Jed Friedman, PhD, MS

Recognitions

• Distinguished Graduate Teaching Award, Kent State University Graduate College (1987)
  
• Academic Fellowship Award, Kent State University Graduate College (1988)
  
• NIH INdividual National Research Service Award (NRSA), NIH-NIDDK (1990)
  NIDDK-F32-DK08477
• Juvenile Diabetes Foundation (JDF) Career Development Award, Juvenile Diabetes Foundation (1993)
  
• New Investigator Award, American College of Sports Medicine (ACSM) (1994)
  
• NATO International Scientific Exchange Collaborative Research Grant, NATO (1996)
  
• FIRST Award, NIH-R29 (1996)
  
• Young Investigator Outstanding Abstract Award, American Diabetes Association (ADA) (1996)
  
• New Investigator Travel Award, Advancing the Genetics of Obesity Workshop, NIH-HIDDK (1997)
  
• Okamoto Young Investigator Award, International Society for SHR & Cardiovascular Genetics (1997)
  
• Arthur C. Guyton Award for Excellence in Integrative Physiology, American Physiological Society (1999)
  
• First Prize-Outstanding Paper, 3rd International Congress for Society for Developmental Origins of Health & Disease (DoHAD), Toronto, CN (2005)
  
• Facilitator, NIH Panel Consensus Conference on: The Intrauterine Environment -Long-Term Consequences for Obesity & Metabolic Disease (2005)
  
• Recipient, Joseph Hoet Prize, European Society for the Study of Diabetes & Pregnancy (2008)
  
• President, American Diabetes Association Council on Pregnancy & Reproductive Health (2010)
  2 year term (2010-2012)
• Co-Chairman & Organizer, 4th International Aspen Perinatal Biology Symposium, Aspen, CO (2010)
  
• Keynote Lecturer, 14th International Congress of Endocrinology (ICE-2010) Kyoto, Japan (2010)
  
• Bill and Melinda Gates Grand Challenge in Global Health Award , Gates Foundation (2011)
  
• NIH Panelist, NIDDK Workshop on Longitudinal Birth Cohort: Role of the Intrauterine Environment (2010)
  

Research Interests

Research focus areas include: Pregnancy, Neonatal, Gestational Diabetes, Early Onset/Childhood Obesity

