Monika Dzieciatkowska, PhD

Publications

• Cendali FI, Lisk C, Dzieciatkowska M, LaCroix IS, Reisz JA, Harral J, Stephenson D, Hay AM, Wartchow EP, Darehshouri A, Dziewulska-Cronk KH, Buehler PW, Norris PJ, Deng X, Busch MP, Earley EJ, Page GP, Hansen KC, Zimring JC, Irwin DC, Nemkov T, D'Alessandro A. Increased exercise tolerance in humanized G6PD-deficient mice. Blood Adv. 2025 Jan 28;9(2):321-334. PubMed PMID: 39514761
• Reitsma SE, Barsoum JR, Hansen KC, Sassin AM, Dzieciatkowska M, James AH, Aagaard KM, Ahmadzia HK, Wolberg AS. Agnostic identification of plasma biomarkers for postpartum hemorrhage risk. Am J Obstet Gynecol. 2025 Feb;232(2):220.e1-220.e18. PubMed PMID: 38710264
• Key AM, Earley EJ, Tzounakas VL, Anastasiadi AT, Nemkov T, Stephenson D, Dzieciatkowska M, Reisz JA, Keele GR, Deng X, Stone M, Kleinman S, Hansen KC, Norris PJ, Busch MP, Roubinian NH, Page GP, D'Alessandro A. Red blood cell urate levels are linked to hemolysis in vitro and post-transfusion as a function of donor sex, population and genetic polymorphisms in SLC2A9 and ABCG2. Transfusion. 2025 Jan 19. [Epub ahead of print] PubMed PMID: 39828898
• Kheyfets VO, Sweatt AJ, Zhang H, Nemkov T, Heerdt P, Dzieciatkowska M, Stephenson D, LaCroix IS, D'Alessandro A, Oldham WM, Hansen K, Zamanian RT, Stenmark KR. Identification of candidate biomarkers and molecular networks associated with Pulmonary Arterial Hypertension using machine learning and plasma multi-Omics analysis. medRxiv. 2024 Dec 20. PubMed PMID: 39763543
• Ruperti F, Dzieciatkowska M, Pankey MS, Asensio CS, Anselmetti D, Fernàndez-Busquets X, Nichols SA. Proteomic analysis of the sponge Aggregation Factor implicates an ancient toolkit for allorecognition and adhesion in animals. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2409125121. PubMed PMID: 39693348
• D'Alessandro A, Keele GR, Hay AM, Nemkov T, Earley EJ, Stephenson D, Vincent M, Deng X, Stone M, Dzieciatkowska M, Hansen KC, Kleinman SH, Spitalnik SL, Roubinian NH, Norris PJ, Busch MP, Page GP, Stockwell B, Churchill GA, Zimring JC. Ferroptosis regulates hemolysis in stored murine and human red blood cells. Blood. 2024 Nov 14. [Epub ahead of print] PubMed PMID: 39541586
• Nemkov T, Cendali F, Dzieciatkowska M, Stephenson D, Hansen KC, Jankowski CM, D'Alessandro A, Marker RJ. A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series. Pathophysiology. 2024 Mar 20;31(1):166-182. PubMed PMID: 38535623
• D'Alessandro A, Le K, Lundt M, Li Q, Dunkelberger EB, Cellmer T, Worth AJ, Patil S, Huston C, Grier A, Dzieciatkowska M, Stephenson D, Eaton WA, Thein SL. Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease. Haematologica. 2024 Aug 1;109(8):2639-2652. PubMed PMID: 38450513
• Nemkov T, Key A, Stephenson D, Earley EJ, Keele GR, Hay A, Amireault P, Casimir M, Dussiot M, Dzieciatkowska M, Reisz JA, Deng X, Stone M, Kleinman S, Spitalnik SL, Hansen KC, Norris PJ, Churchill GA, Busch MP, Roubinian N, Page GP, Zimring JC, Arduini A, D'Alessandro A. Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro. Blood. 2024 Jun 13;143(24):2517-2533. PubMed PMID: 38513237
