Christine Chan, MD

Professional Titles

• Associate Professor of Pediatrics

Recognitions

• Cystic Fibrosis Foundation Leadership & Design Award, Cystic Fibrosis Foundation (2023)
• Clinical Research Scholar (CRSP) Award, Cystic Fibrosis Foundation (2023)

Research Interests

I am an Associate Professor of Pediatrics at the University of Colorado where my clinical research is focused on improving screening and management practices and long-term health outcomes for youth with diabetes and chronic health conditions. I am particularly interested in applications of diabetes technologies for improving quality of life and health outcomes for people living with cystic fibrosis and cystic fibrosis related diabetes (CFRD). I partner with collaborators nationally and internationally on observational and interventional trials to improve CFRD screening and management. I am passionate about teaching and working with junior faculty, graduate students, and trainees interested in endocrinology and diabetes care.

Publications

• Shirley Bezerra M, Zemel BS, Gallop RJ, Walega R, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffamn LR, Narkewicz MR, Rowe SM, Sagel SD, Schwarzenberg SJ, Solomon GM, Chan CL, Kelly A for the PROMISE Endocrine Sub-study Group. Longitudinal Changes in Bone Mineral Density After Initiation of Elexacaftor-Tezacaftor-Ivacaftor in Youth and Adults with CF: PROMISE-ENDO, Journal of Cystic Fibrosis. Accepted Jan 16, 2026.
• Chan CL, Shirley Bezerra M, Stefanovski D, Gallop RJ, Walega R, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Narkewicz MR, Rowe SM, Sagel SD, Schwarzenberg SJ, Solomon GM, Stalvey MS, Kelly A. Glycemia and Insulin Secretion in Cystic Fibrosis 2 Years After Elexacaftor/Tezacaftor/Ivacaftor: PROMISE-ENDO. J Clin Endocrinol Metab. 2025 Aug 7;110(9):2674-2684. PubMed PMID: 39657947
• Friedman JC, Hutchens K, Starkman H, Beaty LE, Sammel MD, Finn E, Appiah LC, Alaniz VI, Chan CL. Sex Hormone Replacement Therapy and Bleeding Patterns among Adolescents and Young Adult Females with Prader-Willi Syndrome. J Pediatr Adolesc Gynecol. 2025 Dec;38(6):724-730. PubMed PMID: 40783001
• Kohler CL, Vigers T, Pyle L, Miller K, Zemanick ET, Moran A, Sagel SD, Chan CL. Trends in Cystic Fibrosis-Related Diabetes Epidemiology Between 2003 and 2018 From the U.S. Cystic Fibrosis Foundation Patient Registry. Diabetes Care. 2025 Jul 1;48(7):1251-1259. PubMed PMID: 40372381
• Hameed S, Barnes EH, Briody J, Wainwright CE, Hilton J, Field PI, Tai A, Belessis Y, Chan CL, Selvadurai H, Prentice B, Katz T, McMahon SK, Neylan M, Pena A, Jaffe A, Verge CF. Insulin for early glycaemic abnormality in children with cystic fibrosis without cystic fibrosis-related diabetes (CF-IDEA): a randomised controlled trial. Lancet Child Adolesc Health. 2025 Jun;9(6):371-382. PubMed PMID: 40379429
• Wood C, Moheet A, Vigers T, Granados A, Lorenz A, Hanley E, Zemanick E, Chan CL. Hemoglobin A1c in youth and adults with cystic fibrosis related diabetes decreases after elexacaftor-tezacaftor-ivacaftor. J Cyst Fibros. 2025 Jul;24(4):755-758. PubMed PMID: 40089409
• Chan CL, Shirley Bezerra M, Stefanovski D, Gallop RJ, Walega R, Donaldson SH, Frederick CA, Freedman SD, Gelfond D, Hoffman LR, Narkewicz MR, Rowe SM, Sagel SD, Schwarzenberg SJ, Solomon GM, Stalvey MS, Kelly A. Glycemia and Insulin Secretion in Cystic Fibrosis Two Years After Elexacaftor/Tezacaftor/Ivacaftor: PROMISE-ENDO. J Clin Endocrinol Metab. 2024 Dec 9. [Epub ahead of print] PubMed PMID: 39657947
