Kristen Nordenholz, MD

Publications

• Courtney DM, Kline JA, and the PE working group includes Nordenholz, KE. Clinical Features From the History and Physical Examination That Predict the Presence or Absence of Pulmonary Embolism in Symptomatic Emergency Department Patients: Results of a Prospective, Multicenter Study Annals Emerg Med. 2009;xx:xxx. In press
• Nordenholz KE, Ryan, J, Atwood, B and Heard K. “Pulmonary Embolism Risk Stratification: Pulse Oximetry and Pulmonary Embolism Severity Index.” Journal of Emergency Medicine in press 2009.
• Marchick, M Courtney DM, and the PE working group includes Nordenholz, KE. “12-Lead Electrocardiogram Findings of Pulmonary Hypertension Occur More Frequently in Emergency Department Patients With Pulmonary Embolism Than In Patients Without Pulmonary Embolism”. Annals of Emergency Med 2009xx in press
• Kabrhel C, Courtney DM, and the PE working group includes Nordenholz KE. Potential Impact of Adjusting the Threshold of the Quantitative D-dimer Based Upon Pretest Probability of Acute Pulmonary Embolism. et al. Academic Emergency Medicine 2009:16:1-8.
• Nordenholz KE, Courtney DM and the PE working group. “The Likelihood of Acute Pulmonary Embolism in ED patients is Not Lower Among Patients Taking Warfarin”. Accepted for Plenary presentation at Western Regional SAEM Research Conference March 19-21, 2010 in Sonoma CA and accepted for Plenary presentation at Society for Academic Emergency Medicine Annual Meeting Phoenix 2010.
• Nordenholz KE, Hamiel C, Cheng SS et al. “Goal-directed intravenous heparin (IVH) versus subcutaneous heparin (SQH) in preventing thromboembolism in post-surgical SICU patients” presented at International Society for Thrombosis and Haemostasis International Conference July 11-16, 2009 Boston and National Clinical & Translational Research Education Annual Meeting, Washington DC April 14-15 2009.
• Wesley Self and the PE working group, includes Nordenholz, KE. “Pulmonary infiltrates revealed on CT in patients with negative evaluation for pulmonary embolism” Poster presentation at the Society for Academic Emergency Medicine Annual Meeting New Orleans 2009
• Jeffrey Kline and the PE working group includes Nordenholz, KE. “Infrequent Use Of Empiric Anticoagulation For Severe Acute Pulmonary Embolism”. Poster presentation at Society for Academic Emergency Medicine Annual Meeting New Orleans 2009
• Michael Marchick and the PE working group includes Nordenholz, KE. “12-Lead Electrocardiogram Findings of Pulmonary Hypertension Occur More Frequently in Emergency Department Patients With Pulmonary Embolism Than In Patients Without Pulmonary Embolism”. Poster presentation at Society for Academic Emergency Medicine Annual Meeting New Orleans 2009
• Jeffrey Kline and the PE working group includes Nordenholz, KE. “History Of Anxiety Significantly Decreases The Probability Of Pulmonary Embolism In Symptomatic Emergency Department Patients.” Poster presentation at Society for Academic Emergency Medicine Annual Meeting New Orleans 2009
• Michael Marchick, and the PE working group includes Nordenholz, KE. “Empiric Systemic Anticoagulation In Patients With Suspected Pulmonary Embolism.” Poster presentation at Society for Academic Emergency Medicine Annual Meeting New Orleans 2009 and submitted for presentation to International Society for Thrombosis and Haemostasis International Conference July 11-16, 2009 Boston.
• Peter Richman and the PE working group includes Nordenholz, KE. “Influence of Gender on the Clinical Presentation of Venous Thromboembolism (VTE) a Prospective, Multi-center, Observational Study of Emergency Department Patients.” Poster presentation at Society for Academic Emergency Medicine Annual Meeting New Orleans 2009