• LaCroix IS, Moore EE, Cralley A, Cendali FI, Dzieciatkowska M, Hom P, Mitra S, Cohen M, Silliman C, Hansen KC, D'Alessandro A. Multiomics Signatures of Coagulopathy in a Polytrauma Swine Model Contrasted with Severe Multisystem Injured Patients. J Proteome Res. 2024 Apr 5;23(4):1163-1173. PubMed PMID: 38386921
• Eberhart T, Stanley FU, Ricci L, Chirico T, Ferrarese R, Sisti S, Scagliola A, Baj A, Badurek S, Sommer A, Culp-Hill R, Dzieciatkowska M, Shokry E, Sumpton D, D'Alessandro A, Clementi N, Mancini N, Cardaci S. ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota. Cell Death Dis. 2024 Feb 1;15(2):105. PubMed PMID: 38302438
• Freire CM, King NR, Dzieciatkowska M, Stephenson D, Moura PL, Dobbe JGG, Streekstra GJ, D'Alessandro A, Toye AM, Satchwell TJ. Complete absence of GLUT1 does not impair human terminal erythroid differentiation. bioRxiv. 2024 Jan 15. PubMed PMID: 38293086
• Nemkov T, Stephenson D, Earley EJ, Keele GR, Hay A, Key A, Haiman Z, Erickson C, Dzieciatkowska M, Reisz JA, Moore A, Stone M, Deng X, Kleinman S, Spitalnik SL, Hod EA, Hudson KE, Hansen KC, Palsson BO, Churchill GA, Roubinian N, Norris PJ, Busch MP, Zimring JC, Page GP, D'Alessandro A. Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes. bioRxiv. 2024 Jun 11. PubMed PMID: 38260479
• D'Alessandro A, Earley EJ, Nemkov T, Stephenson D, Dzieciatkowska M, Hansen KC, Minetti G, Champigneulle B, Stauffer E, Pichon A, Furian M, Verges S, Kleinman S, Norris PJ, Busch MP, Page GP, Kaestner L. Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2315930120. PubMed PMID: 38147558
• Nemkov T, Stephenson D, Erickson C, Dzieciatkowska M, Key A, Moore A, Earley EJ, Page GP, Lacroix IS, Stone M, Deng X, Raife T, Kleinman S, Zimring JC, Roubinian N, Hansen KC, Busch MP, Norris PJ, D'Alessandro A. Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo. Blood. 2024 Feb 1;143(5):456-472. PubMed PMID: 37976448
• Reisz JA, Earley EJ, Nemkov T, Key A, Stephenson D, Keele GR, Dzieciatkowska M, Spitalnik SL, Hod EA, Kleinman S, Roubinian NH, Gladwin MT, Hansen KC, Norris PJ, Busch MP, Zimring JC, Churchill GA, Page GP, D'Alessandro A. Arginine metabolism is a biomarker of red blood cell and human aging. Aging Cell. 2024 Oct 30;:e14388. [Epub ahead of print] PubMed PMID: 39478346
• Ionescu RB, Nicaise AM, Reisz JA, Williams EC, Prasad P, Willis CM, Simões-Abade MBC, Sbarro L, Dzieciatkowska M, Stephenson D, Suarez Cubero M, Rizzi S, Pirvan L, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D'Alessandro A, Pluchino S. Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis. Cell Stem Cell. 2024 Nov 7;31(11):1574-1590.e11. PubMed PMID: 39437792
• Benson TM, Markey GE, Hammer JA, Simerly L, Dzieciatkowska M, Jordan KR, Capocelli KE, Scullion KM, Crowe L, Ryan S, Black JO, Crue T, Andrews R, Burger C, McNamee EN, Furuta GT, Menard-Katcher C, Masterson JC. CSF1-dependent macrophage support matrisome and epithelial stress-induced keratin remodeling in Eosinophilic esophagitis. Mucosal Immunol. 2024 Sep 27. [Epub ahead of print] PubMed PMID: 39343055