Publications

• Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW Jr. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E352-64. PubMed PMID: 22649066
• McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE. Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. Diabetes. 2012 Oct;61(10):2495-505. PubMed PMID: 22698915
• Rahman SM, Janssen RC, Choudhury M, Baquero KC, Aikens RM, de la Houssaye BA, Friedman JE. CCAAT/enhancer-binding protein ß (C/EBPß) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice. J Biol Chem. 2012 Oct 5;287(41):34349-60. PubMed PMID: 22902781
• Suter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, Friedman JE, Grove KL, Tackett AJ, Aagaard KM. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J. 2012 Dec;26(12):5106-14. PubMed PMID: 22982377
• Qadri I, Choudhury M, Rahman SM, Knotts TA, Janssen RC, Schaack J, Iwahashi M, Puljak L, Simon FR, Kilic G, Fitz JG, Friedman JE. Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein ß. J Biol Chem. 2012 Oct 26;287(44):37340-51. PubMed PMID: 22955269
• Dubois BN, O'Tierney-Ginn P, Pearson J, Friedman JE, Thornburg K, Cherala G. Maternal obesity alters feto-placental cytochrome P4501A1 activity. Placenta. 2012 Dec;33(12):1045-51. PubMed PMID: 23046808
• Grant WF, Nicol LE, Thorn SR, Grove KL, Friedman JE, Marks DL. Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One. 2012;7(10):e48119. PubMed PMID: 23118937
• Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
• Rahman SM, Choudhury M, Janssen RC, Baquero KC, Miyazaki M, Friedman JE. CCAAT/enhancer binding protein ß deletion increases mitochondrial function and protects mice from LXR-induced hepatic steatosis. Biochem Biophys Res Commun. 2013 Jan 4;430(1):336-9. PubMed PMID: 23159614
• Brumbaugh DE, Tearse P, Cree-Green M, Fenton LZ, Brown M, Scherzinger A, Reynolds R, Alston M, Hoffman C, Pan Z, Friedman JE, Barbour LA. Intrahepatic Fat Is Increased in the Neonatal Offspring of Obese Women with Gestational Diabetes. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260099
• Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):167-88. PubMed PMID: 22752723
• Choudhury M, Friedman JE. Epigenetics and microRNAs in preeclampsia. Clin Exp Hypertens. 2012;34(5):334-41. PubMed PMID: 22468840
• Barbour LA, Van Pelt RE, Brumbaugh DE, Hernandez TL, Friedman JE. Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284. Diabetes Care. 2012 Mar;35(3):e28; author reply e30. PubMed PMID: 22355031
• Martin-Murphy BV, You Q, Wang H, De La Houssaye BA, Reilly TP, Friedman JE, Ju C. Mice Lacking Natural Killer T Cells Are More Susceptible to Metabolic Alterations following High Fat Diet Feeding. PLoS One. 2014 Jan 20;9(1):e80949. PubMed PMID: 24465369
• Brumbaugh DE, Friedman JE. Developmental origins of nonalcoholic fatty liver disease. Pediatr Res. 2014 Jan;75(1-2):140-7. PubMed PMID: 24192698
• Hernandez TL, Anderson MA, Chartier-Logan C, Friedman JE, Barbour LA. Strategies in the nutritional management of gestational diabetes. Clin Obstet Gynecol. 2013 Dec;56(4):803-15. PubMed PMID: 24047934
• Newsom SA, Boyle KE, Friedman JE. Sirtuin 3: A major control point for obesity-related metabolic diseases?. Drug Discov Today Dis Mech. 2013 Jun 1;10(1-2):e35-e40. PubMed PMID: 23997790
• Martin-Murphy BV, You Q, Wang H, De La Houssaye BA, Reilly TP, Friedman JE, Ju C. Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding. PLoS One. 2014;9(1):e80949. PubMed PMID: 24465369
• Hernandez TL, Van Pelt RE, Anderson MA, Daniels LJ, West NA, Donahoo WT, Friedman JE, Barbour LA. A higher-complex carbohydrate diet in gestational diabetes mellitus achieves glucose targets and lowers postprandial lipids: a randomized crossover study. Diabetes Care. 2014 May;37(5):1254-62. PubMed PMID: 24595632
• Roberts VH, Pound LD, Thorn SR, Gillingham MB, Thornburg KL, Friedman JE, Frias AE, Grove KL. Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates. FASEB J. 2014 Jun;28(6):2466-77. PubMed PMID: 24563374
• Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 2014 Aug;63(8):2702-13. PubMed PMID: 24705404
• Hambidge KM, Krebs NF, Westcott JE, Garces A, Goudar SS, Kodkany BS, Pasha O, Tshefu A, Bose CL, Figueroa L, Goldenberg RL, Derman RJ, Friedman JE, Frank DN, McClure EM, Stolka K, Das A, Koso-Thomas M, Sundberg S, Preconception Trial Group. Preconception maternal nutrition: a multi-site randomized controlled trial. BMC Pregnancy Childbirth. 2014 Mar 20;14:111. PubMed PMID: 24650219
• El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol. 2014 Jul 15;193(2):597-609. PubMed PMID: 24928992
• Heerwagen MJ, Stewart MS, de la Houssaye BA, Janssen RC, Friedman JE. Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice. PLoS One. 2013;8(6):e67791. PubMed PMID: 23825686
• Boyle KE, Hwang H, Janssen RC, DeVente JM, Barbour LA, Hernandez TL, Mandarino LJ, Lappas M, Friedman JE. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle. PLoS One. 2014;9(9):e106872. PubMed PMID: 25216282
• Grab DJ, Nenortas E, Bakshi RP, Nikolskaia OV, Friedman JE, Shapiro TA. Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs. Parasitol Int. 2013 Oct;62(5):461-3. PubMed PMID: 23811202
• Stewart MS, Heerwagen MJ, Friedman JE. Developmental programming of pediatric nonalcoholic fatty liver disease: redefining the"first hit". Clin Obstet Gynecol. 2013 Sep;56(3):577-90. PubMed PMID: 23835912
• Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy C, Garza NG, Hay W, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Jan 4. [Epub ahead of print] PubMed PMID: 28053000
• Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 Jan;105(1):234-236. PubMed PMID: 28049665
• Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE. Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J. 2016 Dec 22. [Epub ahead of print] PubMed PMID: 28007783
• Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2016 Dec 13. [Epub ahead of print] PubMed PMID: 27876761
• Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM. Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model. Sci Rep. 2016 Nov 4;6:36123. PubMed PMID: 27811965
• Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2016 Oct 26. [Epub ahead of print] PubMed PMID: 27780972
• McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 6;1(16):e86612. PubMed PMID: 27734025
• Boyle KE, Friedman JE, Janssen RC, Underkofler C, Houmard JA, Rasouli N. Metabolic Inflexibility with Obesity and the Effects of Fenofibrate on Skeletal Muscle Fatty Acid Oxidation. Horm Metab Res. 2016 Aug 2. [Epub ahead of print] PubMed PMID: 27485593
• Shapiro AL, Boyle KE, Dabelea D, Patinkin ZW, De la Houssaye B, Ringham BM, Glueck DH, Barbour LA, Norris JM, Friedman JE. Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project. PLoS One. 2016 Jul 14;11(7):e0159575. PubMed PMID: 27414406
• Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016 May 4;11(5):e0155282. PubMed PMID: 27145222
• Lemas DJ, Young BE, Baker PR 2nd, Tomczik AC, Soderborg TK, Hernandez TL, de la Houssaye BA, Robertson CE, Rudolph MC, Ir D, Patinkin ZW, Krebs NF, Santorico SA, Weir T, Barbour LA, Frank DN, Friedman JE. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr. 2016 May;103(5):1291-300. PubMed PMID: 27140533
• Shapiro AL, Kaar JL, Crume TL, Starling AP, Siega-Riz AM, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D. Maternal diet quality in pregnancy and neonatal adiposity: the Healthy Start Study. Int J Obes (Lond). 2016 Jul;40(7):1056-62. PubMed PMID: 27133623
• Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016 Apr 20;11(4):e0152877. PubMed PMID: 27097220
• Rahman SM, Baquero KC, Choudhury M, Janssen RC, de la Houssaye BA, Sun M, Miyazaki-Anzai S, Wang S, Moustaid-Moussa N, Miyazaki M, Friedman JE. C/EBPß in bone marrow is essential for diet induced inflammation, cholesterol balance, and atherosclerosis. Atherosclerosis. 2016 Jul;250:172-9. PubMed PMID: 27072340
• Soderborg TK, Borengasser SJ, Barbour LA, Friedman JE. Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle. Diabetologia. 2016 May;59(5):895-906. PubMed PMID: 26843076
• Boyle KE, Patinkin ZW, Shapiro AL, Baker PR 2nd, Dabelea D, Friedman JE. Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2016 Mar;65(3):647-59. PubMed PMID: 26631736
• Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan;39(1):39-42. PubMed PMID: 26223240
• Barbour LA, Hernandez TL, Reynolds RM, Reece MS, Chartier-Logan C, Anderson MK, Kelly T, Friedman JE, Van Pelt RE. Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life. Pediatr Obes. 2016 Aug;11(4):264-71. PubMed PMID: 26198967
• Mulligan C, and Friedman JE. Development of the Infant Gut Microbiome: Implications for Childhood Obesity. In: Childhood Obesity: Causes, Consequences and Intervention Approaches, Goran M (Ed), 2nd ed. Taylor & Francis, 2016
• Baker P, and Friedman JE. Fetal Origins in Adult Disease, In: Fetal and Neonatal Physiology, Polin, Abman, Benitz, and Rowitch (Eds). 5th ed. Elsevier, 2016. .
• Boyle KE, Newsom SA, Janssen RC, Lappas M, Friedman JE. Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. J Clin Endocrinol Metab. 2013 Oct;98(10):E1601-9. PubMed PMID: 23956348
• Mulligan CM, Friedman JE. Maternal modifiers of the infant gut microbiota: metabolic consequences. J Endocrinol. 2017 Oct;235(1):R1-R12. PubMed PMID: 28751453
• Young BE, Patinkin Z, Palmer C, de la Houssaye B, Barbour LA, Hernandez T, Friedman JE, Krebs NF. Human milk insulin is related to maternal plasma insulin and BMI: but other components of human milk do not differ by BMI. Eur J Clin Nutr. 2017 Sep;71(9):1094-1100. PubMed PMID: 28513622
• Friedman JE. The maternal microbiome: Cause or consequence of obesity risk in the next generation?. Obesity (Silver Spring). 2017 Mar;25(3):497-498. PubMed PMID: 28177586
• Friedman JE. The maternal microbiome: Cause or consequence of obesity risk in the next generation?. Obesity (Silver Spring). 2017 Mar;25(3):497-498. PubMed PMID: 28177586
• Shapiro ALB, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D. Infant Adiposity is Independently Associated with a Maternal High Fat Diet but not Related to Niacin Intake: The Healthy Start Study. Matern Child Health J. 2017 Aug;21(8):1662-1668. PubMed PMID: 28161859
• Boyle KE, Friedman JE, Janssen RC, Underkofler C, Houmard JA, Rasouli N. Metabolic Inflexibility with Obesity and the Effects of Fenofibrate on Skeletal Muscle Fatty Acid Oxidation. Horm Metab Res. 2017 Jan;49(1):50-57. PubMed PMID: 28103623
• Brumbaugh DE, Tearse P, Cree-Green M, Fenton LZ, Brown M, Scherzinger A, Reynolds R, Alston M, Hoffman C, Pan Z, Friedman JE, Barbour LA. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr. 2013 May;162(5):930-6.e1. PubMed PMID: 23260099
• Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Mar;232(3):475-491. PubMed PMID: 28053000
• Rahman SM, Choudhury M, Janssen RC, Baquero KC, Miyazaki M, Friedman JE. CCAAT/enhancer binding protein ß deletion increases mitochondrial function and protects mice from LXR-induced hepatic steatosis. Biochem Biophys Res Commun. 2013 Jan 4;430(1):336-9. PubMed PMID: 23159614
• Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 Jan;105(1):234-236. PubMed PMID: 28049665
• Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
• Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE. Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J. 2017 Apr;31(4):1434-1448. PubMed PMID: 28007783
• Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2017 Apr;41(4):510-517. PubMed PMID: 27876761
• Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM. Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model. Sci Rep. 2016 Nov 4;6:36123. PubMed PMID: 27811965
• Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):81-96. PubMed PMID: 27780972
• McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE. Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight. 2016 Oct 6;1(16):e86612. PubMed PMID: 27734025
• Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 Oct 26;9(1):4462. PubMed PMID: 30367045
• Friedman JE. Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?. Diabetes. 2018 Nov;67(11):2137-2151. PubMed PMID: 30348820
• Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Sep 28. [Epub ahead of print] PubMed PMID: 30337225
• Borengasser SJ, Baker PR 2nd, Kerns ME, Miller LV, Palacios AP, Kemp JF, Westcott JE, Morrison SD, Hernandez TL, Garces A, Figueroa L, Friedman JE, Hambidge KM, Krebs NF. Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese. Nutrients. 2018 Sep 11;10(9). PubMed PMID: 30208589
• Baker PR 2nd, Friedman JE. Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. J Clin Invest. 2018 Aug 31;128(9):3692-3703. PubMed PMID: 30168806
• Young BE, Levek C, Reynolds RM, Rudolph MC, MacLean P, Hernandez TL, Friedman JE, Krebs NF. Bioactive components in human milk are differentially associated with rates of lean and fat mass deposition in infants of mothers with normal vs. elevated BMI. Pediatr Obes. 2018 Oct;13(10):598-606. PubMed PMID: 30092608
• Collins CB, Puthoor PR, Nguyen TT, Jedlicka P, Friedman JE, de Zoeten EF. C/EBPß deletion promotes expansion of poorly functional intestinal regulatory T cells. J Crohns Colitis. 2018 Jul 31. [Epub ahead of print] PubMed PMID: 30085016
• Barbour LA, Scifres C, Valent AM, Friedman JE, Buchanan TA, Coustan D, Aagaard K, Thornburg KL, Catalano PM, Galan HL, Hay WW Jr, Frias AE, Shankar K, Simmons RA, Moses RG, Sacks DA, Loeken MR. A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes. Am J Obstet Gynecol. 2018 Oct;219(4):367.e1-367.e7. PubMed PMID: 29959933
• Barbour LA, Farabi SS, Friedman JE, Hirsch NM, Reece MS, Van Pelt RE, Hernandez TL. Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy. Obesity (Silver Spring). 2018 Aug;26(8):1347-1356. PubMed PMID: 29931812
• Heerwagen MJR, Gumina DL, Hernandez TL, Van Pelt RE, Kramer AW, Janssen RC, Jensen DR, Powell TL, Friedman JE, Winn VD, Barbour LA. Placental lipoprotein lipase activity is positively associated with newborn adiposity. Placenta. 2018 Apr;64:53-60. PubMed PMID: 29626981
• Pace RM, Prince AL, Ma J, Belfort BDW, Harvey AS, Hu M, Baquero K, Blundell P, Takahashi D, Dean T, Kievit P, Sullivan EL, Friedman JE, Grove K, Aagaard KM. Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates. BMC Microbiol. 2018 Apr 5;18(1):28. PubMed PMID: 29621980
• Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun. 2018 Mar;2(3):313-328. PubMed PMID: 29507905
• Nash MJ, Frank DN, Friedman JE. Early Microbes Modify Immune System Development and Metabolic Homeostasis-The "Restaurant" Hypothesis Revisited. Front Endocrinol (Lausanne). 2017;8:349. PubMed PMID: 29326657
• Baker PR 2nd, Patinkin ZW, Shapiro ALB, de la Houssaye BA, Janssen RC, Vanderlinden LA, Dabelea D, Friedman JE. Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain. Sci Rep. 2017 Dec 22;7(1):18095. PubMed PMID: 29273781
• Rudolph MC, Jackman MR, Presby DM, Houck JA, Webb PG, Johnson GC, Soderborg TK, de la Houssaye BA, Yang IV, Friedman JE, MacLean PS. Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes. 2018 Apr;67(4):651-661. PubMed PMID: 29138256
• Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE. Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. Mol Metab. 2017 Nov;6(11):1503-1516. PubMed PMID: 29107296
• Baker PR 2nd, Patinkin Z, Shapiro AL, De La Houssaye BA, Woontner M, Boyle KE, Vanderlinden L, Dabelea D, Friedman JE. Maternal obesity and increased neonatal adiposity correspond with altered infant mesenchymal stem cell metabolism. JCI Insight. 2017 Nov 2;2(21). [Epub ahead of print] PubMed PMID: 29093265
• Mulligan CM, Friedman JE. Maternal modifiers of the infant gut microbiota: metabolic consequences. J Endocrinol. 2017 Oct;235(1):R1-R12. PubMed PMID: 28751453
• Young BE, Patinkin Z, Palmer C, de la Houssaye B, Barbour LA, Hernandez T, Friedman JE, Krebs NF. Human milk insulin is related to maternal plasma insulin and BMI: but other components of human milk do not differ by BMI. Eur J Clin Nutr. 2017 Sep;71(9):1094-1100. PubMed PMID: 28513622
• Friedman JE. The maternal microbiome: Cause or consequence of obesity risk in the next generation?. Obesity (Silver Spring). 2017 Mar;25(3):497-498. PubMed PMID: 28177586
• Shapiro ALB, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D. Infant Adiposity is Independently Associated with a Maternal High Fat Diet but not Related to Niacin Intake: The Healthy Start Study. Matern Child Health J. 2017 Aug;21(8):1662-1668. PubMed PMID: 28161859
• Boyle KE, Friedman JE, Janssen RC, Underkofler C, Houmard JA, Rasouli N. Metabolic Inflexibility with Obesity and the Effects of Fenofibrate on Skeletal Muscle Fatty Acid Oxidation. Horm Metab Res. 2017 Jan;49(1):50-57. PubMed PMID: 28103623
• Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Mar;232(3):475-491. PubMed PMID: 28053000
• Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 Jan;105(1):234-236. PubMed PMID: 28049665
• Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE. Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J. 2017 Apr;31(4):1434-1448. PubMed PMID: 28007783
• Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2017 Apr;41(4):510-517. PubMed PMID: 27876761
• Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):81-96. PubMed PMID: 27780972

