Pediatr Pulmonol. 2021 Jul;56(7):2043-2047. PubMed PMID: 33847465
• Lenhart-Pendergrass PM, Caverly LJ, Wagner BD, Sagel SD, Nick JA, LiPuma JJ, Martiniano SL. Clinical characteristics and outcomes associated with Inquilinus infection in cystic fibrosis. J Cyst Fibros. 2021 Mar;20(2):310-315. PubMed PMID: 32747193
• Nick JA, Malcolm KC, Hisert KB, Wheeler EA, Rysavy NM, Poch K, Caceres S, Lovell VK, Armantrout E, Saavedra MT, Calhoun K, Chatterjee D, Aboellail I, De P, Martiniano SL, Jia F, Davidson RM. Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway. Tuberculosis (Edinb). 2022 Nov 17;138:102276. [Epub ahead of print] PubMed PMID: 36417800
• Martiniano SL, Nick JA, Daley CL. Nontuberculous Mycobacterial Infections in Cystic Fibrosis. Clin Chest Med. 2022 Dec;43(4):697-716. PubMed PMID: 36344075
• Hoppe JE, Zemanick ET, Martiniano SL. Evidence for Early Cystic Fibrosis Transmembrane Conductance Regulator Modulator Treatment for Children with Cystic Fibrosis Keeps Growing. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1308-1310. PubMed PMID: 35947636
• Sontag MK, Miller JI, McKasson S, Gaviglio A, Martiniano SL, West R, Vazquez M, Ren CL, Farrell PM, McColley SA, Kellar-Guenther Y. Newborn Screening for Cystic Fibrosis: A Qualitative Study of Successes and Challenges from Universal Screening in the United States. Int J Neonatal Screen. 2022 Jun 23;8(3). PubMed PMID: 35892468
• McColley SA, Martiniano SL, Ren CL, Sontag MK, Rychlik K, Balmert L, Elbert A, Wu R, Farrell PM. Disparities in first evaluation of infants with cystic fibrosis since implementation of newborn screening. J Cyst Fibros. 2022 Jul 21. [Epub ahead of print] PubMed PMID: 35871976
• Nick JA, Dedrick RM, Gray AL, Vladar EK, Smith BE, Freeman KG, Malcolm KC, Epperson LE, Hasan NA, Hendrix J, Callahan K, Walton K, Vestal B, Wheeler E, Rysavy NM, Poch K, Caceres S, Lovell VK, Hisert KB, de Moura VC, Chatterjee D, De P, Weakly N, Martiniano SL, Lynch DA, Daley CL, Strong M, Jia F, Hatfull GF, Davidson RM. Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection. Cell. 2022 May 26;185(11):1860-1874.e12. PubMed PMID: 35568033
• Poore TS, Meier M, Towler E, Martiniano SL, Brinton JT, DeBoer EM, Sagel SD, Wagner BD, Zemanick ET. Clinical characteristics of people with cystic fibrosis and frequent fungal infection. Pediatr Pulmonol. 2022 Jan;57(1):152-161. PubMed PMID: 34687280
• Lenhart-Pendergrass P, Malcolm K, Wheeler E, Rysavy N, Poch K, Caceres S, Calhoun K, Martiniano S, Nick J. Deficient Complement Opsonization Impairs Mycobacterium avium Killing by Neutrophils in Cystic Fibrosis. ASM, 2022, in press
• Martiniano SL, Caceres SM, Poch K, Rysavy NM, Lovell VK, Armantrout E, Jones M, Anthony M, Keck A, Nichols DP, Vandalfsen JM, Sagel SD, Wagner B, Xie J, Weaver K, Heltshe SL, Daley CL, Davidson RM, Nick JA. Prospective evaluation of nontuberculous mycobacteria disease in cystic fibrosis: The design of the PREDICT study. J Cyst Fibros. 2023 Sep 2. [Epub ahead of print] PubMed PMID: 37666709
• Martiniano SL, Wu R, Farrell PM, Ren CL, Sontag MK, Elbert A, McColley SA. Late Diagnosis in the Era of Universal Newborn Screening Negatively Affects Short- and Long-Term Growth and Health Outcomes in Infants with Cystic Fibrosis. J Pediatr. 2023 Nov;262:113595. PubMed PMID: 37406853
• Lenhart-Pendergrass PM, Malcolm KC, Wheeler E, Rysavy NM, Poch K, Caceres S, Calhoun KM, Martiniano SL, Nick JA. Deficient Complement Opsonization Impairs Mycobacterium avium Killing by Neutrophils in Cystic Fibrosis. Microbiol Spectr. 2023 Feb 14;11(1):e0327922. PubMed PMID: 36651756
• Nick JA, Malcolm KC, Hisert KB, Wheeler EA, Rysavy NM, Poch K, Caceres S, Lovell VK, Armantrout E, Saavedra MT, Calhoun K, Chatterjee D, Aboellail I, De P, Martiniano SL, Jia F, Davidson RM. Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway. Tuberculosis (Edinb). 2023 Jan;138:102276. PubMed PMID: 36417800
• McColley SA, Martiniano SL, Ren CL, Sontag MK, Rychlik K, Balmert L, Elbert A, Wu R, Farrell PM. Disparities in first evaluation of infants with cystic fibrosis since implementation of newborn screening. J Cyst Fibros. 2023 Jan;22(1):89-97. PubMed PMID: 35871976
• Martiniano SL, Caceres SM, Poch K, Rysavy NM, Lovell VK, Armantrout E, Jones M, Anthony M, Keck A, Nichols DP, Vandalfsen JM, Sagel SD, Wagner B, Xie J, Weaver K, Heltshe SL, Daley CL, Davidson RM, Nick JA. Prospective evaluation of nontuberculous mycobacteria disease in cystic fibrosis: The design of the PREDICT study. J Cyst Fibros. 2024 Jan;23(1):50-57. PubMed PMID: 37666709
• Martiniano SL, Wu R, Farrell PM, Ren CL, Sontag MK, Elbert A, McColley SA. Late Diagnosis in the Era of Universal Newborn Screening Negatively Affects Short- and Long-Term Growth and Health Outcomes in Infants with Cystic Fibrosis. J Pediatr. 2023 Nov;262:113595. PubMed PMID: 37406853

Professional Memberships

• American Thoracic Society (ATS), Member
• American College of Chest Physicians (ACCP), Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado
• University of Colorado Hospital

Specialty Information

Specialties

• Pediatrics, Board Certification (2009)
• Pediatric Pulmonology, Board Certification (2012)

Conditions & Treatments

• Lungs and Breathing - Pulmonary Disorders
• Lungs and Breathing - Cystic Fibrosis
• Lungs and Breathing
• Lungs and Breathing - Lung Disease