• SHIFTing goals in cystic fibrosis—managing extrapulmonary disease in the era of CFTR modulator therapy; Proceedings of the International Shaping Initiatives and Future Trends (SHIFT) Symposium Jonathan E. M. O'Donnell BMedSci (Hons I), BMed (Dist.) DCH, MMed, Lucy A. Hastings BSc, MBBS (Hons), MMed (Paed), FRACP, Julie N. Briody PhD, Christine L. Chan MD, Carla Colombo MD, PhD, Tonia A. Douglas MBChB, FRACP, MD, Steven D. Freedman MD, PhD, Tanja Gonska PhD, Jerry R. Greenfield MD, PhD, Daniel H. Leung MD, Adeline Y. L. Lim MBBS, FRACP, Antoinette Moran MD, Bernadette J. Prentice MBBS, FRACP, Melissa S. Putman MD, Michael Trotter MBBS, FRACP, Elizabeth Tullis MD, FRCPC, Glen P. Westall MBBS, FRACP, PhD,, Charles F. Verge MBBS (Hons), PhD, FRACP, Claire E. Wainwright MBBS, MD, FRACP, Chee Y. Ooi MBBS, Dip Paeds, PhD, FRACP, the SHIFT Symposium 2021 First published: 12 April 2024 https://doi.org/10.1002/ppul.26970
• Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Diabetes Care. 2023 Jun 1;46(6):1112-1123. PubMed PMID: 37125948
• Hicks R, Ode KL, Vigers T, Chan CL. A provider survey of cystic fibrosis related diabetes screening and management practices at North American CF centers. Front Endocrinol (Lausanne). 2023;14:1183288. PubMed PMID: 37274323
• Davis SM, Urban R, D'Alessandro A, Reisz JA, Chan CL, Kelsey M, Howell S, Tartaglia N, Zeitler P, Baker Ii P. Unique plasma metabolite signature for adolescents with Klinefelter syndrome reveals altered fatty acid metabolism. Endocr Connect. 2023 May 1;12(5). PubMed PMID: 36884262
• Granados A, Chan CL, Moheet A, Vigers T, Arbeláez AM, Larson Ode K. The impact of elexacaftor/tezacaftor/ivacaftor on body composition in a small cohort of youth with cystic fibrosis. Pediatr Pulmonol. 2023 Jun;58(6):1805-1811. PubMed PMID: 36929859
• . Effect of Early Glycemic Control in Youth-Onset Type 2 Diabetes on Longer-Term Glycemic Control and ß-Cell Function: Results From the TODAY Study. Diabetes Care. 2023 Aug 1;46(8):1507-1514. PubMed PMID: 37378967
• Finn E, Severn C, Pyle L, Garrish J, Vigers T, Behn CGD, Zeitler PS, Sagel SD, Nadeau KJ, Chan CL. Hypoglycemia in children and young adults with cystic fibrosis during oral glucose tolerance testing vs. continuous glucose monitoring. Pediatr Pulmonol. 2023 Sep;58(9):2495-2504. PubMed PMID: 37350354
• Lorenz A, Pyle L, Ha J, Sherman A, Cree-Green M, Sagel S, Nadeau K, Chan CL. Predictive Value of 1h Glucose Elevations During the OGTT for CFRD, Pediatric Diabetes, Accepted 4/2023.
• Chan CL, Pyle L, Vigers T, Zeitler PS, Nadeau KJ. The Relationship Between Continuous Glucose Monitoring and OGTT in Youth and Young Adults With Cystic Fibrosis. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e548-e560. PubMed PMID: 34537845
• Taylor AE, Ware MA, Breslow E, Pyle L, Severn C, Nadeau KJ, Chan CL, Kelsey MM, Cree-Green M. 11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome. J Endocr Soc. 2022 Jul 1;6(7):bvac037. PubMed PMID: 35611324
• Abohtyra RM, Chan CL, Albers DJ, Gluckman BJ. Inferring Insulin Secretion Rate from Sparse Patient Glucose and Insulin Measures. Front Physiol. 2022;13:893862. PubMed PMID: 35991187
• Breslow E, Taylor A, Chan CL, Severn C, Pyle L, Torchen L, Sisk R, Legro R, Turcu AF, Auchus RJ, Duanaif A, Kelsey MM, Cree-Green M. 11-Oxygenated Androgen Metabolite Concentrations are Affected by Pubertal Progression and Obesity. Horm Res Paediatr. 2022 Nov 29. [Epub ahead of print] PubMed PMID: 36446347
• Chan CL, Granados A, Moheet A, Singh S, Vigers T, Arbeláez AM, Yi Y, Hu S, Norris AW, Ode KL. Glycemia and ß-cell function before and after elexacaftor/tezacaftor/ivacaftor in youth and adults with cystic fibrosis. J Clin Transl Endocrinol. 2022 Dec;30:100311. PubMed PMID: 36620757
