Ying Yang, Michael T Aubrey, Gongliang Zhang, Yun Ji and Brian M Freed. HLA-B*1586 is a novel, hybrid HLA-B15/B22 allele with unique serology and haplotypic association. Tissue Antigens 67:176, 2006.
IDENTIFICATION OF THE NOVEL HLA-A*6833 WAS COMPLICATED BY LACK OF EXON INFORMATION. Lora L Offord, CHS1 , Michael T Aubrey, CHS and Brian M Freed, DABHI, PhD
Stephen C. Dreskin a, Mark T. Tripputi, Michael T. Aubrey, S. Shahzad Mustafa, Dan Atkins, Harvey L. Leo, Benjamin Song, Darcy Schlichting, Hanna Talwar, Qian Wang, Brian M. Freed. Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II. Clinical Immunology 137, 366–373, 2010.
Association of the HLA–DRB1 Epitope LA67, 74 With Rheumatoid Arthritis and Citrullinated Vimentin Binding. Brian M. Freed, Ronald P. Schuyler, and Michael T. Aubrey. ARTHRITIS & RHEUMATISM
Vol. 63, No. 12, December 2011, pp 3733–3739.
Mack CL,Anderson KM, Aubrey MT, Sokol RJ, Freed BM. Lack of HLA predominance and HLA shared epitopes in biliary atresia. SpringerPlus. 2013. 2:42.
Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, Freed BM. Multiple HLA epitopes contribute to type 1 diabetes susceptibility. Diabetes. 2014 Jan;63(1):323-31. PubMed PMID: 24357703
Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, Freed BM. Multiple HLA epitopes contribute to type 1 diabetes susceptibility. 2014. Diabetes 63:323.
Anderson KM, Roark CL, Portas M, Aubrey MT, Rosloniec EF, Freed BM. A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles. Arthritis Rheumatol. 2016 Jul;68(7):1627-36. PubMed PMID: 26866513
Roark CL, Anderson KM, Aubrey MT, Rosloniec EF, Freed BM. Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis. J Autoimmun. 2016 Aug;72:25-32. PubMed PMID: 27143337
https://doi.org/10.1016/j.humimm.2017.06.073
Danielle R.Crow, Michael T.Aubrey, Christina L.Roark, Loren A.Gragert, Brian Freed. HLA homozygosity is significantly more associated with lymphoma than acute myelogenous leukemia. Human Immunology. 2017. Volume 78, Supplement, September 2017, Page 64
ASH 311
Class II HLA Epitope Level Mismatch Can Predict Chronic Graft-Versus-Host Disease and Survival Following Haploidentical Transplant Using Post-Transplant Cyclophosphamide
Program: Oral and Poster Abstracts
Type: Oral
Session: 732. Clinical Allogeneic Transplantation: Results: Optimizing Outcomes After Allogeneic Transplantation
Hematology Disease Topics & Pathways:
Biological, Adult, Therapies, Study Population, Clinically relevant, transplantation
Sunday, December 2, 2018: 8:30 AM
Grand Hall A (Manchester Grand Hyatt San Diego)
Scott R Solomon, MD1, Michael T Aubrey, CHS2*, Cheri Anobile2*, Xu Zhang, PhD3*, Brian M Freed, PhD, DABHI2*, Lawrence E Morris, MD1, H. Kent Holland, MD1, Melhem Solh, MD1 and Asad Bashey, MD, PhD1
Solomon SR, Aubrey MT, Zhang X, Piluso A, Freed BM, Brown S, Jackson KC, Morris LE, Holland HK, Solh MM, Bashey A. Selecting the Best Donor for Haploidentical Transplant: Impact of HLA, Killer Cell Immunoglobulin-Like Receptor Genotyping, and Other Clinical Variables. Biol Blood Marrow Transplant. 2018 Apr;24(4):789-798. PubMed PMID: 29355721
ASHI P162
PROGRESS TOWARDS GENE EDITING OF HLA-DRB1*04:01 BY CRISPR/CAS9
Christina Roark1
, Kirsten Anderson2
, Michael T. Aubrey1