Professional Memberships

• School of Medicine Dean's Strategic INfrastructure Review Committee (SIRC), Member
• UC Denver NIH Child & Maternal Health Clinical & Translational Science Institute, Advisory Board
• Children's Hospital Colorado Strategic Research Initiative, Steering Committee
• Colorado Center for Obesity Research Initiative (CORI), UC Denver SOM, Co-Chair & Founding Member
• Neuroscience Faculty Search Committee, UC Denver SOM Division of Adult Endocrinology, Chariman
• UC Denver SOM Center for Pre-maturity, Executive Committee
• UC Denver NIH Building Interdisciplinary Research Women's Health Careers, Steering Committee
• Dean's Distinguished Lecture Series Selection Committee, Member
• UC Denver NIH Pediatric Nutrition Training Program, Steering Committee
• Basic Science Training Committee, NIH Perinatal Biology Training Program, Chair

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital
• Children's Hospital Colorado

Center Affiliations

• Nutrition Obesity Research Center

Specialty Information

Specialties

• Neonatal-Perinatal Medicine

Conditions & Treatments

• Pregnancy and Reproduction - Neonatal Intensive Care
• Pregnancy and Reproduction - Maternal and Fetal Health
• Pregnancy and Reproduction - Gestational Diabetes
• Pregnancy and Reproduction - Pregnancy
• Pregnancy and Reproduction