• Kabrhel C, Courtney DM and the PE Research Consortium includes Nordenholz, KE. Factors Associated With Positive D-dimer Results in Patients Evaluated for Pulmonary Embolism. Academic Emergency Medicine on line 2010, published ahead of print Volume17, Issue 6, 2010. Online ISSN: 1553-2712 Print ISSN: 1069-6563
• Courtney DM, Kline JA, and the PE Research Consortium includes Nordenholz, KE. Clinical Features From the History and Physical Examination That Predict the Presence or Absence of Pulmonary Embolism in Symptomatic Emergency Department Patients: Results of a Prospective, Multicenter Study Annals Emerg Med. 2010; 55:307-315. PMID: 20045580
• Marchick M, Courtney DM, and the PE Research Consortium includes Nordenholz, KE. “12-Lead Electrocardiogram Findings of Pulmonary Hypertension Occur More Frequently in Emergency Department Patients With Pulmonary Embolism Than In Patients Without Pulmonary Embolism”. Annals Emerg Med. 2010; 55:331-335 PMID: 19766353
• Nordenholz KE, Ryan, J, Atwood, B and Heard K. “Pulmonary Embolism Risk Stratification: Pulse Oximetry and Pulmonary Embolism Severity Index.” J Emerg Med. 2009 Sep 16. PMID: 19765942
• Venkatesh AK, Kline JA, Courtney DM and the PE Research Consortium includes Nordenholz, KE. Is the Evaluation of Pulmonary Embolism in the Emergency Department Consistent with a National Quality Measure? Quantifying the Opportunity for Improvement. Arch Int Med In press 2012
• Nordenholz KE. Risk Stratification in Acute Pulmonary Embolism: What Does Gamma Glutamyl Transferase Add? American Journal of Emergency Medicine Editorial In press 2012
• Cheng SS, Nordenholz KE, Matero D et al. Standard subcutaneous dosing of unfractionated heparin for VTE prophylaxis in surgical ICU patients leads to subtherapeutic factor Xa inhibition. Intensive Care Medicine In press 2012 Electronic ISSN: 1432-1238
• Eutermoser M and Nordenholz KE. Testicular Compromise Due to Inguinal Hernia http://escholarship.org/uc/uciem_westjem DOI: 10.5811/westjem.2011.7.2329
• Carlson T, Klem P, Trujillo T, Babilonia K, Madrid S, Whitehill C, Nordenholz K, Misky G. Development and Implementation of a Clinical Care Pathway for Acute VTE Improves Clinical Outcomes and Reduces Cost?. Presented at the Rocky Mountain Hospitalist Medicine Symposium. Denver Colorado 2011
• 2.) Brown T, Pace W, Poydal S, Hassell K, LeBlanc W, Misky G, Cantlon J, Nordenholz K, Thienelt, C; Whitehill C, Klem P; Woodhouse, G. “Reduction in Emergency Department Utilization for Complication of Warfarin Therapy using Organized Anticoagulation Clinics in Academic Medical Institutions” Presented at the International Society for Thrombosis and Haemostasis International Conference July 23-28, 2011 Kyoto Japan
• Nordenholz KE, Carlson T, Misky G, Klem P, Woodhouse G, Trujillo T, Madrid S, Whitehill C. “Development And Implementation Of An Acute Deep Venous Thrombosis Clinical Care Pathway Decreases Admissions And 30-day Emergency Department Returns” Presented at Western Regional SAEM Feb 25, 2011 Keystone CO and oral presentation at Society for Academic Emergency Medicine Annual Meeting Boston June 3, 2011
• 1. Jeffrey Kline and Pulmonary Embolism Research Consortium includes Nordenholz, KE “Randomized Trial of Tenecteplase or Placebo with Low Molecular Weight Heparin for Acute Submassive Pulmonary Embolism: Assessment of Patient-Oriented Cardiopulmonary Outcomes at Three Months”. Accepted as oral abstract at the American College of Cardiology 62nd Annual Scientific Session, March 9 - 11, 2013 San Francisco, CA.
• 2. Kendrick M, Nordenholz K, Sachs P, Suby-Long, T. “Emergency Department Utilization of Computed Tomography Angiography for Pulmonary Thromboembolism”. Presented at Radiology Society of North America National Conference Dec 2012
