Andrew Getahun, PhD, MS

Publications

• Fiske BE, Getahun A. Failed down-regulation of PI3K signaling makes autoreactive B cells receptive to bystander T cell help. J. Immunol. 2024 in press
• Fiske BE, Wemlinger SM, Crute BW, Getahun A. The Src-family kinase Lyn plays a critical role in establishing and maintaining B cell anergy by suppressing PI3K-dependent signaling. bioRxiv. 2024 May 24. PubMed PMID: 38826354
• Fiske BE, Getahun A. Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help. J Immunol. 2024 Apr 1;212(7):1150-1160. PubMed PMID: 38353615
• Palmer WH, Leaton LA, Campos Codo A, Crute B, Roest J, Zhu S, Petersen J, Tobin RP, Hume PS, Stone M, van Bokhoven A, Gerich ME, McCarter MD, Zhu Y, Janssen WJ, Vivian JP, Trowsdale J, Getahun A, Rossjohn J, Cambier J, Loh L, Norman PJ. Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. Sci Immunol. 2023 Jun 30;8(84):eade5343. PubMed PMID: 37390222
• Banach M, Harley ITW, Getahun A, Cambier JC. Comparative analysis of the repertoire of insulin-reactive B cells in type 1 diabetes-prone and resistant mice. Front Immunol. 2022;13:961209. PubMed PMID: 36275764
• Wemlinger SM, Parker Harp CR, Yu B, Hardy IR, Seefeldt M, Matsuda J, Mingueneau M, Spilker KA, Cameron TO, Larrick JW, Getahun A, Cambier JC. Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model. J Immunol. 2022 Apr 1;208(7):1566-1584. PubMed PMID: 35321883
• Getahun A. Role of inhibitory signaling in peripheral B cell tolerance. Immunol Rev. 2022 May;307(1):27-42. PubMed PMID: 35128676
• Klarquist J, Cross EW, Thompson SB, Willett B, Aldridge DL, Caffrey-Carr AK, Xu Z, Hunter CA, Getahun A, Kedl RM. B cells promote CD8 T cell primary and memory responses to subunit vaccines. Cell Rep. 2021 Aug 24;36(8):109591. PubMed PMID: 34433030
• Walker MM, Kim S, Crisler WJ, Nguyen K, Lenz LL, Cambier JC, Getahun A. Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020;11:238. PubMed PMID: 32153571
• Crute BW, Sheraden R, Ott VL, Harley ITW, Getahun A, Cambier JC. Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors. Front Immunol. 2020;11:592329. PubMed PMID: 33193438
• Phalke SP, Huang Y, Rubtsova K, Getahun A, Sun D, Reinhardt RL, O'Brien RL, Born WK. ?d T cells shape memory-phenotype aß T cell populations in non-immunized mice. PLoS One. 2019;14(6):e0218827. PubMed PMID: 31237933
• Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019 May 16;5. PubMed PMID: 31094704
• Franks SE, Getahun A, Cambier JC. A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation. J Immunol. 2019 Jun 15;202(12):3381-3393. PubMed PMID: 31076529
• Getahun A, Cambier JC. Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease. Annu Rev Cell Dev Biol. 2019 Oct 6;35:337-356. PubMed PMID: 30883216
• Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insight. 2019 Feb 7;4(3). [Epub ahead of print] PubMed PMID: 30728334
• Benhamou D, Labi V, Getahun A, Benchetrit E, Dowery R, Rajewsky K, Cambier JC, Melamed D. The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development. Front Immunol. 2018;9:2715. PubMed PMID: 30524445
• Walker MM, Crute BW, Cambier JC, Getahun A. B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses. J Immunol. 2018 Nov 1;201(9):2641-2653. PubMed PMID: 30282750
• Smith MJ, Hinman RM, Getahun A, Kim S, Packard TA, Cambier JC. Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice. Diabetologia. 2018 Dec;61(12):2621-2632. PubMed PMID: 30255377
• Kogut I, McCarthy SM, Pavlova M, Astling DP, Chen X, Jakimenko A, Jones KL, Getahun A, Cambier JC, Pasmooij AMG, Jonkman MF, Roop DR, Bilousova G. High-efficiency RNA-based reprogramming of human primary fibroblasts. Nat Commun. 2018 Feb 21;9(1):745. PubMed PMID: 29467427
• Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC. Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway. J Exp Med. 2017 Apr 3;214(4):931-941. PubMed PMID: 28341640
• Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 1;196(1):217-31. PubMed PMID: 26582947
• Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC. B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes. J Clin Med. 2016 Nov 8;5(11). PubMed PMID: 27834793
• Franks SE, Getahun A, Hogarth PM, Cambier JC. Targeting B cells in treatment of autoimmunity. Curr Opin Immunol. 2016 Dec;43:39-45. PubMed PMID: 27718447
• Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 May 2;213(5):751-69. PubMed PMID: 27114609
• Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 1;196(1):217-31. PubMed PMID: 26582947
• Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E39-48. PubMed PMID: 25535377
• Akerlund J, Getahun A, Cambier JC. B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens. J Autoimmun. 2015 Aug;62:45-54. PubMed PMID: 26152931
• Getahun A, Cambier JC. Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling. Immunol Rev. 2015 Nov;268(1):66-73. PubMed PMID: 26497513
• Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 1;195(11):5461-71. PubMed PMID: 26500350
• Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E39-48. PubMed PMID: 25535377
• Luo W, Mayeux J, Gutierrez T, Russell L, Getahun A, Müller J, Tedder T, Parnes J, Rickert R, Nitschke L, Cambier J, Satterthwaite AB, Garrett-Sinha LA. A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. J Immunol. 2014 Jul 15;193(2):909-20. PubMed PMID: 24929000
• Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol. 2014 Feb 15;192(4):1641-50. PubMed PMID: 24442438
• Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol. 2014 Feb 15;192(4):1641-50. PubMed PMID: 24442438
• Bounab Y, Getahun A, Cambier JC, Daëron M. Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Curr Opin Immunol. 2013 Jun;25(3):313-20. PubMed PMID: 23684445
• Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013 Mar 15;190(6):2835-43. PubMed PMID: 23378430
• J Immunol. 2013 Mar 15;190(6):2835-43. doi: 10.4049/jimmunol.1201788. Epub 2013 Feb 1. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6Chi monocyte migration. Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC.
• Curr Opin Immunol. 2013 in press Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Yacine Bounab*1, 2, Andrew Getahun*3, John C. Cambier§ 3 and Marc Daëron§ 1, 4
• J Immunol. 2012 Sep 15;189(6):2965-74. doi: 10.4049/jimmunol.1201407. Epub 2012 Aug 17. Retention of anergy and inhibition of antibody responses during acute ? herpesvirus 68 infection. Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC.
• PLoS One. 2012;7(7):e41968. doi: 10.1371/journal.pone.0041968. Epub 2012 Jul 25. Complement receptors 1 and 2 in murine antibody responses to IgM-complexed and uncomplexed sheep erythrocytes. Rutemark C, Bergman A, Getahun A, Hallgren J, Henningsson F, Heyman B.
• Getahun A, Wemlinger S, Rudra P, Santiago M, van Dyk L and Cambier JC. Impaired B cell function during viral infection due to PTEN-mediated inhibition of the PI3K pathway. J. Exp. Med. in press
• Getahun A, Smith MJ, Cambier JC. Mechanisms of peripheral B cell tolerance. Encyclopedia of Immunobiology MUN3 01011
• Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of autoreactive B cells. J. Exp Med. In press
• Kogut I, McCarthy S, Pavlova M, Astling D, Chen X, Jakimenko A, Jones K, Getahun A, Cambier J, Pasmooij A, Jonkman M, Roop D, and Bilousova G. High-efficiency RNA-based reprogramming of human primary fibroblasts. Nat Commun. In press.
• Getahun A and Cambier JC. Non-antibody-secreting functions of B cells and their contribution to autoimmune disease. Annu Rev Cell Dev Biol, In press
• Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb P, and Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insights. In press