• Peltier S, Marin M, Dzieciatkowska M, Dussiot M, Roy MK, Bruce J, Leblanc L, Hadjou Y, Georgeault S, Fricot A, Roussel C, Stephenson D, Casimir M, Sissoko A, Paye F, Dokmak S, Ndour PA, Roingeard P, Gautier EF, Spitalnik SL, Hermine O, Buffet PA, D'Alessandro A, Amireault P. Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance. bioRxiv. 2024 Sep 12. PubMed PMID: 39314353
• Pak HH, Grossberg AN, Sanderfoot RR, Babygirija R, Green CL, Koller M, Dzieciatkowska M, Paredes DA, Lamming DW. Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions. Cell Rep. 2024 Sep 24;43(9):114663. PubMed PMID: 39167490
• Zimring JC, Hay AM, Dzieciatkowska M, D'Alessandro A. Molecular communication between red blood cells of different phenotypes during blood storage in mice. Transfusion. 2024 Sep;64(9):1762-1771. PubMed PMID: 39095932
• Keele GR, Hay AM, Holness NK, Jash A, Ewald SE, O'Connor C, Vincent M, Dzieciatkowska M, D'Alessandro A, Churchill GA, Zimring JC. Co-transfection of murine NXPE2 and murine glycophorin A confers reactivity with Ter-119. Haematologica. 2024 Nov 1;109(11):3755-3759. PubMed PMID: 39021224
• Nemkov T, Stephenson D, Earley EJ, Keele GR, Hay A, Key A, Haiman ZB, Erickson C, Dzieciatkowska M, Reisz JA, Moore A, Stone M, Deng X, Kleinman S, Spitalnik SL, Hod EA, Hudson KE, Hansen KC, Palsson BO, Churchill GA, Roubinian N, Norris PJ, Busch MP, Zimring JC, Page GP, D'Alessandro A. Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes. Cell Metab. 2024 Sep 3;36(9):1979-1997.e13. PubMed PMID: 38964323
• Martins Freire C, King NR, Dzieciatkowska M, Stephenson D, Moura PL, Dobbe JGG, Streekstra GJ, D'Alessandro A, Toye AM, Satchwell TJ. Complete absence of GLUT1 does not impair human terminal erythroid differentiation. Blood Adv. 2024 Oct 8;8(19):5166-5178. PubMed PMID: 38916993
• D'Alessandro A, Keele GR, Hay A, Nemkov T, Earley EJ, Stephenson D, Vincent M, Deng X, Stone M, Dzieciatkowska M, Hansen KC, Kleinman S, Spitalnik SL, Roubinian NH, Norris PJ, Busch MP, Page GP, Stockwell BR, Churchill GA, Zimring JC. Ferroptosis regulates hemolysis in stored murine and human red blood cells. bioRxiv. 2024 Jun 11. PubMed PMID: 38915523
• Moon SJ, Hu Y, Dzieciatkowska M, Kim AR, Chen PL, Asara JM, D'Alessandro A, Perrimon N. Identification of high sugar diet-induced dysregulated metabolic pathways in muscle using tissue-specific metabolic models in Drosophila. bioRxiv. 2024 Apr 28. PubMed PMID: 38712132
• Nanaware PP, Khan ZN, Clement CC, Shetty M, Mota I, Seltzer ES, Dzieciatkowska M, Gamboni F, D'Alessandro A, Ng C, Nagayama M, Lichti CF, Soni RK, Jacob B Geri, Matei I, Lyden D, Longman R, Lu TT, Wan X, Unanue ER, Stern LJ, Santambrogio L. Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load. Cell Rep. 2024 Jun 25;43(6):114311. PubMed PMID: 38848214
• Setua S, Thangaraju K, Dzieciatkowska M, Wilkerson RB, Nemkov T, Lamb DR, Tagaya Y, Boyer T, Rowden T, Doctor A, D'Alessandro A, Buehler PW. Coagulation potential and the integrated omics of extracellular vesicles from COVID-19 positive patient plasma. Sci Rep. 2022 Dec 23;12(1):22191. PubMed PMID: 36564503
• Recktenwald SM, Simionato G, Lopes MGM, Gamboni F, Dzieciatkowska M, Meybohm P, Zacharowski K, von Knethen A, Wagner C, Kaestner L, D'Alessandro A, Quint S. Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19. Elife. 2022 Dec 20;11. PubMed PMID: 36537079