• Venkatesh AK, Kline JA, Courtney DM and the PE Research Consortium includes Nordenholz, KE. Is the Evaluation of Pulmonary Embolism in the Emergency Department Consistent with a National Quality Measure? Quantifying the Opportunity for Improvement. Arch Int Med 2012; Jul 9;172(13):1028-32 PMID:22664742
• Nordenholz KE. Risk Stratification in Acute Pulmonary Embolism: What Does Gamma Glutamyl Transferase Add? Am J Emerg Med. 2012 Jul;30(6):916-8. Epub 2012 May 31 PMID:22657396
• 3. Cheng SS, Nordenholz KE, Matero D et al. Standard subcutaneous dosing of unfractionated heparin for VTE prophylaxis in surgical ICU patients leads to subtherapeutic factor Xa inhibition. Intensive Care Medicine Med. 2012 Apr;38(4):642-8. Epub 2012 Jan 10.PMID:22231174[PubMed - in process]
• Miller MP, Trujillo TC, Nordenholz KE. Practical considerations in emergency management of bleeding in the setting of target-specific oral anticoagulants. Am J Emerg Med. 2013 Dec 7. [Epub ahead of print] PubMed PMID: 24512886
• Kline JA, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Hernandez J. Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at three months (TOPCOAT): Multicenter double-blind, placebo-controlled randomized trial. J Thromb Haemost. 2014 Jan 31. [Epub ahead of print] PubMed PMID: 24484241
• Stewart LK, Peitz GW, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Kline JA. Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. J Thromb Thrombolysis. 2014 Nov 30. [Epub ahead of print] PubMed PMID: 25433511
• Misky GJ, Carlson T, Thompson E, Trujillo T, Nordenholz K. Implementation of an acute venous thromboembolism clinical pathway reduces healthcare utilization and mitigates health disparities. J Hosp Med. 2014 Jul;9(7):430-5. PubMed PMID: 24639293
• Kline JA, Hernandez J, Hogg MM, Jones AE, Courtney DM, Kabrhel C, Nordenholz KE, Diercks DB, Rondina MT, Klinger JR. Rationale and methodology for a multicentre randomised trial of fibrinolysis for pulmonary embolism that includes quality of life outcomes. Emerg Med Australas. 2013 Dec;25(6):515-26. PubMed PMID: 24224521
• Misky G, Carlson T, Trujillo T, Thompson E, Nordenholz K. Implementation of an Acute Venous Thromboembolism Clinical Pathway Reduces Health Care Utilization and Mitigates Health Disparities. Journal of Hospital Medicine. Feb 2014 in press
• Miller MP, Trujillo TC, Nordenholz KE. Practical considerations in emergency management of bleeding in the setting of target-specific oral anticoagulants. Am J Emerg Med. 2014 Apr;32(4):375-82. PubMed PMID: 24512886
• Kline JA, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Hernandez J. Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial. J Thromb Haemost. 2014 Apr;12(4):459-68. PubMed PMID: 24484241
• Russell FM, Moore CL, Courtney DM, Kabrhel C, Smithline HA, Nordenholz KE, et al. Independent evaluation of a simple clinical prediction rule to identify right ventricular dysfunction in patients with shortness of breath. Am J Emerg Med 2015 http://dx.doi.org/10.1016/j.ajem.2015.01.026.
• Rigual D, Rove M, Robison Z, Nordenholz K, Cumbler E, Dodd G, Borgstede J. Emergency Department CT Expediency: A Time Reduction by Redesign. J Am Coll Radiol. 2016 Feb;13(2):178-81. PubMed PMID: 26507822
• Russell FM, Moore CL, Courtney DM, Kabrhel C, Smithline HA, Nordenholz KE, Richman PB, O'Neil BJ, Plewa MC, Beam DM, Mastouri R, Kline JA. Independent evaluation of a simple clinical prediction rule to identify right ventricular dysfunction in patients with shortness of breath. Am J Emerg Med. 2015 Apr;33(4):542-7. PubMed PMID: 25769797
• Stewart LK, Peitz GW, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Kline JA. Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. J Thromb Thrombolysis. 2015 Aug;40(2):161-6. PubMed PMID: 25433511
• Kim DJ, Byyny RL, Rice CA, Faragher JP, Nordenholz KE, Haukoos JS, Liao MM, Kendall JL. Test Characteristics of Emergency Physician-Performed Limited Compression Ultrasound for Lower-Extremity Deep Vein Thrombosis. J Emerg Med. 2016 Dec;51(6):684-690. PubMed PMID: 27637139