, Brian M. Freed1
Solomon SR, Aubrey MT, Zhang X, Jackson KC, Morris LE, Holland HK, Solh MM, Bashey A. Class II HLA mismatch improves outcomes following haploidentical transplantation with posttransplant cyclophosphamide. Blood Adv. 2020 Oct 27;4(20):5311-5321. PubMed PMID: 33108457
Davis S, Wiebe C, Campbell K, Anobile C, Aubrey M, Stites E, Grafals M, Pomfret E, Nickerson P, Cooper JE. Adequate tacrolimus exposure modulates the impact of HLA class II molecular mismatch: a validation study in an American cohort. Am J Transplant. 2021 Jan;21(1):322-328. PubMed PMID: 32888256
Scott R. Solomon, Michael T Aubrey, Xu Zhang, Katelin C Jackson, Christina L Roark, Brian M Freed, Lawrence E Morris, H. Kent Holland, Asad Bashey, Melhem Solh. Recipient HLA-B Leader Genotype, and Its Relationship to Total KIR Missing Ligand, Informs Relapse and Survival
Following Haploidentical Transplantation Using Post-Transplant Cyclophosphamide. Blood 138 (2021) 418–420
Roark CL, Ho BE, Aubrey MT, Anobile C, Israeli S, Phang TL, Braxton D, Ho AP, Freed BM. HLA homozygosity is associated with Non-Hodgkin lymphoma. Hum Immunol. 2022 Oct;83(10):730-735. PubMed PMID: 35953408
Solomon SR, Aubrey MT, Zhang X, Jackson KC, Roark CL, Freed BM, Morris LE, Holland HK, Solh MM, Bashey A. Lineage-Specific Relapse Prediction After Haploidentical Transplantation With Post-Transplant Cyclophosphamide Based on Recipient HLA-B-Leader Genotype and HLA-C-Group KIR Ligand. Transplant Cell Ther. 2022 Sep;28(9):601.e1-601.e8. PubMed PMID: 35788088
Melhem Solh, MD, Michael T Aubrey, Xu Zhang, Asad Bashey, Brian M Freed, Christina L Roark, Lizamarie Bachier-Rodriguez, Lawrence E. Morris Jr, H. Kent Holland, MD, Scott R. Solomon. HLA Evolutionary Divergence (HED) Informs the Effect of HLA-B-Loci Mismatch on Relapse and Disease Free Survival
after Haploidentical Hematopoietic Cell Transplantation (Haplo) with Post-Transplant Cyclophosphamide (PTCY). Blood (2022) 140 (Supplement 1): 7738–7739.
J. Lee, J. Li, M. Aubrey, C.L. Roark, B. Freed. PREDICTING EPLET MISMATCHES USING DONOR LOW RESOLUTION TYPING AND HAPLOSTATS. ASHI National Meeting Poster Session. 2022.
Selecting the Best Transplant Donor (HLA-Matched vs. Haploidentical) for Patients with Lymphoid Malignancy Based on Recipient HLA-B-Leader Genotype. Scott R. Solomon, Lizamarie Bachier-Rodriguez, Xu Zhang, Michael T. Aubrey, Christina L. Roark, Lawrence E. Morris, Jr., H. Kent Holland, Asad Bashey, Melhem Solh. Blood (2022) 140 (Supplement 1): 4861–4862. https://doi.org/10.1182/blood-2022-158759
Schreiber AR, Santos J, McMahon B, Buckner TW, Olson C, Alberti MO, Guimarães-Young A, Knoeckel C, Broussard L, Aubrey M, Palmer BE, Weiss E, Connors GR, Brunner S, Wisell JA, Pacheco T, Aisner DL, Gutman JA. A Case of Fetal-Induced Graft-versus-Host Disease. N Engl J Med. 2023 Aug 17;389(7):668-670. PubMed PMID: 37585636
Solomon, SR, Aubrey, MT, Bachier-Rodriguez, L, Solh, MM, Jackson, KC, Zhang, X, Roark, C, Holland, HK, Morris, L, Bashey, A. mpact of an HLA-DPB1 Non-Permissive Mismatch By the Revised T Cell Epitope (TCE)-Core Algorithm on Survival Following Haploidentical Donor Transplantation (HIDT) with Post-Transplant Cyclophosphamide (PTCy). ASH Annual Meeting.