• Hay AM, Nemkov T, Gamboni F, Dzieciatkowska M, Key A, Galbraith M, Bartsch K, Sun K, Xia Y, Stone M, Busch MP, Norris PJ, Zimring JC, D'Alessandro A. S1P has a negative effect on RBC storage quality. Blood Adv. 2022 Dec 5. [Epub ahead of print] PubMed PMID: 36469038
• LaCroix IS, Cohen M, Moore EE, Dzieciatkowska M, Nemkov T, Schaid TR Jr, Debot M, Jones K, Silliman CC, Hansen KC, D'Alessandro A. Omics Markers of Red Blood Cell Transfusion in Trauma. Int J Mol Sci. 2022 Nov 10;23(22). PubMed PMID: 36430297
• Schaid TR Jr, Cohen MJ, D'Alessandro A, Silliman CC, Moore EE, Sauaia A, Dzieciatkowska M, Hallas W, Thielen O, DeBot M, Cralley A, LaCroix I, Erickson C, Mitra S, Banerjee A, Jones K, Hansen KC. Trauma Induces Intravascular Hemolysis, Exacerbated by RBC Transfusion and Associated with Disrupted Arginine-Nitric Oxide Metabolism. Shock. 2022 Nov 16. [Epub ahead of print] PubMed PMID: 36378232
• Schafer JB, Lucas ED, Dzieciatkowska M, Forward T, Tamburini BAJ. Programmed death ligand 1 intracellular interactions with STAT3 and focal adhesion protein Paxillin facilitate lymphatic endothelial cell remodeling. J Biol Chem. 2022 Dec;298(12):102694. PubMed PMID: 36375639
• Jacob C, Kitagawa A, Signoretti C, Dzieciatkowska M, D'Alessandro A, Gupte A, Hossain S, D'Addario CA, Gupte R, Gupte SA. Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension. J Biol Chem. 2022 Dec;298(12):102691. PubMed PMID: 36372233
• Liao Y, Luo Z, Lin Y, Chen H, Chen T, Xu L, Orgurek S, Berry K, Dzieciatkowska M, Reisz JA, D'Alessandro A, Zhou W, Lu QR. PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death Dis. 2022 Nov 9;13(11):943. PubMed PMID: 36351894
• Hay A, Dziewulska K, Gamboni F, Nerguizian D, Dzieciatkowska M, Zimring JC, D'Alessandro A. Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries. Blood Transfus. 2022 Oct 21. [Epub ahead of print] PubMed PMID: 36346885
• Bai X, Bai A, Tomasicchio M, Hagman JR, Buckle AM, Gupta A, Kadiyala V, Bevers S, Serban KA, Kim K, Feng Z, Spendier K, Hagen G, Fornis L, Griffith DE, Dzieciatkowska M, Sandhaus RA, Gerber AN, Chan ED. a1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages. J Immunol. 2022 Nov 1;209(9):1746-1759. PubMed PMID: 36162872
• Monks J, Orlicky DJ, Libby AE, Dzieciatkowska M, Ladinsky MS, McManaman JL. Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland. Front Cell Dev Biol. 2022;10:958566. PubMed PMID: 36158190
• Wang RM, Mesfin JM, Hunter J, Cattaneo P, Guimarães-Camboa N, Braden RL, Luo C, Hill RC, Dzieciatkowska M, Hansen KC, Evans S, Christman KL. Myocardial matrix hydrogel acts as a reactive oxygen species scavenger and supports a proliferative microenvironment for cardiomyocytes. Acta Biomater. 2022 Oct 15;152:47-59. PubMed PMID: 36041648
• Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14;27(14). PubMed PMID: 35889366
• McClary WD, Catala A, Zhang W, Gamboni F, Dzieciatkowska M, Sidhu SS, D'Alessandro A, Catalano CE. A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells. ACS Chem Biol. 2022 Jul 15;17(7):1853-1865. PubMed PMID: 35796308