• Rigual D, Rove M, Robison Z, Nordenholz K, Cumbler E, Dodd G, Borgstede J. Emergency Department CT Expediency: A Time Reduction by Redesign. J Am Coll Radiol. 2016 Feb;13(2):178-81. PubMed PMID: 26507822
• Russell FM, Moore CL, Courtney DM, Kabrhel C, Smithline HA, Nordenholz KE, Richman PB, O'Neil BJ, Plewa MC, Beam DM, Mastouri R, Kline JA. Independent evaluation of a simple clinical prediction rule to identify right ventricular dysfunction in patients with shortness of breath. Am J Emerg Med. 2015 Apr;33(4):542-7. PubMed PMID: 25769797
• Stewart LK, Peitz GW, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Kline JA. Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. J Thromb Thrombolysis. 2015 Aug;40(2):161-6. PubMed PMID: 25433511
• Stewart LK, Nordenholz KE, Courtney M, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Kline JA. Comparison of acute and convalescent biomarkers of inflammation in patients with acute pulmonary embolism treated with systemic fibrinolysis vs. placebo. Blood Coagul Fibrinolysis. 2017 Sep 27. [Epub ahead of print] PubMed PMID: 28957940
• Kim DJ, Byyny RL, Rice CA, Faragher JP, Nordenholz KE, Haukoos JS, Liao MM, Kendall JL. Test Characteristics of Emergency Physician-Performed Limited Compression Ultrasound for Lower-Extremity Deep Vein Thrombosis. J Emerg Med. 2016 Dec;51(6):684-690. PubMed PMID: 27637139
• Rigual D, Rove M, Robison Z, Nordenholz K, Cumbler E, Dodd G, Borgstede J. Emergency Department CT Expediency: A Time Reduction by Redesign. J Am Coll Radiol. 2016 Feb;13(2):178-81. PubMed PMID: 26507822
• Kline JA, Pettit KL, Kabrhel C, Courtney DM, Nordenholz KE, Camargo CA. Multicenter registry of United States emergency department patients tested for SARS-CoV-2. J Am Coll Emerg Physicians Open. 2020 Dec;1(6):1341-1348. PubMed PMID: 33392542
• Kline J, Adler D, Alanis N, Bledsoe J, Courtney D, D'Etienne J, B Diercks D, Garrett J, Jones AE, MacKenzie D, Madsen T, Matuskowitz A, Mumma B, Nordenholz K, Pagenhardt J, Runyon M, Stubblefield W, Willoughby C. Study protocol for a multicentre implementation trial of monotherapy anticoagulation to expedite home treatment of patients diagnosed with venous thromboembolism in the emergency department. BMJ Open. 2020 Oct 1;10(10):e038078. PubMed PMID: 33004396
• Nordenholz, K. E., Alvarez, A., Lall, M. D., Stehman, C., Bitter, C. C., Hirsh, E. L., Manfredi, R., Sikora, R. D., Lu, D. W., Sanchez, L. D., Wong, M. L., Bird, S., & Blomkalns, A. L. (2020). Optimizing Wellness in Academic Emergency Medicine. Journal of Wellness, 2(2), article 8, 1-12. doi: 10.18297/jwellness/vol2/iss2/8
• Glober N, Stewart L, Seo J, Kabrhel C, Nordenholz K, Camargo C, Kline J. Incidence and characteristics of arterial thromboemboli in patients with COVID-19. Thromb J. 2021 Dec 20;19(1):104. PubMed PMID: 34930306
• Thomas SA, Puskarich M, Pulia MS, Meltzer AC, Camargo CA, Courtney DM, Nordenholz KE, Kline JA, Kabrhel C. Association between baseline use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers and death among patients tested for COVID-19. J Clin Pharmacol. 2021 Dec 18. [Epub ahead of print] PubMed PMID: 34921684
• Bennett CL, Ogele E, Pettit NR, Bischof JJ, Meng T, Govindarajan P, Camargo CA Jr, Nordenholz K, Kline JA. Multicenter Study of Outcomes Among Persons With HIV Who Presented to US Emergency Departments With Suspected SARS-CoV-2. J Acquir Immune Defic Syndr. 2021 Dec 1;88(4):406-413. PubMed PMID: 34483295
• Kline JA, Adler DH, Alanis N, Bledsoe JR, Courtney DM, d'Etienne JP, Diercks DB, Garrett JS, Jones AE, Mackenzie DC, Madsen T, Matuskowitz AJ, Mumma BE, Nordenholz KE, Pagenhardt J, Runyon MS, Stubblefield WB, Willoughby CB. Monotherapy Anticoagulation to Expedite Home Treatment of Patients Diagnosed With Venous Thromboembolism in the Emergency Department: A Pragmatic Effectiveness Trial. Circ Cardiovasc Qual Outcomes. 2021 Jul;14(7):e007600. PubMed PMID: 34148351