• Ode KL, Ballman M, Battezzati A, Brennan A, Chan CL, Hameed S, Ismail HM, Kelly A, Moran AM, Rabasa-Lhoret R, Saxby NA, Craig ME. ISPAD Clinical Practice Consensus Guidelines 2022: Management of cystic fibrosis-related diabetes in children and adolescents. Pediatr Diabetes. 2022 Dec;23(8):1212-1228. PubMed PMID: 36537525
• Khare S, Desimone M, Kasim N, Chan CL. Cystic fibrosis-related diabetes: Prevalence, screening, and diagnosis. J Clin Transl Endocrinol. 2022 Mar;27:100290. PubMed PMID: 34917485
• Kasim N, Khare S, Sandouk Z, Chan C. Impaired glucose tolerance and indeterminate glycemia in cystic fibrosis. J Clin Transl Endocrinol. 2021 Dec;26:100275. PubMed PMID: 34868882
• Chan CL, Pyle L, Vigers T, Zeitler PS, Nadeau KJ. Full The Relationship between Continuous Glucose Monitoring and OGTT in Youth and Young Adults with Cystic Fibrosis. J Clin Endocrinol Metab. 2021 Sep 19. [Epub ahead of print] PubMed PMID: 34537845
• Chan CL. Continuous glucose monitoring in cystic fibrosis-Benefits, limitations, and opportunities. J Cyst Fibros. 2021 Sep;20(5):725-726. PubMed PMID: 34364815
• Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler P. Long-Term Complications in Youth-Onset Type 2 Diabetes. N Engl J Med. 2021 Jul 29;385(5):416-426. PubMed PMID: 34320286
• Tommerdahl KL, Brinton JT, Vigers T, Cree-Green M, Zeitler PS, Nadeau KJ, Chan CL. Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index. J Cyst Fibros. 2021 Mar;20(2):339-345. PubMed PMID: 32928701
• Tommerdahl KL, Brinton JT, Vigers T, Cree-Green M, Zeitler PS, Nadeau KJ, Chan CL. Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index. J Cyst Fibros. 2020 Sep 11;:2111. [Epub ahead of print] PubMed PMID: 32928701
• Chan CL. Cystic fibrosis related diabetes: Revisiting the OGTT and alternate screening tests. J Cyst Fibros. 2020 Sep;19(5):671-672. PubMed PMID: 32713805
• Arslanian S, El Ghormli L, Haymond MH, Chan CL, Chernausek SD, Gandica RG, Gubitosi-Klug R, Levitsky LL, Siska M, Willi SM. Beta cell function and insulin sensitivity in obese youth with maturity onset diabetes of youth mutations vs type 2 diabetes in TODAY: Longitudinal observations and glycemic failure. Pediatr Diabetes. 2020 Jun;21(4):575-585. PubMed PMID: 32064729
• Chan CL, Steck AK, Severn C, Pyle L, Rewers M, Zeitler PS. Lessons From Continuous Glucose Monitoring in Youth With Pre-Type 1 Diabetes, Obesity, and Cystic Fibrosis. Diabetes Care. 2020 Mar;43(3):e35-e37. PubMed PMID: 31937609
• Chan CL, Steck AK, Severn C, Pyle L, Rewers M, Zeitler PS. Lessons From Continuous Glucose Monitoring in Youth With Pre-Type 1 Diabetes, Obesity, and Cystic Fibrosis. Diabetes Care. 2020 Jan 14. [Epub ahead of print] PubMed PMID: 31937609
• Kelsey MM, Zeitler PS, Drews K, Chan CL. Normal Hemoglobin A1c Variability in Early Adolescence: Adult Criteria for Prediabetes Should Be Applied with Caution. J Pediatr. 2020 Jan;216:232-235. PubMed PMID: 31405525
• Ode KL, Chan CL, Granandos A, Putman M, Moheet A. Endocrine Complications of Cystic Fibrosis: A Multisystem Disease of the Endocrine Organs. Semin Respir Crit Care Med. 2019 Dec;40(6):810-824. PubMed PMID: 31679155
• Weinstock RS, Braffett BH, McGuigan P, Larkin ME, Grover NB, Walders-Abramson N, Laffel LM, Chan CL, Chang N, Schwartzman BE, Barajas RA, Celona-Jacobs N, Haymond MW. Self-Monitoring of Blood Glucose in Youth-Onset Type 2 Diabetes: Results From the TODAY Study. Diabetes Care. 2019 May;42(5):903-909. PubMed PMID: 30833375