• Anastasiadi AT, Tzounakas VL, Dzieciatkowska M, Arvaniti VZ, Papageorgiou EG, Papassideri IS, Stamoulis K, D'Alessandro A, Kriebardis AG, Antonelou MH. Innate Variability in Physiological and Omics Aspects of the Beta Thalassemia Trait-Specific Donor Variation Effects. Front Physiol. 2022;13:907444. PubMed PMID: 35755442
• Rabcuka J, Blonski S, Meli A, Sowemimo-Coker S, Zaremba D, Stephenson D, Dzieciatkowska M, Nerguizian D, Cardigan R, Korczyk PM, Smethurst PA, D'Alessandro A, Swietach P. Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells. Blood Adv. 2022 Sep 27;6(18):5415-5428. PubMed PMID: 35736672
• Moriconi C, Dzieciatkowska M, Roy M, D'Alessandro A, Roingeard P, Lee JY, Gibb DR, Tredicine M, McGill MA, Qiu A, La Carpia F, Francis RO, Hod EA, Thomas T, Picard M, Akpan IJ, Luckey CJ, Zimring JC, Spitalnik SL, Hudson KE. Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. Br J Haematol. 2022 Aug;198(3):574-586. PubMed PMID: 35670632
• Song A, Wen AQ, Wen YE, Dzieciatkowska M, Kellems RE, Juneja HS, D'Alessandro A, Xia Y. p97 dysfunction underlies a loss of quality control of damaged membrane proteins and promotes oxidative stress and sickling in sickle cell disease. FASEB J. 2022 May;36(5):e22246. PubMed PMID: 35405035
• Giordano AMS, Luciani M, Gatto F, Abou Alezz M, Beghè C, Della Volpe L, Migliara A, Valsoni S, Genua M, Dzieciatkowska M, Frati G, Tahraoui-Bories J, Giliani SC, Orcesi S, Fazzi E, Ostuni R, D'Alessandro A, Di Micco R, Merelli I, Lombardo A, Reijns MAM, Gromak N, Gritti A, Kajaste-Rudnitski A. DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes. J Exp Med. 2022 Apr 4;219(4). PubMed PMID: 35262626
• Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JM. Specialized interferon action in COVID-19. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11). PubMed PMID: 35217532
• Nemkov T, Kingsley PD, Dzieciatkowska M, Malik J, McGrath KE, Hansen KC, D'Alessandro A, Palis J. Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation. Blood Adv. 2022 May 24;6(10):3072-3089. PubMed PMID: 35139174
• Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, Xie T, Abdulmalik O, Song A, Tong C, Qi H, Roach R, Kellems RE, D'Alessandro A, Xia Y. Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis. Cell Metab. 2022 Feb 1;34(2):299-316.e6. PubMed PMID: 35108516
• Morton AP, Hadley JB, Ghasabyan A, Kelher MR, Moore EE, Bevers S, Dzieciatkowska M, Hansen KC, Cohen MS, Banerjee A, Silliman CC. The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro. J Trauma Acute Care Surg. 2022 Jan 1;92(1):159-166. PubMed PMID: 34538821
• Tzounakas VL, Anastasiadi AT, Stefanoni D, Cendali F, Bertolone L, Gamboni F, Dzieciatkowska M, Rousakis P, Vergaki A, Soulakis V, Tsitsilonis OE, Stamoulis K, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH. Beta thalassemia minor is a beneficial determinant of red blood cell storage lesion. Haematologica. 2022 Jan 1;107(1):112-125. PubMed PMID: 33730845
• Tzounakas VL, Dzieciatkowska M, Anastasiadi AT, Karadimas DG, Vergaki A, Siourounis P, Stamoulis K, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH. Red cell proteasome modulation by storage, redox metabolism and transfusion. Blood Transfus. 2022 Jan;20(1):27-39. PubMed PMID: 33263521