• Thoppil JJ, Stewart LK, Pung L, Nordenholz KE, Camargo CA, Courtney DM, Kline JA. Increased Body Mass Index and Metabolic Syndrome Are Associated with Poor Outcomes in SARS-CoV-2-Positive Emergency Department Patients. J Obes Metab Syndr. 2022 Sep 30;31(3):245-253. PubMed PMID: 35918837
• Lu DW, Lee J, Alvarez A, Sakamoto JT, Bird SB, Sundaram V, Lall MD, Nordenholz KE, Manfredi RA, Blomkalns AL. Drivers of professional fulfillment and burnout among emergency medicine faculty: A national wellness survey by the Society for Academic Emergency Medicine. Acad Emerg Med. 2022 Aug;29(8):987-998. PubMed PMID: 35304931
• Kline JA, Camargo CA Jr, Courtney DM, Kabrhel C, Nordenholz KE, Aufderheide T, Baugh JJ, Beiser DG, Bennett CL, Bledsoe J, Castillo E, Chisolm-Straker M, Goldberg EM, House H, House S, Jang T, Lim SC, Madsen TE, McCarthy DM, Meltzer A, Moore S, Newgard C, Pagenhardt J, Pettit KL, Pulia MS, Puskarich MA, Southerland LT, Sparks S, Turner-Lawrence D, Vrablik M, Wang A, Weekes AJ, Westafer L, Wilburn J. Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021. PLoS One. 2021;16(3):e0248438. PubMed PMID: 33690722
• Thoppil JJ, Courtney DM, McDonald S, Kabrhel C, Nordenholz KE, Camargo CA Jr, Kline JA. SARS-CoV-2 Positivity in Ambulatory Symptomatic Patients Is Not Associated With Increased Venous or Arterial Thrombotic Events in the Subsequent 30 Days. J Emerg Med. 2022 Jun;62(6):716-724. PubMed PMID: 35177286
• Glober N, Stewart L, Seo J, Kabrhel C, Nordenholz K, Camargo C, Kline J. Incidence and characteristics of arterial thromboemboli in patients with COVID-19. Thromb J. 2021 Dec 20;19(1):104. PubMed PMID: 34930306
• Thomas SA, Puskarich M, Pulia MS, Meltzer AC, Camargo CA, Courtney DM, Nordenholz KE, Kline JA, Kabrhel C. Association Between Baseline Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Death Among Patients Tested for COVID-19. J Clin Pharmacol. 2022 Jun;62(6):777-782. PubMed PMID: 34921684
• Bennett CL, Ogele E, Pettit NR, Bischof JJ, Meng T, Govindarajan P, Camargo CA Jr, Nordenholz K, Kline JA. Multicenter Study of Outcomes Among Persons With HIV Who Presented to US Emergency Departments With Suspected SARS-CoV-2. J Acquir Immune Defic Syndr. 2021 Dec 1;88(4):406-413. PubMed PMID: 34483295
• Kline JA, Adler DH, Alanis N, Bledsoe JR, Courtney DM, d'Etienne JP, Diercks DB, Garrett JS, Jones AE, Mackenzie DC, Madsen T, Matuskowitz AJ, Mumma BE, Nordenholz KE, Pagenhardt J, Runyon MS, Stubblefield WB, Willoughby CB. Monotherapy Anticoagulation to Expedite Home Treatment of Patients Diagnosed With Venous Thromboembolism in the Emergency Department: A Pragmatic Effectiveness Trial. Circ Cardiovasc Qual Outcomes. 2021 Jul;14(7):e007600. PubMed PMID: 34148351
• Kline JA, Camargo CA Jr, Courtney DM, Kabrhel C, Nordenholz KE, Aufderheide T, Baugh JJ, Beiser DG, Bennett CL, Bledsoe J, Castillo E, Chisolm-Straker M, Goldberg EM, House H, House S, Jang T, Lim SC, Madsen TE, McCarthy DM, Meltzer A, Moore S, Newgard C, Pagenhardt J, Pettit KL, Pulia MS, Puskarich MA, Southerland LT, Sparks S, Turner-Lawrence D, Vrablik M, Wang A, Weekes AJ, Westafer L, Wilburn J. Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021. PLoS One. 2021;16(3):e0248438. PubMed PMID: 33690722

Professional Memberships

• American College of Emergency Physicians (ACEP) , Fellow
• Society of Emergency Medicine , Member
• International Society of Thrombosis and Haemostasis, Member

Practice Locations

• University of Colorado Hospital

Specialty Information

• Emergency Medicine, Board Certification
• IHQSE, Certificate (2014)

• Emergency Care