• Tommerdahl KL, Brinton JT, Vigers T, Nadeau KJ, Zeitler PS, Chan CL. Screening for cystic fibrosis-related diabetes and prediabetes: Evaluating 1,5-anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c. Pediatr Diabetes. 2019 Dec;20(8):1080-1086. PubMed PMID: 31469470
• Ode KL, Chan CL, Granados A, Moheet A, Moran A, Brennan AL. Cystic fibrosis related diabetes: Medical management. J Cyst Fibros. 2019 Oct;18 Suppl 2:S10-S18. PubMed PMID: 31679720
• Moheet A, Chan CL, Granados A, Ode KL, Moran A, Battezzati A. Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment. J Cyst Fibros. 2019 Oct;18 Suppl 2:S19-S24. PubMed PMID: 31679723
• Chan CL, Ode KL, Granados A, Moheet A, Moran A, Hameed S. Continuous glucose monitoring in cystic fibrosis - A practical guide. J Cyst Fibros. 2019 Oct;18 Suppl 2:S25-S31. PubMed PMID: 31679725
• Granados A, Chan CL, Ode KL, Moheet A, Moran A, Holl R. Cystic fibrosis related diabetes: Pathophysiology, screening and diagnosis. J Cyst Fibros. 2019 Oct;18 Suppl 2:S3-S9. PubMed PMID: 31679726
• Vigers T, Chan CL, Snell-Bergeon J, Bjornstad P, Zeitler PS, Forlenza G, Pyle L. cgmanalysis: An R package for descriptive analysis of continuous glucose monitor data. PLoS One. 2019;14(10):e0216851. PubMed PMID: 31603912
• Arslanian S, El Ghormli L, Young Kim J, Bacha F, Chan C, Ismail HM, Levitt Katz LE, Levitsky L, Tryggestad JB, White NH. The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in ß-Cell Function in TODAY. Diabetes Care. 2019 Jan;42(1):164-172. PubMed PMID: 30455329
• Li A, Vigers T, Pyle L, Zemanick E, Nadeau K, Sagel SD, Chan CL. Continuous glucose monitoring in youth with cystic fibrosis treated with lumacaftor-ivacaftor. J Cyst Fibros. 2019 Jan;18(1):144-149. PubMed PMID: 30104123
• Li A, Vigers T, Pyle L, Zemanick E, Nadeau K, Sagel SD, Chan CL. Continuous glucose monitoring in youth with cystic fibrosis treated with lumacaftor-ivacaftor. J Cyst Fibros. 2019 Jan;18(1):144-149. PubMed PMID: 30104123
• Simon SL, Vigers T, Campbell K, Pyle L, Branscomb R, Nadeau KJ, Chan CL. Reduced insulin sensitivity is correlated with impaired sleep in adolescents with cystic fibrosis. Pediatr Diabetes. 2018 Nov;19(7):1183-1190. PubMed PMID: 30022572
• Chan CL, Vigers T, Pyle L, Zeitler PS, Sagel SD, Nadeau KJ. Continuous glucose monitoring abnormalities in cystic fibrosis youth correlate with pulmonary function decline. J Cyst Fibros. 2018 Nov;17(6):783-790. PubMed PMID: 29580828
• Chan CL, Hope E, Thurston J, Vigers T, Pyle L, Zeitler PS, Nadeau KJ. Hemoglobin A(1c) Accurately Predicts Continuous Glucose Monitoring-Derived Average Glucose in Youth and Young Adults With Cystic Fibrosis. Diabetes Care. 2018 Jul;41(7):1406-1413. PubMed PMID: 29674323
• Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ. Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls. J Endocr Soc. 2018 Jun 1;2(6):547-562. PubMed PMID: 29942919
• Arslanian S, El Ghormli L, Kim JY, Bacha F, Chan C, Ismail HM, Levitt Katz LE, Levitsky L, Tryggestad JB, White NH. The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in ß-Cell Function in TODAY. Diabetes Care. 2018 Nov 19. [Epub ahead of print] PubMed PMID: 30455329
• Chan CL. Use of Continuous Glucose Monitoring in Youth-Onset Type 2 Diabetes. Curr Diab Rep. 2017 Sep;17(9):66. PubMed PMID: 28726154
• McCandless SE, Yanovski JA, Miller J, Fu C, Bird LM, Salehi P, Chan CL, Stafford D, Abuzzahab MJ, Viskochil D, Barlow SE, Angulo M, Myers SE, Whitman BY, Styne D, Roof E, Dykens EM, Scheimann AO, Malloy J, Zhuang D, Taylor K, Hughes TE, Kim DD, Butler MG. Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2017 Dec;19(12):1751-1761. PubMed PMID: 28556449
• Chan CL, Pyle L, Kelsey MM, Newnes L, Baumgartner A, Zeitler PS, Nadeau KJ. Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes. Pediatr Diabetes. 2017 Nov;18(7):629-636. PubMed PMID: 27873436
• Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2017 Sep;18(6):470-477. PubMed PMID: 27503277
• Chan CL, Pyle L, Kelsey M, Newnes L, Zeitler PS, Nadeau KJ. Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin. Pediatr Diabetes. 2016 May;17(3):206-11. PubMed PMID: 25652226
• Chan CL, Pyle L, Kelsey MM, Newnes L, Baumgartner A, Zeitler PS, Nadeau KJ. Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes. Pediatr Diabetes. 2016 Nov 22. [Epub ahead of print] PubMed PMID: 27873436
• Chan CL, Pyle L, Morehead R, Baumgartner A, Cree-Green M, Nadeau KJ. The role of glycemia in insulin resistance in youth with type 1 and type 2 diabetes. Pediatr Diabetes. 2016 Aug 9. [Epub ahead of print] PubMed PMID: 27503277
• Chan CL, Pyle L, Kelsey M, Newnes L, Zeitler PS, Nadeau KJ. Screening for type 2 diabetes and prediabetes in obese youth: evaluating alternate markers of glycemia - 1,5-anhydroglucitol, fructosamine, and glycated albumin. Pediatr Diabetes. 2015 Feb 5. [Epub ahead of print] PubMed PMID: 25652226
• Chan CL, Pyle L, Newnes L, Nadeau KJ, Zeitler PS, Kelsey MM. Continuous glucose monitoring and its relationship to hemoglobin A1c and oral glucose tolerance testing in obese and prediabetic youth. J Clin Endocrinol Metab. 2015 Mar;100(3):902-10. PubMed PMID: 25532041
• Chan CL, Taki I, Dong F, Hoffman M, Norris JM, Klingensmith G, Rewers MJ, Steck AK. Comparison of Metabolic Outcomes in Children Diagnosed with Type 1 Diabetes Through Research Screening (Diabetes Autoimmunity Study in the Young [DAISY]) Versus in the Community. Diabetes Technol Ther. 2015 Sep;17(9):649-56. PubMed PMID: 26317880
• Chan CL, Pyle L, Newnes L, Nadeau KJ, Zeitler PS, Kelsey MM. Continuous Glucose Monitoring and its Relationship to Hemoglobin A1c and Oral Glucose Tolerance Testing in Obese and Prediabetic Youth. J Clin Endocrinol Metab. 2014 Dec 22;:jc20143612. [Epub ahead of print] PubMed PMID: 25532041
• Chan CL, McFann K, Newnes L, Nadeau KJ, Zeitler PS, Kelsey M. Hemoglobin A1c assay variations and implications for diabetes screening in obese youth. Pediatr Diabetes. 2014 Dec;15(8):557-63. PubMed PMID: 24636682
• Chan CL, McFann K, Taylor L, Wright D, Zeitler PS, Barker JM. Congenital adrenal hyperplasia and the second newborn screen. J Pediatr. 2013 Jul;163(1):109-13.e1. PubMed PMID: 23414665
• Love-Osborne KA, Sheeder J, Svircev A, Chan C, Zeitler P, Nadeau KJ. Use of glycosylated hemoglobin increases diabetes screening for at-risk adolescents in primary care settings. Pediatr Diabetes. 2013 Nov;14(7):512-8. PubMed PMID: 23659706

Professional Memberships

• The Endocrine Society (ENDO), Member
• Pediatric Endocrine Society (LWPES), Member
• American Diabetes Association (ADA), Member
• American Academy of Pediatrics (AAP), Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Children's Colorado Outpatient Care at Uptown - Denver
1830 Franklin St
Denver, CO 80218
720-777-1360

CU Anschutz Barbara Davis Center for Diabetes Pediatric Clinic
1775 Aurora Ct
Suite A140
Aurora, CO 80045
303-724-2323

Hospital Affiliation

• Children's Hospital Colorado
• University of Colorado Hospital

Center Affiliations

• Barbara Davis Center for Childhood Diabetes

Specialty Information

Specialties

• Pediatrics, Board Certification (2009)
• Pediatric Endocrinology, Board Certification (2013)